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Recent reports in Science and Medicine for Academic Year to Date July 2005 - January 2006

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::::::::::            April 28

:::::::::  Weekend Reading - Basic Science and general interest articles  :::::::::

1. FDA
• MedWatch: Promethazine Products Contraindicated in Children Under 2 Years. [Medcape]
2. *  Postexposure protection against Marburg haemorrhagic fever with recombinant vesicular stomatitis virus vectors in non-human primates: an efficacy assessment. [The Lancet (limited access). Reviews: ScienceNOW, Science Daily, New Scientist]
3. Effect of a US National Institutes of Health programme of clinical trials on public health and costs. Lancet. 2006 Apr 22;367(9519):1319-27. [Pubmed]
4. Oxyntomodulin increases energy expenditure in addition to decreasing energy intake in overweight and obese humans: a randomised controlled trial. Intl J Obesity Online publication 18 April 2006. [Eurekalert]
5. Haplotype Insufficiency for Suppressor of Cytokine Signaling-2 Enhances Intestinal Growth and Promotes Polyp Formation in Growth Hormone-Transgenic Mice. Endocrinology 2006 147: 1632-1641.
6. Obesity, Disordered Eating, and Eating Disorders in a Longitudinal Study of Adolescents: How Do Dieters Fare 5 Years Later? J Am Dietetic Ass. 2006. [News] [Eurekalert]

::::::::::            April 27            ::::::::::

1. * An Inducible Mouse Model of Melanoma Expressing a Defined Tumor Antigen. Cancer Res 2006 66: 3278-3286.  
2. Effects of weight training on quality of life in recent breast cancer survivors. The Weight Training for Breast Cancer Survivors (WTBS) study. Cancer 2006 published online 27 March. [Medscape]
3. High-resolution genomic profiles define distinct clinico-pathogenetic subgroups of multiple myeloma patients. Cancer Cell 2006; 9: 313-325. [MedNews]
4. Archives of Internal Medicine  Vol. 166 No. 8, pp. 824-932, April 24, 2006
   • * Prevention of Relapse After Quitting Smoking: A Systematic Review of Trials. Arch Intern Med. 2006;166:828-835.
     
   • Oxycodone for Cancer-Related Pain: Meta-analysis of Randomized Controlled Trials. Arch Intern Med. 2006;166:837-843.
   • * Association of Impaired Diurnal Blood Pressure Variation With a Subsequent Decline in Glomerular Filtration Rate. Arch Intern Med. 2006;166:846-852. [Medscape]
   • Comparison of Bleeding in Patients With Nonvalvular Atrial Fibrillation Treated With Ximelagatran or Warfarin: Assessment of Incidence, Case-Fatality Rate, Time Course and Sites of Bleeding, and Risk Factors for Bleeding. Arch Intern Med. 2006;166:853-859.
   • Effect of Weight Loss and Exercise on Frailty in Obese Older Adults. Arch Intern Med. 2006;166:860-866.
   • Effects of Calcium Supplementation on Clinical Fracture and Bone Structure: Results of a 5-Year, Double-blind, Placebo-Controlled Trial in Elderly Women. Arch Intern Med. 2006;166:869-875.
   • Depressive Symptoms After Acute Myocardial Infarction: Evidence for Highest Rates in Younger Women. The PREMIER Registry Investigators. Arch Intern Med. 2006;166:876-883.
   • Proteinuria and Risk for Stroke and Coronary Heart Disease During 27 Years of Follow-up: The Honolulu Heart Program. Arch Intern Med. 2006;166:884-889.
   • Prospective Study of Health Status Preferences and Changes in Preferences Over Time in Older Adults. Arch Intern Med. 2006;166:890-895.
   • Racial Differences in Trust in Health Care Providers. Arch Intern Med. 2006;166:896-901.
   • Effects of Etanercept in Patients With the Metabolic Syndrome. Arch Intern Med. 2006;166:902-908. [Medscape]
   • Prognostic Impact of Prolonged Ventricular Repolarization in Hypertension. Arch Intern Med. 2006;166:909-913.
   • Predicting Medical and Surgical Complications of Carotid Endarterectomy: Comparing the Risk Indexes. Arch Intern Med. 2006;166:914-920.
   • End-of-Life Decision Making in Europe and Australia: A Physician Survey. The European End-of-Life (EURELD) Consortium. Arch Intern Med. 2006;166:921-929.

::::::::::            April 26            ::::::::::

1. * Variant Creutzfeldt-Jakob disease: prion protein genotype analysis of positive appendix tissue samples from a retrospective prevalence study. BMJ (published 10 April 2006)
2. Bone-patellar tendon-bone autografts versus hamstring autografts for reconstruction of anterior cruciate ligament: meta-analysis. BMJ (published 7 April 2006)
3. * Active and passive smoking and development of glucose intolerance among young adults in a prospective cohort: CARDIA study. BMJ (published 7 April 2006)
4. Early determinants of physical activity in adolescence: prospective birth cohort study. BMJ, (published 6 April 2006)
5. New England Journal of Medicine  Volume 354 April 20, 2006 Number 16
   • Private Health Care in Canada. R. Steinbrook
   • The NIH Budget and the Future of Biomedical Research. J. Loscalzo
   • * Statistics and Medicine: The Challenge of Subgroup Analyses — Reporting without Distorting. S. W. Lagakos
   • * Efficacy and Safety of Corticosteroids for Persistent Acute Respiratory Distress Syndrome. The National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network [Medscape]
   • Feasibility of Treating Prehypertension with an Angiotensin-Receptor Blocker. S. Julius and Others
   • Oral Ondansetron for Gastroenteritis in a Pediatric Emergency Department. S. B. Freedman, M. Adler, R. Seshadri, and E. C. Powell [Medscape]
   • * Clopidogrel and Aspirin versus Aspirin Alone for the Prevention of Atherothrombotic Events. D. L. Bhatt and Others
   • Scabies. O. Chosidow
   • Lung Inflammation in ARDS — Friend or Foe? P. M. Suter
   • Pharmacotherapy for Prehypertension — Mission Accomplished? H. Schunkert
   • The Charisma of Subgroups and the Subgroups of CHARISMA. M. A. Pfeffer and J. A. Jarcho

::::::::::            April 25            ::::::::::

1. *  The Antimicrobial Treatment Strategies (MIKSTRA) Program: A 5-Year Follow-Up of Infection-Specific Antibiotic Use in Primary Health Care and the Effect of Implementation of Treatment Guidelines. The MIKSTRA Collaborative Study Group. Clin Inf Dis 2006;42:1221-1230. [Eurekalert]
2. High Rate of Spontaneous Negativity for Hepatitis C Virus RNA after Establishment of Chronic Infection in Alaska Natives. Clin Infect Dis 2006;42:945-954. UpToDate Topic Review: Clinical features and natural history of hepatitis C virus infection. [Medscape]
3. JAMA Vol. 295 No. 15, pp. 1741-1860, April 19, 2006
   • Neuropsychological and Renal Effects of Dental Amalgam in Children: A Randomized Clinical Trial. JAMA. 2006;295:1775-1783.
   • Neurobehavioral Effects of Dental Amalgam in Children: A Randomized Clinical Trial. JAMA. 2006;295:1784-1792.
   • Education, 15-Year Risk Factor Progression, and Coronary Artery Calcium in Young Adulthood and Early Middle Age: The Coronary Artery Risk Development in Young Adults Study. JAMA. 2006;295:1793-1800.
   • Second-Order Peer Review of the Medical Literature for Clinical Practitioners. The McMaster Premium Literature Service (PLUS) Project. JAMA. 2006;295:1801-1808.
   • Reviews: Birth Spacing and Risk of Adverse Perinatal Outcomes: A Meta-analysis. JAMA. 2006;295:1809-1823.
   • Clinical Review: The Influence of Estrogen on Migraine: A Systematic Review. JAMA. 2006;295:1824-1830.
   • Commentaries: Will Physician-Level Measures of Clinical Performance Be Used in Medical Malpractice Litigation? JAMA. 2006;295:1831-1834.
   • Editorials: Mercury in Dental Amalgam—A Neurotoxic Risk? JAMA. 2006;295:1835-1836.
   • Birth Spacing—The Long and Short of It. JAMA. 2006;295:1837-1838.

::::::::::            April 24            ::::::::::

1. Targeting the inflamed synovium: The quest for specificity. Arth & Rheum 2006; 54: 1055-1060. [Eurekalert]
2. * Potent induction of chondrocytic differentiation of human adipose-derived adult stem cells by bone morphogenetic protein 6. Arth & Rheum 2006; 54: 1222-1232. [Eurekalert]
3. Use of a collagen-platelet rich plasma scaffold to stimulate healing of a central defect in the canine ACL. J Orthopaedic Res 2006; 24: 820-830. [Getting ACL tears to heal themselves- Growth-factor-rich gel regenerates knee ligament, with 40% increase in strength. [Eurekalert]
4. A randomised controlled trial evaluating the effects of two workstation interventions on upper body pain and incident musculoskeletal disorders among computer operators. Occup Environ Med 2006; 63: 300-306. [Eurekalert]
5. Annals of Internal Medicine  18 April 2006 Volume 144 Issue 8 Previous Issue
   • Does Utilization of Screening Mammography Explain Racial and Ethnic Differences in Breast Cancer? R. Smith-Bindman, and Others.
   • The Relationship between Green Tea and Total Caffeine Intake and Risk for Self-Reported Type 2 Diabetes among Japanese Adults. The JACC Study Group*
   • Telephone Care Management To Improve Cancer Screening among Low-Income Women: A Randomized, Controlled Trial. Allen J. Dietrich, and Others.
   • Brief Communication: Atrial–Esophageal Fistulas after Radiofrequency Ablation. Jennifer E. Cummings and Others.
   • Medicine and Public Issues: Research Misconduct, Retraction, and Cleansing the Medical Literature: Lessons from the Poehlman Case. Harold C. Sox and Drummond Rennie
     
   • Clinical Guidelines: Risk Assessment for and Strategies To Reduce Perioperative Pulmonary Complications for Patients Undergoing Noncardiothoracic Surgery: A Guideline from the American College of Physicians
   • * Preoperative Pulmonary Risk Stratification for Noncardiothoracic Surgery: Systematic Review for the American College of Physicians. [Eurekalert]
   • * Strategies To Reduce Postoperative Pulmonary Complications after Noncardiothoracic Surgery: Systematic Review for the American College of Physicians.
   • Editorial: Exploring and Crossing the Disparity Divide in Cancer Mortality. Mary B. Barton

::::::::::            April 21

:::::::::  Weekend Reading - Basic Science and general interest articles  :::::::::

1. FDA
   • MedWatch:
     • Macugen (pegaptanib ) Important changes in the approved product labeling. Rare reports of anaphylaxis/anaphylactoid reactions, including angioedema following the administration of Macugen along with various medications administered as part of the injection preparation. [Medscape]
     • Fungal Keratitis Infections Related to Contact Lens Use. Medwatch [Medscape]
     • FDA News: Investigation of Serious Eye Infections Associated With Soft Contact Lens Use and Contact Lens Solution. Consumers Are Advised to Follow Good Hygiene Practices and Manufacturers’ Instructions to Prevent Infection. [Medscape]
   • FDA Safety Changes: Naprosyn/Anaprox and Other Prescription NSAIDs [Medscape]
   • FDA Approvals: Orphan Drug [Medscape]
     • Lestaurtinib (CEP-701 ) for the treatment of acute myeloid leukemia (AML).
     • TRX4 (hAglyCD3) for the treatment of new-onset type 1 diabetes mellitus.
     • EPI-A0001 for the treatment of inherited mitochondrial respiratory chain diseases.
   • Summary View: Safety Labeling Changes Approved By FDA Center for Drug Evaluation and Research (CDER) -- January 2006
2. Hypothalamic huntingtin-associated protein 1 as a mediator of feeding behavior. Nature: Medicine Published online: 9 April 2006.
3. Induction of leptin resistance through direct interaction of C-reactive protein with leptin. Nature Medicine 12, 425 - 432 (2006). [Eurekalert: Clues to obesity’s cause ]
4. * Losartan, an AT1 Antagonist, Prevents Aortic Aneurysm in a Mouse Model of Marfan Syndrome. Science 7 April 2006 312: 117-121. [Eurekalert and Medscape reviews]

   Podcast  suggestion:	New England Journal of Medicine audio
   	Find out more about podcasting on the iTunes site or see the Wikipedia definition.

::::::::::            April 20            ::::::::::

1. Randomized clinical trial comparing surgery with conservative treatment for uncomplicated varicose veins. Br J Surg. 2006; 93(2):175-81 [Medscape review]
2. Indomethacin and Celecoxib Impair Rotator Cuff Tendon-to-Bone Healing. Am J Sports Med 2006 34: 362-369. [Medscape]
3. Archives of Internal Medicine Vol. 166 No. 7, pp. 708-812, April 10, 2006
   • Editorial: The Role of Fibrates in a Statin World. Arch Intern Med. 2006;166:715-716.
   • Review: Antiarrhythmic Drugs for Maintaining Sinus Rhythm After Cardioversion of Atrial Fibrillation: A Systematic Review of Randomized Controlled Trials. Arch Intern Med. 2006;166:719-728.
   • Risk of Recurrent Venous Thromboembolism in Patients With Common Thrombophilia: A Systematic Review. Arch Intern Med. 2006;166:729-736.
   • Attenuation of Progression of Insulin Resistance in Patients With Coronary Artery Disease by Bezafibrate. Arch Intern Med. 2006;166:737-741.
   • Gemfibrozil in the Treatment of Dyslipidemia: An 18-Year Mortality Follow-up of the Helsinki Heart Study. Arch Intern Med. 2006;166:743-748.
   • Terminal Sedation and Euthanasia: A Comparison of Clinical Practices. Arch Intern Med. 2006;166:749-753.
   • Adoption of Patient-Centered Care Practices by Physicians: Results From a National Survey. Arch Intern Med. 2006;166:754-759.
   • A Prospective Study of Female Hormone Use and Breast Cancer Among Black Women. Arch Intern Med. 2006;166:760-765.
   • Early Ambulation After Hip Fracture: Effects on Function and Mortality. Arch Intern Med. 2006;166:766-771.
   • Venous Thrombosis and Conjugated Equine Estrogen in Women Without a Uterus. Arch Intern Med. 2006;166:772-780. [Medscape]
   • Hyponatremia and Long-term Mortality in Survivors of Acute ST-Elevation Myocardial Infarction. Arch Intern Med. 2006;166:781-786.
   • Angiotensin-Converting Enzyme Inhibitors in Patients With Coronary Artery Disease and Absence of Heart Failure or Left Ventricular Systolic Dysfunction: An Overview of Long-term Randomized Controlled Trials. Arch Intern Med. 2006;166:787-796.
   • Differing Effects of Antihypertensive Drugs on the Incidence of Diabetes Mellitus Among Patients With Hypertensive Kidney Disease.
     Arch Intern Med. 2006;166:797-805.
   • Clopidogrel to Treat Patients With Non–ST-Segment Elevation Acute Coronary Syndromes After Hospital Discharge. Arch Intern Med. 2006;166:806-811.

::::::::::            April 19            ::::::::::

1. * Initial Results of the Study of Tamoxifen and Raloxifene (STAR) Released: Osteoporosis Drug Raloxifene Shown to be as Effective as Tamoxifen in Preventing Invasive Breast Cancer. NIH News report [Medscape]
2. New England Journal of Medicine Volume 354 April 13, 2006 Number 15
   • After the Storm — Health Care Infrastructure in Post-Katrina New Orleans. R. E. Berggren and T. J. Curiel
   • Adaptations. R. E. Berggren
   • Access to the Scientific Literature — A Difficult Balance. M. Frank
   • Abdominal Sacrocolpopexy with Burch Colposuspension to Reduce Urinary Stress Incontinence. L. Brubaker and Others
   • Homocysteine Lowering with Folic Acid and B Vitamins in Vascular Disease. The Heart Outcomes Prevention Evaluation (HOPE) 2 Investigators
   • Homocysteine Lowering and Cardiovascular Events after Acute Myocardial Infarction. K. H. Bønaa and Others
   • The Effect of Telithromycin in Acute Exacerbations of Asthma. S. L. Johnston and Others
   • Medical Progress: Trans Fatty Acids and Cardiovascular Disease. D. Mozaffarian and Others
   • Placement of an Arterial Line. K. Tegtmeyer and Others. Video
   • Pellagra-like Dermatitis. N. Ashourian and N. Mousdicas
   • Pseudoclubbing. A. Farzaneh-Far
   • The Vexing Problem of Hidden Incontinence. R. G. Rogers
   • Homocysteine Trials — Clear Outcomes for Complex Reasons. J. Loscalzo
   • Treating Acute Asthma with Antibiotics — Not Quite Yet. F. F. Little
   • Videos in Clinical Medicine — A New Journal Feature. G. T. McMahon, J. R. Ingelfinger, and E. W. Campion
   • A Toggle for Type 2 Diabetes? B. Thorens

::::::::::            April 18            ::::::::::

1. Epstein-Barr Virus Tied to Multiple Sclerosis in Long-Term Study. Arch Neurol 2006;63:E1-E5.[Medscape]
2. JAMA Vol. 295 No. 14, pp. 1619-1730, April 12, 2006
   • * Effects of Conjugated Equine Estrogens on Breast Cancer and Mammography Screening in Postmenopausal Women With Hysterectomy. JAMA 2006;295:1647-1657. [Medscape]
   • * Estrogen-Receptor Status and Outcomes of Modern Chemotherapy for Patients With Node-Positive Breast Cancer. JAMA 2006;295:1658-1667.
   • * Invasive Pneumococcal Disease Among Infants Before and After Introduction of Pneumococcal Conjugate Vaccine. JAMA 2006;295:1668-1674.
   • Effect of Blinded Peer Review on Abstract Acceptance. JAMA 2006;295:1675-1680.
   • * Activation of Oxidative Stress by Acute Glucose Fluctuations Compared With Sustained Chronic Hyperglycemia in Patients With Type 2 Diabetes. JAMA. 2006;295:1681-1687.
   • Assessing Glycemia in Diabetes Using Self-monitoring Blood Glucose and Hemoglobin A1c. JAMA. 2006;295:1688-1697`
   • Public Health Strategies for Pandemic Influenza: Ethics and the Law. JAMA. 2006;295:1700-1704.
   • Recent Trials in Hypertension: Compelling Science or Commercial Speech? JAMA. 2006;295:1704-1706.
   • Editorial: Glycemic Variability: A Hemoglobin A1c–Independent Risk Factor for Diabetic Complications. JAMA 2006;295:1707-1708.
   • From the Archives Journals: The Hidden and Potent Effects of Television Advertising. JAMA 2006;295:1698-1699.

