Recent reports in Science and Medicine for August 2003

Some of these links are very transient and may expire within days of posting. Some may require prior registration. Check-in and view frequently to avoid missing great news items. I welcome any suggested articles. (email link). "§" indicates a faculty recommended article.

August 29

1. Molecules discovered that extend life in yeast, human cells: Group of compounds found in red wine, vegetables simulate benefit of low-calorie diet [Eurekalert news and Science Daily] Report in Nature AOP, published online 24 August 2003; doi:10.1038/nature01960 .
2. Medscape Expert Column: New Perspectives on the Quality of Care: Reducing Medical Errors Through Cultural Change and Clinical Transformation August 25, 2003
3. FDA approves Anakinra (Kineret) for the reduction in signs and symptoms and slowing the progression of structural damage in moderately to severely active rheumatoid arthritis, in patients 18 years of age or older who have failed one or more disease modifying antirheumatic drugs.  August 25, 2003.
4. FDA Approves New Drug for Treatment of Erectile Dysfunction in Men [FDA Talk Paper]
5. The Electronic Medical Record: Promises and Pitfalls [Medscape General Medicine] Jacob Reider, MD
6. Cancer Genetics Program pinpoints gene that increases cancer risk by 26 percent [Eurekalert report] of in process citation TGFBR1 *6A and Cancer Risk: A Meta-Analysis of Seven Case-Control Studies. Kaklamani VG, et al. JCO Sep 1 2003: 3236-3243.

Weekend Reading

1. Dissecting the Helicobacter arsenal (The Scientist news) Helicobacter pylori Vacuolating Cytotoxin Inhibits T Lymphocyte Activation. Gebert B, et al.Science 2003; 301:1099-1102.
2. Smaller Food Portions May Explain The 'French Paradox' Of Rich Foods And A Svelte Population [Science Daily and U Penn report]. Article in Psychological Science Sept.9subscribers)
3. ACTN3 Genotype Is Associated with Human Elite Athletic Performance. Yang N, et al.American Journal of Human Genetics 2003; 73: 627. (news report in New Scientist: Gene variant linked to athletic performance )

August 28

This Week in JAMA  2003;290:989.

1. Efficacy of Sertraline in the Treatment of Children and Adolescents With Major Depressive Disorder: Two Randomized Controlled Trials. Wagner et al. JAMA. 2003;290:1033-1041.
2. Ultralow-Dose Micronized 17 -Estradiol and Bone Density and Bone Metabolism in Older Women: A Randomized Controlled Trial. Prestwood et al. JAMA. 2003;290:1042-1048.
3. A Risk Score for Predicting Stroke or Death in Individuals With New-Onset Atrial Fibrillation in the Community: The Framingham Heart Study. Wang et al. JAMA. 2003;290:1049-1056.
4. Provision of Pneumococcal Prophylaxis for Publicly Insured Children With Sickle Cell Disease.Sox, et al. JAMA. 2003;290:1057-1061.
5. Methodological Differences in Clinical Trials Evaluating Nonpharmacological and Pharmacological Treatments of Hip and Knee Osteoarthritis. Boutron, et al. JAMA. 2003;290:1062-1070.
6. BRIEF REPORTS: D-Dimer Levels and Risk of Recurrent Venous Thromboembolism Eichinger, et al. JAMA. 2003;290:1071-1074.
7. SPECIAL COMMUNICATIONS Ethics of Phase 1 Oncology Studies: Reexamining the Arguments and Data. Agrawal and Emanuel. JAMA. 2003;290:1075-1082.
8. CONTEMPO UPDATES: Update on Genital Lesions. Ted Rosen JAMA. 2003;290:1001-1005.
9. CLINICAL CROSSROADS A 41-Year-Old Woman With Chronic Myelogenous Leukemia Joseph H. Antin JAMA. 2003;290:1083-1090.
10. EDITORIALS Psychopharmacological Treatment of Major Depressive Disorder in Children and Adolescents Christopher K. Varley JAMA. 2003;290:1091-1093.
11. Stroke Prevention in Atrial Fibrillation. Albert L. Waldo. JAMA. 2003;290:1093-1095.

