Recent reports in Science and Medicine for July 2003
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of these links are very transient and may expire within days of posting.
Some may require prior registration. Check-in and view frequently to avoid
missing great news items. I welcome any suggested articles. (email
link). "§" indicates
a faculty recommended article
July 31
Effect of Verification Bias on Screening for Prostate Cancer by Measurement
of Prostate-Specific Antigen Punglia RS, et al. N
Engl J Med 2003; 349:335-342 and commentary: Schroder and Kranse. Verification
Bias and the Prostate-Specific Antigen Test -- Is There a Case for a Lower
Threshold for Biopsy?. N
Engl J Med 32003; 49: 393-395.
Epidermal Growth Factor Enemas with Oral Mesalamine for Mild-to-Moderate
Left-Sided Ulcerative Colitis or Proctitis. Sinha A, et al.N
Engl J Med 2003; 349:350-357 and Commentary: Farrell, R. J. (2003). Epidermal
Growth Factor for Ulcerative Colitis. N
Engl J Med 2003; 349: 395-397
Inflammation Modifies the Effects of a Reduced-Fat Low-Cholesterol Diet
on Lipids: Results From the DASH-Sodium Trial Erlinger TP, et al Circulation
2003 108: 150 - 154.
BMJ series on death and dying:
Papers:
Doctors' emotional reactions to recent death of a patient:
cross sectional study of hospital doctors Redinbaugh EM, et al.BMJ
2003; 327: 185.
Effects of euthanasia on the bereaved family and friends: a
cross sectional study Swarte NB, et al. BMJ
2003; 327: 189
A systematic review of physicians' survival predictions in
terminally ill cancer patients Glare P, et al. BMJ
2003; 327: 195.
Planning for a good death: responding to unexpected events.
Saunders Y, et al. BMJ 2003;327:204-206 and
Commentary: mother's response, A healthy view of dying, Patients'
voices are needed in debates on euthanasia, Historical and cultural
variants on the good death
July 29
Factors Associated With Failure to Publish Large Randomized Trials Presented
at an Oncology Meeting. Krzyzanowska MK, et al. JAMA.
2003;290:495-501.
Effects of a Dietary Portfolio of Cholesterol-Lowering Foods vs Lovastatin
on Serum Lipids and C-Reactive Protein. Jenkins DJA, et al. JAMA.
2003;290:502-510. (Medscape
news)and EDITORIAL: Diet First, Then Medication for Hypercholesterolemia
James W. Anderson JAMA.
2003;290:531-533.
Neurologic Manifestations and Outcome of West Nile Virus Infection. Sejvar
JJ, et al. JAMA.
2003;290:511-515.
Gynecologic Surgeries and Risk of Ovarian Cancer in Women With BRCA1 and
BRCA2 Ashkenazi Founder Mutations: An Israeli Population-Based Case–Control
Study. Rutter JL, et al. J
Natl Cancer Inst 2003; 95: 1072-1078.
Providing social support may be more beneficial than receiving it: results
from a prospective study of mortality. Brown SL, et al.Psychological
Science2003; 14: 320.
Euthanasia and other end-of-life decisions in the Netherlands in 1990,
1995, and 2001. Onwuteaka-Philipsen BD, et al. Lancet 362, Number 9379
19 July 2003
Promoting Reflection on Professionalism: A Comparison Trial of Educational
Interventions for Medical Students. Baernstein A and Fryer-Edwards K. Acad
Med 2003 78: 742-747.
July 25
Breast Cancer Following Radiotherapy and Chemotherapy Among Young Women
With Hodgkin Disease. Travis LB, et al. JAMA. 2003;290:465-475. and
EDITORIAL : Breast Cancer After Hodgkin Disease: Hope for a Safer Cure. Yahalom JAMA.
2003;290:529-531.
Incidence of Cancer and Mortality Following -Tocopherol and -Carotene Supplementation:
A Postintervention Follow-up: The ATBC Study Group JAMA.