::::::::::            April 12            ::::::::::

1. Randomized clinical trial comparing surgery with conservative treatment for uncomplicated varicose veins. Br J Surg. 2006; 93(2):175-81 [Medscape review]
2. Indomethacin and Celecoxib Impair Rotator Cuff Tendon-to-Bone Healing. Am J Sports Med 2006 34: 362-369. [Medscape]

::::::::::            April 11            ::::::::::

1. Mitigation strategies for pandemic influenza in the United States. PNAS 2006; published online April 3. [Medscape] [LiveScience animation]
2. New England Journal of Medicine Volume 354 April 6, 2006 Number 14
   • * ADHD Drugs and Cardiovascular Risk. S. E. Nissen
   • The Changing Face of Teenage Drug Abuse — The Trend toward Prescription Drugs. R. A. Friedman
   • Research on Stroke: Small Vessels, Big Problems. S. M. Greenberg [Medscape]
   • * Effect of Introduction of the Pneumococcal Conjugate Vaccine on Drug-Resistant Streptococcus pneumoniae. M. H. Kyaw and Others [Medscape]
   • * Comparison of Fondaparinux and Enoxaparin in Acute Coronary Syndromes. The Fifth Organization to Assess Strategies in Acute Ischemic Syndromes Investigators
   • * Enoxaparin versus Unfractionated Heparin with Fibrinolysis for ST-Elevation Myocardial Infarction. E. M. Antman and Others
   • Brief Report: Role of COL4A1 in Small-Vessel Disease and Hemorrhagic Stroke. D. B. Gould and Others
   • Sexual Desire and Arousal Disorders in Women. R. Basson
   • Current Concepts: The Biology of Human Sex Differences. D. D. Federman
   • Pneumococcal Vaccine — Direct and Indirect ("Herd") Effects. D. M. Musher
   • Therapy for Patients with Acute Coronary Syndromes — New Opportunities. R. J. Gibbons and V. Fuster

::::::::::            April 10            ::::::::::

1. ß-Glucan incorporated into a fruit drink effectively lowers serum LDL-cholesterol concentrations. Am J Clin Nutr 2006;83:601-605. [Medscape]
2. JAMA Vol. 295 No. 13, pp. 1481-1612, April 5, 2006
   • Effects of Fondaparinux on Mortality and Reinfarction in Patients With Acute ST-Segment Elevation Myocardial Infarction: The OASIS-6 Randomized Trial. The OASIS-6 Trial Group*. JAMA. 2006;295:1519-1530.
   • Abciximab in Patients With Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention After Clopidogrel Pretreatment: The ISAR-REACT 2 Randomized Trial. Intracoronary Stenting and Antithrombotic Regimen: Rapid Early Action for Coronary Treatment 2 (ISAR-REACT 2) Trial Investigators. JAMA. 2006;295:1531-1538.
   • * Effect of 6-Month Calorie Restriction on Biomarkers of Longevity, Metabolic Adaptation, and Oxidative Stress in Overweight Individuals: A Randomized Controlled Trial. Pennington CALERIE Team. JAMA. 2006;295:1539-1548. [Medscape] [NYTimes]
   • * Prevalence of Overweight and Obesity in the United States, 1999-2004. JAMA. 2006;295:1549-1555.
   • * Preliminary Communications: Effect of Very High-Intensity Statin Therapy on Regression of Coronary Atherosclerosis: The ASTEROID Trial. ASTEROID Investigators. JAMA. 2006;295:1556-1565.
   • The Rational Clinical Examination: Can the Clinical History Distinguish Between Organic and Functional Dyspepsia? JAMA. 2006;295:1566-1576.
   • * Editorials: Excessive Adiposity, Calorie Restriction, and Aging. JAMA. 2006;295:1577-1578.
     
   • Fondaparinux in ST-Segment Elevation Myocardial Infarction: The Drug, the Strategy, the Environment, or All of the Above? JAMA. 2006;295:1579-1580.
   • Clopidogrel Treatment Prior to Percutaneous Coronary Intervention: When Enough Isn't Enough. JAMA. 2006;295:1581-1582.
   • Can a Potent Statin Actually Regress Coronary Atherosclerosis? JAMA. 2006;295:1583-1584.

::::::::::            April 7

:::::::::  Weekend Reading - Basic Science and general interest articles  :::::::::

1. FDA
   1. MedWatch: Ontak (denileukin diftitox) warning of the risk for visual loss associated with use. [Medscape]
   2. FDA Approvals: Orphan Drug Approvals: [Medscape]
      • Ceflatonin (homoharringtonine) for the treatment of chronic myeloid leukemia (CML).
      • Valortim ( MDX-1303) for the treatment of anthrax infection.
      • TQ-1018 (topical capsaicin) for the management of postherpetic neuralgia.
   3. The FDA has warned of flagrant violations of donor screening regulations by BioMedical Tissue Services, Inc. which have brought the safety of implanted tissues into question. [Medscape]
2. Tissue-Engineered Bladders Successfully Implanted Into 7 Patients Needing Cystoplasty [Medscape from April 4 Lancet (limited access)]
3. Acute Infections May Raise Risk of Venous Thromboembolic Events [Medscape review from Lancet 2006;367:1075-1079. (limited access)]
4. Religious Attendance: More Cost-Effective Than Lipitor? D. E. Hall. J Am Board Family Med 19:103-109 (2006). [BBC News]
5. Intellectual ability and cortical development in children and adolescents. Nature 440, 676-679 (30 March 2006) [Brain Development Linked to IQ. ScienceNOW]
6. Time for the renaissance of medicine in the Middle East. The Lancet 2006; 367:959

::::::::::            April 6             ::::::::::

1. News in Cardiology
   • *  Low-Density Lipoprotein and High-Density Lipoprotein Particle Subclasses Predict Coronary Events and Are Favorably Changed by Gemfibrozil Therapy in the Veterans Affairs High-Density Lipoprotein Intervention Trial. Circulation. 2006;113:1556-1563.
   • *  Editorial: Cardioprotective Properties of Fibrates -Which Fibrate, Which Patients, What Mechanism? Circulation. 2006;113:1553-1555.
   • Magnesium Intake and Incidence of Metabolic Syndrome Among Young Adults. Circulation 2006: published online March 27, 2006 [Medscape]
   • Personal health habits of american cardiologists. Am J Cardiol. 2006 Apr 1;97(7):1093-6.
   • *  Impaired Capacity for Stimulated Fibrinolysis in Primary Hypertension Is Restored by Antihypertensive Therapy. Hypertension. 2006;47:686.
   • Endothelium-Derived Epoxyeicosatrienoic Acids and Vascular Function. Hypertension. 2006;47:629.
   • *  Sport practice and the risk of lone atrial fibrillation: A case–control study. Intl J Cardiol 2006;108: 332-337.
   • Population-Based Analysis of Sudden Cardiac Death With and Without Left Ventricular Systolic Dysfunction: Two-Year Findings from the Oregon Sudden Unexpected Death Study. J Am Coll Cardiol 2006;47:1161-1166. [Medscape]
   • *  Obstructive Sleep Apnea Syndrome: More Insights on Structural and Functional Cardiac Alterations, and the Effects of Treatment With Continuous Positive Airway Pressure. J Am Coll Cardiol 2006 47: 1433-1439. [Eurekalert]
   • Effects of Normal Aging on Left Ventricular Lusitropic, Inotropic, and Chronotropic Responses to Dobutamine. J Am Coll Cardiol 2006 47: 1440-1447.
   • Robotic Magnetic Navigation for Atrial Fibrillation Ablation. J Am Coll Cardiol 2006 47: 1390-1400. [Eurekalert]
   • *  Cholesteryl Ester Transfer Protein (CETP) Inhibition Beyond Raising High-Density Lipoprotein Cholesterol Levels: Pathways by Which Modulation of CETP Activity May Alter Atherogenesis. Arteriosclerosis, Thrombosis, and Vascular Biology. 2006;26:706.
   • Cardiovascular, cerebrovascular, and respiratory changes induced by different types of music in musicians and non-musicians: the importance of silence. Heart 2006;92:445-452. Editorial: The sound of silence is music to the heart . Heart 2006;92:433-434.
   • * B-type natriuretic peptide identifies silent myocardial ischaemia in stroke survivors. Heart 2006;92:487-489. [Medscape]
   • Left ventricular function after exercise training in young men. Am J Cardiol. 2006; 97:1089-92.
   • * Long-Term Caloric Restriction Ameliorates the Decline in Diastolic Function in Humans. J Am Coll Cardiol 2006 47: 398-402.

::::::::::            April 5            ::::::::::

1. Infectious mononucleosis and risk for multiple sclerosis: A meta-analysis. Ann Neurol 2006;59:499-503. [Medscape]
2. Anxiety and stress in the postpartum: is there more to postnatal distress than depression? BMC Psychiatry 2006, 6:12. [Medscape]
3. Chronic stress at work and the metabolic syndrome: prospective study. BMJ 2006;332:521-525. [Medscape]
4. Is There Cross-Reactivity Between Penicillins and Cephalosporins? Am J Med 2006 119: 354.
5. Annals of Internal Medicine 4 April 2006 Volume 144 Issue 7
   • Improvements in Diabetes Processes of Care and Intermediate Outcomes: United States, 1988–2002. J. B. Saaddine, and Others. [Medscape]
   • Therapy Modifications in Response to Poorly Controlled Hypertension, Dyslipidemia, and Diabetes Mellitus. N. Rodondi, and Others.
   • *  Effects of Comprehensive Lifestyle Modification on Diet, Weight, Physical Fitness, and Blood Pressure Control: 18-Month Results of a Randomized Trial. P. J. Elmer, and Others.
   • Outcomes of Minor and Subsyndromal Depression among Elderly Patients in Primary Care Settings. J. M. Lyness, and Others.
   • Brief Communication: Sirolimus-Associated Pneumonitis: 24 Cases in Renal Transplant Recipients. L. Champion, and Others.
     
   • Improving Patient Care : Computerization Can Create Safety Hazards: A Bar-Coding Near Miss. C. J. McDonald
     
   • Reviews: Adiposity of the Heart*, Revisited. J. M. McGavock, and Others
     
   • Editorials: Improving the Outcomes of Metabolic Conditions: Managing Momentum To Overcome Clinical Inertia. J. B. Perlin and L. M. Pogach
   • Minor Depression: Midway between Major Depression and Euthymia. K. Kroenke
     
   • On Being a Doctor: The Pediatric Arrest. A. A. Peterson

::::::::::            April 4            ::::::::::

1. * Antiinflammatory Effects of Salmeterol/Fluticasone Propionate in Chronic Obstructive Lung Disease. Am. J. Respir. Crit. Care Med. 2006; 173: 736-743. [Eurekalert]
2. Brain Natriuretic Peptide Is a Prognostic Parameter in Chronic Lung Disease. Am. J. Respir. Crit. Care Med. 2006; 173: 744-750. [Eurekalert]
3. * Novel Endovascular Treatment of Blunt Thoracic Aortic Trauma with a Self-Expanding Stent Lined with Aortic Extender Cuffs. J. K. Thompson, and Others. Annals Vasc Surg 2006; online. [News: Surgeons have developed a new, minimally invasive method for repairing blunt thoracic aortic trauma injuries.]
4. Archives of Internal Medicine Vol. 166 No. 6, pp. 598-696, March 27, 2006
   • Editorials: Time, Now, to Recover the Fun in the Physical Examination Rather Than Abandon It. Arch Intern Med. 2006;166:603-604.
     
   • Commentaries: Reconsidering Medication Appropriateness for Patients Late in Life. Arch Intern Med. 2006;166:605-609.
   • *  Competency in Cardiac Examination Skills in Medical Students, Trainees, Physicians, and Faculty: A Multicenter Study. Arch Intern Med. 2006;166:610-616.
   • *  Relationship Between Accurate Auscultation of a Clinically Useful Third Heart Sound and Level of Experience. Arch Intern Med. 2006;166:617-622.
     
   • A Trial of Disclosing Physicians' Financial Incentives to Patients. Arch Intern Med. 2006;166:623-628. [Medscape]
   • Associations Between the Age at Diagnosis and Location of Colorectal Cancer and the Use of Alcohol and Tobacco: Implications for Screening. Arch Intern Med. 2006;166:629-634.
   • Current Antibiotic Therapy for Isolated Urinary Tract Infections in Women. Arch Intern Med. 2006;166:635-639.
   • Management of Acute Pharyngitis in Adults: Reliability of Rapid Streptococcal Tests and Clinical Findings. Arch Intern Med. 2006;166:640-644. [Medscape]
   • Prolonged Effects of a Home-Based Intervention in Patients With Chronic Illness. Arch Intern Med. 2006;166:645-650.
   • Natural History of Knee Cartilage Defects and Factors Affecting Change. Arch Intern Med. 2006;166:651-658.
   • Effects of Angiotensin-Converting Enzyme Inhibition With Perindopril on Left Ventricular Remodeling and Clinical Outcome: Results of the Randomized Perindopril and Remodeling in Elderly With Acute Myocardial Infarction (PREAMI) Study. The PREAMI Investigators* Arch Intern Med. 2006;166:659-666.
   • A Controlled Trial of Naltrexone Augmentation of Nicotine Replacement Therapy for Smoking Cessation. Arch Intern Med. 2006;166:667-674. [Medscape]
   • Effect of Quality Improvement on Racial Disparities in Diabetes Care. Arch Intern Med. 2006;166:675-681.
   • Type 2 Diabetes Mellitus in Midlife Estimated From the Cambridge Risk Score and Body Mass Index. Arch Intern Med. 2006;166:682-688.
   • Use of a Blood Glucose Monitoring Manual to Enhance Monitoring Adherence in Adults With Diabetes: A Randomized Controlled Trial. Arch Intern Med. 2006;166:689-695. [Medscape]

::::::::::            April 3            ::::::::::

1. Infectious Disease News
   • Prolonged Illness after Infectious Mononucleosis Is Associated with Altered Immunity but Not with Increased Viral Load. J.I.D. 2006;193:664-671. [MedNews]
   • Eligibility for Treatment of Hepatitis C Virus Infection among Young Injection Drug Users in 3 US Cities . Clin Infect Dis 2006;42:669-675. [Medscape]
   • Bad Bugs Need Drugs: An Update on the Development Pipeline from the Antimicrobial Availability Task Force of the Infectious Diseases Society of America. Clin Inf Dis 2006;42:657-668.
   • * Clinical efficacy of anti-pneumococcal vaccination in patients with COPD. Thorax 2006; 61: 189-195. [Medscape]
   • * Synchrony, Waves, and Spatial Hierarchies in the Spread of Influenza. Science 2006; Published Online March 30, 2006. [Medscape]
2. New England Journal of Medicine   Volume 354 March 30, 2006 Number 13
   • Politics and Independence — The Collapse of the Canadian Medical Association Journal. M. Shuchman and D. A. Redelmeier
   • Part "D" for "Defective" — The Medicare Drug-Benefit Chaos. J. Avorn
   • Safety and Immunogenicity of an Inactivated Subvirion Influenza A (H5N1) Vaccine. J. J. Treanor and Others
   • *  Outpatient Gatifloxacin Therapy and Dysglycemia in Older Adults. L. Y. Park-Wyllie and Others
   • Prevalence of Monoclonal Gammopathy of Undetermined Significance. R. A. Kyle and Others ]
   • Brief Report: Recessive Symptomatic Focal Epilepsy and Mutant Contactin-Associated Protein-like 2. K. A. Strauss and Others
   • Behavioral Health Insurance Parity for Federal Employees. H. H. Goldman and Others
   • Mechanisms of Disease: Hereditary Proteinuria Syndromes and Mechanisms of Proteinuria. K. Tryggvason, J. Patrakka, and J. Wartiovaara
   • Vaccines against Avian Influenza — A Race against Time. G. A. Poland
   • Serious Adverse Drug Effects — Seeing the Trees through the Forest. J. H. Gurwitz
   • Better Behavioral Health Care Coverage for Everyone. S. Glied and A. Cuellar
   • Targeting Rickettsia. D. H. Walker

:::::::       February 28       :::::::

1. New England Journal of Medicine  Volume 354 February 23, 2006 Number 8
   • Antiviral Resistance in Influenza Viruses — Implications for Management and Pandemic Response. F. G. Hayden
   • Focus on Research: Herceptin and the Heart — A Molecular Modifier of Cardiac Failure. K. R. Chien
   • Functional Dyspepsia — Managing the Conundrum. G. F. Longstreth
   • * Glucosamine, Chondroitin Sulfate, and the Two in Combination for Painful Knee Osteoarthritis. D. O. Clegg and Others [Medscape]
   • Adjuvant Docetaxel or Vinorelbine with or without Trastuzumab for Breast Cancer. H. Joensuu and Others
   • * Denosumab in Postmenopausal Women with Low Bone Mineral Density. M. R. McClung and Others [Eurekalert]
   • A Placebo-Controlled Trial of Itopride in Functional Dyspepsia. G. Holtmann and Others [Medscape]
     
   • Osteoarthritis of the Knee. D. T. Felson
   • Nutritional Supplements for Knee Osteoarthritis — Still No Resolution. M. C. Hochberg
   • The Long and the Short of Bone Therapy. M. P. Whyte
   • Strategies for Improving Surgical Quality — Should Payers Reward Excellence or Effort? N. J.O. Birkmeyer and J. D. Birkmeyer
   • Early Release
     • Expression of Concern Reaffirmed. Published at www.nejm.org February 22, 2006 (10.1056/NEJMe068054)
     • Response to Expression of Concern Regarding VIGOR Study. Published at www.nejm.org February 22, 2006 (10.1056/NEJMc066096) [Medscape]

:::::::       February 27       :::::::

1. JAMA Vol. 295 No. 8, pp. 859-960, February 22, 2006
   • * Adamantane Resistance Among Influenza A Viruses Isolated Early During the 2005-2006 Influenza Season in the United States. JAMA. 2006;295:891-894.
   • * Sirolimus- vs Paclitaxel-Eluting Stents in De Novo Coronary Artery Lesions: The REALITY Trial: A Randomized Controlled Trial. JAMA. 2006;295:895-904.
   • Policies and Practices Related to the Role of Board Certification and Recertification of Pediatricians in Hospital Privileging. JAMA. 2006;295:905-912.
   • Use of Board Certification and Recertification of Pediatricians in Health Plan Credentialing Policies. JAMA. 2006;295:913-918.
   • Helmet Use and Risk of Head Injuries in Alpine Skiers and Snowboarders. JAMA. 2006;295:919-924.
   • Clinical Crossroads: A 54-Year-Old Woman With Constipation-Predominant Irritable Bowel Syndrome. JAMA. 2006;295:925-933.
   • Editorials: Adamantane Resistance in Influenza A. JAMA. 2006;295:934-936.
   • Wish List and REALITY: Choice of Stents and End Points for Treatment of De Novo Coronary Artery Lesions. JAMA. 2006;295:937-938.
   • Credentialing and Public Accountability: A Central Role for Board Certification. JAMA. 2006;295:939-940.

