Recent reports in Science and Medicine for October 2003

Some of these links are very transient and may expire within days of posting. Some may require prior registration. Check-in and view frequently to avoid missing great news items. I welcome any suggested articles. (email link). "§" indicates a faculty recommended article.

October 31

Weekend Reading - Basic Science and general interest article (Science and some pdfs available from library and Dr. Holbein)

1. §Healthy Animals with Extreme Longevity. Arantes-Oliveira , et al. Science 10.1126/science.1089169 [Worms hold 'eternal life' secret BBC news]
2. New Class Of Antibiotics Stops Pathogens In Their Genetic Tracks [Science Daily report from A New Class of Bacterial RNA Polymerase Inhibitor Affects Nucleotide Addition. Artsimovitch, et al. Science Oct 24 2003: 650-654]
3. Immune Control of Tuberculosis by IFN- -Inducible LRG-47. MacMicking, et al.Science Oct 24 2003: 654-659. [Eurekalert : Improving the body's 'homeland security' against TB]
4. Experts Debate Effectiveness of Immunotherapy for Asthma . [Medscape review from World Allergy Organization Congress -- XVIII ICACI]
5. Drug tackles hepatitis C: Positive pilot study for new anti-viral. [Nature news report from Lamarre, D. et al . An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus. Nature , published online, doi:10.1038/nature02099 (2003).]
6. Root of hep C persistence: Inadequate CD4 +T-lymphocyte responses may be responsible for HCV immune evasion.[The Scientist report from Science Oct 24 2003]
7. Study: Motorcycle Deaths Rose by 100 Percent in Louisiana After Repeal of Helmet Laws [NTHSA report]
8. Pre-Issue Publication: Pten Dose Dictates Cancer Progression in the Prostate. PLOS: Biology (pdf of full-text)
9. §Breast and Ovarian Cancer Risks Due to Inherited Mutations in BRCA1 and BRCA2 King, et al. Science Oct 24 2003: 643-646. [Eurekalert report: Landmark study offers new information about breast cancer genes ][Eurekalert and The Scientist reports Exercise and healthy weight delay cancer]
10. Drug May Treat Previously Incurable Brain Cancer, Say Stanford Researchers [Science Daily report from the meeting of the American Society for Therapeutic Radiology and Oncology.]
11. Muscle Relaxants for Nonspecific Low Back Pain: A Systematic Review Within the Framework of the Cochrane Collaboration. Van Tulder, et al. Medscape Review
12. Evidence Of Pharmacogenomic Differences In Patients' Responses To MS Drug. [Science Daily report from meeting of the American Neurological Association]
13. Cochlear hair cells can be produced by controlled differentiation of embryonic stem cells. [The Scientist report from the October 27 PNAS]
14. A presenilin dimer at the core of the -secretase enzyme: Insights from parallel analysis of Notch 1 and APP proteolysis Schroeter, et al. PNAS published October 17, 2003, 10.1073 ( Neuroscience ) [Eurekalert report]
15. Temozolomide Stops Growth of Gliomas in Long-term Study [Medscape report from annual meeting of the American Neurological Association ]
16. Analysis of the ARMD1 locus: Evidence that a mutation in HEMICENTIN-1 is associated with age-related macular degeneration in a large family. Schultz, et al. Human Molecular Genetics Advance Access published October 21, 2003, 10.1093/hmg/ddg348
17. Summaries of reports in Nature:
    • Scientists Find Genetic 'Fountain Of Youth' For Adult Stem Cells [Science Daily report of Oct. 22 Nature's advance online edition.]
    • Researcher Discovers 'Control Room' That Regulates Immune Responses [Science Daily report of recently published online in Nature Immunology ]
    • Evidence That Neurons Prune Only 'Twigs' To Rewire Themselves [Science Daily report from November 2003 issue of the journal Nature Neuroscience ]
    • Bone cells help call the shots for the blood's stem cells within: a new role for the osteoblast [Eurekalert report from the October 23 Nature ]
    • Identifying a stem cell niche:Osteogenic cells regulate the birth and differentiation of hematopoietic stem cells [The Scientist report of 2 papaers from the October 23 Nature ]
    • Embryonic pathway critical to growth of digestive tract tumors [Eurekalert report from the Oct. 23 issue of Nature.]

October 30

1. §FDA Advises Physicians of Adverse Events Associated with Cordis Cypher Coronary Stents [Medscape report: Sirolimus-Eluting Stent Linked to Subacute Thrombosis, Hypersensitivity Reactions]
2. In This Issue of Archives of Internal Medicine Arch Intern Med. 2003;163:2269.
   • Ethical Challenges of Partial Do-Not-Resuscitate (DNR) Orders: Placing DNR Orders in the Context of a Life-Threatening Conditions Care Plan
     Jeffrey T. Berger Arch Intern Med. 2003;163:2270-2275.
   • §Inhaled Insulin Provides Improved Glycemic Control in Patients With Type 2 Diabetes Mellitus Inadequately Controlled With Oral Agents: A Randomized Controlled Trial. Weisset al. Arch Intern Med. 2003;163:2277-2282.
   • Relevance of Carotid Stenosis Progression as a Predictor of Ischemic Neurological Outcomes. Bertges; et al. Arch Intern Med. 2003;163:2285-2289
   • Variations in Product Choices of Frequently Purchased Herbs: Caveat Emptor. Garrard; et al. Arch Intern Med. 2003;163:2290-2295.
   • Evaluation of Walking Capacity Over Time in 500 Patients With Intermittent Claudication Who Underwent Clinical Treatment. Wolosker; et al. Arch Intern Med. 2003;163:2296-2300.
   • Current Smoking, Smoking Cessation, and the Risk of Sudden Cardiac Death in Patients With Coronary Artery Disease. Goldenberg; et al. Arch Intern Med. 2003;163:2301-2305.
   • Peripheral Arterial Disease: Identification and Implications Emile R. Mohler III Arch Intern Med. 2003;163:2306-2314.
   • §" Successful Aging": Effect of Subclinical Cardiovascular Disease Newman; et al. Arch Intern Med. 2003;163:2315-2322.
   • Restless Legs Syndrome Symptoms in Primary Care: A Prevalence Study Nichols; et al. Arch Intern Med. 2003;163:2323-2329.
   • How Physicians Perceive Hospitalist Services After Implementation: Anticipation vs Reality. Auerbach; et al Arch Intern Med. 2003;163:2330-2336.
   • Effectiveness of Bupropion Sustained Release for Smoking Cessation in a Health Care Setting: A Randomized Trial. Swan; et al. Arch Intern Med. 2003;163:2337-2344.
   • Predictors of Hospital Mortality in the Global Registry of Acute Coronary Events. Granger; et al. Arch Intern Med. 2003;163:2345-2353.
   • §Relationship of Serotonergic Antidepressants and Need for Blood Transfusion in Orthopedic Surgical Patients. Movig; et al. Arch Intern Med. 2003;163:2354-2358.
   • The Impact of Dedicated Medication Nurses on the Medication Administration Error Rate: A Randomized Controlled Trial. Greengold; et al. Arch Intern Med. 2003;163:2359-2367.
   • REVIEW ARTICLE Effects of Lifestyle on Hemostasis, Fibrinolysis, and Platelet Reactivity: Arch Intern Med. 2003;163:2368-2392.
   • EDITOR'S CORRESPONDENCE Anti-inflammatory Effects of Alcohol;Definition of Acute Pyelonephritis vs the Urosepsis Syndrome; Possible Differences Between Fibrates in Pharmacokinetic Interactions With Statins; Depression and Adverse Drug Reactions. beginning p. Arch Intern Med. 2003;163:2393.
   • The Cortical Ischemic Core and Not the Consistently Present Penumbra Is a Determinant of Clinical Outcome in Acute Middle Cerebral Artery Occlusion. Jovin, et al. Stroke 2003 34: 2426 - 2433.