2003;290:476-485.
Acarbose Treatment and the Risk of Cardiovascular Disease and Hypertension
in Patients With Impaired Glucose Tolerance: The STOP-NIDDM Trial. Chiasson
JL, et al.. JAMA.
2003;290:486-494. (Medscape
news report)
Weekend
Reading
Eurekalert and Science
Now (Science 17 July 2003) Drug Deals Diabetes a One-Two Punch [Allosteric
Activators of Glucokinase: Potential Role in Diabetes Therapy Grimsby J,
et al. Science
Jul 18 2003: 370-373.]
Influence of Life Stress on Depression: Moderation by a Polymorphism in
the 5-HTT Gene. Caspi A. Science
2003 301: 386-389. (Gene More Than Doubles Risk Of Depression Following
Life Stresses - Science
Daily report)
Impaired inflammatory and pain responses in mice lacking an inducible
prostaglandin E synthase TrebinoCE, et al. PNAS published online 10.1073/pnas.1332766100.
The human multidrug resistance protein MRP4 functions as a prostaglandin
efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs.
Reid G, et al.
PNAS published online, 10.1073/pnas.1033060100
Salicylic acid attenuates virulence in endovascular infections by targeting
global regulatory pathways in Staphylococcus aureus Kupferwasser LI, et al. J.
Clin. Invest. 2003 112: 222-233.
Treatment Goals of Bipolar Disorder Medscape
Review in Psychiatry & Mental Health
Working Paper from EU on Health Effects and Risks of Tattoos and Body Piercings
(pdf)
July 24
Nurses' Experiences with Hospice Patients Who Refuse Food and Fluids to
Hasten Death. Ganzini L, et al.N
Engl J Med 2003; 349:359-365
A randomized controlled trial of a pharmacist consultation program for
family physicians and their elderly patients. Sellors J, et al.CMAJ
2003; 169:17-22. and Commentary: Why most interventions to improve physician
prescribing do not seem to work. Majumdar and Soumera CMAJ • July
8, 2003; 169:30-31
Most women can skip Pap smears after hysterectomy. July issue of the Journal
of Lower Genital Tract Disease (journal not online) Eurekalert
news report
Development and Progression of Leukoaraiosis in Patients With Brain Ischemia
and Carotid Artery Disease Streifler JY, et al. Stroke
published online July 17, 2003.
Consumption of Fish and n-3 Fatty Acids and Risk of Incident Alzheimer
Disease Morris MC, et al. Arch
Neurol. 2003;60:940-946. and accompanying EDITORIALS: Fish Consumption
and the Risk of Alzheimer Disease: Is It Time to Make Dietary Recommendations?
Friedland RP. Arch
Neurol. 2003;60:923-924.
The Response of Skin Disease to Stress Changes in the Severity of Acne
Vulgaris as Affected by Examination Stress. Chiu A, et al. Arch
Dermatol. 2003;139:897-900.
Qualitative research-enhanced understanding of patients' beliefs: Results
of focus groups with low-income, urban, African American adults with asthma.Georg
e M, et al. J
Allergy Clin Immunol 2003;111:967-73.
Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's
disease: systematic review and meta-analysis of observational studies. Etminan
M, et al.BMJ 2003;327:128 (19 July)
Efficacy of knee tape in the management of osteoarthritis of the knee:
blinded randomised controlled trial. Hinman RS. BMJ 2003;327:135 (19 July)
Effect of Behavioral Training With or Without Pelvic Floor Electrical Stimulation
on Stress Incontinence in Women: A Randomized Controlled Trial. Goode PS,
et al. JAMA.
2003;290:345-352.
Cardiac Troponin T and C-Reactive Protein for Predicting Prognosis, Coronary
Atherosclerosis, and Cardiomyopathy in Patients Undergoing Long-term Hemodialysis.
DeFilippi C, et al. JAMA.
2003;290:353-359.
