Recent reports in Science and Medicine for November
2003
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of these links are very transient and may expire within days of posting.
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missing great news items. I welcome any suggested articles. (email
link). "§" indicates
a recommended article.
Week of November 24 - 28
The New England Journal of Medicine Volume 349 November 20, 2003 Number
21 Article
Summaries
§A
Comparison of 15% Azelaic Acid Gel and 0.75% Metronidazole Gel in the Topical
Treatment of Papulopustular Rosacea: Results of a Randomized Trial. Elewski,
et al. Arch
Dermatol. 2003;139:1444-1450.[Eurekalert report]
Lymphoma Rates Are Low but Increased in Patients With Psoriasis Results
From a Population-Based Cohort Study in the United Kingdom. Gelfand, et al. Arch
Dermatol. 2003;139:1425-1429
Effects of 5-aza-2'-deoxycytidine on fetal hemoglobin levels, red cell
adhesion, and hematopoietic differentiation in patients with sickle cell
disease. Saunthararajah, et al. Blood
2003 102: 3865-3870. [Eurekalert report]
Effect of a High Saturated Fat and No-Starch Diet on Serum Lipid Subfractions
in Patients With Documented Atherosclerotic Cardiovascular Disease. Hays,
et al. Mayo
Clin Proc. 2003: 78:1331-1336 [Medscape news
report]
§Study
of deadliest form of stroke demostrates much lower morality rates at high
caseload hospitals [Eurekalert report
from Journal of Neurosurgery]
Direct link found between chronic inflammation, colon cancer [Eúrekalert report
from the Proceedings of the National Academy of Science]
Journal of Clinical Investigation November 1 2003, Volume 112, Issue 9 Contents
Epidemiology of Autoimmune Liver Disease [Medscape review
of J Gastroenterol Hepatol 18(10):1118-1128, 2003. ]
Racial Differences in Mortality Among Medicare Recipients After Treatment
for Localized Prostate Cancer. Godley, et al. JNCI
2003; 95: 1702-1710. [Eurekalert report]
Hypoglycemic Neuronal Death and Cognitive Impairment Are Prevented by Poly(ADP-Ribose)
Polymerase Inhibitors Administered after Hypoglycemia. Swanson, et al. J.
Neurosci. 2003 23: 10681-10690. [Eurekalert report]
In vivo selection of MGMT(P140K) lentivirus–transduced human NOD/SCID
repopulating cells without pretransplant irradiation conditioning. J.
Clin. Invest. 2003 112: 1561-1570.
Methylguanine methyltransferase–mediated in vivo selection and chemoprotection
of allogeneic stem cells in a large-animal model
J. Clin. Invest. 2003 112: 1581-1588.
§Research
on spleen cells could yield potential cure for Type 1 diabetes [Eurekalert from
Islet Regeneration During the Reversal of Autoimmune Diabetes in NOD Mice.
Kodama, et al Science
Nov 14 2003: 1223-1227. ]
Review of Evidence and Explanations for Suboptimal Screening and Treatment
of Dyslipidemia in Women [Medscape review
from the Journal of General Internal Medicine]
Paperless, Wireless and Almost No Typing. [Medscape review
from Private Practice Success]
The genetic basis of Pseudomonas biofilm antibiotic resistance linked to
glucans[The Scientist report
from the November 20 Nature]
Glitazone Use May Be Associated With Macular Edema in Diabetics. [Medscape report
from the annual meeting of the American Academy of Ophthalmology.]
Reducing inflammation decreases secondary degeneration and functional deficit
after spinal cord injury. Gonzalez, et al. Experimental Neurology 2003;184:456-463
[Science
Daily report Blocking Immune Response To Spinal Cord Injury Can Improve
Chances For Recovery]
§Cumulative
Effects Associated With Recurrent Concussion in Collegiate Football
Players: The NCAA Concussion Study. Guskiewicz; et al JAMA.
2003;290:2549-2555. [Eurekalert report]
§Acute
Effects and Recovery Time Following Concussion in Collegiate Football
Players: The NCAA Concussion Study. McCrea; et al. JAMA.