October 29

1. FDA Press Releases and Talk Papers
   • FDA Statement on THG (October 28, 2003)
   • A Milestone for ClinicalTrials.gov Web Site (October 27, 2003)
   • §FDA Issues Advisory on Antidepressants and Pediatric Suicide (October 27, 2003)
   • FDA Issues Guidance on Evaluating the Safety of Antimicrobial New Animal Drugs to Help Prevent Creating New Resistant Bacteria (October 23, 2003)
   • New Psoriasis Drug Wins FDA Approval: Raptiva, a New Drug for the Itchy-Skin Condition Psoriasis.(presentation)
2. Leisure Activity May Reduce Risk of Alzheimer's [News report of study from The Journal of Gerontology: Psychological Sciences (Vol. 58B, No.5, September, 2003)]
3. Identification of Subjects with Insulin Resistance and ß-Cell Dysfunction Using Alternative Definitions of the Metabolic Syndrome. Hanley, et al. Diabetes 2003 52: 2740-2747. [Medscape review]
4. §Physical Activity and Stroke Risk: A Meta-Analysis. Lee, et al. Stroke 2003 34: 2475 - 2481; and Editorial Comment: Physical Exercise and Stroke: The Sitting Majority Has a Lesson to Learn Stroke 2003 34: 2481 - 2482;.
5. Detrimental effect of blood pressure reduction in the first 24 hours of acute stroke onset. Oliveira-Filho, et al. Neurology 2003 61: 1047-1051. [Eurekalert news]
6. Vegetable and Fruit Intake and Stroke Mortality in the Hiroshima/Nagasaki Life Span Study. C. Sauvaget, MD. Stroke. 2003;34:2355.
7. §The Outcome of Liver Transplantation in Patients With Hepatocellular Carcinoma in the Unites States Between 1988 and 2001: 5-Year Survival Has Improved Significantly With Time Yoo; et al. JCO October 27, 2003, 10.1200/JCO.2003.11.137 [Eurekalert report]
8. Obesity and the risk of early and late mortality after coronary artery bypass graft surgery, Kim, et al. Am Heart J 2003; 146:555-560 (requires ScienceDirect registration)

October 28

1. §Risk of Mortality by Histologic Type of Breast Cancer Among Women Aged 50 to 79 Years. Li; et al. Arch Intern Med. 2003;163:2149-2153. [Medscape: Mortality Rates Lower for Breast Cancers Linked to HRT Use ]
2. Inflammatory Cytokines Stimulated C-Reactive Protein Production by Human Coronary Artery Smooth Muscle Cells. Calabró, et al. Circulation 2003 108: 1930 - 1932
3. Predictive Value of D-Dimer Test for Recurrent Venous Thromboembolism After Anticoagulation Withdrawal in Subjects With a Previous Idiopathic Event and in Carriers of Congenital Thrombophilia. Palareti, et al. Circulation 2003 108: 313 - 318.
4. Cephalon Receives Approvable Lette from FDA to Broaden PROVIGIL Label
5. FDA approves new HIV protease inhibitor, Lexiva (TM) [Eurekalet]
6. New England Journal of Medicine Volume 349 October 23, 2003 Number 17
   • Prognostic Value of Myeloperoxidase in Patients with Chest Pain. M.-L. Brennan and Others
   • Glutathione Peroxidase 1 Activity and Cardiovascular Events in Patients with Coronary Artery Disease. S. Blankenberg and Others
   • The GPR54 Gene as a Regulator of Puberty. S. B. Seminara and Others
   • §Absence of Cross-Reactivity between Sulfonamide Antibiotics and Sulfonamide Nonantibiotics . B. L. Strom and Others
   • Hospital Use and Survival among Veterans Affairs Beneficiaries. C. M. Ashton and Others
   • Gout R. A. Terkeltaub
   • Novel Risk Markers and Clinical Practice T. Manolio
   • Bench and Bedside — The G Protein–Coupled Receptor GPR54 and Puberty D. R. Beier and R. G. Dluhy
   • §Population-Based Studies of Adverse Drug Effects W. A. Ray
   • Medical Care — Is More Always Better? E. S. Fisher