:::::::       February 24        :::::::

:::::::  Weekend Reading - Basic Science and general interest articles  :::::::

1. FDA
• Approval: Eraxis™ (anidulafungin) to treat certain infections caused by Candida, a yeast-like fungus that can cause serious infections in hospitalized patients or patients with compromised immune systems.
2. * Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates. Nature-Medicine published online: 19 February 2006. (Milestone in diabetes research using pig islets [Eurekalert] )
3. * Gum Chewing Reduces Ileus After Elective Open Sigmoid Colectomy. Arch Surg. 2006;141:174-176.
4. * Activity-Dependent Regulation of MEF2 Transcription Factors Suppresses Excitatory Synapse Number. Science 17 February 2006: Vol. 311. no. 5763, pp. 1008 - 1012. [ScienceDaily]
5. Death and Injury from Motor Vehicle Crashes: A Tale of Two Countries. Am J Prev Med 2005; 5:440-449. [Eurekalert: Study indicates speed cameras could curb US road deaths.]
6. A Calcium-Regulated MEF2 Sumoylation Switch Controls Postsynaptic Differentiation. Science 17 February 2006:Vol. 311. no. 5763, pp. 1012 - 1017. [ScienceDaily]
   
7. * DNase Expression Allows the Pathogen Group A Streptococcus to Escape Killing in Neutrophil Extracellular Traps. Current Biology, Vol 16, 396-400, 21 February 2006. [Eurekalert : So-called flesh-eating "Strep" bacteria use a specific enzyme to break free of the body's immune system]
8. Clot Risk for Birth-Control Patch Is Found to Be Double That of Pill. New York Times, U.S. - Feb 17, 2006.
9. F.D.A. Allows Some Patients to Resume M.S. Drug. New York times. U.S. - Feb 16, 2006.

:::::::       February 23       :::::::

1. Bias in published cost effectiveness studies: systematic review. BMJ, doi:10.1136/bmj.38737.607558.80 (published 22 February 2006).
2. *  Treatment of low back pain by acupressure and physical therapy: randomised controlled trial. BMJ, doi:10.1136/bmj.38744.672616.AE (published 17 February 2006). [Medscape]
3. Annals of Internal Medicine  21 February 2006 Volume 144 Issue 4 Previous Issue
   
   • *  Statin and ß-Blocker Therapy and the Initial Presentation of Coronary Heart Disease. AS Go, and Others. [Medscape]
   • Zoledronic Acid Prevents Bone Loss after Liver Transplantation: A Randomized, Double-Blind, Placebo-Controlled Trial. BAL Crawford, and Others.
   • Preclinical Carotid Atherosclerosis in Patients with Rheumatoid Arthritis. MJ Roman, and Others
   • Brief Communication: Better Ways To Question Patients about Adverse Medical Events: A Randomized, Controlled Trial. S Bent, and Others.
     
   • Improving Patient Care: Volume, Quality of Care, and Outcome in Pneumonia. PK Lindenauer, and Others. [Medscape]
     
   • Update in Nephrology and Hypertension. PL Kimmel
     
   • Review: A Century of Inhalational Anthrax Cases from 1900 to 2005. JEC Holty, and Others
     
   • History of Medicine. John Loesch, Discoverer of Renovascular Hypertension, and Harry Goldblatt: Two Great Pioneers in Circulation Research.
     
   • Editorial: Can Preventive Therapy Alter the Initial Presentation of Coronary Heart Disease?
   • *   Adverse Events: The More You Search, the More You Find.
     
   • On Being a Doctor: First Response.

:::::::       February 22        :::::::

1. Prognostic Significance for Stroke of a Morning Pressor Surge and a Nocturnal Blood Pressure Decline: The Ohasama Study. Hypertension 2006 47: 149-154. [Medscape]
2. *  Evidence in Female Rhesus Monkeys (Macaca mulatta) that Nighttime Caloric Intake is not Associated with Weight Gain. Obesity Research 2005; 13:2072-2080. [Eurekalert]
3. Sexual Function and Endocrine Profile in Fertile Women With Type 1 Diabetes. Diabetes Care 2006 29: 312-316. [Medscape]
4. *  Non-degenerative mild cognitive impairment in elderly people and use of anticholinergic drugs: longitudinal cohort study. BMJ online 1 Feb 2006. [Medscape]
5. Brain imaging evidence of preclinical Alzheimer's disease in normal aging (p NA). Ann Neurology. Online: 8 Feb 2006 . [ScienceDaily]
6. Rates of Acute Care Admissions for Frail Older People Living with Met Versus Unmet Activity. J Am Geriatr Soc 54:339–344, 2006.
7. Top-10 List of Herbal and Supplemental Medicines Used by Cosmetic Patients: What the Plastic Surgeon Needs to Know. Plas & Reconst Surg 117(2):436-445, Feb 2006. [Eurekalert]
8. *  Increased Hippocampal Plaques and Tangles in Patients With Alzheimer Disease With a Lifetime History of Major Depression. Arch Gen Psychiatry. 2006;63:161-167. [ScienceDaily]
9. *  Depressive Symptoms and Cognitive Decline in Late Life: A Prospective Epidemiological Study. Arch Gen Psychiatry. 2006;63:153-160. [Medscape]
10. *  Pyridostigmine Treatment Trial in Neurogenic Orthostatic Hypotension. Arch Neurol. 2006;63:(early release). [Medscape]

:::::::       February 21       :::::::

1. *  Multicycle Dose-Intensive Chemotherapy for Women With High-Risk Primary Breast Cancer: Results of International Breast Cancer Study Group Trial 15-95. J Clin Oncol 2006;24:370-378. [Medscape: Intensive Therapy May Benefit Women With Breast Cancer of a Poor Prognosis]
2. Supplemental and Dietary Vitamin E, -Carotene, and Vitamin C Intakes and Prostate Cancer Risk. J Natl Cancer Inst 2006;98:245-254. Editorial: Vitamin E in the Prevention of Prostate Cancer: Where Are We Today?
3. New England Journal of Medicine Volume 354 February 16, 2006 Number 7
   • The "Dis-location" of U.S. Medicine — The Implications of Medical Outsourcing. R. M. Wachter
   • International Teleradiology. R. M. Wachter
   • The Words Count — Radiology and Medical Linguistics. J. F. Bruzzi
   • *   Calcium plus Vitamin D Supplementation and the Risk of Fractures. R. D. Jackson and Others [Medscape]
   • *   Calcium plus Vitamin D Supplementation and the Risk of Colorectal Cancer. J. Wactawski-Wende and Others [Medscape]
   • Evidence of a Role of Tumor Necrosis Factor in Refractory Asthma. M. A. Berry and Others
   • *  Prognostic Significance of Autoimmunity during Treatment of Melanoma with Interferon. H. Gogas and Others
   • *  Mortality after the Hospitalization of a Spouse. N. A. Christakis and P. D. Allison [LiveScience]
   • Current Concepts: Drug-Related Hepatotoxicity. V. J. Navarro and J. R. Senior [Eurekalert]
   • Calcium plus Vitamin D for Postmenopausal Women — Bone Appétit? J. S. Finkelstein
   • Calcium plus Vitamin D3 Supplementation and Colorectal Cancer in Women. M. R. Forman and B. Levin
   • Inhibition of Tumor Necrosis Factor for Refractory Asthma. S. C. Erzurum
   • Autoimmunity and Immunotherapy for Cancer. H. Koon and M. Atkins
   • Colon Cancer — Understanding How NSAIDs Work. H. Clevers

:::::::       February 20        :::::::

1. *  Antiplatelet use after intracerebral hemorrhage . Neurology 2006 66: 206-209. [MedNews] Editorial: Primum non nocere: Antithombotics after intracerebral hemorrhage? Neurology 2006 66: 162-163.
2. IV tissue plasminogen activator use in acute stroke: Experience from a statewide registry. Neurology 2006 66: 306-312. [Medscape]
3. JAMA Vol. 295 No. 7, pp. 723-850, February 15, 2006
   • Effect of Rimonabant, a Cannabinoid-1 Receptor Blocker, on Weight and Cardiometabolic Risk Factors in Overweight or Obese Patients: RIO-North America: A Randomized Controlled Trial. JAMA. 2006;295:761-775. [ScienceDaily]
   • Body Weight and Mortality Among Men and Women in China. JAMA. 2006;295:776-783.
   • Association of Socioeconomic Status With Functional Capacity, Heart Rate Recovery, and All-Cause Mortality. JAMA. 2006;295:784-792. [Eurekalert]
   • Intravenous Morphine and Topical Tetracaine for Treatment of Pain in Preterm Neonates Undergoing Central Line Placement. JAMA. 2006;295:793-800.
   • Development and Validation of a Prognostic Index for 4-Year Mortality in Older Adults. JAMA. 2006;295:801-808.
   • Clinical Review: Implantable Cardioverter-Defibrillators: Expanding Indications and Technologies. JAMA. 2006;295:809-818.
   • Commentary: Law Enforcement Interviews of Hospital Patients: A Conundrum for Clinicians. JAMA. 2006;295:822-825.
   • Editorial: Obesity Research—Limitations of Methods, Measurements, and Medications. JAMA. 2006;295:826-828. [Medscape]
   • From the Archives Journals: Role of the Metabolic Syndrome in Risk Assessment for Coronary Heart Disease. JAMA. 2006;295:819-821.

:::::::       February 17        :::::::

:::::::::::::::::::::  Weekend Reading - Basic Science and general interest articles  :::::::::::::::::::::

1. FDA
• Medwatch:
  • Nimotop (nimodipine) labeling changes including a boxed warning about medication administration errors with nimodipine. Nimodipine must not be administered intravenously or by any parenteral route. [Medscape]
  • Tequin (gatifloxacin) Stronger WARNINGS in labeling regarding hypoglycemia (low blood sugar) and hyperglycemia (high blood sugar), and a CONTRAINDICATION for use in diabetic patients. The changes also include information identifying other risk factors for developing low blood sugar and high blood sugar, including advanced age, renal insufficiency, and concomitant glucose-altering medications while taking Tequin.
  • Benzocaine spray (Hurricaine, Topex, Cetacaine) Public Health Advisory - adverse events, including methemoglobinemia, associated with the use of benzocaine sprays used in the mouth and throat.
• News:
  • Retapamulin (topical antibacterial) Accepted for review.
  • FDA Allows Clinical Studies of Tysabri (natalizumab) for Treatment of MS to Proceed
  • Rituxan (rituximab) approved for use in the first line treatment of patients with diffuse large B-cell, CD20 positive, non-Hodgkin’s lymphoma in combination with CHOP or other anthracycline based chemotherapy regimens.
2. Identification of Inflicted Traumatic Brain Injury in Well-Appearing Infants Using Serum and Cerebrospinal Markers: A Possible Screening Tool. Pediatrics 2006; 117: 325-332. [Eurekalert]
3. The Health Status of Southern Children: A Neglected Regional Disparity. Pediatrics 2005; 116: e746-e753.
4. Neonatal Abstinence Syndrome After In Utero Exposure to Selective Serotonin Reuptake Inhibitors in Term Infants. Arch Pediatr Adolesc Med. 2006;160:173-176. [Medscape & ScienceDaily]
5. Antipyretic Treatment in Young Children With Fever: Acetaminophen, Ibuprofen, or Both Alternating in a Randomized, Double-blind Study. Arch Pediatr Adolesc Med. 2006;160:197-202. [Medscape]
6. Macrophage/Cancer Cell Interactions Mediate Hormone Resistance Through A Conserved Nuclear Receptor Derepression Pathway. Cell 2006; 124, 615-629. [ScienceDaily]
7. Evidence of focal small-fiber axonal degeneration in complex regional pain syndrome-I (reflex sympathetic dystrophy). Pain Article in Press, [Eurekalert: Reduction in small-fiber nerves may underlie complex regional pain syndrome-I ]

:::::::       February 16       :::::::

1. Archives of Internal Medicine  Vol. 166 No. 3,  February 13, 2006
   • Editorial: Screening for Hemochromatosis. Arch Intern Med. 2006;166:269-270.
     
   • Editorial: Universal Patient Disinfection as a Tool for Infection Control: Rub-A-Dub-Dub, No Need for a Tub. Arch Intern Med. 2006;166:274-276.
     
   • Commentaries: An American Physician in the Canadian Health Care System. Arch Intern Med. 2006;166:281-282.
   • Review: Effects of Low-Carbohydrate vs Low-Fat Diets on Weight Loss and Cardiovascular Risk Factors: A Meta-analysis of Randomized Controlled Trials. Arch Intern Med. 2006;166:285-293.
     
   • Screening for Hemochromatosis in Asymptomatic Subjects With or Without a Family History. Arch Intern Med. 2006;166:294-301.
   • Chlorhexidine Gluconate to Cleanse Patients in a Medical Intensive Care Unit: The Effectiveness of Source Control to Reduce the Bioburden of Vancomycin-Resistant Enterococci. The Chicago Antimicrobial Resistance Project (CARP) Arch Intern Med. 2006;166:306-312.
   • Utility of Amino-Terminal Pro–Brain Natriuretic Peptide Testing for Prediction of 1-Year Mortality in Patients With Dyspnea Treated in the Emergency Department. Arch Intern Med. 2006;166:315-320.
   • Computed Tomographic Screening for Lung Cancer: The Relationship of Disease Stage to Tumor Size. The International Early Lung Cancer Action Program Investigators. Arch Intern Med. 2006;166:321-325. [Medscape]
   • Differences in Health Care Utilization at the End of Life Among Patients With Chronic Obstructive Pulmonary Disease and Patients With Lung Cancer. Arch Intern Med. 2006;166:326-331.
   • The Implications of Choice: Prescribing Generic or Preferred Pharmaceuticals Improves Medication Adherence for Chronic Condition. s Arch Intern Med. 2006;166:332-337.
   • Adherence to Black Box Warnings for Prescription Medications in Outpatients. Arch Intern Med. 2006;166:338-344. [Medscape]
   • C-Reactive Protein Concentration and Incident Hypertension in Young Adults: The CARDIA Study. Arch Intern Med. 2006;166:345-349.
   • Adipocytokines and Incident Diabetes Mellitus in Older Adults: The Independent Effect of Plasminogen Activator Inhibitor 1. Arch Intern Med. 2006;166:350-356.
   • Conjugated Equine Estrogens and Coronary Heart Disease: The Women's Health Initiative. The Women's Health Initiative Investigators. Arch Intern Med. 2006;166:357-365.

:::::::       February 15       :::::::

1. New England Journal of Medicine Volume 354 February 9, 2006 Number 6
   • Facing the Diabetes Epidemic — Mandatory Reporting of Glycosylated Hemoglobin Values in New York City. R. Steinbrook
   • Becoming a Physician: The Demise of the Physical Exam. S. Jauhar
   • The Stethoscope and the Art of Listening. H. Markel
   • Focus on Research: Stroke and Neurovascular Protection. G. J. del Zoppo
   • *  Saw Palmetto for Benign Prostatic Hyperplasia. S. Bent and Others
   • Radiotherapy plus Cetuximab for Squamous-Cell Carcinoma of the Head and Neck. J. A. Bonner and Others
   • *  Selective Serotonin-Reuptake Inhibitors and Risk of Persistent Pulmonary Hypertension of the Newborn. C. D. Chambers and Others
   • NXY-059 for Acute Ischemic Stroke. K. R. Lees and Others [Medscape]
   • *  Antibiotic Allergy. R. S. Gruchalla and M. Pirmohamed
   • Mechanisms of Disease: The Many Roles of Chemokines and Chemokine Receptors in Inflammation. I. F. Charo and R. M. Ransohoff
     
   • Proven and Unproven Therapy for Benign Prostatic Hyperplasia. R. S. DiPaola and R. A. Morton
   • Cetuximab and Radiotherapy for Head and Neck Cancer. M. R. Posner and L. J. Wirth
   • Depressing Observations on the Use of Selective Serotonin-Reuptake Inhibitors during Pregnancy. J. L. Mills
   • Expression of Concern: Sudbø J et al. DNA Content as a Prognostic Marker in Patients with Oral Leukoplakia. N Engl J Med 2001;344:1270-8 and Sudbø J et al. The Influence of Resection and Aneuploidy on Mortality in Oral Leukoplakia. N Engl J Med 2004;350:1405-13. G. D. Curfman, S. Morrissey, and J. M. Drazen

:::::::       February 14        :::::::

1. Racial/Ethnic Preferences, Sex Preferences, and Perceived Discrimination Related to End-of-Life Care. J Am Geriatrics Soc 2006; 54: 150. [LiveScience]
2. Communication in Critical Care Environments: Mobile Telephones Improve Patient Care . Anesth Analg 2006 102: 535-541. [Eurekalert]
3. Changing Incidence and Survival for Heart Failure in a Well-Defined Older Population, 1970-1974 and 1990-1994. Circulation 2006: published online Feb 6. [Medscape]
4. Renal Function as a Predictor of Outcome in a Broad Spectrum of Patients With Heart Failure. Circulation. 2006;113:671-678. (pdf)
5. AHA Scientific Statement: Dietary Approaches to Prevent and Treat Hypertension. A Scientific Statement From the American Heart Association. Hypertension. 2006;47:296.
6. Challenging Existing Paradigms in Ischemic Heart Disease: The NHLBI-Sponsored Women's Ischemia Syndrome Evaluation (WISE). J Am Coll Cardiology 2006 Feb; 47 (3) : 1-71. (ScienceDirect) [Eurekalert]
7. Increased Myocardial Fatty Acid Metabolism in Patients With Type 1 Diabetes Mellitus. J Am Coll Cardiol 2006 47: 598-604. [Eurekalert]
8. Electrocardiographic Abnormalities That Predict Coronary Heart Disease Events and Mortality in Postmenopausal Women: The Women’s Health Initiative. Circulation 2006 113: 473 - 480. [Medscape]
9. Dyslipidemia Prevalence, Treatment, and Control in the Multi-Ethnic Study of Atherosclerosis (MESA): Gender, Ethnicity, and Coronary Artery Calcium. Circulation 2006 113: 647 - 656.
10. Blood pressure usually considered normal is associated with an elevated risk of cardiovascular disease. Am J Med. 2006 Feb;119(2):133-41.

:::::::       February 13        :::::::

1. Effects of Enhanced Depression Treatment on Diabetes Self-Care. Ann Fam Med 4:46-53 (2006). [Medscape]
2. *  Multicenter Investigation of the Opioid Antagonist Nalmefene in the Treatment of Pathological Gambling. Am J Psychiatry 2006 163: 303-312.
3. Diagnosis, prevention and management of hepatitis B virus reactivation during anticancer therapy. Hepatology 2006; 43: 209 - 220. [Eurekalert]
4. Sham device v inert pill: randomised controlled trial of two placebo treatments. BMJ (published 1 Feb 2006) [Eurekalert , ScienceNOW ]
5. Association between Adrenal Insufficiency and Ventilator Weaning. Am. J. Respir. Crit. Care Med. 2006; 173: 276-280. [Eurekalert]
6. JAMA. Vol. 295 No. 6, February 8, 2006
   
   • *  Low-Fat Dietary Pattern and Risk of Invasive Breast Cancer: The Women's Health Initiative Randomized Controlled Dietary Modification Trial. JAMA. 2006;295:629-642.
   • *  Low-Fat Dietary Pattern and Risk of Colorectal Cancer: The Women's Health Initiative Randomized Controlled Dietary Modification Trial. JAMA. 2006;295:643-654.
   • *  Low-Fat Dietary Pattern and Risk of Cardiovascular Disease: The Women's Health Initiative Randomized Controlled Dietary Modification Trial. JAMA. 2006;295:655-666.
   • Transition of Extremely Low-Birth-Weight Infants From Adolescence to Young Adulthood: Comparison With Normal Birth-Weight Controls. JAMA. 2006;295:667-675. [Medscape]
   • Comparison of Two Methods to Detect Publication Bias in Meta-analysis. JAMA. 2006;295:676-680.
   • Meeting Palliative Care Needs in Post–Acute Care Settings: "To Help Them Live Until They Die". JAMA. 2006;295:681-686.
   • Commentaries: The Automated External Defibrillator: Clinical Benefits and Legal Liability. JAMA. 2006;295:687-690.
   • Editorials: Dietary Modification and Risk of Breast Cancer. JAMA. 2006;295:691-692.
   • Dietary Modification and CVD Prevention: A Matter of Fat. JAMA. 2006;295:693-695.
   • Young Adult Attainments of Preterm Infants. JAMA. 2006;295:695-696.