Critically Ill Patients With Severe Acute Respiratory Syndrome Fowler RA,
et al. JAMA.
2003;290:367-373.
Acute Respiratory Distress Syndrome in Critically Ill Patients With Severe
Acute Respiratory Syndrome. Lew TWK, et al.JAMA.
2003;290:374-380.
Tumor Microsatellite-Instability Status as a Predictor of Benefit from
Fluorouracil-Based Adjuvant Chemotherapy for Colon Cancer. Ribic CM, et al. N
Engl J Med 2003;349:247-257 and PERSPECTIVE: Microsatellite Instability.de
la Chapelle AM. pp:209-210
High-Density vs Low-Density Lipoprotein Cholesterol as the Risk Factor
for Coronary Artery Disease and Stroke in Old Age. Weverling-RijnsburgerAWE,
et al. Arch
Intern Med. 2003;163:1549-1554.
§Dr.
Knochel's suggested Resident Conference topic: "All the World's a Phage.
Viruses that eat bacteria abound—and surprise" John Travis. Science
News Report includes Genome sequence of a serotype M3 strain of group
A Streptococcus : Phage-encoded toxins, the high-virulence phenotype, and
clone emergence. Beres, et al PNAS
2003;Vol 99(July 23):10078-10083.
Science in conflict Symposium explores conflicts of interest and the extent
of industry influence on scientific findings. By Eugene Russo (The
Scientist July 15, 2003)
Building a National Health Information Infrastructure: A Newsmaker Interview
With William Yasnoff, MD, PhD (Medscape
News)
U.S. Outlines Plans for More Health Claims on Food (Medscape
News)
UT Southwestern Researchers Define Regions Of Human Genes Highly Prone
To Mutation (Science
Daily news service)
Unruptured intracranial aneurysms: natural history, clinical outcome, and
risks of surgical and endovascular treatment International Study of Unruptured
Intracranial Aneurysms Investigators * Lancet 2003; 362, Number 9378 12 July 2003 (article
not posted for public. See news report on Eurekalert:
Latest data from 12-year brain aneurysm study )
5-HT 4(a) Receptors Avert Opioid-Induced Breathing Depression Without Loss
of Analgesia Manzke T, et al. Science
Jul 11 2003: 226-229.
Yale Researcher Discovers 'Brain Temperature Tunnel' That For The First
Time Allows External Continuous Measurement Of Brain Temperature (Science
News)
July 17
CRP related articles and editorial in this week's Circulation:
Progress in peanut allergy research: Are we closer to a cure?
Leung D and Bock A.p.12
Persistent protective effect of heat-killed Escherichia coli
producing “engineered,” recombinant peanut proteins
in a murine model of peanut allergy. Li XM, et al.p.159 (news
report)
Food allergy as a risk factor for life-threatening asthma in
childhood: A case-controlled study. Roberts G, et al. p.168.
Activated charcoal forms non–IgE binding complexes with
peanut proteins. Vadas P and Perelman B. p 175.
Relevance of casual contact with peanut butter in children with
peanut allergy Simonte SJ, et al. p.
180.
The natural progression of peanut allergy: Resolution and the
possibility of recurrence. Fleischer DM, et al. p.
183.
The major peanut allergen, Ara h 2, functions as a trypsin inhibitor,
and roasting enhances this function Maleki SJ, et al. p.190
Measurement of peptide-specific IgE as an additional tool in
identifying patients with clinical reactivity to peanuts. Beyer
K, et al. p.
202.
July 16
Comparison of carvedilol and metoprolol on clinical outcomes in patients
with chronic heart failure in the Carvedilol Or Metoprolol European Trial
(COMET): randomised controlled trial. Poole-WilsonPA, et al. Lancet
2003; 362: 7-13 (subscribers/registration; others use Science Direct)
Myocardial viability as a determinant of the ejection fraction response
to carvedilol in patients with heart failure (CHRISTMAS trial): randomised
controlled trial. Cleland JGF, et al. Lancet
2003; 362, Number 9377 05 July 2003. (subscribers/registration)
Structural and Symptomatic Efficacy of Glucosamine and Chondroitin in Knee
Osteoarthritis: A Comprehensive Meta-analysis. Richy F, et al. Arch
Intern Med. 2003;163:1514-1522.