October 27

1. Active and Passive Vaccination against Hantavirus Pulmonary Syndrome with Andes Virus M Genome Segment-Based DNA Vaccine. Custer, et al.J. Virol. 2003. 77: 9894-9905. [Eurekalert report ]
2. Pulsed-dye laser treatment for inflammatory acne vulgaris: randomised controlled trial. Seaton, et al. Lancet 2003; 362: 1347-52
3. Editorial The statin wars: why AstraZeneca must retreat. Lancet Volume 362, Number 9393;  25 October 2003  [Medscape report]
4. This Week in JAMA JAMA. 2003;290:2095.
   • §Comparison of Screening Mammography in the United States and the United Kingdom. Smith-Bindman; et al. JAMA. 2003;290:2129-2137.
   • Psychosocial Factors and Risk of Hypertension: The Coronary Artery Risk Development in Young Adults (CARDIA) Study. Yan; et al. JAMA. 2003;290:2138-2148.
   • §Efficacy of Gefitinib, an Inhibitor of the Epidermal Growth Factor Receptor Tyrosine Kinase, in Symptomatic Patients With Non–Small Cell Lung Cancer: A Randomized Trial.Kris; et al. JAMA. 2003;290:2149-2158.
   • Sustained Effect of Intensive Treatment of Type 1 Diabetes Mellitus on Development and Progression of Diabetic Nephropathy: The Epidemiology of Diabetes Interventions and Complications (EDIC) Study: Writing Team for the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group. JAMA. 2003;290:2159-2167.
   • Bile Duct Injury During Cholecystectomy and Survival in Medicare Beneficiaries. Flum; et al. JAMA. 2003;290:2168-2173.
   • Prognostic Importance of Physical Examination for Heart Failure in Non–ST-Elevation Acute Coronary Syndromes: The Enduring Value of Killip Classification. Khot; et al. JAMA. 2003;290:2174-2181.
   • A 60-Year-Old Woman With Atrial Fibrillation. Singer JAMA. 2003;290:2182-2189.
   • EDITORIALS Psychosocial Risk Factors for Cardiovascular Disease: More Than One Culprit at Work Williams; et al. JAMA. 2003;290:2190-2192.

October 24

1. Transcriptional Repression of Atherogenic Inflammation: Modulation by PPAR. Lee, et al. Science Oct 17 2003: 453-457.[Eurekalert report: Cellular fat sensor slows heart disease]
2. New research links lung cancer screening to accelerated rates of smoking cessation [Eurekalert report early release of study in Cancer published online]
3. Induction of APOBEC3G Ubiquitination and Degradation by an HIV-1 Vif-Cul5-SCF Complex. Yu, et al. Science 10.1126/science.1089591 online) [Science Daily news report : Proteins Enable HIV To Override Cell's Defenses ]
4. Sexually dimorphic gene expression in mouse brain precedes gonadal differentiation. Dewing, et al.[Eurekalert report "Brain May 'Hard-Wire' Sexuality Before Birth " from Molecular Brain Research 2003: 118: 82-90.(link via Sciencedirect or PHS library)]
5. Researchers Identify Molecular Alterations In Patients With Irritable Bowel Syndrome [Science Daily report from the 68th Annual Scientific Meeting of the American College of Gastroenterology in Baltimore.
6. New Protein Provides Clue To Diabetes {Science Daily report of study in Nature 425 , 727 - 733 (subscribers)]
7. Nitric Oxide Regulates Exocytosis by S-Nitrosylation of N-ethylmaleimide-Sensitive Factor. Matsushita, eet ak, Cell, Vol 115, 139-150, 17 October 2003 [Eurekalert news report: Researchers discover how nitric oxide prevents blood vessel inflammation]
8. A new molecular culprit for type II diabetes, Alzheimer's and Parkinson's [Eurekalert report from the Sept. 23 edition of Biochemistry]
9. What You Should Know About Statistics [Science Daily]
10. 'Genetic switch' proves two mechanisms exist by which immune system cells differentiate [Eurekalert news report of Nature Immunology- subscribers only]
11. Researchers identify novel treatment for polycystic kidney disease in animals published in the October 2003 issue of Nature Medicine (subscription required). [Eurekalert report]
12. Prostaglandin E2 precursor is the main switch during febrile response to immune challenge [The Scientist report of study in the October 19 Nature Neuroscience]
13. Omi gone in mnd2 mice. Failure of mitochondrial protein causes progressive neurodegeneration in mice [The Scientist report of Nature OI:10.1038/nature02052, October 9, 2003].
14. Doubts About Bone Marrow-Derived Adult Stem Cells Ability To Differentiate [Science Daily report of on-line issue of Nature AOP, published online 12 October 2003; doi:10.1038/nature02069 ]

October 23

1. Annals of Internal Medicine 21 October 2003 | Volume 139 Issue 8 | Pages 635-699.
   • Topical Treatment of Pressure Ulcers with Nerve Growth Factor: A Randomized Clinical Trial . Landi, et al.
   • Serum Insulin-like Growth Factor I and Risk for Heart Failure in Elderly Individuals without a Previous Myocardial Infarction: The Framingham Heart Study. Vasan, et al.
   • §Association of Hospital Procedure Volume and Outcomes in Patients with Colon Cancer at High Risk for Recurrence. Meyerhardt, et al
   • §The Effect of Clustering of Outcomes on the Association of Procedure Volume and Surgical Outcomes. Panageas, et al.
   • Update in Oncology. S H Stein
   • Effects of Statins on Nonlipid Serum Markers Associated with Cardiovascular Disease: A Systematic Review. Balk, et al.
   • Delayed Drug Hypersensitivity Reactions. W J Pichler
   • Editorials : The Promise of Topical Growth Factors in Healing Pressure Ulcers. . D R Thomas
   • Editorials: §Does Practice Really Make Perfect? Laine and Sox
   • On Being a Doctor : A Sudden Change in Vision G E Terrell
2. Aortic aneurysm death risk hinges on choice of surgeon, study finds [Eurekalert report from the October issue of the Journal of Vascular Surgery]
3. Sustained Efficacy of Eszopiclone Over 6 Months of Nightly Treatment: Results of a Randomized, Double-Blind, Placebo-Controlled Study in Adults with Chronic Insomnia. Krystal, et al. Sleep 2003; Volume 26/ Issue 7, November 1, 2003
4. In Vivo Assessment of Brain Interstitial Fluid with Microdialysis Reveals Plaque-Associated Changes in Amyloid- Metabolism and Half-Life. Cirrito, et al. J. Neurosci. 2003 23: 8844-8853. [New Research Technique Provides Unique Glimpse Into Alzheimer's Disease Science Daily]
5. Racial Differences in the Progression from Chronic Renal Insufficiency to End-Stage Renal Disease in the United States. Hsu, et al. J Am Soc Nephrol 14: 2902-2907. [Eurekalert report "U.S. blacks five times as likely as whites to progress to kidney failure" ]