August 27

1. Prognostic Value of Cardiac Risk Factors and Coronary Artery Calcium Screening for All-Cause Mortality Shaw LJ, et al. Radiology published online July 17, 2003, in September issue. [Coronary artery calcium can be a warning sign of fatal cardiac event Eurekalert]
2. Differences in Medical Care and Disease Outcomes Among Black and White Women With Heart Disease Jha AK, et al. Circulation 2003: published online before print August 25, 2003, 10.1161/01
3. Randomized Clinical Trial of Therapeutic Exercise in Subacute Stroke. Duncan P, et al. Stroke published August 18, 2003, 10.1161/01
4. Impact of Viral and Bacterial Burden on Cognitive Impairment in Elderly Persons With Cardiovascular Diseases. Strandberg TE, et al.Stroke published online August 14, 2003.
5. Inhibition of Clinical Benefits of Aspirin on First Myocardial Infarction by Nonsteroidal Antiinflammatory Drugs Kurth T, et al. Circulation 2003: published online August 25, 2003, 10.1161/01.
6. Mayo Clinic proceedings releases West Nile virus manuscript early [pdf of manuscript: West Nile Virus: Epidemiology, Clinical Presentation, Diagnosis and Prevention]
7. St. Jude Medical announces publication of results of its ADOPT-A trial [Eurekalert news] JACC
8. Prognostic Value of PET Using 18 F-FDG in Hodgkin’s Disease for Posttreatment Evaluation Guay C, et al. J Nucl Med 2003 44: 1225-1231.

August 26

This Week in JAMA: JAMA. 2003;290:853.

1. Major Risk Factors as Antecedents of Fatal and Nonfatal Coronary Heart Disease Events. Greenland P, et al. JAMA. 2003;290:891-897.
2. Prevalence of Conventional Risk Factors in Patients With Coronary Heart Disease Khot UN, et al. JAMA. 2003;290:898-904.
3. Pediatric Drug Labeling: Improving the Safety and Efficacy of Pediatric Therapies. JAMA. 2003;290:905-911.
4. Effect of a High-Fat Ketogenic Diet on Plasma Levels of Lipids, Lipoproteins, and Apolipoproteins in Children JAMA. 2003;290:912-920.
5. Association of Funding and Conclusions in Randomized Drug Trials: A Reflection of Treatment Effect or Adverse Events? Als-Nielsen B, et al. JAMA. 2003;290:921-928.
6. Emerging Risk Factors for Atherosclerotic Vascular Disease: A Critical Review of the Evidence. Hackam and Anand JAMA. 2003;290:932-940.
7. Association Between BRCA1 Mutations and Ratio of Female to Male Births in Offspring of Families With Breast Cancer, Ovarian Cancer, or Both. de la Hoya M, et al. JAMA. 2003;290:929-931.
8. SPECIAL COMMUNICATIONS Physician Discontent: Challenges and Opportunities David Mechanic JAMA. 2003;290:941-946.
9. EDITORIALS: Major Risk Factors for Cardiovascular Disease: Debunking the "Only 50%" Myth. Canto and. Iskandrian JAMA. 2003;290:947-949.
10. THE PATIENT-PHYSICIAN RELATIONSHIP Patient-Physician Communication About Out-of-Pocket Costs. JAMA. 2003;290:953-958.