:::::::       February 10        :::::::

:::::::::::::::::::::  Weekend Reading - Basic Science and general interest articles  :::::::::::::::::::::

1. FDA news
• Approval: RotaTeq™ (live, oral, vaccine) for use in preventing rotavirus gastroenteritis in infants. It is the only vaccine approved in the United States that can help protect against rotavirus, a viral infection that may cause diarrhea, vomiting, fever, and dehydration.
• Public Health Advisory for Trasylol (aprotinin) alerting doctors and their patients that Trasyolol has been linked in two scientific publications to higher risks of serious side effects including kidney problems, heart attacks and strokes in patients who undergo artery bypass graft surgery.
  
2. Physical and Mental Health Costs of Traumatic War Experiences Among Civil War Veterans. Arch Gen Psychiatry 2006;63:193-200. [ ScienceDaily]
3. Self-Management of Warfarin Dosing May Be Safe. Lancet. 2006;367:404-411.(limited sccess) [Medscape report][PubMed source]
4. CSF Markers Predict Progression From Mild Cognitive Impairment to Alzheimer's. Lancet Neurol 2006;5:228-234. [Medscape report]
5. *  Statins and sepsis in patients with cardiovascular disease: a population-based cohort analysis. Lancet 2006 (limited access) . [Medscape report]
6. Podcast: American College of Cardiology Conversations with Experts (free)
   • 

:::::::       February 9        :::::::

1. Vaginal estradiol appears to be contraindicated in postmenopausal women on adjuvant aromatase inhibitors. Ann Oncol published online Jan 27, 2006. [Medscape]
2. Associations Between Hospital and Surgeon Procedure Volumes and Patient Outcomes After Ovarian Cancer Resection. J Natl Cancer Inst 2006; 98: 163-171. [Medscape]
3. Effect of Surgeon Specialty on Processes of Care and Outcomes for Ovarian Cancer Patients. J Natl Cancer Inst 2006; 98: 172-180.
4. Video-Assisted Thoracic Surgery Lobectomy: Experience With 1,100 Cases. Ann Thorac Surg 2006 81: 421-426. [MedNews: Minimally invasive lung surgery has low risk with same results as open surgery]
5. Annals of Internal Medicine 7 February 2006 Volume 144 Issue 3
   • *  Appropriateness of Diagnostic Management and Outcomes of Suspected Pulmonary Embolism. The EMDEPU Study Group
   • *  Prediction of Pulmonary Embolism in the Emergency Department: The Revised Geneva Score. Gal, and Others.
   • Cardiovascular Outcomes in High-Risk Hypertensive Patients Stratified by Baseline Glomerular Filtration Rate. The ALLHAT Collaborative Research Group. [ScienceDaily] [Medscape]
   • * Successful Treatment of Pure Red-Cell Aplasia with an Anti–Interleukin-2 Receptor Antibody (Daclizumab). Sloand, and Others.
   • Translating Clinical Research into Clinical Practice: Impact of Using Prediction Rules To Make Decisions. Reilly and Evans.
   • Update in Hospital Medicine. Wiese and Holman
   • Review: Nephrogenic Diabetes Insipidus
   • Editorial: Better Care for Patients with Suspected Pulmonary Embolism. Sox
   • Editorial: Which Antihypertensive Agents in Chronic Kidney Disease? Levey and Uhlig
   • On Being a Doctor: Transport. Gianakos
   • On Being a Doctor: The Middle Time. Aylward

:::::::       February 8        :::::::

1. *  Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis. J. Clin. Invest. 2006 116: 536-547.
2. *  Protection of Mice and Poultry from Lethal H5N1 Avian Influenza Virus through Adenovirus-Based Immunization. J. Virol. 2006 80: 1959-1964. [Eurekalert] [NewScientist]
3. Development of adenoviral-vector-based pandemic influenza vaccine against antigenically distinct human H5N1 strains in mice: The Lancet (limited access)
4. Highlights From MMWR:
   • New Laboratory Assay for Diagnostic Testing of Avian Influenza A/H5 (Asian Lineage) [Early release]
   • Surveillance Guidelines for Smallpox Vaccine (vaccinia) Adverse Reactions. February 3, 2006 / 55(RR01);1-16. [Medscape]
   • Orf Virus Infection in Humans --- New York, Illinois, California, and Tennessee, 2004--2005. January 27, 2006 / 55(03);65-68.
5. Influenza Vaccination and Health Care Workers in the United States. J Gen Internal Med Online Early. [Medscape]
6. Adipogenic potential of multiple human adenoviruses in vivo and in vitro in animals. Am J Physiol Regul Integr Comp Physiol 290: R190-R194, 2006. [ScienceDaily]
7. Anaerobic killing of mucoid Pseudomonas aeruginosa by acidified nitrite derivatives under cystic fibrosis airway conditions. JCI 2006; Published January 26, 2006. [New Scientist ]
8. Hormone replacement therapy, body mass index and asthma in perimenopausal women: a cross sectional survey. Thorax 2006; 61: 34-40. [Medscape]
9. Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals. J. Clin. Invest. 2006 116: 309-321.
10. Role of Genes and Environments for Explaining Alzheimer Disease. Arch Gen Psychiatry. 2006;63:168-174. [Medscape] [ScienceDaily]

:::::::       February 7        :::::::

1. Diagnostic Value of CT Enteroclysis Compared with Conventional Enteroclysis in Patients with Crohn's Disease. AJR 2005; 185:1575-1581. Improved diagnostic technology for Crohn's disease. [Eurekalert]
2. Kinetics of hepatitis C virus reinfection after liver transplantation. Liver Transplantation 2006; 12: 207-216. [Eurekalert].
3. *  Apoptosis of Rheumatoid Synovial Cells by Statins Through the Blocking of Protein Geranlgeranylation. Arth & Rheum 2006; 54: 579-586. [Eurekalert]
4. *  Vaccination against influenza in rheumatoid arthritis: the effect of disease modifying drugs, including TNF blockers. Ann Rheum Dis. 2006;65:191-194. [Medscape]
5. New England Journal of Medicine Volume 354 February 2, 2006 Number 5
   • Home Testing for HIV. A. A. Wright and I. T. Katz
   • Unfinished Business — Expanding HIV Testing in Developing Countries. K. M. De Cock, R. Bunnell, and J. Mermin
   • Volunteering Overseas — Lessons from Surgical Brigades. A. J. Wolfberg
   • Focus on Research: Adopting Orphan Drugs — Two Dozen Years of Treating Rare Diseases. M. E. Haffner
   • Empirically Incorrect. A. Schmitt, D. J. Gilden, S. Saint, and R. H. Moseley
   • Intensive Insulin Therapy in the Medical ICU. G. Van den Berghe and Others
   • Human Botulism Immune Globulin for the Treatment of Infant Botulism. S. S. Arnon and Others
   • Clozapine Alone versus Clozapine and Risperidone with Refractory Schizophrenia. W. G. Honer and Others
   • Drug Therapy: Coronary-Artery Stents. P. W. Serruys, M. J.B. Kutryk, and A. T.L. Ong
   • Current Concepts: Positron-Emission Tomography and Assessment of Cancer Therapy. M. E. Juweid and B. D. Cheson
   • Intensive Insulin in Intensive Care. A. Malhotra
   • The Choice of Drugs for Schizophrenia. J. M. Davis
   • No Stem Cell Is an Islet (Yet). D. Stainier

:::::::       February 6        :::::::

1. JAMA Vol. 295 No. 5, pp. 469-584, February 1, 2006
   • Relapse of Major Depression During Pregnancy in Women Who Maintain or Discontinue Antidepressant Treatment. JAMA. 2006;295:499-507.
     
   • Bone Marrow Transplantation for Severe Combined Immune Deficiency. JAMA. 2006;295:508-518.
   • Prevalence of HIV-1 in Blood Donations Following Implementation of a Structured Blood Safety Policy in South Africa. JAMA. 2006;295:519-526.
   • *  Nonmyeloablative Hematopoietic Stem Cell Transplantation for Systemic Lupus Erythematosus. JAMA. 2006;295:527-535. [NewScientist}
   • The Rational Clinical Examination: Does the Clinical Examination Predict Lower Extremity Peripheral Arterial Disease? JAMA. 2006;295:536-546.
   • Clinical Review: Medical Treatment of Peripheral Arterial Disease. JAMA. 2006;295:547-553.
   • Medical Countermeasures for Pandemic Influenza: Ethics and the Law. JAMA. 2006;295:554-556. [Medscape]
   • Editorials: Blood Safety—At What Cost? JAMA. 2006;295:557-558.
   • High-Dose Cyclophosphamide and Stem Cell Transplantation for Refractory Systemic Lupus Erythematosus. JAMA. 2006;295:559-560.

:::::::       February 3        :::::::

:::::::  Weekend Reading - Basic Science and general interest articles  :::::::

1. FDA news
• Approvals
  • Ranexa (ranolazine) a new molecular entity (NME) for the treatment of chronic angina. The precise way the drug works is not fully understood. Because Ranexa affects electrical conduction in the heart (prolong the QT interval), it should only be used by patients who have not responded to other anti-anginal (long-acting nitrates, calcium channel blockers and beta blockers) drugs.
  • Amitiza (lubiprostone) a new molecular entity (NME) for the treatment of chronic constipation in the adult population where there is no known cause for the condition.
  • *  Exubera (inhaled insulin) an inhaled powder form of recombinant human insulin (rDNA) for the treatment of adult patients with type 1 and type 2 diabetes.
2. Proposals to Avert Looming Collapse of Primary Care. American College of Physicians - Annual Report on "The State of the Nation's Health Care". [Medscape]
• The Impending Collapse of Primary Care Medicine and Its Implications for the State of the Nation's Health Care: a report from the ACCP.
3. Spectrin mutations cause spinocerebellar ataxia type 5. Nature Genetics Published online: 22 Jan 2006. [ News: Disease May Have Caused Lincoln's Gait]
4. *  Mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys polymorphism contributes to the variation in efficacy of sublingual nitroglycerin. JCI 2006; online first. Published Jan 26, 2006. [ScienceDaily: Asian Populations Less Likely To Get Relief From Chest Pain With Nitroglycerin]
5. *  Prions in Skeletal Muscles of Deer with Chronic Wasting Disease. Science Published online Jan. 26, 2006. [MedNews]

:::::::       February 2      :::::::

1. Circulation Volume 113, Issue 4; January 31, 2006: Cardiovascular Disease in Women (NIH National Awareness Site)
   • *  Electrocardiographic Abnormalities That Predict Coronary Heart Disease Events and Mortality in Postmenopausal Women: The Women’s Health Initiative. Circulation 2006 113: 473 - 480.
   • *  Electrocardiographic Predictors of Incident Congestive Heart Failure and All-Cause Mortality in Postmenopausal Women: The Women’s Health Initiative. Circulation 2006 113: 481 - 489.
   • *  Gender Differences in the Management and Clinical Outcome of Stable Angina. Circulation 2006 113: 490 - 498.
   • *  Obesity as Compared With Physical Activity in Predicting Risk of Coronary Heart Disease in Women. Circulation 2006 113: 499 - 506.
   • Gender Differences in Outcomes After Hospital Discharge From Coronary Artery Bypass Grafting. Circulation 2006 113: 507 - 516.
   • Pregnancy Outcomes in Women With Congenital Heart Disease. Circulation 2006 113: 517 - 524.
   • National Study of Women’s Awareness, Preventive Action, and Barriers to Cardiovascular Health. Circulation 2006 113: 525 - 534.
2. *  Antiplatelet use after intracerebral hemorrhage . Neurology 2006 66: 206-209. [MedNews] Editorial: Primum non nocere: Antithombotics after intracerebral hemorrhage? Neurology 2006 66: 162-163.
3. *  Fatigue in long-term breast carcinoma survivors: A longitudinal investigation (p NA) . Cancer 2006: Published Online: 9 Jan 2006. [MedNews]
4. Failures in the Management of Elderly Women with Breast Cancer. PLoS 2006; 3(3): e92. [Eurekalert]
5. Differences in Management of Older Women Influence Breast Cancer Survival: Results from a Population-Based Database in Sweden. PLoS Med 2006; 3(3): e48. [Eurekalert]
6. *  Unexpected long-term survival after low-dose palliative radiotherapy for nonsmall cell lung cancer (p NA). Cancer 2006 Published Online: 23 Jan 2006 [ScienceDaily]

:::::::       February 1       :::::::

1. *  The Effects of Aerobic Exercise on Glucose and Counterregulatory Hormone Concentrations in Children With Type 1 Diabetes. Diabetes Care 29:20-25, 2006. [Medscape]
2. *  A Single Factor Underlies the Metabolic Syndrome: A confirmatory factor analysis. Diabetes Care 2006;29:113-122. [Medscape]
3. Lifestyle Intervention Is Associated With Lower Prevalence of Urinary Incontinence: The Diabetes Prevention Program. Diabetes Care 2006; 29 (2). [Eurekalert]
4. Ribose Versus Dextrose Supplementation, Association With Rowing Performance: A Double-Blind Study. Clin J Sport Med 16(1):68-71, Jan 2006. [Eurekalert]
5. Cross-sectional Study of Bisphosphonate Use in Dermatology Patients Receiving Long-term Oral Corticosteroid Therapy. Arch Dermatol. 2006;142:37-41. [Eurekalert]
6. New England Journal of Medicine Volume 354 January 26, 2006 Number 4
   • Beyond Fraud — Stem-Cell Research Continues. E. Y. Snyder and J. F. Loring
   • Egg Donation and Human Embryonic Stem-Cell Research. R. Steinbrook
   • Becoming a Physician: The Physical Exam and the Sense of Smell. A. Bomback
   • Focus on Research: First, Gather the Data. D. Hunter
   • Ethnic and Racial Differences in the Smoking-Related Risk of Lung Cancer. C. A. Haiman and Others
   • Long-Term Outcome of Renal Transplantation from Older Donors. G. Remuzzi and Others
   • *  The Risk Associated with Aprotinin in Cardiac Surgery. D. T. Mangano, I. C. Tudor, and C. Dietzel
   • A National Evaluation of the Effect of Trauma-Center Care on Mortality. E. J. MacKenzie and Others
   • Preventing Nephropathy Induced by Contrast Medium. B. J. Barrett and P. S. Parfrey
   • Current Concepts: Aneurysmal Subarachnoid Hemorrhage. J. I. Suarez, R. W. Tarr, and W. R. Selman
   • Dissecting Racial and Ethnic Differences. N. Risch
   • Maximizing the Success of Transplantation with Kidneys from Older Donors. F. L. Delmonico and J. F. Burdick
   • The Value of Phase 4 Clinical Testing. G. J. Vlahakes

:::::::       January 31      :::::::

1. CARDIOLOGY: Recent news
   • Soy Protein, Isoflavones, and Cardiovascular Health. An American Heart Association Science Advisory for Professionals From the Nutrition Committee. Circulation 2006 Published online Jan 17.
   • Predictors of Ischemic Stroke in the Territory of a Symptomatic Intracranial Arterial Stenosis. Circulation 2006: published online. [Eurekalert]
   • *  Long-Term Adherence to Evidence-Based Secondary Prevention Therapies in Coronary Artery Disease. Circulation 2006 113: 203 - 212.
   • Antihypertensive Medication Use Among US Adults With Hypertension. Circulation 2006 113: 213 - 221.
   • *  Relation Between Hospital Specialization With Primary Percutaneous Coronary Intervention and Clinical Outcomes in ST-Segment Elevation Myocardial Infarction: National Registry of Myocardial Infarction-4 Analysis. Circulation 2006 113: 222 - 229. [Eurekalert]
   • Myocardial Viability Testing and the Effect of Early Intervention in Patients With Advanced Left Ventricular Systolic Dysfunction. Circulation. 2006;113:230-237.
   • Rising Rates of Cardiac Procedures in the United States and Canada. Too Much of a Good Thing? Circulation 2006;113:333-335.
   • Temporal Trends in the Utilization of Diagnostic Testing and Treatments for Cardiovascular Disease in the United States, 1993–2001. Circulation 2006;113:374-379.
   • *  The association between blood pressure and mortality in patients with heart failure. Am Heart J 2006;151:76-83. [Medscape]
   • Imp of cinematic viewing on endothelial function. Heart 2006; 92: 261-262. [Eurekalert]
   • Long-term cardiovascular consequences of obesity: 20-year follow-up of more than 15 000 middle-aged men and women (the Renfrew–Paisley study) Eur Heart J 2006 27: 96-106. [Medscape]
   • *  New Guidelines on Diet and Blood Pressure. Hypertension 2006 47: 135-136.
   • Prognostic Relevance of Blood Pressure Variability. Hypertension 2006 47: 137-138.
   • *  Microvolt T-Wave Alternans and the Risk of Death or Sustained Ventricular Arrhythmias in Patients With Left Ventricular Dysfunction. JACC 2006;47: 456-463. (via ScienceDirect) [Eurekalert: Test identifies best candidates for implanted cardiac defibrillator, screens out those not helped; one third of candidates are unlikely to benefit]
2. *  Impact of Helicobacter pylori eradication on dyspepsia, health resource use, and quality of life in the Bristol helicobacter project: randomised controlled trial. BMJ 2006;332:199-204.
3. *  Long term outcomes from the IMPACT randomised trial for depressed elderly patients in primary care. BMJ (published 20 January 2006) .
4. Thiazide diuretic prescription and electrolyte abnormalities in primary care. Br J Clin Pharm 2006; 61: 87-95. [Eurekalert]

:::::::       January 30       :::::::

1. JAMA  Vol. 295 No. 4, pp. 355-460, January 25, 2006
   
   • Frequency and Effect of Adjuvant Radiation Therapy Among Women With Stage I Endometrial Adenocarcinom. JAMA. 2006;295:389-397.
   • *  Myocardial Injury and Long-term Mortality Following Moderate to Severe Carbon Monoxide Poisoning. JAMA. 2006;295:398-402. [Medscape]
   • Reviews: Effects of Omega-3 Fatty Acids on Cancer Risk: A Systematic Review. JAMA. 2006;295:403-415. [Medscape]
   • *   Health Industry Practices That Create Conflicts of Interest: A Policy Proposal for Academic Medical Centers. JAMA. 2006;295:429-433. [Medscape]
   • The Rational Clinical Examination: Does This Patient Have Hearing Impairment? JAMA. 2006;295:416-428.
   • Biomedical Patents and the Public's Health: Is There a Role for Eminent Domain? JAMA. 2006;295:434-437.
   • US Health Policy in the Aftermath of Hurricane Katrina. JAMA. 2006;295:437-440.
   • *  Black Box Warnings. JAMA. 2006;295:377.
2. *  FDA drug prescribing warnings: is the black box half empty or half full? Pharmacoepidemiol Drug Saf Early Release.