October 22

1. §AHA Scientific Statements:: Nonvalvular Cardiovascular Device–Related Infections Baddour, et al.Circulation 2003 108: 2015 - 2031, [Medscape review]
2. §Practice Guidelines from the Infectious Diseases Society of America Guidelines for the Selection of Anti-infective Agents for Complicated Intra-abdominal Infections Clinical Infectious Diseases    2003;37:997-1005
3. This Week in JAMA. 2003;290:1953.
   • Results of Therapy for Acute Lymphoblastic Leukemia in Black and White Children. Pui; et al. JAMA. 2003;290:2001-2007.
   • Survival Variability by Race and Ethnicity in Childhood Acute Lymphoblastic Leukemia Kadan-Lottick, et al.JAMA. 2003;290:2015-2022.
   • Relationships Between Poverty and Psychopathology: A Natural Experiment . Costello;et al. JAMA. 2003;290:2023-2029.
   • Unique Lipoprotein Phenotype and Genotype Associated With Exceptional Longevity Barzilai, et al. JAMA. 2003;290:2030-2040.
   • Glucose Control and Mortality in Critically Ill Patients Finney, et al. JAMA. 2003;290:2041-2047.
   • Important Causes of Visual Impairment in the World Today Congdon, et al. JAMA. 2003;290:2057-2060.
   • PERSPECTIVES ON CARE AT THE CLOSE OF LIFE Care of the Dying Doctor: On the Other End of the Stethoscope Fromme and Billings JAMA. 2003;290:2048-2055.
   • Complexities in Prognostication in Advanced Cancer: "To Help Them Live Their Lives the Way They Want to" Markowitz and McPhee JAMA. 2003;290:2056.
   • EDITORIALS : Race and Outcome in Childhood Acute Lymphoblastic Leukemia JAMA. 2003;290:2061-2063.; Poverty and Child Mental Health: Natural Experiments and Social Causation JAMA. 2003;290:2063-2064.
4. Journal of Clinical Investigation 112 :1125 (2003).
   • Enigmatic role for NF-kB in atherosclerosis [Inhibition of NF-k B activation in macrophages increases atherosclerosis in LDL receptor–deficient mice J. Clin. Invest. 112 :1176-1185 (2003) - Eurekalert report]
   • FGF-2 to the rescue in the brain[ FGF-2 regulates neurogenesis and degeneration in the dentate gyrus after traumatic brain injury in mice . J. Clin. Invest. 112 :1202-1210 (2003) - Eurekalert report]

october 21

1. FDA Approves Memantine (Namenda) for Alzheimer's Disease [FDA news release]
2. American Journal of Respiratory and Critical Care MedicineVolume 168, Issue 8; October 15, 2003
   • Clinical Diagnosis of Hypersensitivity Pneumonitis Am. J. Respir. Crit. Care Med. 2003; 168: 952-958.
   • Pathophysiology and Management of Pulmonary Infections in Cystic Fibrosis Am. J. Respir. Crit. Care Med. 2003; 168: 918-951
3. The New England Journal of Medicine: Article Summaries
   • Risk of Cervical Cancer Associated with Extending the Interval between Cervical-Cancer Screenings. Sawaya and Others N Engl J Med 2003; 349:1501-1509
   • Delayed Onset of Malaria — Implications for Chemoprophylaxis in Travelers, Schwartz, and Others. N Engl J Med 2003; 349:1510.
   • Early Malignant Progression of Hereditary Medullary Thyroid Cancer A. Machens and Others
   • Development of Autoantibodies before the Clinical Onset of Systemic Lupus Erythematosus M. R. Arbuckle and Others
   • Current Concepts: Primary Progressive Aphasia — A Language-Based Dementia M.-M. Mesulam
   • Mechanisms of Disease: Paraneoplastic Syndromes Involving the Nervous System R. B. Darnell and J. B. Posner
   • How Often Should We Screen for Cervical Cancer? S. Feldman
   • Two Worlds of Malaria T. E. Wellems and L. H. Miller
   • Autoantibodies in Systemic Lupus Erythematosus — There before You Know It R. H. Shmerling

October 20

1. This week in the BMJ Volume 327, Number 7420, Issue of 18 Oct 2003
   • Montelukast and fluticasone compared with salmeterol and fluticasone in protecting against asthma exacerbation in adults: one year, double blind, randomised, comparative trial. Bjermer,et al. BMJ 2003; 327: 891.
   • Prognosis of angina with and without a diagnosis: 11 year follow up in the Whitehall II prospective cohort study. Hemingway, et al. BMJ 2003; 327: 895.
   • Breast feeding and obesity in childhood: cross sectional study. Li, et al. BMJ 2003; 327: 904-905.
   • Drug points: Weight loss associated with levetiracetam. Hadjikoutis, et al. BMJ 2003; 327: 905.
2. The Lancet Volume 362, Number 9392 -  18 October 2003
   • §Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy: randomised, double-blind, placebo-controlled trial   Henke, et al.
   • Prediction of outcome in acute lower-gastrointestinal haemorrhage based on an artificial neural network: internal and external validation of a predictive model . Das, et al.
   • Determinants of survival following HIV-1 seroconversion after the introduction of HAART. CASCADE Collaboration*
   • Genetic cause of hyperglycaemia and response to treatment in diabetes . Pearson, et al.
   • Occam's razor; anaemia and orthostatic hypotension . Gomes,et al.
   • A newly identified tick-borne Borrelia species and relapsing fever in Tanzania. Kisinza,
   • Solar disinfection of infectious biomedical waste: a new approach for developing countries Chitnis, et al.