August 25

The New England Journal of Medicine Volume 349, Issue 8: August 21, 2003

1. A Comparison of Coronary Angioplasty with Fibrinolytic Therapy in Acute Myocardial Infarction. H. R. Andersen and Others.N Engl J Med 2003: 349: 733
2. Effect of Priming with Granulocyte Colony-Stimulating Factor on the Outcome of Chemotherapy for Acute Myeloid Leukemia. B. Löwenberg and Others N Engl J Med 2003: 349: 743
3. A Chorionic Gonadotropin–Sensitive Mutation in the Follicle-Stimulating Hormone Receptor as a Cause of Familial Gestational Spontaneous Ovarian Hyperstimulation Syndrome
   C. Vasseur and Others. N Engl J Med 2003: 349: 753
4. Ovarian Hyperstimulation Syndrome Due to a Mutation in the Follicle-Stimulating Hormone Receptor. G. Smits and Others. N Engl J Med 2003: 349: 760
5. Costs of Health Care Administration in the United States and Canada. S. Woolhandler, T. Campbell, and D. U. Himmelstein. N Engl J Med 2003: 349: 768
6. Medical Progress: Congenital Adrenal Hyperplasia. P. W. Speiser and P. C. White. N Engl J Med 2003: 349:776
7. Review: Hematopoietic Growth Factors and the Future of Therapeutic Research on Acute Myeloid Leukemia C. A. Schiffer. N Engl J Med 2003: 349: 727
8. The Pathogenesis of the Ovarian Hyperstimulation Syndrome. N Engl J Med 2003: 349: 729
9. Primary Angioplasty for Acute Myocardial Infarction — Is It Worth the Wait? A. K. Jacobs, N Engl J Med 2003: 349: 798
10. The Costs of Health Care Administration in the United States and Canada — Questionable Answers to a Questionable Question. H. J. Aaron. N Engl J Med 2003: 349: 801

August 22

1. NMEs Approved in Calendar Year 2003 to date (FDA news)
2. Different patterns of N-acetylaspartate loss in subcortical ischemic vascular dementia and AD Schuff N, et al. Neurology 2003 61: 358-364.
3. Toxic Protein Could Explain Alzheimer's And Lead To Breakthroughs { Eurekalert news} Alzheimer's disease-affected brain: Presence of oligomeric A ligands (ADDLs) suggests a molecular basis for reversible memory loss Gong Y, et al. PNAS published August 18, 2003
4. New Alzheimer projections add urgency to search for prevention, cure [Eurekalert news] Alzheimer Disease in the US Population: Prevalence Estimates Using the 2000 Census. Hebert LE, et al. Arch Neurol. 2003;60:1119-1122.

Weekend Reading

1. Researchers One Step Closer To Holy Grail Of Neurobiology (Science Daily) from PNAS
2. Promising West Nile virus vaccine protects monkeys {Eurekalert announcement]
3. Progress on Lou Gehrig's Disease, Science review (open access)
4. Antibiotic ban cuts drug resistant bugs [NewScientist news] from reort in the WHO Bulletin
5. Gastric Versus Post-Pyloric Feeding: A Systematic Review [Medscape review of Critical Care 2003;7:

August 21

1. Randomized trial of the adenosine A 2A receptor antagonist istradefylline in advanced PD Hauser RA, et al. Neurology 2003 61: 297-303. [Science Daily news report: Study Shows New Drug Reduces Advanced Parkinson's Disease Symptoms ]
2. FDA Approves New Drug for Treatment of Erectile Dysfunction in Men : FDA News August 19, 2003.
3. Symptoms of Rhinosinusitis in Patients With Unexplained Chronic Fatigue or Bodily Pain: A Pilot Study. Chester AC. Arch Intern Med. 2003;163:1832-1836.
4. New Prevalence Study Suggests Dramatically Rising Numbers Of People With Alzheimer’s Disease [Science Daily news adapted from a news release issued by NIH/National Institute On Aging].
5. Annals of Internal Medicine 19 August 2003 Volume 139 Issue 4:
   • Articles 
     • The Effect of Endoscopic Therapy in Patients Receiving Omeprazole for Bleeding Ulcers with Nonbleeding Visible Vessels or Adherent Clots: A Randomized Comparison
     • Progression of Chronic Kidney Disease: The Role of Blood Pressure Control, Proteinuria, and Angiotensin-Converting Enzyme Inhibition: A Patient-Level Meta-Analysis
     • Obesity: Associations with Acute Mountain Sickness
     • Short-Term Effects of Cannabinoids in Patients with HIV-1 Infection: A Randomized, Placebo-Controlled Clinical Trial
   • Patient Safety and Medical Malpractice: A Case Study
   • Academia and Clinic : Evaluation of Abnormal Mammography Results and Palpable Breast Abnormalities
   • Update in General Internal Medicine