Cohort study of hepatotoxicity associated with nimesulide and other non-steroidal
anti-inflammatory drugs. Traversa G, et al. BMJ
2003; 327: 18-22.
Management of Dyslipidemia in Children and Adolescents With Diabetes. Consensus
Statement American Diabetes Association Diabetes
Care. 2003;26:2194-2197
Vascular Risk Factors and Markers of Endothelial Function as Determinants
of Inflammatory Markers in Type 1 Diabetes: The EURODIAB Prospective Complications
Study. Schram MT, et al.. Diabetes
Care 2003 26: 2165-2173
Antimyelin Antibodies as a Predictor of Clinically Definite Multiple Sclerosis
after a First Demyelinating Event. Berger T, et al. N
Engl J Med 2003; 349:139-145
Low-Molecular-Weight Heparin versus a Coumarin for the Prevention of Recurrent
Venous Thromboembolism in Patients with Cancer. Lee AYY, et al.N
Engl J Med 2003; 349:146-153.
Radiotherapy and tamoxifen in women with completely excised ductal carcinoma
in situ of the breast in the UK, Australia, and New Zealand: randomised controlled
trial
UK Coordinating Committee on Cancer Research (UKCCCR) Ductal Carcinoma in
situ (DCIS) Working Party *on behalf of DCIS trialists in the UK, Australia,
and New Zealand Lancet
2003; 362, Number 9378 12 July 2003
July 14
Trends in Prevalence, Awareness, Treatment, and Control of Hypertension
in the United States, 1988-2000. Hajjar I, and Kotchen TA. JAMA.
2003;290:199-206.
Phytoestrogen Supplements for the Treatment of Hot Flashes: The Isoflavone
Clover Extract (ICE) Study: A Randomized Controlled Trial. Tice JA, et al. JAMA.
2003;290:207-214.
Depressive Symptoms and Health-Related Quality of Life: The Heart and Soul
Study. Ruo B, et al JAMA.
2003;290:215-221.
Impact of an Annual Dollar Limit or "Cap" on Prescription Drug
Benefits for Medicare Patients. Tseng CW, et al. JAMA.
2003;290:222-227.
Cost-effectiveness of Treatment for Chronic Hepatitis C Infection in an
Evolving Patient Population. Salomon JA, et al.JAMA.
2003;290:228-237.
Efficacy and Safety of Tifacogin (Recombinant Tissue Factor Pathway Inhibitor)
in Severe Sepsis: A Randomized Controlled Trial. Abraham E, et al.JAMA.
2003;290:238-247.
Recent Advances and Future Frontiers in Treating Age-Related Cataracts
Solomon R and Donnenfeld ED. JAMA.
2003;290:248-251.
July 11
§ILCOR
Advisory Statement:: Therapeutic Hypothermia After Cardiac Arrest: An Advisory
Statement by the Advanced Life Support Task Force of the International
Liaison Committee on Resuscitation. Nolan JP, et al. Circulation
2003 108: 118 - 121 (AHA
Statement)
Human Embryonic Germ Cell Derivatives Facilitate Motor Recovery of Rats
with Diffuse Motor Neuron Injury Kerr DA, et al.J
Neuroscience 2003,;23:5131-5140 (Eurekalert
news release Human stem cells improve movement in paralyzed rats)
The Role of Topical Antibiotics in Dermatologic Practice Medscape:
CME
Fracture Risks for Women in Long-Term Care: High Prevalence of Calcaneal
Osteoporosis and Hypovitaminosis D. Medscape
Treatment of Heart Failure in Older Persons Dilemmas With Coexisting Conditions:
Diabetes Mellitus, Chronic Obstructive Pulmonary Disease, and Arthritis from
Congestive Heart Failure Medscape
Review
Selective stimulation of VEGFR-1 prevents oxygen-induced retinal vascular
degeneration in retinopathy of prematurity Shu-Ching Shih J.