:::::::       January 27        :::::::

:::::::  Weekend Reading - Basic Science and general interest articles  :::::::

1. FDA News
   • MedWatch:
     • Ketek (telithromycin) Serious liver toxicity following administration of Ketek (telithromycin). FDA Advisory. FDA information. [Medscape]
     • Hydrea and Droxia (hydroxyurea) Revisions to the prescribing information to describe cutaneous vasculitic toxicities, including vasculitic ulcerations and gangrene, in patients with myeloproliferative disorders during therapy with hydroxyurea, most often reported in patients with a history of or currently receiving interferon therapy. [Medscape]
   • FDA Safety Changes:
     • Humira (adalimumab) Warning of the risk for serious infections, neurologic events, and malignancies associated with its use. Some cases of opportunistic infections and tuberculosis have resulted in fatality.
     • Biaxin (clarithromycin) Contraindications associated with its use. Reports of cardiac arrhythmias (QT prolongation, ventricular tachycardia, ventricular fibrillation, and torsades de pointes) with use of clarithromycin and/or erythromycin in patients receiving cisapride, pimozide, astemizole, or terfenadine. Some of these cases have been fatal. [Medscape]
     • Flomax (tamsulosin) Risk of intraoperative floppy iris syndrome during cataract surgery in patients receiving this or other alpha-1 blockers. [Medscape]
   • FDA Regulations: New Requirements for Prescribing Information.
2. *  The Power of Repetition in Mastering Cardiac Auscultation. Am J Med 2006; 119: 73-75. Time:Web Exclusive | Science & Health. Updating the Stethoscope with an iPod *   [Eurekalert]
3. Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase. Nature Medicine 12, 83 - 88 (2005)
   Published online: 20 December 2005; | doi:10.1038/nm1347. [ScienceDaily]
4. Thinking Thin ScienceNOW Daily News 18 January 2006
5. (-)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans. PNAS published Jan 17, 2006, ( Medical Sciences ). [Eurekalert Researchers identify a compound in cocoa responsible for improving blood flow ]
6. A critical role for eukaryotic elongation factor 1A-1 in lipotoxic cell death. Mol. Biol. Cell 2006 17: [Eurekalert: Fat overload kills mammalian cells — key culprit identified]
   
7. Bird flu's bodily harm revealed. Nature: Published online: 20 January 2006; | doi:10.1038/news060116-15. Alarms ring over bird flu mutations. Nature news.
8. Nitric Oxide Cytoskeletal–Induced Alterations Reverse the Endothelial Progenitor Cell Migratory Defect Associated With Diabetes. Diabetes 2006 55: 102-109. [Eurekalert: Diabetes complications rooted in faulty cell repair]
   
9. Defective cerebellar response to mitogenic Hedgehog signaling in Down's syndrome mice. PNAS Published online Jan 23, 2006.

:::::::       January 26       :::::::

1. Archives of Internal Medicine Vol. 166 No. 2, pp. 139-250, January 23, 2006
   • Editorials: Diagnosis and Management of Pulmonary Embolism: Are We Moving Toward an Outcome Standard? Arch Intern Med. 2006;166:147-148.
     
   • Relief of Suffering Is the Business of Every Discipline. Arch Intern Med. 2006;166:149-150.
   • *  Review Articles: Medication-Attributed Adverse Effects in Placebo Groups: Implications for Assessment of Adverse Effects. Arch Intern Med. 2006;166:155-160.
   • Acetylcysteine in the Prevention of Contrast-Induced Nephropathy: A Case Study of the Pitfalls in the Evolution of Evidence. Arch Intern Med. 2006;166:161-166.
   • *  A Prediction Rule to Identify Low-Risk Patients With Pulmonary Embolism. Arch Intern Med. 2006;166:169-175.
   • *   Value of D-Dimer Testing for the Exclusion of Pulmonary Embolism in Patients With Previous Venous Thromboembolism. Arch Intern Med. 2006;166:176-180.
   • *  The Bedside Investigation of Pulmonary Embolism Diagnosis Study: A Double-blind Randomized Controlled Trial Comparing Combinations of 3 Bedside Tests vs Ventilation-Perfusion Scan for the Initial Investigation of Suspected Pulmonary Embolism. Arch Intern Med. 2006;166:181-187.
   • Association Between Circulating White Blood Cell Count and Cancer Mortality: A Population-Based Cohort Study. Arch Intern Med. 2006;166:188-194. [MedNews]
   • Clinical Depression and Risk of Out-of-Hospital Cardiac Arrest. Arch Intern Med. 2006;166:195-200.
   • Prediction of Coronary Heart Disease by Erectile Dysfunction in Men Referred for Nuclear Stress Testing. Arch Intern Med. 2006;166:201-206.
   • Predictors and Prevalence of Erectile Dysfunction in a Racially Diverse Population. Arch Intern Med. 2006;166:207-212.
   • The Prevalence of Erectile Dysfunction in the Primary Care Setting: Importance of Risk Factors for Diabetes and Vascular Disease. Arch Intern Med. 2006;166:213-219.
   • Health-Related Quality of Life and Appropriateness of Knee or Hip Joint Replacement. Arch Intern Med. 2006;166:220-226.
   • Evaluating the California Hospital Initiative in Palliative Services. Arch Intern Med. 2006;166:227-230.
   • Phosphodiesterase Type 5 Inhibition Is a Novel Therapeutic Option in Raynaud Disease. Arch Intern Med. 2006;166:231-233.
   • Assessing the Performance of Overseas Tuberculosis Screening Programs: A Study Among US-Bound Immigrants in Vietnam. Arch Intern Med. 2006;166:234-240.
   • *  Risk of Osteoporotic Fracture in Elderly Patients Taking Warfarin: Results From the National Registry of Atrial Fibrillation 2. Arch Intern Med. 2006;166:241-246. [Eurekalert] [Medscape]

:::::::       January 25      :::::::

1. Acetazolamide Improves Central Sleep Apnea in Heart Failure. Am J Respir Crit Care Med 2006; 173: 234-237. [MedNews]
2. Protective Effect of Fish Oil Supplementation on Exercise-Induced Bronchoconstriction in Asthma. Chest 2006;129:39-49. [Medscape]
3. * Diagnosis and Management of Cough: ACCP Evidence-Based Clinical Practice Guidelines. Chest 2006;129:1S-23S. [Medscape]
4. The Salmeterol Multicenter Asthma Research Trial: A Comparison of Usual Pharmacotherapy for Asthma or Usual Pharmacotherapy Plus Salmeterol. Chest 2006 129: 15-26. [Medscape]
5. Anterior cingulate activity correlates with blood pressure during stress . Psychophysiology 2006; 42: 627 . [Eurekalert]
6. Effect of a brief intervention on evidence-based medicine skills of pediatric residents. BMC Medical Education 2006, 6:1
7. A chronic fatigue syndrome - related proteome in human cerebrospinal fluid. BMC Neurology 2005, 5:22 doi:10.1186/1471-2377-5-22. [ScienceDaily]
8. The use of antidepressants to treat depression in children and adolescents -- A.H. Cheung et al. CMAJ 2006; 174L 193-200.
9. * Single crossclamp improves 6-month cognitive outcome in high-risk coronary bypass patients: The effect of reduced aortic manipulation. J Thorac Cardiovasc Surg 2006 131: 114-121. [MedNews report]
10. A 24-Week Open-Label Extension Study of Memantine in Moderate to Severe Alzheimer Disease. Arch Neurol. 2006;63:49-54. [Medscape]

:::::::       January 24       :::::::

1. * Severe Hepatotoxicity of Telithromycin: Three Case Reports and Literature Review. Ann Int Med Early Release. [Eurekalert]
2. * Non-arteritic anterior ischaemic optic neuropathy and the treatment of erectile dysfunction. Br J Ophthalmol 2006; 90: 154-57. [Eurekalert] [BBC Report]
3. Case reports of suspected adverse drug reactions--systematic literature survey of follow-up. BMJ, doi:10.1136/bmj.38701.399942.63 (published 18 January 2006)
4. * Food buying habits of people who buy wine or beer: cross sectional study. BMJ published 20 Jan 2006. [People who buy wine also buy healthier food - Eurekalert] [ScienceDaily]
5. * Chronic stress at work and the metabolic syndrome: prospective study. BMJ online, doi:10.1136. [Medscape] [Eurekalert]
6. Impact of adverse events on prescribing warfarin in patients with atrial fibrillation: matched pair analysis. BMJ 2006;332:141-145.
7. New England Journal of Medicine Previous Volume 354 January 19, 2006 Number 3
   • Noma — The Ulcer of Extreme Poverty. C. O. Enwonwu
   • Crisis in Niger — Outpatient Care for Severe Acute Malnutrition. M. Tectonidis
   • * A Controlled Trial of Long-Term Inhaled Hypertonic Saline in Patients with Cystic Fibrosis. M. R. Elkins and Others. [Medscape]
   • * Mucus Clearance and Lung Function in Cystic Fibrosis with Hypertonic Saline. S. H. Donaldson and Others.
   • Tenofovir DF, Emtricitabine, and Efavirenz vs. Zidovudine, Lamivudine, and Efavirenz for HIV. J. E. Gallant and Others
   • Prophylactic Surgery to Reduce the Risk of Gynecologic Cancers in the Lynch Syndrome. K. M. Schmeler and Others. [Medscape]
   • Mechanisms of Disease: Estrogen Carcinogenesis in Breast Cancer. J. D. Yager and N. E. Davidson .
   • Bleeding Angiodysplasia in the Duodenum. K.-I Fu and T. Fujimori .
   • Heavy-Metal Meals of Mercury. J. K.C. Yoong
   • Restoring Airway Surface Liquid in Cystic Fibrosis. F. Ratjen
   • Reducing the Risk of Gynecologic Cancer in the Lynch Syndrome. K. Offit and N. D. Kauff
   • Disarming Pathogens — A New Approach for Antibiotic Development. M. K. Waldor

:::::::       January 23      :::::::

1. Expression of Concern: Sudbø J et al. DNA Content as a Prognostic Marker in Patients with Oral Leukoplakia. N Engl J Med 2001;344:1270-8 and Sudbø J et al. The Influence of Resection and Aneuploidy on Mortality in Oral Leukoplakia. N Engl J Med 2004;350:1405-13. Published at www.nejm.org January 20, 2006 (10.1056/NEJMe068020).
2. Canadian Medical Association Journal 17 January 2006, Volume 174, Issue 2
   • * Dose-response relation between sulfonylurea drugs and mortality in type 2 diabetes mellitus: a population-based cohort study. CMAJ. 2006 174: 169-174. pdf [Eurekalert]. Do sulfonylurea drugs increase the risk of cardiac events? CMAJ 2006; 174(2): 185 - 186. [Medscape]
   • Inequalities in access to medical care by income in developed countries. CMAJ 2006 174: 177-183. pdf [Eurekalert]. Income and equity of access to physician services. CMAJ 2006; 174: 187. pdf
3. JAMA Vol. 295 No. 3, pp. 249-348, January 18, 2006
   
   • * Watchful Waiting vs Repair of Inguinal Hernia in Minimally Symptomatic Men: A Randomized Clinical Trial. JAMA. 2006;295:285-292. [Medscape]
     
   • Thromboembolic Adverse Events After Use of Recombinant Human Coagulation Factor VIIa. JAMA. 2006;295:293-298.
   • Surveillance for Recurrent Bladder Cancer Using a Point-of-Care Proteomic Assay. JAMA. 2006;295:299-305.
   • Differences in Review Quality and Recommendations for Publication Between Peer Reviewers Suggested by Authors or by Editors. JAMA. 2006;295:314-317.
   • * Review: Aspirin for the Primary Prevention of Cardiovascular Events in Women and Men: A Sex-Specific Meta-analysis of Randomized Controlled Trials. JAMA. 2006;295:306-313. [Eurekalert] [NewScientist]
   • Clinical Crossroads: A 60-Year-Old Woman Who Has Felt Sad for Much of Her Life. JAMA. 2006;295:318-323.
   • Commentaries: The 100 000 Lives Campaign: Setting a Goal and a Deadline for Improving Health Care Quality. JAMA. 2006;295:324-327.
   • Editorials: The Asymptomatic Hernia: "If It's Not Broken, Don't Fix It" JAMA. 2006;295:328-329.
   • From the Centers for Disease Control and Prevention
     • West Nile Virus Activity—United States, January 1–December 1, 2005. JAMA. 2006;295:266-267.
     • Brief Report: Respiratory Syncytial Virus Activity—United States, 2004-2005. JAMA. 2006;295:267-268.
     • Reduction in Central Line–Associated Bloodstream Infections Among Patients in Intensive Care Units—Pennsylvania, April 2001–March 2005. JAMA. 2006;295:269-270.
     • Ninth Annual Conference on Vaccine Research, May 8-10, 2006. JAMA. 2006;295:270.

:::::::       January 20        :::::::

:::::::  Weekend Reading - Basic Science and general interest articles  :::::::

1. FDA News
   • Approvals: [Medscape]
     • Boniva (injectable ibandronate) for quarterly administration by a healthcare professional in the treatment of postmenopausal osteoporosis.
     • Femara (letrozole) for use in the adjuvant treatment of postmenopausal women with hormone-receptor–positive early breast cancer.
   • FDA Safety Changes:
     • Elidel and Protopic: Updated labeling for eczema drugs with Boxed Warning of increased risk of cancer. [Medscape]
   • New Prescription Drug Information Format to Improve Patient Safety
   • MedWatch
     • Clozaril (clozapine) revised prescribing information eith modification of the white blood cell monitoring schedule, dementia-related psychosis, parlytic ileus, hypercholesterolemia and pharmacokinetic interaction with citalopram. [Medscape]
2. * CDC HEALTH ALERT: CDC Recommends against the Use of Amantadine and Rimantadine for the Treatment or Prophylaxis of Influenza in the United States during the 2005–06 Influenza Season. [Medscape]
3. MMWR January 13, 2006 / Vol. 55 / No. 1 : Nonfatal, Unintentional Medication Exposures Among Young Children: United States, 2001--2003. [Medscape]
4. * WHO calls for an immediate halt to provision of single-drug artemisinin malaria pills. WHO News release.
5. * Reversing the defective induction of IL-10–secreting regulatory T cells in glucocorticoid-resistant asthma patients. J. Clin. Invest. 116:146-155 .
6. Leptin neutralization interferes with pathogenic T cell autoreactivity in autoimmune encephalomyelitis . J. Clin. Invest. published January 12, 2006. [ScienceDaily]
7. Transcription factor T-bet regulates inflammatory arthritis through its function in dendritic cells. J Clin Invest published January 12, 2006.
8. Soy diet worsens heart disease in mice. J. Clin. Invest. 116:209-216.
9. * Mutations in the CEL VNTR cause a syndrome of diabetes and pancreatic exocrine dysfunction. Nature Genetics 38, 54 - 62 (2006) .
10. * (-)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans. PNAS published January 17, 2006. [Eurekalert: Heart-healthy compound in chocolate identified.]

:::::::       January 19        :::::::

1. *  ACC/AHA Clinical Performance Measures for Adults With ST-Elevation and Non-ST-Elevation Myocardial Infarction. A Report of the American College of Cardiology/American Heart Association Task Force on Performance Measures (Writing Committee to Develop Performance Measures on ST-Elevation and Non-ST-Elevation Myocardial Infarction) Circulation 2006 published online [Eurekalert]
2. Myocardial Viability Testing and the Effect of Early Intervention in Patients With Advanced Left Ventricular Systolic Dysfunction. Circulation 2006: published online before print January 3, 2006. [Medscape]
3. Long-Term Adherence to Evidence-Based Secondary Prevention Therapies in Coronary Artery Disease. Circulation 2006: published online January 9, 2006, [Medscape]
4. * Regular Aspirin-Use Preceding the Onset of Primary Intracerebral Hemorrhage is an Independent Predictor for Death. Stroke 2006;37:4-5,129-133. [Medscape]
5. * Moderate Alcohol Consumption Reduces Risk of Ischemic Stroke: The Northern Manhattan Study. Stroke 2006 37: 13 - 19. [Medscape]
6. Detection of Coronary Artery Disease in Asymptomatic Patients With Type 2 Diabetes Mellitus. J Am Coll Cardiol 2006 47: 65-71. [Medscape]
7. * Caffeine Decreases Exercise-Induced Myocardial Flow Reserve. J Am Coll Cardiol 2006; 47: 405-410. [Eurekalert]
8. The Prevalence of Thiamin Deficiency in Hospitalized Patients With Congestive Heart Failure. J Am Coll Cardiol 2006; 47:354-361. [Eurekalert]
9. * Long-Term Caloric Restriction Ameliorates the Decline in Diastolic Function in Humans. J Am Coll Cardiol 2006 47: 398-402. [MedNews]
10. Tooth Loss and Heart Disease: Findings from the Behavioral Risk Factor Surveillance System. Am J Prev Med 2006; 29: 50-56. (ScienceDirect) [Medscape]
11. Annals of Internal Medicine 17 January 2006 Volume 144 Issue 2
    
    • * Exercise Is Associated with Reduced Risk for Incident Dementia among Persons 65 Years of Age and Older. E. B. Larson, and Others. [Medscape] [Eurekalert][Eurekalert]
    • * Socioeconomic Status and Mortality after Acute Myocardial Infarction. The SESAMI Study Group*
    • * Clarithromycin-Resistant Genotypes and Eradication of Helicobacter pylori. V. De Francesco, and Others.
    • Brief Communication: Tamoxifen Therapy for Nonmalignant Retroperitoneal Fibrosis. E.F.H. van Bommel, and Others.
      
    • Improving Patient Care : Problem Doctors: Is There a System-Level Solution? L. L. Leape and J. A. Fromson [Eurekalert]
      
    • Reviews: Systematic Review: Antimicrobial Urinary Catheters To Prevent Catheter-Associated Urinary Tract Infection in Hospitalized Patients. J. R. Johnson, and Others.
      
    • Perspectives: Acute Pain Management for Patients Receiving Maintenance Methadone or Buprenorphine Therapy. D. P. Alford, and Others.
      
    • Editorial: Mens Sana in Corpore Sano. L. J. Podewils and E. Guallar
    • Editorial: Going Back To Understand the Future: Socioeconomic Position and Survival after Myocardial Infarction. G. A. Kaplan
    • Editorial: Improving Helicobacter pylori Eradication Regimens. F. Francois and M. J. Blaser
      
    • On Being a Doctor: Of Poems and Patients.
    • On Being a Doctor: Aziza.