October 17

Weekend Reading - Basic Science and general interest articles

1. Does Rejection Hurt? An fMRI Study of Social Exclusion Eisenberger, et al. Science 2003 302: 290-292. (New Scientist Reports)
2. Medical Training Could Predict Likelihood of Malpractice Claims Cathy Tokarski [Medscape News Reports]
3. Deconstructing Prions [Science now report - subscribers- or request pdf] and Pinning down prion pathogenesis
   In Nature , studies of how prions travel and suggestions for improved diagnostics [The Scientist report of studies in Nature]
4. West Nile Structure [News release]
5. Stages Of Memory Described In New Study [Science Daily report of article in Nature]
6. Elevated gene expression levels distinguish human from non-human primate brains Cáceres, et al. PNAS 0.1073/pnas.2135499100 [Eurekalert news report]
7. Nerve Disorder In Mice And Men Linked To Mutated Gene [Science Daily report of study in Nature Genetics (2003), November 2003. (subscribers)]
8. Effect of Part-time Practice on Patient Outcomes Parkerton, et al. [Medscape report from J Gen Intern Med 18(9):717-724, 2003 ]
   Posted 10/13/2003
9. Do Perceptions of Risk and Quality of Life Affect Use of Hormone Replacement Therapy by Postmenopausal Women? Scheid, et al. [Medscape report from Journal of the American Board of Family Practice ]
10. Community exercise program use and changes in healthcare costs for older adults, American Journal of Preventive Medicine 2003; 25,: 232-237 (ScienceDirect)
11. Researchers Urge Caution Over Using Ginseng In Early Pregnancy (Science Daily)
12. Folic acid food fortification is associated with a decline in neuroblastoma French et al.Clin Pharm & Ther 2003; 74. [Eurekalert]
13. Salmonella SipA Polymerizes Actin by Stapling Filaments with Nonglobular Protein Arms. Lilic, et al. Science Sep 26 2003: 1918-1921. (subscribers). [Salmonella Uses Molecular Staples To Change Structure Of Infected Cells. Science Daily report]
14. Stanford Computer Model Shows Bypass Surgery More Cost-effective Than Stents [Science Direct report of American Journal of Medicine-subscribers]
15. Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes. Alvarez-Dolado, et al. Nature (Early release: doi:10.1038/nature02069 ) [Eurekalert news report: Study raises doubts about marrow cell treatment for brain, heart ]
16. Membrane channel work wins Nobel: Peter Agre and Roderick MacKinnon share chemistry prize [The Scientist report]

October 16

1. In This Issue of Archives of Internal Medicine Arch Intern Med. 2003;163:2119.
   • EDITORIALS Health Insurance and Cancer Survival Arch Intern Med. 2003;163:2123-2124.
   • Cancer Survival in Kentucky and Health Insurance Coverage McDavidet al. Arch Intern Med. 2003;163:2135-2144.
   • Increases in Clinically Severe Obesity in the United States, 1986-2000 Sturm Arch Intern Med. 2003;163:2146-2148.
   • Risk of Mortality by Histologic Type of Breast Cancer Among Women Aged 50 to 79 Years. Li; et al. Arch Intern Med. 2003;163:2149-2153.
   • Knowledge and Attitudes Regarding Cardiovascular Disease Risk and Prevention in Patients With Coronary or Peripheral Arterial Disease McDermott; et al. Arch Intern Med. 2003;163:2157-2162.
   • Bone Mineral Density Measurement and Treatment for Osteoporosis in Older Individuals With Fractures: A Gap in Evidence-Based Practice Guideline Implementation Feldstein; et al. Arch Intern Med. 2003;163:2165-2172.
   • Communitywide Trends in the Use and Outcomes Associated With -Blockers in Patients With Acute Myocardial Infarction: The Worcester Heart Attack Study. Silvet; et al Arch Intern Med. 2003;163:2175-2183.
   • CD4 T-Lymphocyte Recovery in Individuals With Advanced HIV-1 Infection Receiving Potent Antiretroviral Therapy for 4 Years: The Swiss HIV Cohort Study Kaufmann; et al. Arch Intern Med. 2003;163:2187-2195.
   • Sustained Benefit of a Community and Professional Intervention to Increase Acute Stroke Therapy Morgenstern; et al. Arch Intern Med. 2003;163:2198-2202.
   • The Effect of Ethnicity on Survival in Male Veterans Referred for Electrocardiography and Treadmill Testing Prakash; et al. Arch Intern Med. 2003;163:2204-2210.
   • Are Gifts From Pharmaceutical Companies Ethically Problematic?: A Survey of Physicians . Brett; et al Arch Intern Med. 2003;163:2213-2218.
   • The Decreasing Prevalence of Reversible Dementias: An Updated Meta-analysis Clarfield Arch Intern Med. 2003;163:2219-2229.
   • Optimizing Long-term Cardiac Management After Major Vascular Surgery: Role of -Blocker Therapy, Clinical Characteristics, and Dobutamine Stress Echocardiography to Optimize Long-term Cardiac Management After Major Vascular Surgery . Kertai; et al. Arch Intern Med. 2003;163:2230-2235.
   • Should Older Drivers Have to Prove That They Are Able to Drive? Arch Intern Med. 2003;163:2126-2128. and Driver Screening for Older Adults Arch Intern Med. 2003;163:2129-2131.
2. Driving performance declines with dementia and age [Eurekalert news report from the Journal of the American Geriatrics Society (not available online)]
3. Half of Elderly Patients With Painful Neuropathy Receive Inappropriate Meds [Medscapre report from the American Academy of Family Physicians annual scientific assembly.]
4. Study Shows Younger Women Don’t Die A Sudden Cardiac Death For The Same Reasons As Men [Science Daily report of study in American Heart Journal (subscribers)]