2003;290:2556-2563.
Effect of Expanded Newborn Screening for Biochemical Genetic Disorders
on Child Outcomes and Parental Stress. Waisbren; et al. JAMA.
2003;290:2564-2572.
Extracorporeal Shock Wave Therapy for the Treatment of Chronic Calcifying
Tendonitis of the Rotator Cuff: A Randomized Controlled Trial. Gerdesmeyer;
et al. JAMA.
2003;290:2573-2580.
§Predicting
Mortality Among Patients Hospitalized for Heart Failure: Derivation
and Validation of a Clinical Model. Lee; et al. JAMA.
2003;290:2581-2587.
§Comparison
of 8 vs 15 Days of Antibiotic Therapy for Ventilator-Associated Pneumonia
in Adults: A Randomized Trial. Chastre; et al. JAMA.
2003;290:2588-2598.
§Retrospective
analysis of evidence base for tests used in diagnosis and monitoring of disease
in respiratory medicine. BMJ 2003;327:1136-1138. [Eurekalert :
Many diagnostic tests are not based on good evidence ]
§Support
for National Health Insurance among U.S. Physicians: A National Survey. Ackermann and
Carroll.
Effect of Medication Adherence on Survival of HIV-Infected Adults
Who Start Highly Active Antiretroviral Therapy When the CD4+Cell Count
Is 0.200 to 0.350 x 109 cells/L. Wood,
et al.
The Continuing Increase in the Incidence of Hepatocellular Carcinoma
in the United States: An Update. El-Serag,
et al.
Reviews Increased Incidence of Coronary Atherosclerosis in Type
2 Diabetes Mellitus: Mechanisms and Management.Hurst and
Lee
§The
Cost-Effectiveness of Screening Mammography beyond Age 65 Years: A
Systematic Review for the U.S. Preventive Services Task Force. Mandelblatt,
et al.
Clinical Guidelines Consensus Recommendations for Managing Patients
with Nonvariceal Upper Gastrointestinal Bleeding. Barkun,
et al.
Editorials Physician Support for Covering the Uninsured: Is
the Cup Half Empty or Half Full? Kellermann
Annals Faces the Future: Quicker Service, Broader Access, Tailored
Formats. The
Editors
November 18
§Long-Term
Improvement in Insulin Sensitivity by Changing Lifestyles of People with
Impaired Glucose Tolerance: 4-Year Results From the Finnish Diabetes Prevention
Study. Uusitupa, et al. Diabetes
2003 52: 2532-2538. [Medscape analysis]
§Insulin
Sensitivity, Insulin Secretion, and Abdominal Fat: The Insulin Resistance
Atherosclerosis Study (IRAS) Family Study. Wagenknecht, et al. Diabetes
2003 52: 2490-2496.
Weekend Reading
- Basic Science and general interest article
Pill helps people unlearn fears [Science
NOW and CNN-Health report
from the annual meeting of the Society for Neuroscience.]
§Modeling
the Time Dependence of the Association between Human Papillomavirus Infection
and Cervical Cancer Precursor Lesions. Schlecht, et al. Am.
J. Epidemiol. 2003 158: 878-886. [Medscape report]
Teaching hospital physicians report trouble obtaining specialty services
for the uninsured [Eurekalert report
from the November/December issue of Health Affairs.]
§Antihistamine-Induced
Rhabdomyolysis [Medscape report
from the Southern Medical Journal ]
Why Fat Raises Your Blood Pressure [Science
NOW report from the Proceedings of the National Academy of Sciences]
Epigallocatechin gallate, the main component of tea polyphenol, binds to
CD4 and interferes with gp120 binding. [Eurekalert and AAAAI
posting]
Protein identified that may play central role in inflammatory bowel disease
[Eurekalert report
of "Expression, Localization, and Functional Activity of TL1A, a Novel
Th1-Polarizing Cytokine in Inflammatory Bowel Disease ". Bamias, et
al. J Immunol
2003 171: 4868-4874. ]
Ten-year study leads researchers to psoriasis genes [Eurekalert report
from Nature Genetics]
Gene Variant Linked to Autism [Eurekalert report
from he annual meeting of the American Society of Human Genetics ]
Diet Rich in Vitamin C Decreases Stroke Risk [Medscape report
from Dietary antioxidants and the risk of ischemic stroke: The Rotterdam
Study Vokó, et al. Neurology
2003 61: 1273-1275. ]
Comparison of Oral vs
Intravenous Phytonadione
(Vitamin K 1) in Patients
With Excessive Anticoagulation:
A Prospective Randomized
Controlled Study Arch
Intern Med. 2003;163:2469-2473.