:::::::       January 18      :::::::

1. Evaluation of Plasma Homocysteine and Risk of Age-Related Macular Degeneration. Am J Ophth 2006; 141:201-203. [Eurekalert]
2. Randomized Trial of the Efficacy of Tamsulosin, Nefedipine and Phloroglucinol in Medical Expulsive Therapy for Distal Ureteral Cacluli Therapy. J Urology 2005; 174:167-172.
3. Familial Lung Cancer: Genetic Susceptibility and Relationship to Chronic Obstructive Pulmonary Disease. Am. J. Respir. Crit. Care Med. 2006; 173: 16-22. [Eurekalert]
4. Genetics plays a role in the side effects experienced by people taking painkillers. Gastroenerology [Eurekalert]
5. A Comparison of Short-term Changes in Health-related Quality of Life in Thyroid Carcinoma Patients Undergoing Diagnostic Evaluation with rhTSH Compared to Thyroid Hormone Withdrawal. J Clin Endocrinol Metab published January 4, 2006. [Eurekalert]
6. New England Journal of Medicine Volume 354 January 12, 2006 Number 2
   • Research in the Hot Zone. R. Steinbrook
   • Bioterrorism — Preparing to Fight the Next War. D. A. Relman
   • The Burden of Illness in International Travelers. D. R. Hill  [Medscape]
   • Spectrum of Disease and Relation to Place of Exposure among Ill Returned Travelers. D. O. Freedman and Others
   • * Efficacy and Safety of Benazepril for Advanced Chronic Renal Insufficiency. F. F. Hou and Others
   • * A Randomized Trial of Inhaled Cyclosporine in Lung-Transplant Recipients. A. T. Iacono and Others. [Medscape]
   • Brief Report: Familial Sinus Bradycardia Associated with a Mutation in the Cardiac Pacemaker Channel. R. Milanesi, M. Baruscotti, T. Gnecchi-Ruscone, and D. DiFrancesco
   • Chronic Daily Headache. D. W. Dodick
   • Drug Therapy: Treatment of Acute Lymphoblastic Leukemia. C.-H. Pui and W. E. Evans
   • Optimizing ACE-Inhibitor Therapy for Chronic Kidney Disease. L. A. Hebert
   • Inhaled Cyclosporine — A Breath of Fresh Air? M. M. DeCamp Jr.
   • Reform of Drug Regulation — Beyond an Independent Drug-Safety Board. W. A. Ray and C. M. Stein

:::::::       January 17       :::::::

1. * Impact of adverse events on prescribing warfarin in patients with atrial fibrillation: matched pair analysis. BMJ published online 10 January 2006.
2. * A Multicenter Prospective Randomized Study Testing Non-Inferiority of Thalidomide 100 mg/day as Compared with 400 mg/day in Patients with Refractory/Relapsed Multiple Myeloma: First Results of the Final Analysis of the IFM 01-02 Study. Blood (ASH Annual Meeting Abstracts) 2005 106: Abstract 364.
3. Randomised placebo controlled multicentre trial to assess short term clarithromycin for patients with stable coronary heart disease: CLARICOR trial. BMJ 2006;332:22-27.
4. Systematic review and meta-analysis of randomised controlled trials of gastro-oesophageal reflux interventions for chronic cough associated with gastro-oesophageal reflux. BMJ 2006;332:11-17.
5. Editorial: Magnet therapy. BMJ 2006;332:4 (7 January). [MedNews]
6. Archives of Internal Medicine Vol. 166 No. 1, pp. 3-127, January 9, 2006
   • The PSA Conundrum. Arch Intern Med. 2006;166:7-8.
   • Treatment of Hepatitis B: Who, When, and How? Arch Intern Med. 2006;166:9-12.
   • A Call for Fairness in Formulary Decisions. Arch Intern Med. 2006;166:16-18.
   • Review: Women Exposed to Intimate Partner Violence: Expectations and Experiences When They Encounter Health Care Professionals: A Meta-analysis of Qualitative Studies. Arch Intern Med. 2006;166:22-37.
   • * The Effectiveness of Screening for Prostate Cancer: A Nested Case-Control Study. Arch Intern Med. 2006;166:38-43. [Medscape]
   • Preemptive Transplantation for Patients With Diabetes-Related Kidney Disease. Arch Intern Med. 2006;166:44-48.
   • A Double-blind Placebo-Controlled Study of Emtricitabine in Chronic Hepatitis B. Arch Intern Med. 2006;166:49-56.
   • Medicare Coverage of Tumor Necrosis Factor Inhibitors as an Influence on Physicians’ Prescribing Behavior. Arch Intern Med. 2006;166:57-63.
   • C-Reactive Protein Is a Marker for Human Immunodeficiency Virus Disease Progression. Arch Intern Med. 2006;166:64-70.
   • 10-Year Follow-up of Subclinical Cardiovascular Disease and Risk of Coronary Heart Disease in the Cardiovascular Health Study. Arch Intern Med. 2006;166:71-78
   • * Association Between Protein Intake and Blood Pressure: The INTERMAP Study. Arch Intern Med. 2006;166:79-87. [Medscape]
   • Plasma Total Homocysteine Level and Bone Mineral Density: The Hordaland Homocysteine Study. Arch Intern Med. 2006;166:88-94. [Medscape]
   • Etiologic Diagnosis of Chronic Osteomyelitis: A Prospective Study. Arch Intern Med. 2006;166:95-100.
   • "Are You at Peace?": One Item to Probe Spiritual Concerns at the End of Life. Arch Intern Med. 2006;166:101-105.
   • Metabolic Syndrome Compared With Type 2 Diabetes Mellitus as a Risk Factor for Stroke: The Framingham Offspring Study. Arch Intern Med. 2006;166:106-111.
   • Costs for Heart Failure With Normal vs Reduced Ejection Fraction. Arch Intern Med. 2006;166:112-118.
   • Is Exposure to Sick or Dead Poultry Associated With Flulike Illness?: A Population-Based Study From a Rural Area in Vietnam With Outbreaks of Highly Pathogenic Avian Influenza. Arch Intern Med. 2006;166:119-123.

:::::::       January 16      :::::::

1. JAMA Vol. 295 No. 2, pp. 131-240, January 11, 2006
   • Comparison of -Blockers, Amiodarone Plus -Blockers, or Sotalol for Prevention of Shocks From Implantable Cardioverter Defibrillators: The OPTIC Study: A Randomized Trial. JAMA. 2006;295:165-171.
   • Effectiveness of Managing Suspected Pulmonary Embolism Using an Algorithm Combining Clinical Probability, D-Dimer Testing, and Computed Tomography. JAMA. 2006;295:172-179.
   • International Prevalence, Recognition, and Treatment of Cardiovascular Risk Factors in Outpatients With Atherothrombosis. JAMA. 2006;295:180-189.
   • * Midlife Body Mass Index and Hospitalization and Mortality in Older Age. JAMA. 2006;295:190-198. [Medscape]
   • The Rational Clinical Examination: Does This Patient Have Deep Vein Thrombosis? JAMA. 2006;295:199-207.
   • Editorials: Antiarrhythmic Drugs for All Patients With an ICD? JAMA. 2006;295:211-213.
   • Diagnosing Pulmonary Embolism With Improved Certainty and Simplicity. JAMA. 2006;295:213-215.
   • From the Archives Journals Obesity, Smoking, and Psoriasis. JAMA. 2006;295:208-210.
     
   • Research Letters: Effects of Sleep Inertia on Cognition. JAMA. 2006;295:163-164. [NewScientist]
2. Long-Term Caloric Restriction Ameliorates the Decline in Diastolic Function in Humans. JACC 2006; 47: 398-402. [Eurekalert]
3. Effect of a Diet and Exercise Intervention on Oxidative Stress, Inflammation, MMP-9 and Monocyte Chemotactic Activity in Men with Metabolic Syndrome Factors. J Appl Physiol (December 15, 2005). [NewScientist]
4. Cyclic Vomiting Syndrome in 41 adults: the illness, the patients, and problems of management. BMC Medicine 2005, 3:20. [Medscape]
5. Nurse Staffing In Hospitals: Is There A Business Case For Quality? Health Affairs 2006; 25: 204-211. [Eurekalert: Increasing nursing staff improves safety and quality in hospitals.]

:::::::       January 13        :::::::

:::::::  Weekend Reading - Basic Science and general interest articles  :::::::

1. FDA NEWS:
   • MedWatch: [Medscape]
     • WinRho SDF (Rho(D) Immune Globulin Intravenous [Human]) labeling changes to address two important safety concerns. Continued postmarketing safety surveillance has shown rare, but severe and sometimes fatal, intravascular hemolysis and potentially serious complications, including:
       1. Disseminated intravascular coagulation in patients with ITP. P
       2. Maltose in the liquid formulation of WinRho SDF has been shown to give falsely high blood glucose levels in certain types of blood glucose testing systems.
   • FDA Safety Changes: [Medscape]
     • Vytorin (ezetimibe/simvastatin) warning of a drug interaction between its simvastatin component and fibrates (especially gemfibrozil) that increases the risk for myopathy.
     • Efudex (fluorouracil topical) safety labeling for to advise against its use in patients with dihydropyrimidine dehydrogenase (DPD) enzyme deficiency.
     • Prinivil (lisinopril) safety labeling revisions to warn of the rare risk for head/neck angioedema and hepatic failure associated with its use.
   • FDA Approvals: [Medscape]
     • CellCept (mycophenolate mofetil) approved orphan drug status for the treatment of myasthenia gravis (MG).
     • Prochymal (adult stem cell product) approved orphan drug status for the treatment of acute graft-versus-host disease (GVHD).
     • Shiga Toxin Antibodies (chimeric anti-Shiga toxin antibodies {caStx1 and caStx2}) orphan drug status for the treatment of Shiga toxin–producing Escherichia coli (STEC) infections.
2. * Alterations in 5-HT1B Receptor Function by p11 in Depression-Like States. Science 2006: 311: 77 - 80.
3. * Dendritic cells pulsed with hepatitis C virus NS3 protein induce immune responses and protection from infection with recombinant vaccinia virus expressing NS3. J Gen Virol 87 (2006), 1-10. [ScienceDaily: Researchers Develop New Vaccine Candidate Against Hepatitis C]
4. Polyphosphate modulates blood coagulation and fibrinolysis. PNAS published January 12, 2006.

:::::::       January 12        :::::::

1. * A Comprehensive Immunization Strategy to Eliminate Transmission of Hepatitis B Virus Infection in the United States. Recommendations of the Advisory Committee on Immunization Practices (ACIP) Part 1: Immunization of Infants, Children, and Adolescents. Recommendations and Reports. MMWR Dec 23, 2005 / 54(RR16);1-23. [Medscape]
2. * Etiologies of Nongonococcal Urethritis: Bacteria, Viruses, and the Association with Orogenital Exposure. JID 2006;193:336-345.
3. * Prevalence of Staphylococcus aureus Nasal Colonization in the United States, 2001 - 2002 . JID 2006;193:172-179. [Medscape] [Editorial]
4. * Smoking and age related macular degeneration: the number of pack years of cigarette smoking is a major determinant of risk for both geographic atrophy and choroidal neovascularisation. Br J Ophthalmol 2006; 90: 75-80. [Science Daily]
5. The PREMIER Study: A Multicenter, Randomized, Double-Blind Clinical Trial of Combination Therapy With Adalimumab Plus Methotrexate Versus Methotrexate Alone or Adalimumab Alone in Patients with Early, Aggressive Rheumatoid Arthritis Who Had Not Had Previous Methotrexate Treatment. Arth & Rheum 2006, 54:1: 41-52. [Eurekalert] [Medscape]
6. Subjective Complaints Precede Parkinson Disease. Arch Neurol. 2006;63:(early release). [Medscape]
7. Effects of Testosterone on Cognition and Mood in Male Patients With Mild Alzheimer Disease and Healthy Elderly Men. Arch Neurol. 2006;63: (early release). [ScienceDaily]
8. Response Profiles to Fluticasone and Montelukast in Mild-to-Moderate Persistent Childhood Asthma J Allergy Clin Imm 2006; 117: 45-52. [Eurekalert]
9. Ropinirole in the Treatment of Patients With Restless Legs Syndrome: A US-Based Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Mayo Clin Proc. 2006;81:17-27. [Medscape]
10. Exercise Accelerates Wound Healing Among Healthy Older Adults: A Preliminary Investigation. J Gerontol A Biol Sci Med Sci 2005 60: 1432-1436.

:::::::       January 11      :::::::

1. * Patients' Expectations and Satisfaction in Lumbar Spine Surgery. Spine. 30(23):2689-2694, December 1, 2005. [Medscape]
2. * Natural history of depression in the oldest old: Population-based prospective study. Br J Psychiatry 2006 188: 65-69. [MedNews]
3. Frontline Treatment of Combat Stress Reaction: A 20-Year Longitudinal Evaluation Study. Am J Psychiatry 2005 162: 2309-2314. [Medscape]
4. How Should Remission From Depression Be Defined? The Depressed Patient’s Perspective. Am J Psychiatry 2006 163: 148-150. [Eurekalert]
5. Beyond Efficacy: The STAR*D Trial. Am J Psychiatry 2006 163: 5-7. [Eurekalert]
6. Suicide Risk During Antidepressant Treatment. Am J Psychiatry 2006 163: 41-47. [Eurekalert]
7. New England Journal of Medicine Volume 354 January 5, 2006 Number 1
   • The Big Chill — Inserting the DEA into End-of-Life Care. T. E. Quill and D. E. Meier
   • * Searching for the Right Search — Reaching the Medical Literature. R. Steinbrook
   • Is Our Behavior Written in Our Genes? D. Drayna
   • * Safety and Efficacy of an Attenuated Vaccine against Severe Rotavirus Gastroenteritis. G. M. Ruiz-Palacios and Others [Euerkalert]
   • * Safety and Efficacy of a Pentavalent Human–Bovine (WC3) Reassortant Rotavirus Vaccine. T. Vesikari and Others
   • * Intraperitoneal Cisplatin and Paclitaxel in Ovarian Cancer. D. K. Armstrong and Others. [NCI report and Eurekalert]
   • Current Concepts: Community-Acquired Bacterial Meningitis in Adults. D. van de Beek, J. de Gans, A. R. Tunkel, and E. F.M. Wijdicks
   • Medical Progress: Autoimmune Hepatitis. E. L. Krawitt
   • * The Promise of New Rotavirus Vaccines. R. I. Glass and U. D. Parashar
   • Intraperitoneal Chemotherapy Comes of Age. S. A. Cannistra
   • Inhibiting Inflammation in Rheumatoid Arthritis. G. S. Firestein

:::::::       January 10      :::::::

1. * Effects of Acute Exercise on Mood and Well-Being in Patients with Major Depressive Disorder. Med Sci Sports Exerc. 2005;37:2032-2037. [Eurekalert]
2. * Effects of Alcohol Advertising Exposure on Drinking Among Youth. Arch Pediatr Adolesc Med. 2006;160:18-24. [Eurekalert]
3. Impact of Adolescent Mental Disorders and Physical Illnesses on Quality of Life 17 Years Later. Arch Pediatr Adolesc Med. 2006;160:93-99.
4. Enabling Parents Who Smoke to Prevent Their Children From Initiating Smoking. Results From a 3-Year Intervention Evaluation. Arch Pediatr Adolesc Med. 2006;160:56-62.
5. Neighborhood Safety and Overweight Status in Children. Arch Pediatr Adolesc Med. 2006;160:25-31.
6. Intrinsic Abnormalities of Lymphocyte Counts in Children with Down Syndrome. J Pediatr 2005;147: 744-752. [Medscape]
7. Cheerleading-Related Injuries to Children 5 to 18 Years of Age: United States, 1990–2002. Pediatrics 2006; 117: 122-129.
8. Annals of Internal Medicine 3 January 2006 Volume 144 Issue 1
   • Changes in Invasive Pneumococcal Disease among HIV-Infected Adults Living in the Era of Childhood Pneumococcal Immunization. Flannery, and others.
   • * Physical Performance in Peripheral Arterial Disease: A Slower Rate of Decline in Patients Who Walk More. McDermott, and others. [Eurekalert]
   • Body Mass Index and Risk for End-Stage Renal Disease. Hsu, and Others. [Eurekalert]
   • Who Is Maintaining Certification in Internal Medicine—and Why? A National Survey 10 Years after Initial Certification. Lipner, and Others . [Eurekalert]
   • Update in Infectious Diseases. Bartlett
   • REVIEWS: Meta-Analysis: Protein and Energy Supplementation in Older People. Milne, Avenell, and Potter.
   • EDITORIALS: Leaving (Internal) Medicine. Sox
   • Feeding Patients after Stroke: Who, When, and How. Williams
   • ON BEING A DOCTOR: Customer Disservice? Glazer
   • Twenty Minutes: Cavanaugh
   • Commentary: Customer Disservice? Brennan

:::::::       January 9       :::::::

1. * Renal Function, Congestive Heart Failure, and Amino-Terminal Pro-Brain Natriuretic Peptide Measurement: Results From the ProBNP Investigation of Dyspnea in the Emergency Department (PRIDE) Study. J Am Coll Cardiol 2006 47: 91-97. [Science Daily]
2. * Women with a low Framingham risk score and a family history of premature coronary heart disease have a high prevalence of subclinical coronary atherosclerosis. Am Heart J; 2005: 1276-1281. [Eurekalert]
3. Controversies in Cardiovascular Medicine: Noninvasive Screening for Coronary Artery Disease With Computed Tomography Is Useful. How useful is computed tomography for screening for coronary artery disease? Circulation. 2006;113:125-146.
   