October 15

1. The Lancet Volume 362, Number 9391 11 October 2003
   • Short postexposure prophylaxis in newborn babies to reduce mother-to-child transmission of HIV-1: NVAZ randomised clinical trial. Taha E Taha, et al.
   • Birthweight, childhood social class, and change in adult blood pressure in the 1946 British birth cohort Rebecca Hardy, et al. [Medscape review]
   • Clinical importance of neutralising antibodies against interferon beta in patients with relapsing-remitting multiple sclerosis. Per Soelberg Sorenson and the Danish Multiple Sclerosis Study Group. [Medscape review]
   • Association between antenatal cytokine production and the development of atopy and asthma at age 6 years. C Macaubas, et al.
2. The Spectrum of Smoking-Related Interstitial Lung Disorders The Never-Ending Story of Smoke and Disease Selman, Chest. 2003;124:1185-1187.
3. Dosing Inhaled Steroids in Asthma Is Once-a-Day Administration Effective? Marcus. Chest. 2003;124:1196-1198.
4. A Comparison of the Clinical Characteristics of Children and Adults With Severe Asthma. Jenkins, et al. Chest 2003 124: 1318-1324.
5. Aspirin Does Not Adversely Affect Survival in Patients With Stable Congestive Heart Failure Treated With Angiotensin-Converting Enzyme Inhibitors. Aumégeat, et al. Chest 2003 124: 1250-1258.
6. Interaction of Angiotensin-Converting Enzyme Inhibition and Aspirin in Congestive Heart Failure Long Controversy Finally Resolved? Brunner-La Rocca, Chest. 2003;124:1192-1194.
7. Serum creatinine is an inadequate screening test for renal failure in elderly patientsSwedko PJ, et al. Arch Intern Med. 2003;163:356-360.
8. Exercise for elders: It's never too late [Eurekalert report from American Journal of Preventive Medicine (Science Direct)
9. Sleep boosts ability to learn language [Eurekalert report from Nature 425 , 614 - 616 (09 October 2003);Consolidation during sleep of perceptual learning of spoken language. Fenn, et al.(subscribers)]
10. Stages of memory described in new study [Eurekalert report from .Nature 425 , 616 - 620 (09 October 2003); Dissociable stages of human memory consolidation and reconsolidation. Walker, et al (subscribers)]
11. Sarcopenia in elderly men and women: The Rancho Bernardo study, American Journal of Preventive Medicine 2003; 25,:226-231 (ScienceDirect)

October 14

1. A Genetic Screen in Drosophila for Metastatic Behavior. Raymond A. Pagliarini and Tian Xu Published online October 9 2003; 10.1126/science.1088474 (The Scientist report: Ras mutations require additional cell polarity genetic alterations to promote metastatic progression.
2. Structure Of West Nile Virus [Science Daily report of Science in]
3. Respiratory and Critical Care Medicine  news for October 2003 [Eurekalert summary]
   • Tiny air pollution particles rigger chronic Bronchitis in Children with asthma.
   • Airway inflammation in children with asthma show pathologic features of adule disease.
   • New alpha-1 antitrypsin deficiency standards for disease diagnosis and management
4. New England Journal of Medicine early release publication: A Randomized Trial of Letrozole in Postmenopausal: Women after Five Years of Tamoxifen Therapy for Early-Stage Breast Cancer. P.E. Goss and Others [Eurekalert news report]
   • Editorial: Letrozole after Tamoxifen for Breast Cancer -- What Is the Price of Success? J. Bryant and N. Wolmark
   • Editorial: Beyond Tamoxifen -- Extending Endocrine Treatment for Early-Stage Breast Cancer H. Burstein

October 13

1. HIV protein attacks body's innate protection system that could prevent virus' replication [Eurekalert and New Scientist news report from Nature Medicine November "HIV-1 Vif protein binds the editing enzyme APOBEC3G and induces its degradation" ]
2. The New England Journal of Medicine Volume 349 October 9,2003 Number 15
   • First-Trimester Screening for Trisomies 21 and 18. R. Wapner and Others
   • A Longitudinal, Population-Based, Cohort Study of Childhood Asthma Followed to Adulthood. M. R. Sears and Others
   • Frequency of Major Molecular Responses to Imatinib or Interferon Alfa plus Cytarabine in Newly Diagnosed Chronic Myeloid Leukemia. T. P. Hughes and Others
   • Gentamicin-Induced Correction of CFTR Function in Patients with Cystic Fibrosis and CFTR Stop Mutations. M. Wilschanski and Others
   • Combination Estrogen–Progestin Oral Contraceptives D. B. Petitti
   • Mechanisms of Disease: Chronic Myeloid Leukemia — Advances in Biology and New Approaches to Treatment. J. M. Goldman and J. V. Melo
   • Minimal Residual Disease in Chronic Myeloid Leukemia . B. Löwenberg
   • Pharmacologic Approaches to Correcting the Basic Defect in Cystic Fibrosis G. L. Lukacs and P. R. Durie
   • Screening for Down's Syndrome — Too Many Choices? M. T. Mennuti and D. A. Driscoll
   • Toward Asthma Prevention — Does All That Really Matters Happen before We Learn to Read? F. D. Martinez
   • Mind the Gap. Alexander Turchin, M.D., Julian L. Seifter, M.D., and Ellen W. Seely, M.D

October 10

Weekend Reading - Basic Science and general interest articles

1. Research breakthrough in understanding treatment resistant depression [Eurekalert report from Biological Psychiatry, (October 15, 2003)]
2. Stanford Research Builds Link Between Sleep, Cancer Progression (Science Daily) published in the October issue of Brain, Behavior, and Immunity.
3. Pharmacogenetics of Antidepressant Medication Intolerance Murphy, et al. Am J Psychiatry 2003 160: 1830-1835. [Science Daily report]
4. Benchmark study of brain tumors points to resection over biopsy as one key to survival [Eurekalert news report from the Journal of Neurosurgery]
5. Protein Implicated In Decline Of Aging Hearts [Science Daily and Duke Medical news report from Journal of Cardiovascular Pharmacology - not online]
6. Angiogenesis interlaced with obesity [The Scientist report from Circulation Research 2003, 10.1161/01 Paracrine Regulation of Angiogenesis and Adipocyte Differentiation During In Vivo Adipogenesis]
7. Researchers Identify Novel Treatment For Polycystic Kidney Disease In Animals [Science Daily news report from Nature Medicine - subscribers only]
8. Stanford computer model shows bypass surgery more cost-effective than stents (Eurekalert) October edition of the American Journal of Medicine.
9. Most U.S. oldest old lack some basic assistance [Eurekalert] October issue of The Gerontologist
10. When heme attacks: After trauma, the molecule that makes life possible rampages [Eurekalert] the October 2nd issue of the journal Nature.
11. Early signs of cardiovascular disease detected in asymptomatic individuals in need of treatment [Eurekalert] American Heart Journal, Cohn explain [The Scientist]
12. Scientists Show Cell Environment Is Important In ALS [Science Daily news report from Science (subscribers only): Wild-Type Nonneuronal Cells Extend Survival of SOD1 Mutant Motor Neurons in ALS Mice. Clement et al. and Science News]