August 20

1. Regression of Electrocardiographic Left Ventricular Hypertrophy by Losartan Versus Atenolol: The Losartan Intervention For Endpoint Reduction in Hypertension (LIFE) Study. Okin PM, et al. Circulation 2003 108: 684 - 690.
2. Disruption of Leptin Signaling Contributes to Cardiac Hypertrophy Independently of Body Weight in Mice.Barouch LA, et al.Circulation. 2003;108:754 . [Editorial: Leptin
   A Novel Link Between Obesity, Diabetes, Cardiovascular Risk, and Ventricular Hypertrophy. Sawsan Sader Circulation. 2003;108:644. ]
3. Subtype-Selective Antagonists of Lysophosphatidic Acid Receptors Inhibit Platelet Activation Triggered by the Lipid Core of Atherosclerotic Plaques. RotherE, et al.Circulation. 2003;108:741 [Editorial: Plaque Rupture, Lysophosphatidic Acid, and Thrombosis. A. Spector Circulation. 2003;108:641 ]
4. Delaying Decline in Pulmonary Function with Physical Activity: A 25-Year Follow-up Pelkonen M, et al. Am. J. Respir. Crit. Care Med. 2003; 168: 494-499.
5. Snoring, Intermittent Hypoxia and Academic Performance in Primary School Children Urschitz MS, et al. Am. J. Respir. Crit. Care Med. 2003; 168: 464-468
6. Nonsteroidal Anti-inflammatory Drugs and the Risk of Parkinson Disease Chen H, et al. Arch Neurol. 2003;60:1059-1064. and EDITORIAL: Nonsteroidal Anti-inflammatory Drugs Protect Against Parkinson Neurodegeneration: Can an NSAID a Day Keep Parkinson Disease Away? Arch Neurol. 2003;60:1043-1044.

August 19

1. A self-administered screener for migraine in primary care: The ID Migraine TM validation study Lipton RB, et al. Neurology 2003 61: 375-382
2. Lancet Volume 362, Number 9383   16 August 2003 .
   • Long-term effect of a watch and wait policy versus immediate systemic treatment for asymptomatic advanced-stage non-Hodgkin lymphoma: a randomised controlled trial. Ardeshna K M et al. Lancet 2003: 362:
   • Incidence of recurrent venous thromboembolism in relation to clinical and thrombophilic risk factors: prospective cohort study. Baglin T, et al.Lancet 2003; 362: 523-26
   • Role of HER2 in wound-induced breast carcinoma proliferation. Tagliabue E, et al.
3. Diabetes and Driving Mishaps: Frequency and correlations from a multinational survey. Cox DJ, et al. Diabetes Care 2003 26: 2329-2334 [Medscape review]
4. Impact of Aerobic Exercise Training on Age-Related Changes in Insulin Sensitivity and Muscle Oxidative Capacity Short KR, et al.Diabetes 2003 52: 1888-1896. [Eurekalert news: study finds people over 40 need frequent exercise to prevent or treat Type 2 diabetes ]