Clin. Invest. 112 :50-57 (2003).
July 10
Treating Depression in Predominantly Low-Income Young Minority Women: A
Randomized Controlled Trial. Miranda J, et al.JAMA. 2003;290:57-65.
Obesity and Estrogen as Risk Factors for Gastroesophageal Reflux Symptoms.Nilsson
M, et al. JAMA.
2003;290:66-72.
Clinical and Organizational Factors Associated With Feeding Tube Use Among
Nursing Home Residents With Advanced Cognitive Impairment. Mitchell SL, et
al. JAMA.
2003;290:73-80.
Metformin and Thiazolidinedione Use in Medicare Patients With Heart Failure
Masoudi FA, et al.JAMA.
2003;290:81-85.
Serum Urate as an Independent Predictor of Poor Outcome and Future Vascular
Events After Acute Stroke. Weir CJ, et al. Stroke
published July 3, 2003, 10.1161/01.STR.0000081983.34771.D2
REVIEWS: Mortality Risk Reduction Associated With Smoking Cessation in
Patients With Coronary Heart Disease: A Systematic Review.Critchley JA et
al. JAMA.
2003;290:86-97.
PERSPECTIVES ON CARE AT THE CLOSE OF LIFE: Complexities in Prognostication
in Advanced Cancer: "To Help Them Live Their Lives the Way They Want
to" JAMA.
2003;290:98-104.
July 9
The ACCESS Study: Evaluation of Acute Candesartan Cilexetil Therapy in
Stroke Survivors Schrader J, et al. Stroke
2003 34: 1699 - 1703;
Use of Continuous Quality Improvement to Increase Use of Process Measures
in Patients Undergoing Coronary Artery Bypass Graft Surgery: A Randomized
Controlled Trial. Ferguson TB, et al. JAMA.
2003;290:49-56.
Therapeutic Hypothermia After Cardiac Arrest: An Advisory Statement by
the Advanced Life Support Task Force of the International Liaison Committee
on Resuscitation Circulation
2003 108: 118 - 121
Nutritional and energetic consequences of sweetened drink consumption in
6- to 13-year-old children Mrdjenovic G and Levitsky DA. J
Pediatr 2003;142:604-10
Use of Automated External Defibrillators for Children: An Update: An Advisory
Statement From the Pediatric Advanced Life Support Task Force, International
Liaison Committee on Resuscitation. Samso RA, et al. Circulation
2003 107: 3250 - 3255
July 3
Randomized, double-blind, placebo-controlled, dose-titration, phase III
study assessing the efficacy and tolerability of lanthanum carbonate: A new
phosphate binder for the treatment of hyperphosphatemia. Joy MS and others.Am
J K Dis 2003;42.
Achieving Goal Blood Pressure in Patients With Type 2 Diabetes: Conventional
Versus Fixed-Dose Combination Approaches. Bakrsi GL and Weir ME in Journal
of Clinical Hypertension (no online availability; reported in Medscape
News)
Increase in Deaths Due to Methadone in North Carolina. Ballesteros MF,
et al. JAMA.
2003;290:40.
Routine Vitamin Supplementation To Prevent Cancer and Cardiovascular Disease:
Recommendations and Rationale. U.S. Preventive Services Task Force Ann
Intern Med. 2003;139:51–55.
Routine Vitamin Supplementation To Prevent Cardiovascular Disease: A Summary
of the Evidence for the U.S. Preventive Services Task Force. Morris and Carson Ann
Intern Med. 2003;139:56–70.
Treatment of Pemphigus Vulgaris and Pemphigus Foliaceus With Mycophenolate
Mofetil Mimouni D, et al. Arch
Dermatol. 2003;139:739-742.