Medical and Psychiatric
Conditions of Alcohol and
Drug Treatment Patients in
an HMO: Comparison With Matched
Controls Arch
Intern Med. 2003;163:2511-2517.
Quality improvement program enhances heart care, closes gender gap
Heart failure care inconsistent
Elementary signs of heart disease found in children
More risk factors for heart disease increase Medicare cost
Heal thyself: Patients’ bone marrow cells restore failing hearts
Studies describe heart disease following smallpox vaccination
Bone marrow cells improve failing heart function
Bone marrow stem cells build new circulation to lungs
Universal bone marrow cell spurs growth of vessels and heart muscle
A heart-strengthening pace: brisk but comfortable
A little electrical boost may help many heart failure patients
Poor neighborhood linked to poor heart attack survival
Air pollution, even at “safe” levels, is bad for the
heart
Four Popular Diets Equally Effective for Weight Loss [Medscape report
from AHA SS}
November 12
§Effect
of a High Saturated Fat and No-Starch Diet on Serum Lipid Subfractions in
Patients With Documented Atherosclerotic Cardiovascular Disease. Hays, et
al. Mayo Clin
Proc 2003;78:1331.editorial and
issue contents.
Suppressive effect of aspirin on aberrant crypt foci in patients with colorectal
cancer. Shpitz, et al Gut
2003; 52: 1598-1601. and editorial. Aspirin: still learning about the
wonder drug Gut
2003; 52: 1535-1536.
Improving management of obesity in primary care: cluster randomised trial.
Moore, and others. BMJ
2003; 327: 1085.
Randomised controlled trial of clinical decision support tools to improve
learning of evidence based medicine in medical students. Leung, et al. BMJ
2003; 327: 1090.
Effects of Perioperative Administration of a Selective Cyclooxygenase
2 Inhibitor on Pain Management and Recovery of Function After Knee
Replacement: A Randomized Controlled Trial. Buvanendran; et al JAMA.
2003;290:2411-2418.
Effect of Improving Depression Care on Pain and Functional Outcomes
Among Older Adults With Arthritis: A Randomized Controlled Trial. Lin;
et al. JAMA.
2003;290:2428-2429.
§ Valsartan,
Captopril, or Both in Myocardial Infarction Complicated by Heart Failure,
Left Ventricular Dysfunction, or Both. M A. Pfeffer, and Others. Early release
publication at www.nejm.org November 10, 2003 (10.1056/NEJMoa032292)
§CII-DC-AdTRAIL
cell gene therapy inhibits infiltration of CII-reactive T cells and CII-induced
arthritis Liu, et al. J.
Clin. Invest. 2003 112: 1332-134 and Editorial:
The TRAIL to arthritis
Developmental adaptation of the mouse cardiovascular system to elastin
haploinsufficiency Faury, et al. JCI
2003 112: 1419-1428. and Editorial.
Comparison of effectiveness of angiotensin-converting enzyme inhibitors
after acute myocardial infarction in diabetic versus nondiabetic patients
Gottlieb, et al Am
J Cardiol 2003;92:1020-1025. [Medscape report]
EDITORIALS: Tomatoes or Lycopene Versus Prostate Cancer: Is Evolution
Anti-Reductionist? Gann and Khachik J Natl Cancer Inst 2003; 95: 1563-1565.
Playing the Old Piano: Another Tune for Endocrine Therapy? Hayes,
et al. J Natl Cancer Inst 2003; 95: 1565-1567.