August 18

1. A Little Bit Longer. Spiro,D. JAMA2003; 290 (6): 716
2. This week's New England Journal of Medicine: Volume 349, Issue 7: August 14, 2003
   • Perspective: Childhood Leukemia -- Successes and Challenges for Survivors. J.V. Simone
   • Perspective: Trial Design and Patient Safety -- The Debate Continues. R. Steinbrook
   • Comparison of Low-Intensity Warfarin Therapy with Conventional-Intensity Warfarin Therapy for Long-Term Prevention of Recurrent Venous Thromboembolism. C. Kearon and Others. N Engl J Med 2003;349: 361- 369 :
   • Care of Patients Receiving Long-Term Anticoagulant Therapy. S. Schulman N Engl J Med 349: 675-683
   • Buller, H. R., Prins, M. H. (2003). Secondary Prophylaxis with Warfarin for Venous Thromboembolism. N Engl J Med 349: 702-704
   • Extended Follow-up of Long-Term Survivors of Childhood Acute Lymphoblastic Leukemia.C.-H. Pui and Others
   • Methotrexate versus Cyclosporine in Moderate-to-Severe Chronic Plaque Psoriasis. V.M.R. Heydendael and Others
   • Current Concepts: Acute Cardiac Tamponade. D.H. Spodick

August 15

1. Review of the Centers for Disease Control and Prevention's Smallpox Vaccination Program Implementation, Letter Report from Institute of Medicine Published On: August 12, 2003
2. West Nile Virus's milder cousin provides vaccine hope Proceedings of the National Academy of Sciences (DOI: 10.1073/pnas.1834270100) [New Scientist news]
3. FDA approved statin Crestor from AstraZeneca - August 12, 2003.

Weekend Reading

1. This week in Science Volume 301, Number 5634, Issue of 8 August 2003 : (subscribers)
   • §Retrograde Viral Delivery of IGF-1 Prolongs Survival in a Mouse ALS Model. Kaspar BK, et al. Scinece 2003; 301: (subscribers and Science news release ). Gene therapy delays death in mouse with symptoms of Lou Gehrig's disease (Eurekalert news report). Gene Therapy Delays Death In Mouse With Symptoms Of Lou Gehrig's Disease (Science Daily news)
   • Creation Of New Neurons Critical To Antidepressant Action In Mice (Science Daily news)
2. From Cell
   • Phosphatidylinositol 4 Phosphate Regulates Targeting of Clathrin Adaptor AP-1 Complexes to the Golgi. Ying JW, et al.Cell, Vol 114, 299-310, 8 August 2003 Main regulator of membrane trafficking not what researchers once thought, scientists discover (UTSWMC news release)
   • Newly Identified Tumor Suppressor Cooperates With P53 To Protect Mice Against Tumors (Science Daily news).
3. Untangling the Brain: Enzyme counters Alzheimer's-like snarls (Science News report)
4. Stanford research shows targeted DNA vaccine may reverse autoimmune disease (Eurekalert news report) in Nature: Biotechnology (subscribers)
5. Scientists Report Why Taste And Smell Differ Among Individuals (Science Daily news) Nature Genetics (subscribers)

August 14

1. Direct Observation of Requests for Clinical Services in Office Practice: What Do Patients Want and Do They Get It? Kravitz, RL , et al. Arch Intern Med.  2003;163:1673-1681.
2. Hypoglycemia as a Predictor of Mortality in Hospitalized Elderly Patients Kagansky N, et al. Arch Intern Med.  2003;163:1825-1829.
3. Quality Assessment of a Collaborative Approach for Decreasing Drug-Related Morbidity and Achieving Therapeutic Goals Isetts BJ, et al. Arch Intern Med.  2003;163:1813-1820.
4. Antioxidant Vitamins C and E Improve Endothelial Function in Children With Hyperlipidemia. Endothelial Assessment of Risk from Lipids in Youth (EARLY) Trial Engler MM, et al. Circulation 2003: published online before print August 11, 2003,
5. Disruption of Leptin Signaling Contributes to Cardiac Hypertrophy Independently of Body Weight in Mice Barouch LA, et al. Circulation 2003 108: 754 - 759
6. This week's JAMA:
   • §Proposal of the Physicians' Working Group for Single-Payer National Health Insurance. The Physicians' Working Group for Single-Payer National Health Insurance. JAMA.  2003;290:798-805. and Editorial: Universal Health Insurance—Let the Debate Resume Fein R. JAMA. 2003;290:818-820. [Medscape interview]
   • Impact of Medicare Coverage on Basic Clinical Services for Previously Uninsured Adults McWilliams JM, et al. JAMA.  2003;290:757-764. and editorial Small Steps or a Giant Leap for the Uninsured? Bindman AB et al. JAMA.  2003;290:816-818.