October 9

1. FDA Talk Paper October 8, 2003 : FDA Approves Inspra for Improving Survival of Congestive Heart Failure Patients After a Heart Attack
2. Dual-Energy Contrast-enhanced Digital Subtraction Mammography: Feasibility. Lewin JM, et al. Radiology 2003 229: 261-268.
3. This Week in JAMA 2003;290:1817.
   • Association of Low-Level Ozone and Fine Particles With Respiratory Symptoms in Children With Asthma JAMA. 2003;290:1859-1867.
   • Excess Length of Stay, Charges, and Mortality Attributable to Medical Injuries During Hospitalization JAMA. 2003;290:1868-1874.
   • Treatment of Corticosteroid-Responsive Autoimmune Inner Ear Disease With Methotrexate: A Randomized Controlled Trial JAMA. 2003;290:1875-1883.
   • Lifetime Risk for Diabetes Mellitus in the United States JAMA. 2003;290:1884-1890.
   • Mortality Benefit of Immediate Revascularization of Acute ST-Segment Elevation Myocardial Infarction in Patients With Contraindications to Thrombolytic Therapy: A Propensity Analysis JAMA. 2003;290:1891-1898.
   • Safety of Patients Isolated for Infection Control JAMA. 2003;290:1899-1905.
   • Obstructive Sleep Apnea: Implications for Cardiac and Vascular Disease JAMA. 2003;290:1906-1914.
   • EDITORIALS Air Pollution as an Underappreciated Cause of Asthma Symptoms JAMA. 2003;290:1915-1917.
   • Looking for Medical Injuries Where the Light Is Bright JAMA. 2003;290:1917-1919.

October 8

1. Working out may keep breast cells working well [Eurekalert report; journal link on page]
2. Inhibition of receptor-localized PI3K preserves cardiac ß-adrenergic receptor function and ameliorates pressure overload heart failure Nienaber, et al. J. Clin. Invest. 2003 112: 1067-1079. [New Insight Into Heart Failure Suggests Novel Drug Target - Science Daily]
3. Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics. Flood-Page, et al. J. Clin. Invest. 2003 112: 1029-1036.
4. Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells Du, et al. JCI 2003 112: 1049-1057.
5. Commentary: Diabetes, microvascular complications, and cardiovascular complications: what is it about glucose? J. Clin. Invest. 112 :986-988 (2003)
6. Annals of Internal Medicine TABLE OF CONTENTS 7 October 2003 Volume 139 Issue 7
   • Gastrointestinal Tolerability and Effectiveness of Rofecoxib versus Naproxen in the Treatment of Osteoarthritis: A Randomized, Controlled Trial. Lisse, et al.
   • Magnetic Resonance Cholangiopancreatography: A Meta-Analysis of Test Performance in Suspected Biliary Disease. Romagnuolo, et al.
   • Racial Differences Pertaining to a Belief about Lung Cancer Surgery: Results of a Multicenter Survey. Margolis, et al.
   • An Outbreak of Severe Acute Respiratory Syndrome among Hospital Workers in a Community Hospital in Hong Kong. Ho, et al.
   • Improving Patient Care : Innovations in Access to Care: A Patient-Centered Approach. . Berry, et al.
   • Academia and Clinic: Evaluation of Acute Knee Pain in Primary Care. Jackson, et al.
   • Perspectives: The Lessons of SARS. E J. Emanuel
   • Editorials:
     • Listening to SARS: Lessons for Infection Control. Wenzel
     • General Internists and Family Physicians Partners in Geriatric Medicine? Mold
     • General Internal Medicine and Geriatrics: Collaboration To Address the Aging Imperative Can’t Wait Hazzard

October 7

1. This week in the BMJ Vol 327 Issue 7418
   • Time trends and demography of mortality after fractured neck of femur in an English population, 1968-98: database study. Roberts and Goldacre.BMJ 2003; 327: 771-775.
   • Hysterectomy and sexual wellbeing: prospective observational study of vaginal hysterectomy, subtotal abdominal hysterectomy, and total abdominal hysterectomy
     Roovers, et al. BMJ 2003; 327: 774-778.
   • Dietary fat intake and risk of stroke in male US healthcare professionals: 14 year prospective cohort study He, et al. BMJ 2003; 327: 777-782.
   • Family attitudes to research using samples taken at coroner's postmortem examinations: review of records. Womack and Jack
   • British hospitals and different versions of the Glasgow coma scale: telephone survey.Wiese BMJ 2003; 327: 782-783.
   • Substance misuse in psychiatric inpatients: comparison of a screening questionnaire survey with case notes. Barnaby, et al. BMJ 2003; 327: 783-784.
   • Evidence for risk of bias in cluster randomised trials: review of recent trials published in three general medical journals Puffer, et al. BMJ 2003; 327: 785-789.
   • Taking simvastatin in the morning compared with in the evening: randomised controlled trial. Wallace, et al. BMJ 2003; 327: 788.
   • Diagnostic impact of signs and symptoms in acute infectious conjunctivitis: systematic literature search. Rietveld, et al. BMJ 2003; 327: 789.
2. The Lancet Volume 362, Number 9390     04 October 2003
• Sirolimus-eluting stents for treatment of patients with long atherosclerotic lesions in small coronary arteries: double-blind, randomised controlled trial (E-SIRIUS) Schofer, et al. Lancet 2003; 362: 1093-99. Published online Sept 30, 2003
• Physical examination in the care of medical inpatients: an observational study. Brendan M Reilly Lancet 2003; 362: 1100-05 [Medscape report]
• Cerebral palsy and intrauterine growth in single births: European collaborative study. Jarvis, et al. Lancet 2003; 362: 1106-11
• Change in rates of cerebral atrophy over time in early-onset Alzheimer's disease: longitudinal MRI study. Chan, et al.
• Vibrating insoles and balance control in elderly people. Priplata, et al.