Prostate Carcinogenesis in N-methyl- N-nitrosourea (NMU)-Testosterone-Treated
Rats Fed Tomato Powder, Lycopene, or Energy-Restricted Diets Thomas
Boileau, et al J Natl Cancer Inst 2003; 95: 1578-1586.
§Apoptotic
Action of 17 -Estradiol in Raloxifene-Resistant MCF-7 Cells In Vitro
and In Vivo Liu, et al. J Natl Cancer Inst 2003; 95: 1586-1597. [Medscape report]
Paradoxical Action of Fulvestrant in Estradiol-Induced Regression
of Tamoxifen-Stimulated Breast Cancer. Osipo, et al J Natl Cancer Inst
2003; 95: 1597-1608.
November 10
New England Journal of Medicine Article
Summaries Volume 349 November 6, 2003 Number 19
§A
Randomized Trial of Letrozole in Postmenopausal Women after Five Years
of Tamoxifen Therapy for Early-Stage Breast Cancer. P.
E. Goss and Others
A Randomized Study of Prophylactic Catheter Ablation in Asymptomatic
Patients with the Wolff–Parkinson–White Syndrome. C.
Pappone and Others
§Extraneural
Pathologic Prion Protein in Sporadic Creutzfeldt–Jakob Disease M.
Glatzel, and Others
Brief Report: Effect of CD3 Deficiency on Maturation of /ß and
/T-Cell Lineages in Severe Combined Immunodeficiency H.
K. Dadi, and Others
Weekend Reading
- Basic Science and general interest article
§Prevention
of Organ Allograft Rejection by a Specific Janus Kinase 3 Inhibitor. Changelian,
et al. Science
2003; 302, pp. 875-878 [Eurekalertreport:Radically
new anti-rejection drug shown to offer safe control of immune system ]
§Anti-platelet
Drug Blocks Bone Metastases In Mice; Treatment Also Slows Development Of
Other Tumors [Eurekalert report
from PNAS early online edition]
Study Offers New Insight Into Rett Syndrome [Science
Daily report of Derepression of BDNF Transcription Involves Calcium-Dependent
Phosphorylation of MeCP2. Chen, et al. Science
Oct 31 2003: 885-889.
Mast cells regulate lymph node hypertrophy through the rapid secretion
of TNF ( The Scientist report
from Nature Immunology , DOI:10.1038/ni1005, November 2, 2003).
Role in Type 1 diabetes provides clue for researchers who discovered
'obesity gene' [Eurekalert report
from the journal Public Library of Science-pdf]
Major New Finding On Genetics Of Parkinson's Disease Zeroes In On Activity
Of Alpha Synuclein [Science
Daily report from Alpha-Synuclein Locus Triplication Causes Parkinson's
Disease. Singleton, et al. Science
Oct 31 2003: 841.
Low-Dose Theophylline Highly Effective for Asthma Control [Medscape
report of the annual meeting of the American College of Chest Physicians.]
Aggressive Care Results in High Degree of Improvement in RA [Medscape report
of meeting of American College of Rheumatology.]
Association Between Estrogen Receptor Gene Variation and Cardiovascular
Disease. Shearman, et al. JAMA.
2003;290:2263-2270.
§ Childhood
Cardiovascular Risk Factors and Carotid Vascular Changes in Adulthood:
The Bogalusa Heart Study. Li; et al. JAMA.
2003;290:2271-2276.
§Cardiovascular
Risk Factors in Childhood and Carotid Artery Intima-Media Thickness
in Adulthood: The Cardiovascular Risk in Young Finns Study. Raitakari;
etal. JAMA.
2003;290:2277-2283.
Fenoldopam Mesylate for the Prevention of Contrast-Induced Nephropathy:
A Randomized Controlled Trial. Stone; et al. JAMA.
2003;290:2284-2291.
§Effect
of Recombinant ApoA-I Milano on Coronary Atherosclerosis in Patients
With Acute Coronary Syndromes: A Randomized Controlled Trial. Nissen;et
al. JAMA.
2003;290:2292-2300.