August 13

1. Lancet Volume 362, Number 9382 ; 09 August 2003
   • Breast cancer and hormone-replacement therapy in the Million Women Study. Beral V, et al. Lancet 2003; 362: 419-27
   • Proteomic patterns of tumour subsets in non-small-cell lung cancer. Yanagisawa K, et al. Lancet 2003; 362: 433-39. [Protein Profile Predicts Prognosis For Lung Cancer - Science news and Eurekalert news]
2. BMJ Volume 327, Issue 7410 ; 09 August 2003
   • Past exposure to sun, skin phenotype, and risk of multiple sclerosis: case-control study. van der Mei IAF, et al. BMJ   2003;327:316 
   • Acute low back pain: systematic review of its prognosis. Pengel LHM, et al.BMJ  2003;327:323
3. Increased Risk of Achilles Tendon Rupture With Quinolone Antibacterial Use, Especially in Elderly Patients Taking Oral Corticosteroids.van der Linden;PD, et al. Arch Intern Med. 2003;163:1801-1807.
4. Platelet/Endothelial Biomarkers in Depressed Patients Treated With the Selective Serotonin Reuptake Inhibitor Sertraline After Acute Coronary Events. The Sertraline AntiDepressant Heart Attack Randomized Trial (SADHART) Platelet Substudy. Serebruany VL,et al. . Circulation 2003: published online before print August 11, 2003.

August 12

1. Anemia and decline in physical performance among older persons Penninx B, et al. A J Med 2003:115:104-110, - (Cardiosource-register) (Science Daily report)
2. A prospective randomized comparison of loop recorders versus Holter monitors in patients with syncope or presyncope Sivakumaran S, et al. A J Med 2003: 115: 1-5
3. Waiting times, revascularization modality, and outcomes after acute myocardial infarction at hospitals with and without on-site revascularization facilities in Canada Alter DA, et al. JACC 2003; 42: 410-419  [Editorial: The early days after ST-segment elevation acute myocardial infarction. pp. 420-423]
4. Percutaneous coronary interventions in octogenarians Sadeghi HM, et al. JACC 2003: 42: 428-432  [Editorial: Percutaneous coronary intervention in octogenarians and the safety of glycoprotein IIb/IIIa inhibitors. pp. 433-436]
5. FDA Approves Axcan's Photofrin Esophagus Therapy (press and FDA news releases)

August 11

In this week's New England Journal of Medicine (Volume 349 August 7, 2003 Number 6)

1. Estrogen plus Progestin and the Risk of Coronary Heart Disease. J. E. Manson et al.
2. Hormone Therapy and the Progression of Coronary-Artery Atherosclerosis in Postmenopausal Women. H. N. Hodis et al.
3. A Randomized Comparison of Sentinel-Node Biopsy with Routine Axillary Dissection in Breast Cancer U. Veronesi et al.
4. Genomic Medicine: Ethical, Legal, and Social Implications of Genomic Medicine. E. W. Clayton
5. Medical Progress: Adult Stem Cells for Tissue Repair — A New Therapeutic Concept? M. Körbling and Z. Estrov
6. Mechanisms of Disease: Molecular Mechanisms of Amyloidosis G. Merlini and V. Bellotti
7. From Presumed Benefit to Potential Harm — Hormone Therapy and Heart Disease D. M. Herrington and T. D. Howard
8. Retrospective: Hormone-Replacement Therapy and Cardiovascular Diseases J. Bailar
9. The Design of Trials Comparing Sentinel-Node Surgery and Axillary Resection. D. Krag and T. Ashikaga