4. * A critique of the Women’s Health Initiative hormone therapy study. Fertil Steril 2005;6:1589-1601. [Medscape]
5. * Clarithromycin reduces recurrent cardiovascular events in patients without periodontitis. S Puja, and Others. Atherosclerosis online Jan 4 2006. [Eurekalert]
6. New England Journal of Medicine Volume 353 December 29, 2005 Number 26
   • Medicare Drug Benefit: A Prescription for a Modern Medicare Program. P. B. Bach and M. B. McClellan
   • Medicare Drug Benefit: Promise and Perils for Patients and Physicians. R. L. Kravitz and S. Chang
   • Medicare Drug Benefit: Benefits and Consequences for the Poor and the Disabled. R. A. Elliott, S. R. Majumdar, M. R. Gillick, and S. B. Soumerai [Eurekalert]
   • Medicare Drug Benefit: A Beneficial Side Effect of the Medicare Drug Benefit. R. Platt and A. Ommaya [Eurekalert]
   • Focus on Research: Preventing Stroke in Sickle Cell Anemia. O. S. Platt
   • A Comparison of Letrozole and Tamoxifen in Postmenopausal Women with Early Breast Cancer. The Breast International Group (BIG) 1-98 Collaborative Group
   • Rescue Angioplasty after Failed Thrombolytic Therapy for Acute Myocardial Infarction. A. H. Gershlick and Others
   • * Discontinuing Prophylactic Transfusions Used to Prevent Stroke in Sickle Cell Disease. The Optimizing Primary Stroke Prevention in Sickle Cell Anemia (STOP 2) Trial Investigators. [Eurekalert]
   • Trial Registration at ClinicalTrials.gov between May and October 2005. D. A. Zarin, T. Tse, and N. C. Ide
   • Acute Pulmonary Edema. L. B. Ware and M. A. Matthay
   • Aromatase Inhibitors — A Triumph of Translational Oncology. S. M. Swain
   • Trial Registration Report Card. J. M. Drazen and A. J.J. Wood
   • Registries and Registration of Clinical Trials. C. Haug, P. C. Gøtzsche, and T. V. Schroeder
   • Expression of Concern: Bombardier et al., "Comparison of Upper Gastrointestinal Toxicity of Rofecoxib and Naproxen in Patients with Rheumatoid Arthritis," N Engl J Med 2000;343:1520-8. G. D. Curfman, S. Morrissey, and J. M. Drazen

:::::::       January 6        :::::::

:::::::  Weekend Reading - Basic Science and general interest articles  :::::::

1. MedWatch:
• Avandia (rosiglitazone maleate) and Avandamet (rosiglitazone maleate/metformin HCl) post-marketing reports of new onset and worsening diabetic macular edema. In the majority of these cases, the patients also reported concurrent peripheral edema. In some cases, the macular edema resolved or improved following discontinuation of therapy and in one case, macular edema resolved after dose reduction.
2. FDA Approvals [Medscape] and Safety Changes: [Medscape]
• Nexavar (sorafenib tosylate), a new anti-cancer medicine used to treat adults with advanced renal cell carcinoma, the most common type of kidney cancer.
• Orencia (abatacept) for reducing signs and symptoms, inducing major clinical response, slowing the progression of structural damage, and improving physical function in adult patients with moderately to severely active rheumatoid arthritis (RA). [Medscape]
• Revlimid (lenalidomide) for the treatment of patients with transfusion-dependant anemia due to low- or intermediate-1-risk myelodysplastic syndromes (MDS) associated with a deletion 5q cytogenetic abnormality with or without additional abnormalities. A deletion involving the 5q chromosome may be involved in 20% to 30% of all MDS cases. FDA News
• Prinzide (lisinopril plus hydrochlorothiazide) labeling revisions to warn that the lisinopril component has been associated with rare incidences of head/neck angioedema and hepatic failure.
• Avinza (morphine extended-release) labeling revisions to warn of the risk for morphine overdose in patients concomitantly consuming alcohol.
• Epogen (epoetin alfa) labeling to reflect postmarketing reports of pure red cell aplasia (PRCA) and severe anemia, with or without other cytopenias, associated with the development of neutralizing antibodies to erythropoietin in patients receiving the product.
3. * Structure of the parainfluenza virus 5 F protein in its metastable, prefusion conformation. H-S Yin et al. Nature 439, 38-44 (5 Jan 2006) [Eurekalert: Structure of viral harpoon protein reveals how viruses enter cells]
4. * Dietary and Genetic Control of Glucose Transporter 2 Glycosylation Promotes Insulin Secretion in Suppressing Diabetes. Cell, Vol 123, 1307-1321, 29 December 2005. [Eurekalert: How a high-fat diet causes type 2 diabetes]
5. Stem cell mobilization by hyperbaric oxygen. Am J Physiol Heart Circ Physiol (November 18, 2005). doi:10.1152/ajpheart.00888.2005 . [Eurekalert]
6. Integration of Endocannabinoid and Leptin Signaling in an Appetite-Related Neural Circuit. Neuron, Vol 48, 1055-1066, 22 December 2005. [ScienceNOW]
7. Macrophage expression of active MMP-9 induces acute plaque disruption in apoE-deficient mice. JCI; online December 22, 2005. [ScienceDaily]
   

:::::::       January 5       :::::::

1. JAMA Vol. 295 No. 1, pp. 9-124, January 4, 2006
   • * Low-Fat Dietary Pattern and Weight Change Over 7 Years: The Women's Health Initiative Dietary Modification Trial. JAMA. 2006;295:39-49. [Medscape]
   • First Documented Rhythm and Clinical Outcome From In-Hospital Cardiac Arrest Among Children and Adults. JAMA. 2006;295:50-57. [Eurekalert]
   • L-Arginine Therapy in Acute Myocardial Infarction: The Vascular Interaction With Age in Myocardial Infarction (VINTAGE MI) Randomized Clinical Trial. JAMA. 2006;295:58-64.
   • * Risk of Hepatocellular Carcinoma Across a Biological Gradient of Serum Hepatitis B Virus DNA Level. JAMA. 2006;295:65-73.
   • * Reviews: Statins and Cancer Risk: A Meta-analysis. JAMA. 2006;295:74-80. [Medscape]
   • Special Communications: Messenger Molecules and Cell Death: Therapeutic Implications. JAMA. 2006;295:81-89.
   • Commentaries: The History and Meaning of the Journal Impact Factor. JAMA. 2006;295:90-93.
   • Editorials: Low-Fat Diets and Weight Change. JAMA. 2006;295:94-95.
   • Adult and Pediatric Resuscitation: Finding Common Ground. JAMA. 2006;295:96-98.
2. JAMA Vol. 294 No. 24, pp. 3057-3200, December 28, 2005
• Prophylactic Oral Amiodarone for the Prevention of Arrhythmias That Begin Early After Revascularization, Valve Replacement, or Repair: PAPABEAR: A Randomized Controlled Trial. JAMA. 2005;294:3093-3100. [Eurekalert and Medscape]
• * Dietary Intake of Antioxidants and Risk of Age-Related Macular Degeneration. JAMA. 2005;294:3101-3107. [Eurekalert]
• Excess Dosing of Antiplatelet and Antithrombin Agents in the Treatment of Non–ST-Segment Elevation Acute Coronary Syndromes. JAMA. 2005;294:3108-3116.
• Sibling Cardiovascular Disease as a Risk Factor for Cardiovascular Disease in Middle-aged Adults. JAMA. 2005;294:3117-3123. [Eurekalert]
• Noninvasive Ventilation in Acute Cardiogenic Pulmonary Edema: Systematic Review and Meta-analysis. JAMA. 2005;294:3124-3130.
• Special Communications: Adrenoleukodystrophy: New Approaches to a Neurodegenerative Disease. JAMA. 2005;294:3131-3134.
• The 100-Year Anniversary of the Description of the Frozen Section Procedure. JAMA. 2005;294:3135-3137.
• Technology Licensing: Lessons From the US Experience. JAMA. 2005;294:3137-3140.
• Editorials: Prophylaxis Against Postoperative Atrial Fibrillation: Current Progress and Future Directions. JAMA. 2005;294:3140-3142.

:::::::       January 4       :::::::

1. Annals of Internal Medicine 20 December 2005 Volume 143 Issue 12
   • * Comparing Yoga, Exercise, and a Self-Care Book for Chronic Low Back Pain: A Randomized, Controlled Trial. KJ Sherman, and Others. [Medscape]
   • Empirical Anti-Candida Therapy among Selected Patients in the Intensive Care Unit: A Cost-Effectiveness Analysis. Y Golan, and Others.
   • Meta-Analysis: The Efficacy of Strategies To Prevent Organ Disease by Cytomegalovirus in Solid Organ Transplant Recipients. AC Kalil, and Others.
   • Improving Patient Care: Effect of Increasing the Intensity of Implementing Pneumonia Guidelines: A Randomized, Controlled Trial. DM Yealy, and Others.
     
   • Review: New Concepts in the Pathophysiology of Inflammatory Bowel Disease. G Bamias,and Others.
     
   • Perspectives: Letter from New Orleans. KB DeSalvo
   • History of Medicine: The Discovery of Insulin: The Rochester, New York, Connection. R Madeb, and Others.
   • Editorials: Controlling the Troll: Management of Cytomegalovirus Infection after Transplantation. S Dummer.
     
   • On Being a Doctor: The Man with No Heart. A Mosenkis.
2. Archives of Internal Medicine Vol. 165 No. 22, pp. 2551-2719, Dec 12/26, 2005
   • Editorials: Peer Review and Professionalism at the Archives of Internal Medicine. Arch Intern Med. 2005;165:2559-2560.
   • Residency Training in the Modern Era: The Pipe Dream of Less Time to Learn More, Care Better, and Be More Professional. Arch Intern Med. 2005;165:2561-2562.
   • History Forgotten Is History Relived: Nosocomial Infection Control Is Also Essential in the Outpatient Setting. Arch Intern Med. 2005;165:2565-2567.
   • Refusal of Hydration and Nutrition: Irrelevance of the "Artificial" vs "Natural" Distinction. Arch Intern Med. 2005;165:2574-2576.
   • Special Articles: The American Public and the Terri Schiavo Case. Arch Intern Med. 2005;165:2580-2584.
   • Controversies in Internal Medicine:
     • The Case for Medical Treatment in Chronic Stable Coronary Artery Disease. Arch Intern Med. 2005;165:2587-2589. Rebuttal
     • Angioplasty Is Better Than Medical Therapy for Alleviating Chronic Angina Pectoris. Arch Intern Med. 2005;165:2589-2592. Rebuttal
   • Burnout and Internal Medicine Resident Work-Hour Restrictions. Arch Intern Med. 2005;165:2595-2600.
   • The Effects of Work-Hour Limitations on Resident Well-being, Patient Care, and Education in an Internal Medicine Residency Program. Arch Intern Med. 2005;165:2601-2606.
   • Residents Report on Adverse Events and Their Causes. Arch Intern Med. 2005;165:2607-2613.
   • Trust and Sources of Health Information: The Impact of the Internet and Its Implications for Health Care Providers: Findings From the First Health Information National Trends Survey. Arch Intern Med. 2005;165:2618-2624.
   • Overestimation of Chronic Disability Among Elderly Persons. Arch Intern Med. 2005;165:2625-2630.
   • Disparities in Diabetes Care: Impact of Mental Illness. Arch Intern Med. 2005;165:2631-2638.
   • Outbreak of Catheter-Associated Klebsiella oxytoca and Enterobacter cloacae Bloodstream Infections in an Oncology Chemotherapy Center. Arch Intern Med. 2005;165:2639-2643.
   • Metabolic Syndrome vs Framingham Risk Score for Prediction of Coronary Heart Disease, Stroke, and Type 2 Diabetes Mellitus. Arch Intern Med. 2005;165:2644-2650.
     
   • Long-term Outcome of 231 Patients With Essential Thrombocythemia: Prognostic Factors for Thrombosis, Bleeding, Myelofibrosis, and Leukemia. Arch Intern Med. 2005;165:2651-2658.
   • Renal Function and Risk of Myocardial Infarction in an Elderly Population: The Rotterdam Study. Arch Intern Med. 2005;165:2659-2665. [Medscape]
   • Cystatin C and Incident Peripheral Arterial Disease Events in the Elderly: Results From the Cardiovascular Health Study. Arch Intern Med. 2005;165:2666-2670.
   • Outcomes in 45 Patients With Statin-Associated Myopathy. Arch Intern Med. 2005;165:2671-2676. [Medscape]
     
   • Venous Thromboembolism Among Elderly Patients Treated With Atypical and Conventional Antipsychotic Agents. Arch Intern Med. 2005;165:2677-2682.
   • Tea Consumption and Ovarian Cancer Risk in a Population-Based Cohort. Arch Intern Med. 2005;165:2683-2686.

:::::::       January 3      :::::::

1. JAMA Vol. 294 No. 23, pp. 2943-3048, December 21, 2005
   • Genetic Testing in the Long QT Syndrome: Development and Validation of an Efficient Approach to Genotyping in Clinical Practice. JAMA. 2005;294:2975-2980.
     
   • Prevalence and Cardiovascular Disease Correlates of Low Cardiorespiratory Fitness in Adolescents and AdultS. JAMA. 2005;294:2981-2988.
   • * Use of Gastric Acid–Suppressive Agents and the Risk of Community-Acquired Clostridium difficile–Associated Disease. JAMA. 2005;294:2989-2995. [Eurekalert]
   • Erectile Dysfunction and Subsequent Cardiovascular Disease. JAMA. 2005;294:2996-3002.
   • Long-term Air Pollution Exposure and Acceleration of Atherosclerosis and Vascular Inflammation in an Animal Model. JAMA. 2005;294:3003-3010.
   • Immunological Memory: The Role of B Cells in Long-term Protection Against Invasive Bacterial Pathogens. JAMA. 2005;294:3019-3023.
   • Medical and Legal Issues in the Cardiovascular Evaluation of Competitive Athletes. JAMA. 2005;294:3011-3018.
   • On the Preservation of Health. JAMA. 2005;294:3024-3026.
   • Editorials: Efficient Genotyping for Congenital Long QT Syndrome. JAMA. 2005;294:3027-3028.
2. Diesel Exhaust Inhalation Causes Vascular Dysfunction and Impaired Endogenous Fibrinolysis. Circulation 2005;112:3930-3936. [Medscape]
3. Pharmacotherapy Primer – Based on the ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult
4. Excess risk of fatal coronary heart disease associated with diabetes in men and women: meta-analysis of 37 prospective cohort studies. BMJ, doi:10.1136.
5. * The relationship between C-reactive protein and subclinical cardiovascular disease in the Diabetes Heart Study (DHS). Am Heart J. 2005; 150(5):1032-1038. [Medscape]

:::::::       January 2       :::::::

1. New England Journal of Medicine Volume 353 December 22, 2005 Number 25
   • Oseltamivir Resistance — Disabling Our Influenza Defenses. A. Moscona
   • The Run on Tamiflu — Should Physicians Prescribe on Demand? A. S. Brett and A. Zuger
   • Safety of Long-Acting Beta-Agonists — An Urgent Need to Clear the Air. F. D. Martinez
   • Tumor-Infiltrating T Cells — Friend or Foe of Neoplastic Cells? G. Parmiani. [Medscape]
   • Intensive Diabetes Treatment and Cardiovascular Disease in Patients with Type 1 Diabetes. The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study Research Group
   • Effector Memory T Cells, Early Metastasis, and Survival in Colorectal Cancer. F. Pagès and Others [Medscape]
   • Brief Report: Oseltamivir Resistance during Treatment of Influenza A (H5N1) Infection. M. D. de Jong and Others
   • Disciplinary Action by Medical Boards and Prior Behavior in Medical School. M. A. Papadakis and Others
   • Drug Therapy: Inhaled Nitric Oxide Therapy in Adults. M. J.D. Griffiths and T. W. Evans
   • Glycemic Control and Cardiovascular Disease — Should We Reassess Clinical Goals? W. T. Cefalu
   • Professional Behavior — A Learner's Permit for Licensure. L. M. Kirk and L. L. Blank
   • Immunosuppression, Skin Cancer, and Ultraviolet A Radiation. J. A. Parrish
2. Guidelines for the Investigation of Contacts of Persons with Infectious Tuberculosis: Recommendations from the National Tuberculosis Controllers Association and CDC. Published in the December 16 MMWR: Recommendations and Reports. [Medscape] (pdf of issue)
3. The Effects of Pulmonary Rehabilitation in the National Emphysema Treatment Trial. Chest 2005;128: 3799-3809. Editorial: 3783-3784 [Medscape]

:::::::       December 22        :::::::

:::::::  Holiday Reading - Basic Science and general interest articles  :::::::

1. Medwatch Alert:
• NeutroSpec (technetium [99m Tc] fanolesomab) reports of serious and life-threatening cardiopulmonary events after administration. [Medscape]
2. FDA
• Approval: Nexavar (sorafenib tosylate), a new anti-cancer medicine used to treat adults with advanced renal cell carcinoma, the most common type of kidney cancer.
• News: FDA to Require Food Manufacturers to List Food Allergens. Consumers with Allergies Will Benefit From Improved Food Labels

:::::::       December 21      :::::::

1. New England Journal of Medicine  Volume 353 December 15, 2005 Number 24
   • Glimpses of Guantanamo — Medical Ethics and the War on Terror. S. Okie
   • Influenza — Interpandemic as Well as Pandemic Disease. R. Dolin
   • *  A Trial of Contraceptive Methods in Women with Systemic Lupus Erythematosus. J. Sánchez-Guerrero and Others
   • *  Combined Oral Contraceptives in Women with Systemic Lupus Erythematosus. M. Petri and Others
   • Influenza-Associated Deaths among Children in the United States, 2003–2004. N. Bhat and Others N Engl J Med 2005;353:2559-2567. [Medscape]
     
   • *  Atrial Overdrive Pacing for the Obstructive Sleep Apnea–Hypopnea Syndrome. E. N. Simantirakis and Others
   • Hirsutism. R. L. Rosenfield
   • Oral Contraceptives in Systemic Lupus Erythematosus — A Tough Pill to Swallow? B. L. Bermas
   • Can Sleep Apnea Be Treated without Modifying Anatomy? D. J. Gottlieb
   • Appropriate Use of Artificial Nutrition and Hydration — Fundamental Principles and Recommendations. D. Casarett, J. Kapo, and A. Caplan
2. Efficacy and safety of mometasone furoate nasal spray in nasal polyposis. J Allergy Clin Immunol. 2005;116:1272-1281. [Medscape]
3. Nasal sensory nerve populations responding to histamine and capsaicin. J Allergy Clin Immunol. 2005;116: 1282-1288.

:::::::       December 20       :::::::

1. JAMA. 2005 Vol. 294 No. 22, pp. 2811-2934, December 14, 2005
   • *  Dietary Fiber Intake and Risk of Colorectal Cancer: A Pooled Analysis of Prospective Cohort Studies. JAMA. 2005;294:2849-2857. [Medscape]
   • *  The Long Road to Patient Safety: A Status Report on Patient Safety Systems. JAMA. 2005;294:2858-2865. [Medscape]
   • *   Prognostic Value of Serial B-Type Natriuretic Peptide Testing During Follow-up of Patients With Unstable Coronary Artery Disease. JAMA. 2005;294:2866-2871. [Medscape]
   • Insulin, Glucose, Insulin Resistance, and Pancreatic Cancer in Male Smokers. JAMA. 2005;294:2872-2878.
   • Socioeconomic Status in Health Research: One Size Does Not Fit All. JAMA. 2005;294:2879-2888.
   • Ventilatory Management of Acute Lung Injury and Acute Respiratory Distress Syndrome. JAMA. 2005;294:2889-2896.
   • Electron-Beam Computed Tomography for Coronary Calcium: A Useful Test to Screen for Coronary Heart Disease? JAMA. 2005;294:2897-2901.
   • The Use of Stories in Clinical Research and Health Policy. JAMA. 2005;294:2901-2904.
   • Editorials: Dietary Fiber and Colorectal Cancer: An Ongoing Saga. JAMA. 2005;294:2904-2906.
   • Creating a Safer Health Care System: Finding the Constraint. JAMA. 2005;294:2906-2908.