Contemporary Management of Chronic Obstructive Pulmonary Disease:
Scientific Review. Sin; et al. JAMA.
2003;290:2301-2312.
Contemporary Management of Chronic Obstructive Pulmonary Disease:
Clinical Applications. Man; et al. JAMA.
2003;290:2313-2316.
Estrogen Receptor 1 Variants and Coronary Artery Disease: Shedding
Light Into a Murky Pool. Hopkins and Brinton. JAMA.
2003;290:2317-2319.
High-Density Lipoproteins as an Emerging Therapeutic Target for Atherosclerosis.
Rader JAMA.
2003;290:2322-2324.
November 5
§Women’s
Early Warning Symptoms of Acute Myocardial Infarction. McSweeney, et al. Circulation 2003:
published online.[Medscape and Eurekalert summaries]
Outcomes and Prognostic Factors in 267 Patients with Severe Acute
Respiratory Syndrome in Hong Kong. Choi,
et al.
Effectiveness of Leech Therapy in Osteoarthritis of the Knee: A Randomized,
Controlled Trial. Michalsen
et al.
§Systolic
Blood Pressure, Diastolic Blood Pressure, and Pulse Pressure: An Evaluation
of Their Joint Effect on Mortality. Pastor-Barriuso,
et al.[Eurekalert review]
The Quality of Medical Care Provided to Vulnerable Community-Dwelling
Older Patients. Wenger,
et al.
Perspectives : ALLHAT, or the Soft Science of the Secondary
End Point. Franz
H. Messerli
Editorials Multidisciplinary
Integrative Approach to Treating Knee Pain in Patients with Osteoarthritis,
Establishing Benchmarks for Quality Care for an Aging Population: Caring
for Vulnerable Older Adults,
§In
a new policy statement, " Poison
Treatment in the Home ," the American Academy of Pediatrics (AAP)
recommends that syrup of ipecac no longer be used routinely as a home treatment
strategy. [Committee on Injury, Violence, and Poison Prevention: Poison Treatment
in the Home Pediatrics
2003; 112: 1182-1185 ]
Treatment Failure, NRTI Resistance Seen With Tenofovir-Based Anti-HIV Drug
Regimen [Medscape alert]
Clinical and Immunologic Results of a Randomized Phase II Trial of Vaccination
Using Four Melanoma Peptides Either Administered in Granulocyte-Macrophage
Colony-Stimulating Factor in Adjuvant or Pulsed on Dendritic Cells. Slingluff,
et al. JCO
Nov 1 2003: 4016-4026.
The Outcome of Liver Transplantation in Patients With Hepatocellular Carcinoma
in the Unites States Between 1988 and 2001: 5-Year Survival Has Improved
Significantly With Time. Yoo, et al. JCO
published October 27, 2003
§Adherence
to advance directives in critical care decision making: vignette study. Thompson,
et al. BMJ 2003;327:1011 (1 November)
November 3
Impairment of Olfactory Identification Ability in Individuals at Ultra-High
Risk for Psychosis Who Later Develop Schizophrenia. Brewer, et al. Am
J Psychiatry 2003 160: 1790-1794. [Editorial: The Neural Substrates of
Affect Impairment in Schizophrenia. Richard D. Lane Am
J Psychiatry 2003 160: 1723-1725. ]
The New England Journal of Medicine October 30, 1003 [Summaries]
Subcutaneous Fondaparinux versus Intravenous Unfractionated Heparin in
the Initial Treatment of Pulmonary Embolism. The
Matisse Investigators
§Comparison
of Ximelagatran with Warfarin for the Prevention of Venous Thromboembolism
after Total Knee Replacement. C.W.
Francis and Others
Secondary Prevention of Venous Thromboembolism with the Oral Direct Thrombin
Inhibitor Ximelagatran. Schulman
and Others
Somatic and Germ-Line Mutations of the HRPT2 Gene in Sporadic Parathyroid
Carcinoma. T.M.
Shattuck and Others
Current Concepts: The Toxicology of Mercury -- Current Exposures and Clinical
Manifestations. T.W.
Clarkson and Others