August 8

1. Detection and Verification of Mycobacterium avium subsp. paratuberculosis in Fresh Ileocolonic Mucosal Biopsy Specimens from Individuals with and without Crohn's Disease. Bull TJ, et al. J. Clin. Microbiol. 2003. 41: 2915-2923.
2. REVIEW: Diagnosis of Adrenal Insufficiency.  Dorin I, et al. Ann Intern Med. 2003;139:194–204.
3. Updated Guidelines on the Use of Echocardiography Issued. ACC/AHA Clinical Competence Statement on Echocardiography
4. Health Disparities Experienced by American Indians and Alaska Natives MMWR 2003 / 52(30);697
5. National Institute of Allergy and Infectious Diseases press release: Fast-Acting Ebola Vaccine Protects Monkeys (news report in Nature) (The Scientist news)

Weekend Reading

1. Hepatic lipase expression in macrophages contributes to atherosclerosis in apoE-deficient and LCAT-transgenic mice Nong Z, et al. J. Clin. Invest. 2003 112: 367-378. (The Scientist news Hepatic lipase expression in aortic macrophages contributes to atherosclerosis )
2. Science graduates live long and prosper (New Scientist)
3. Mouse studies reveal immune mechanism involved in bone loss caused by estrogen deficiency (Eurekalert news from PNAS
4. Mutation may help cause acute myeloid leukemia . (Eurekalert news) NIH/National Cancer Institute, Leukemia and Lymphoma Society
5. Antidepressant drugs may protect brain from damage due to depression (Eurekalert news alert) Am J Psy (Medscape news)

August 7

1. T-Cell Homeostasis in Breast Cancer Survivors With Persistent Fatigue Bower JE, et al. J Natl Cancer Inst 2003; 95: 1165-1168.
2. Relation of Serum Ascorbic Acid to Helicobacter pylori Serology in US Adults: The Third National Health and Nutrition Examination Survey. Simon JA, et al. J Am Coll Nutr 2003. 22: 283-289. (Science Daily report)
3. Rapid Diagnosis of Active Tuberculosis by Detecting Antibodiesfrom Lymphocyte Secretions Raqib R, et al. JID 2003;188:364-370
4. Renoprotective Effects of Adding Angiotensin II Receptor Blocker to Maximal Recommended Doses of ACE Inhibitor in Diabetic Nephropathy: A randomized double-blind crossover trial Rossing,K, et al. Diabetes Care. 2003;26:2268-2274 (CME Medscape)
5. Editorials: Saving Office Practice H.C. Sox Ann Intern Med. 2003;139:227–228.
6. On Being a Doctor
   • Confession H.J. Merchant Ann Intern Med. 2003;139:229–230.
   • Untaken Steps and Untold Stories J.D. Rowlett Ann Intern Med. 2003;139:231.

August 6

1. Relation of aggressiveness of lipid-lowering treatment to changes in calcified plaque burden by electron beam tomography. Hecht HS and Harman SM. Am J Cardiol 2003;92:334-336.
2. REVIEW: Regulation of Nitric Oxide-Sensitive Guanylyl Cyclase Friebe A AND and Koesling D. Circ Res 2003 93: 96 - 105
3. Sexual Function in Men Older Than 50 Years of Age: Results from the Health Professionals Follow-up Study.  Bacon CG, et al.Ann Intern Med. 2003;139:161–168.
4. Effects of Losartan or Atenolol in Hypertensive Patients without Clinically Evident Vascular Disease: A Substudy of the LIFE Randomized Trial Devereux RB, et al. Ann Intern Med. 2003;139:169–177.
5. The Effect of Selective Intestinal Decontamination on the Hyperdynamic Circulatory State in Cirrhosis. A Randomized Trial Rasaratnam B, et al.  Ann Intern Med. 2003;139:186–193.