October 6

1. Prediction of Disease Outcome in Melanoma Patients by Molecular Analysis of Paraffin-Embedded Sentinel Lymph Nodes. Kuo, et al. JCO 2003: 21: 3566-3572.
2. New research technique provides unique glimpse into Alzheimer's disease [Eurekalert news report] J Neuroscience 2003
3. New England Journal of Medicine 2003; This Week in the Journal Volume 349:1324-1332 October 2, 2003 Number 14
   • Sirolimus-Eluting Stents versus Standard Stents in Patients with Stenosis in a Native Coronary Artery
     J. W. Moses and Others
   • Characteristics of Hodgkin's Lymphoma after Infectious Mononucleosis H. Hjalgrim and Others
   • The Prevention of Radiocontrast-Agent–Induced Nephropathy by Hemofiltration G. Marenzi and Others
   • A Trial of a 9-Valent Pneumococcal Conjugate Vaccine in Children with and Those without HIV Infection K. P. Klugman and Others
   • Racial, Ethnic, and Geographic Disparities in Rates of Knee Arthroplasty among Medicare Patients J. Skinner and others.
   • Sirolimus for the Prevention of In-Stent Restenosis in a Coronary Artery. A. R. Marks
   • Infection and Lymphoma R. Ambinder
   • Invasive Cardiovascular Procedures — Optimizing Patient Safety J. W. Hirshfeld Jr.
   • Great Expectations for a New Vaccine K. M. Edwards and M. R. Griffin
   • Racial Disparities — The Need for Research and Action R. Lavizzo-Mourey and J. R. Knickman

October 3

Weekend Reading - Basic Science and general interest articles

1. Can Heart Failure Impair Thinking? The American Physiological Society news report of study in the Journal of Applied Physiology (not available online). (Science Daily news)
2. Infants Treated With Antibiotics at Increased Risk for Atopy and Asthma [New Scientist and Medscape news reports of European Respiratory Society meeting]
3. FDA Report on Antibiotic Resistance
4. FDA Public Health Advisory: Reports of blue discoloration and death in patients receiving enteral feedings tinted with the dye, FD&C BLUE NO. 1
5. Congress Hears Testimony Calling for New Food Pyramid [Medscape news]
6. Headache Management Program Improves Outcome for Chronic Headache [Medscape review]
7. Systematic analysis provides means for early detection of systemic scleroderma [The Scientist report of PNAS, DOI:/10.1073/ pnas.1635114100, September 29, 2003 ]
8. Drug produces faster healing and fewer scars [New Scientist] and Deconstructing Wound Repair [Scinece]

October 2

1. NEJM 349:1205-1206 Emerging Infections, Transfusion Safety, and Epidemiology Roger Y. Dodd, Ph.D.
2. New England Journal of Medicine Vol. 349 September 25, 2003
3. Physical Activity, Obesity, and the Incidence of Type 2 Diabetes in a High-Risk Population Kriska, et al. Am. J. Epidemiol. 2003 158: 669-675. (Science Daily news report)
4. This Week in JAMA JAMA. 2003;290:1675.
   • Timing of Initial Cereal Exposure in Infancy and Risk of Islet Autoimmunity. Norris, et al. JAMA. 2003;290:1713-1720.
   • Early Infant Feeding and Risk of Developing Type 1 Diabetes–Associated Autoantibodies. Ziegler; et al. JAMA. 2003;290:1721-1728.
   • Effects of Estrogen Plus Progestin on Risk of Fracture and Bone Mineral Density: The Women's Health Initiative Randomized Trial. Cauley; et al. JAMA. 2003;290:1729-1738.
   • Effects of Estrogen Plus Progestin on Gynecologic Cancers and Associated Diagnostic Procedures: The Women's Health Initiative Randomized Trial.Anderson, et al. JAMA. 2003;290:1739-1748.
   • Azithromycin in Patients With Cystic Fibrosis Chronically Infected With Pseudomonas aeruginosa : A Randomized Controlled Trial Saiman;et al. JAMA. 2003;290:1749-1756.
   • Analgesic Effect of the Synthetic Cannabinoid CT-3 on Chronic Neuropathic Pain: A Randomized Controlled Trial. Karst; et al. JAMA. 2003;290:1757-1762.
   • Association Between Thimerosal-Containing Vaccine and Autism. Hviid, et al. JAMA. 2003;290:1763-1766.
   • Diagnosis and Management of Female Infertility. Smith, et al. JAMA. 2003;290:1767-1770.
   • EDITORIALS: Infant Diets and Type 1 Diabetes: Too Early, Too Late, or Just Too Complicated? JAMA. 2003;290:1771-1772.

October 1

1. CDC Flu home page: Flu Season 2003-04
2. High Blood Pressure Does Not Accelerate Age-Related Cognitive Decline reported in the September issue of the journal Aging, Neuropsychology and Cognition(not onlinie). [Science Daily report]
3. Efficacy of Cold Gel for Soft Tissue Injuries: A Prospective Randomized Double-Blinded Trial Airaksinen et al. Am J Sports Med 2003 31: 680-684. [Medscape report]
4. Percutaneous coronary intervention versus fibrinolytic therapy in acute myocardial infarction: is timing (almost) everything? Nallamothu and Bates. Am J Cardiol. 2003; 92:824-826.(registration reequired) [Eurekalert report]
5. Significant Gender Differences in Referral for Catheter Ablation [Medscape news report from J Am Coll Cardiol 2003;42:1103-1107.}