Journal Club 2020-2021 Year to Date Articles
June 30, 2020: Goodsett, Nyaundi
The Combination of Tocilizumab and Methylpresnisolone Along with Initial Lung Recruitment Strategy in Coronavirus Disease 2019 Patients Requiring Mechanical Ventilation: A Series of 21 Consecutive Cases (CG)
Timing of Endoscopy for Acute Upper Gastrointestinal Bleeding (TN)
July 14, 2020: Leidner, Shankar

Phase 3 Trial of RNAi Therapeutic Givosiran for Acute Intermittent Porphyria & Appendix (JL)

Initial Invasive or Conservative Strategy for Stable Coronary Disease (AS)

July 28, 2020: Tayon, Tumyan

Effect of Antihypertensive Medication Reduction vs Usual Care on Short-term Blood Pressure Control in Patients With Hypertension Aged 80 Years and Older: The OPTIMISE Randomized Clinical Trial (KT)

Rivaroxaban in Peripheral Artery Disease after Revascularization (GT)

August 11, 2020: Anjum, Leidner

Effect of Levothyroxine on Left Ventricular Ejection Fraction in Patients With Subclinical Hypothyroidism and Acute Myocardial Infarction A Randomized Clinical Trial (AA)

Effect of Rotigotine vs Placebo on Cognitive Functions Among Patients With Mild to Moderate Alzheimer Disease A Randomized Clinical Trial (JL)

August 25, 2020: Ford, Ramachandran

Early Surgery or Conservative Care for Asymptomatic Aortic Stenosis (WCF)

Ruxolitinib Cream for Treatment of Vitiligo: A Randomised, Controlled, Phase 2 Trial (VR)

September 8, 2020: Sannapaneni, Duff

Effects of Allopurinol on the Progression of Chronic Kidney Disease (SS)

Assessment of Overall and Specific Cancer Risks in Patients With Hidradenitis Suppurativa (DD)

September 22, 2020: You, Hosseini
Effect of Continuous Glucose Monitoring on Hypoglycemia in Older Adults with Type 1 Diabetes A Randomized Clinical Trial (HY)
Early Rhythm-Control Therapy in Patients with Atrial Fibrillation (PH)
October 6, 2020: Farrington, Tejani

Association of Intra-arrest Transport vs. Continued On-Scene Resuscitation with Survival to Hospital Discharge Among Patients with Out-of-Hospital Cardiac Arrest (WTF)

Diagnostic Performance of RO948 F 18 Tau Positron Emission Tomography in the Differentiation of Alzheimer Disease From Other Neurodegenerative Disorders (AT)
October 20, 2020: Bhattarai, Kabani

Cardiovascular and Renal Outcomes with Empagliflozin in Heart Failure (UB)

A Randomized Trial Comparing Antibiotics with Appendectomy for Appendicitis (AK)
November 3, 2020: Martinez, Nyaundi

Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes (LM)

Trial of Upadacitinib or Abatacept in Rheumatoid Arthritis (TN)
November 24, 2020: Duff, Shankar

Rivaroxaban in Patients with Atrial Fibrillation and a Bioprosthetic Mitral Valve (DD)

Colchicine in Patients with Chronic Coronary Disease (AS)

December 1, 2020: Mantha, Goodsett

Mavacamten for treatment of symptomatic obstructive hypertrophic cardiomyopathy (EXPLORER-HCM): a randomised, double-blind, placebo-controlled, phase 3 trial (YM)

An mRNA Vaccine against SARS-CoV-2— Preliminary Report (CG)

December 15, 2020: Tejani, Sannapaneni

Atypical Femur Fracture Risk versus Fragility Fracture Prevention with Bisphosphonates (AT)

Sotagliflozin in Patients with Diabetes and Chronic Kidney Disease (SS)

January 12, 2021: Bhattarai, Farrington

Mortality with Paclitaxel-Coated Devices in Peripheral Artery Disease (UB)

Effect of a Lower vs Higher Positive End-Expiratory Pressure Strategy on Ventilator-Free Days in ICU Patients Without ARDS A Randomized Clinical Trial (TF)

January 26, 2021: You, Ford

Bupropion and Naltrexone in Methamphetamine Use Disorder (HY)

Artificial Intelligence to Detect Papilledema from Ocular Fundus Photographs (CF)

February 9, 2021: Kabani, Ramachandran

Phase 3 Trial of Interleukin-1 Trap Rilonacept in Recurrent Pericarditis (AK)

Five-Year Analysis of Adjuvant Dabrafenib plus Trametinib in Stage III Melanoma (VR)

February 23, 2021: Mantha, Tseng

Cryoablation or Drug Therapy for Initial Treatment of Atrial Fibrillation (YM)

Bag-Mask Ventilation during Tracheal Intubation of Critically Ill Adults (JT)

March 9, 2021: Swanson, Martinez

A Randomized Trial of Albumin Infusions in Hospitalized Patients with Cirrhosis (WS)

Once-Weekly Semaglutide in Adults with Overweight or Obesity (LM)

March 23, 2021: Abbas, Hosseini

Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19 (AA)

Randomized Trial of Nocturnal Oxygen in Chronic Obstructive Pulmonary Disease (PH)

April 13, 2021: Narula, Anjum

Dapagliflozin in Patients with Chronic Kidney Disease (SN)

Avacopan for the Treatment of Anca Associated Vasculitis (AA)

April 27, 2021: Shankar, Sharifi

Tocilizumab in Hospitalized Patients with Severe Covid-19 Pneumonia (AS)

Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19 A Randomized Clinical Trial (AS)

May 11, 2021: Tayon, Tseng

Effect of High-Intensity Interval Training, Moderate Continuous Training, or Guideline-Based Physical Activity Advice on Peak Oxygen Consumption in Patients With Heart Failure With Preserved Ejection Fraction (KT)

Safety and efficacy of inhaled nebulised interferon beta-1a (SNG001) for treatment of SARS-CoV-2 infection: a randomised, double-blind, placebo-controlled, phase 2 trial (JT)

May 25, 2021: Tumyan, Sharifi

Once-Weekly Semaglutide in Adults with Overweight or Obesity (GT)

Donanemab in Early Alzheimer’s Disease (AS)
June 1, 2021: Narula, Abbas

Comparative Effectiveness of Aspirin Dosing in Cardiovascular Disease (SN)

Healthy Weight Loss Maintenance with Exercise, Liralglutide, or Both Combined (AA)