August 5

1. Drug-Induced Hepatotoxicity William M. Lee, M.D. N Engl J Med 2003;349:474-485
2. A Randomized Trial of Bevacizumab, an Anti–Vascular Endothelial Growth Factor Antibody, for Metastatic Renal Cancer. Yang, JC, et al.N Engl J Med 2003; 349:427-434
3. The von Hippel–Lindau Protein, Vascular Endothelial Growth Factor, and Kidney Cancer. George DJ and Kaelin WG. N Engl J Med 2003; 349:419-421
4. Survival of Patients Undergoing Hemodialysis with Paricalcitol or Calcitriol Therapy. Teng M, et al., N Engl J Med 2003; 349:446-456
5. From the AMA: The Physician's Guide to Assessing and Counseling Older Drivers
6. Relationship Between Periodontal Disease, Tooth Loss, and Carotid Artery Plaque. The Oral Infections and Vascular Disease Epidemiology Study (INVEST) Desvarieux M, et al. Stroke published online July 31, 2003, 10.116

August 4

1. The Impact of Health Information on the Internet on the Physician-Patient Relationship: Patient Perceptions. Murray E, et al. Arch Intern Med. 2003;163:1727-1734.
2. Cardiorespiratory Fitness and the Risk for Stroke in Men Kurl S, et al.Arch Intern Med. 2003;163:1682-1688.
3. Venous Thromboembolic Disease: Comparison of the Diagnostic Process in Men and Women Stein PD, et al. Arch Intern Med. 2003;163:1689-1694.
4. Predictors of Warfarin Use Among Ohio Medicaid Patients With New-Onset Nonvalvular Atrial Fibrillation Johnston JA, et al. Arch Intern Med. 2003;163:1705-1710.
5. Pulmonary Embolism Mortality in the United States, 1979-1998: An Analysis Using Multiple-Cause Mortality Data Horlander KT, et al.Arch Intern Med. 2003;163:1711-1717.

August 1

1. "Inappropriate" Treatment Near the End of Life: Conflict Between Religious Convictions and Clinical Judgment. Brett AS, ET AL. Arch Intern Med. 2003;163:1645-1649.
2. Initial and Maintenance Naltrexone Treatment for Alcohol Dependence Using Primary Care vs Specialty Care: A Nested Sequence of 3 Randomized Trials Arch Intern Med. 2003;163:1695-1704.
3. Selecting Asymptomatic Patients for Coronary Computed Tomography or Electrocardiographic Exercise Testing Greenland P and Gaziano JM, N Engl J Med 2003;349:465-473
4. Bisphosphonate-Induced Osteopetrosis. Whyte MP et al.N Engl J Med 2003; 349:457-463
5. Paricalcitol as Compared with Calcitriol in Patients Undergoing Hemodialysis. Drüeke TB and McCarron DA. N Engl J Med 2003; 349:496-499.

Weekend Reading

1. FDA approves Baxter’s ADVATE for the treatment of hemophilia A (news) (Advate site)
2. Selective thyroid hormone receptor- activation: A strategy for reduction of weight, cholesterol, and lipoprotein (a) with reduced cardiovascular liability. Grover GJ, et al. PNAS published July 29, 2003, 10.1073/pnas. [Scientific Am Med report]
3. Caspase cleavage of tau: Linking amyloid and neurofibrillary tangles in Alzheimer's disease. Gamblin TC, et al. PNAS published July 29, 2003, 10.1073 [New Scientist report]
4. Cytomegalovirus cell receptor: Epidermal growth factor receptor mediates human cytomegalovirus cell entry [The Scientist news release] (published in Nature; subscribers only)
5. Association between Acquisition of Herpes Simplex Virus Type 2in Women and Bacterial Vaginosis Cherpes Tl, et a.CID 2003;37:000 (Eurekalert news report)
6. Bone adaptation requires oestrogen receptor. Lee K, et al. Nature 424 , 389 (24 July 2003).
7. Medscape Reviews: Gene Profiling of Lymphoma, Myeloma, and AML Lars Rogge, PhD, Elisabetta Bianchi, MD, PhD
8. Promotion of G i3 subunit down-regulation by GIPN, a putative E3 ubiquitin ligase that interacts with RGS-GAIP Fischer T et al. PNAS 2003 100: 8270-8275 (ScienceDaily report Researchers Determine Mechanism For Degradation Of G Proteins)