:::::::       December 19      :::::::

1. *  A Low-Glycemic Load Diet Facilitates Greater Weight Loss in Overweight Adults With High Insulin Secretion but Not in Overweight Adults With Low Insulin Secretion in the CALERIE Trial. Diabetes Care 2005 28: 2939-2941. [ScienceDaily] [Medscape]
2. *  Appetite assessment: simple appetite questionnaire predicts weight loss in community-dwelling adults and nursing home residents. Am J Clin Nutr 2005 82: 1074-1081. [Eurekalert]
3. *  MMWR Recommendations and Reports: December 9, 2005 / Vol. 54 / No. RR–14 Recommended Antimicrobial Agents for Treatment and Postexposure Prophylaxis of Pertussis: 2005 CDC Guidelines [Medscape]
4. *  The Metabolic Syndrome: Time for a Critical Appraisal: Joint statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 2005 9;28(9):2289-304.
5. Study Provides First Estimate Of US Population Affected By Barrett's Esophagus According to estimates put forth in a study published today in the American Gastroenterological Association (AGA) journal Gastroenterology, [ScienceDaily]
6. *  Generation of Neoantigenic Epitopes After Posttranslational Modification of Type II Collagen by Factors Present Within the Inflamed Joint. Arthritis & Rheumatism, December 2005; 52:12; pp. 3829-3838. [Eurekalert]
7. Ototoxicity in Children Receiving Platinum Chemotherapy: Underestimating a Commonly Occurring Toxicity That May Influence Academic and Social Development. JCO Dec 1 2005: 8588-8596. [Eurekalert and Science Daily]

:::::::       December 16        :::::::

:::::::  Weekend Reading - Basic Science and general interest articles  :::::::

1. FDA ALERT [12/2005] Biaxin (clarithromycin). BMJ article [Medscape]
2. *  Lost in Translation: Challenges and Opportunities in Physician-to-Physician Communication During Patient Handoffs. Acad Med 2005 80: 1094-1099. [Eurekalert]
3. Late-Breaking Basic Science Abstracts from AHA Scientific Sessions 2005.
4. *  Phytosterol Composition of Nuts and Seeds Commonly Consumed in the United States. J. Agric. Food Chem., 53 (24), 9436 -9445, 2005. [Science Daily]
5. Use of a dummy (pacifier) during sleep and risk of sudden infant death syndrome (SIDS): population based case-control study. BMJ 2005; published online. [Online First PDF] . [Eurekalert]
6. Anti-A42- and anti-A40-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model. JCI Published December 8, 2005. [Science Daily]
7. Thinking the Pain Away -- Science 2005 (1212): 1 -- ScienceNOW

:::::::       December 15      :::::::

1. *  ACC/AHA Guidelines for the Management of Patients With Peripheral Arterial Disease (Lower Extremity, Renal, Mesenteric, and Abdominal Aortic) - Executive Summary.
• Groundbreaking Guidelines Promote Early Detection, News Treatment of Arterial Disease. ACC Guidelines JACC and Guidelines
2. *  Patent Foramen Ovale: Innocent or Guilty? Evidence From a Prospective Population-Based Study. J Am Coll Cardiol, Published online 5 December 2005. [Medscape] [Eurekalert]
3. *  Time Is Brain - Quantified. Stroke published December 8, 2005. [Medscape]
4. Fast Food, Central Nervous System Insulin Resistance, and Obesity. Arterioscler Thromb Vasc Biol. 2005 Dec;25(12):2451-62.
5. Cross-Sectional Relations of Peripheral Microvascular Function, Cardiovascular Disease Risk Factors, and Aortic Stiffness: The Framingham Heart Study. Circ 2005;112:3722-3728.
6. Adherence to candesartan and placebo and outcomes in chronic heart failure in the CHARM programme: double-blind, randomised, controlled clinical trial. The Lancet Early Online Publication, 7 December 2005. [Medscape: Medication Adherence Linked to Improved Heart Failure Survival]
7. Arrhythmogenic Mutation-Linked Defects in Ryanodine Receptor Autoregulation Reveal a Novel Mechanism of Ca2+ Release Channel Dysfunction. Circulation Research published December 8, 2005. [Eurekalert Breakthrough in unravelling the causes of sudden cardiac death in young people]
8. Mechanisms of Mineralocorticoid Action. Hypertension. 2005;46:1227.
9. Arrhythmogenic Right Ventricular Dysplasia. A United States Experience. Circulation 2005: published online before print December 12, 2005. [Eurekalert]
10. Cost-Effectiveness of Fixed-Dose Combination of Isosorbide Dinitrate and Hydralazine Therapy for Blacks With Heart Failure. Circulation 2005 112: 3745 - 3753. [Eurekalert]

:::::::       December 14      :::::::

*  Expression of Concern: Bombardier et al., "Comparison of Upper Gastrointestinal Toxicity of Rofecoxib and Naproxen in Patients with Rheumatoid Arthritis," N Engl J Med 2000;343:1520-8. Published at www.nejm.org December 8, 2005 . [Medscape]

New England Journal of Medicine  Volume 353 December 8, 2005 Number 23

• *  Clinician-Discoverers — Marshall, Warren, and H. pylori. J. Parsonnet
• *  Robert Koch, the Nobel Prize, and the Ongoing Threat of Tuberculosis. S. H.E. Kaufmann
• *  Medical History: The Medical Detectives. H. Markel
• Remembering Berton Roueché — Master of Medical Mysteries. B. H. Lerner
• *   An Epidemic, Toxin Gene–Variant Strain of Clostridium difficile. L. C. McDonald and Others [Medscape]
• *   A Predominantly Clonal Multi-Institutional Outbreak of Clostridium difficile–Associated Diarrhea with High Morbidity and Mortality. V. G. Loo and Others [Medscape]
• Febuxostat Compared with Allopurinol in Patients with Hyperuricemia and Gout. M. A. Becker and Others
• Infliximab for Induction and Maintenance Therapy for Ulcerative Colitis. P. Rutgeerts and Others. [Eurekalert]
• Medical Progress: Renal-Cell Carcinoma. H. T. Cohen and F. J. McGovern
• Pseudomembranous Colitis Associated with Clostridium difficile. P. L. Wolf and A. Kasyan
• Deforming Gout. G. Pacheco and J. A. Cavallasca
• The New Clostridium difficile — What Does It Mean? J. G. Bartlett and T. M. Perl
• Febuxostat — Treatment for Hyperuricemia and Gout? L. W. Moreland
• Understanding Heme Transport. N. C. Andrews

:::::::       December 13      :::::::

1. JAMA Vol. 294 No. 21, pp. 2669-2800, December 7, 2005
   • Adjuvant Chemotherapy for Stage III Colon Cancer: Implications of Race/Ethnicity, Age, and Differentiation. JAMA. 2005;294:2703-2711. [ScienceDaily]
   • *   Trends in Hospitalizations for Pneumonia Among Persons Aged 65 Years or Older in the United States, 1988-2002. JAMA. 2005;294:2712-2719. [ScienceDaily]
   • *   Adverse Events Reported Following Live, Cold-Adapted, Intranasal Influenza Vaccine. JAMA. 2005;294:2720-2725. [ScienceDaily]
   • *   Deceased-Donor Characteristics and the Survival Benefit of Kidney Transplantation. JAMA. 2005;294:2726-2733.
   • Adverse Events Associated With Smallpox Vaccination in the United States, January-October 2003. JAMA. 2005;294:2734-2743. [Medscape]
   • Neurologic Adverse Events Associated With Smallpox Vaccination in the United States, 2002-2004. JAMA. 2005;294:2744-2750.
   • Manifestations of Chronic Disease During Pregnancy. JAMA. 2005;294:2751-2757.
   • Editorials: Progress in the Adjuvant Treatment of Colon Cancer: Has It Influenced Clinical Practice? JAMA. 2005;294:2758-2760.
   • Pneumonia in Older Adults: Reversing the Trend. JAMA. 2005;294:2760-2763.
   • Vaccine Safety—Achieving the Proper Balance. JAMA. 2005;294:2763-2765.
2. Endothelial Function in Healthy 11-Year-Old Children After Dietary Intervention With Onset in Infancy. The Special Turku Coronary Risk Factor Intervention Project for Children (STRIP) Circulation 2005: published online before print December 5, 2005. [Medscape]
3. Quick Assessment of Literacy in Primary Care: The Newest Vital Sign. Ann Fam Med. 2005;3:514-522. [Medscape]

:::::::       December 12      :::::::

1. Cannabinoids in multiple sclerosis (CAMS) study: safety and efficacy data for 12 months follow up. J Neurol Neurosurg Psychiatry 2005;76:1612,1664-1669. [Medscape]
2. Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans. J. Neurosci. 2005 25: 11489-11493. [Eurekalert]
3. Annals of Internal Medicine 6 December 2005 Volume 143 Issue 11
   • Plasma Exchange When Myeloma Presents as Acute Renal Failure: A Randomized, Controlled Trial. Clark, and Others.
   • *   A Community-Based Study of Stroke Incidence after Myocardial Infarction. Witt, and Others. [Medscape]
   • Treatment of Lateral Epicondylitis with Botulinum Toxin: A Randomized, Double-Blind, Placebo-Controlled Trial. Wong, and Others.
   • *   Hospital at Home: Feasibility and Outcomes of a Program To Provide Hospital-Level Care at Home for Acutely Ill Older Patients. Leff, and Others. [Medscape]
   • The Practitioner's Dilemma: Can We Use a Patient's Race To Predict Genetics, Ancestry, and the Expected Outcomes of Treatment? Barr
   • Update in Women's Health. Crandall and Pregler
   • REVIEWS: Pathogenesis of Early Lung Disease in Cystic Fibrosis: A Window of Opportunity To Eradicate Bacteria. Starner and McCray
   • HISTORY OF MEDICINE: Benjamin Franklin and Medicine. Hirschmann
   • Managing Myeloma Kidney. Gertz
   • The Myriad Uses of Botulinum Toxin. Pullman
   • Hospital at Home: The Evidence Is Not Compelling. Shepperd
   • ON BEING A DOCTOR: An Arctic Moon. Glazer

:::::::       December 9        :::::::

:::::::  Weekend Reading - Basic Science and general interest articles  :::::::

1. FDA
   • *  News: FDA Advising of Risk of Birth Defects with Paxil
   • MedWatch:
     • NeutroSpec (Technetium [99m Tc] fanolesomab, murine IgM monoclonal antibody labeled with technetium) reports of serious and life-threatening cardiopulmonary events following the administration. Onset generally occurred within minutes of injection and included two deaths attributed to cardiopulmonary failure within 30 minutes of injection.
     • Paroxetine (Paxil and generic) exposure to paroxetine in the first trimester of pregnancy may increase the risk for congenital malformations, particularly cardiac malformations.Paroxetine’s pregnancy category has been changed from C to D and added new data and recommendations to the WARNINGS section of paroxetine’s prescribing information. [Medscape]
   • FDA Approvals: [Medscape]
     • Angiomax (bivalirudin) expanded indication for use in patients with or at risk of heparin-induced thrombocytopenia and thrombosis syndrome (HIT/HITTS) undergoing percutaneous coronary intervention (PCI).
     • Depakote (divalproex) new indication for use in the treatment of acute manic or mixed episodes associated with bipolar disorder (with or without psychotic features).
     • Hylenex (recombinant hyaluronidase) for use as an adjuvant to increase the absorption and dispersion of other injected drugs; for hypodermoclysis; and as an adjunct in subcutaneous urography for improving resorption of radiopaque agents.
2. *   From Medscape Med Students: The Examining Room of Dr. Charles. (The medical weblog as a newliterature paradigm.)
3. Sex differences in the relationship between body image change and subjective and objective physical changes following a 12-week strength-training program. Body Image 2005; 2: 363-372.
4. *   A Causal Role for Uric acid in Fructose-induced Metabolic Syndrome. Am J Physiol Renal Physiol online before publicaiton. [Eurekalert]
5. Upregulation of Forebrain NMDA NR2B Receptors Contributes to Behavioral Sensitization after Inflammation. J. Neurosci. 2005 25: 11107-11116. [Eurekalert]
6. Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight. J. Clin. Invest. 115:3579-3586. [ScienceNOW]

:::::::       December 8      :::::::

1. *  Severe Clostridium difficile--Associated Disease in Populations Previously at Low Risk. MMWR December 2, 2005 / Vol. 54 / No. 47. [Medscape]
2. Systematic review and meta-analysis of randomised controlled trials of gastro-oesophageal reflux interventions for chronic cough associated with gastro-oesophageal reflux. BMJ online before print (published 5 December 2005).
3. Risk of adverse gastrointestinal outcomes in patients taking cyclo-oxygenase-2 inhibitors or conventional non-steroidal anti-inflammatory drugs: population based nested case-control analysis. BMJ 2005;331:1310-1312. [Medscape]
4. *   The diagnosis and management of sinusitis: A practice parameter update. J All Clin Immun 2005; 116 (Supplement): S13-S47 [Medscape]
5. Acetaminophen-induced acute liver failure: Results of a United States multicenter, prospective study. Hepatology. 2005;42:1252-1254, 1364-1372. [Medscape]
6. Efficacy of bystander cardiopulmonary resuscitation and out-of-hospital automated external defibrillation as life-saving therapy in commotio cordis. J Pediatrics 2005; 147, Number 6 (December 2005), published by [Eurekalert].
7. *  The Break-Even Point: When Medical Advances Are Less Important Than Improving the Fidelity With Which They Are Delivered. Ann Fam Med 2005 3: 545-552. [Eurekalert]

:::::::       December 7      :::::::

1. New England Journal of Medicine online before print Dec 1, 2005.
   • *  An Epidemic, Toxin Gene-Variant Strain of Clostridium difficile Published Dec 1, 2005 [Medscape]
   • *  A Predominantly Clonal Multi-Institutional Outbreak of Clostridium difficile-Associated Diarrhea with High Morbidity and Mortality. Published Dec 1, 2005
   • The New Clostridium difficile -- What Does It Mean? Published Dec 1, 2005
2. New England Journal of Medicine Volume 353 December 1, 2005 Number 22
   • Fatal Infections Associated with Mifepristone-Induced Abortion. M. F. Greene
   • Observational Studies of Drugs and Mortality. W. A. Ray
   • Politically Correct Human Embryonic Stem Cells? D. Solter
   • Antiretroviral Therapy in a Thousand Patients with AIDS in Haiti. P. Severe and Others
   • *   Risk of Death in Elderly Users of Conventional vs. Atypical Antipsychotic Medications. P. S. Wang and Others [Medscape]
   • Messenger RNA for FOXP3 in the Urine of Renal-Allograft Recipients. T. Muthukumar and Others
   • Brief Report: Fatal Toxic Shock Syndrome Associated with Clostridium sordellii after Medical Abortion. M. Fischer and Others
   • Patent Foramen Ovale in Young Adults with Unexplained Stroke. J. R. Kizer and R. B. Devereux
   • Drug Therapy: Low-Dose Aspirin for the Prevention of Atherothrombosis. C. Patrono, L. A. García Rodríguez, R. Landolfi, and C. Baigent
   • Scaling Up Treatment — Why We Can't Wait. J. Y. Kim and C. Gilks
   • Rejection — More Than the Eye Can See. T. B. Strom
   • Applying Public Health Principles to the HIV Epidemic. T. R. Frieden, M. Das-Douglas, S. E. Kellerman, and K. J. Henning

:::::::       December 6      :::::::

1. *  The diagnosis and management of sinusitis: A practice parameter up. JACI online before print Dec 2005. [Eurekalert]
2. Long-Term NSAIDs May Not Be Useful for Osteoarthritis. [Medscape]
3. * Gender and perceived severity of cardiac disease: Evidence that women are “tougher” Am J Med 2005; 118: 1256-1261.[Eurekalert and Science Daily]
4. Endotoxin Exposure Is a Risk Factor for Asthma: The National Survey of Endotoxin in United States Housing. Am. J. Respir. Crit. Care Med. 2005; 172: 1371-1377. [Eurekalert]
5. Association of Sleep-disordered Breathing and the Occurrence of Stroke. Am. J. Respir. Crit. Care Med. 2005; 172: 1447-1451. [Eurekalert]

:::::::       December 5      :::::::

1. Archives of Internal Medicine Vol. 165 No. 21, pp. 2447-2541, November 28, 2005
   • Editorials: Subclinical Hypothyroidism and Cardiovascular Disease. Arch Intern Med. 2005;165:2451-2452.
   • When Is a New Prediction Marker Useful?: A Consideration of Lipoprotein-Associated Phospholipase A2 and C-Reactive Protein for Stroke Risk. Arch Intern Med. 2005;165:2454-2456.
   • Doctoring Through Katrina: Dedicated to All the People Who Suffered During a Natural Disaster. Arch Intern Med. 2005;165:2458-2459.
   • Subclinical Hypothyroidism and the Risk of Heart Failure, Other Cardiovascular Events, and Death. Arch Intern Med. 2005;165:2460-2466.
   • Subclinical Thyroid Dysfunction as a Risk Factor for Cardiovascular Disease. Arch Intern Med. 2005;165:2467-2472.
   • C-Reactive Protein and Risk of Cardiovascular Disease in Men and Women From the Framingham Heart Study. Arch Intern Med. 2005;165:2473-2478.
   • Lipoprotein-Associated Phospholipase A2, High-Sensitivity C-Reactive Protein, and Risk for Incident Ischemic Stroke in Middle-aged Men and Women in the Atherosclerosis Risk in Communities (ARIC) Study. Arch Intern Med. 2005;165:2479-2484.
   • Quality of Care and Outcomes of Older Patients With Heart Failure Hospitalized in the United States and Canada. Arch Intern Med. 2005;165:2486-2492.
   • Ties That Bind: Multiple Relationships Between Clinical Researchers and the Pharmaceutical Industry. Arch Intern Med. 2005;165:2493-2496.
   • Impact of Antidepressant Drug Adherence on Comorbid Medication Use and Resource Utilization. Arch Intern Med. 2005;165:2497-2503.
   • Depression and Medication Adherence in Outpatients With Coronary Heart Disease: Findings From the Heart and Soul Study. Arch Intern Med. 2005;165:2508-2513.
   • Infectious Disease Hospitalizations Among Older Adults in the United States From 1990 Through 2002. Arch Intern Med. 2005;165:2514-2520.
   • Allergic Rhinitis, Asthma, and Atherosclerosis in the Bruneck and ARMY Studies. Arch Intern Med. 2005;165:2521-2526.
     
   • Behavioral Insomnia Therapy for Fibromyalgia Patients: A Randomized Clinical Trial. Arch Intern Med. 2005;165:2527-2535

:::::::       December 2        :::::::

:::::::  Weekend Reading - Basic Science and general interest articles  :::::::

1. FDA News
   • MedWatch
     • Aranesp (darbepoetin alfa) and Epogen and Procrit (epoetin alfa) Revised labeling: reports of pure red cell aplasia and severe anemia, with or without other cytopenias, associated with neutralizing antibodies to erythropoietin in patients treated with Aranesp; predominantly in patients with CRF .
     • NovoSeven Coagulation Factor VIIa (Recombinant) Revisioned prescribing information to provide updated safety information on thrombotic and thromboembolic adverse events, based on clinical studies in non-hemophilia patients and on post-marketing safety surveillance. A clinical study in elderly, non-hemophiliac, intracerebral hemorrhage patients indicated a potential increased risk of arterial thromboembolic adverse events with use of NovoSeven, including myocardial ischemia, myocardial infarction, cerebral ischemia and/or infarction.
   • FDA Patient Safety News: Video News Show for Health Professionals
   • FDA Labeling Approvals: [Medscape]
     • Avelox (moxifloxacin) new indication for the treatment of complicated intra-abdominal infections.
     • Avandaryl (rosiglitazone plus glimepiride) for use as an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus who are already receiving rosiglitazone plus a sulfonylurea or who are not adequately controlled on either drug alone.
     • Trileptal (oxcarbazepine) expanded indication for use as adjunctive therapy for partial seizures in epileptic children aged 2 to 4 years.
2. Giving Cancer Vaccines a Boost. [AAAS ScienceNOW report] [News report]
3. Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells. J. Clin. Invest. 115:3623-3633.
4. Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients. Science 18 November 2005: 1193-1196. [Study of genetic pathway linking nutrient response and the aging process. Dramatically reducing food intake boosts the lifespan of model organisms, but the new results point to a possible mechanism through which drastic calorie restriction affects aging. [Science Daily]
5. Weblogs and Medicine: "Over My Med Body: A Proactive Med Student Blog" [Medscape]

:::::::       December 1      :::::::

1. *  Risk of cervical and other cancers after treatment of cervical intraepithelial neoplasia: retrospective cohort study. BMJ 2005;331:1183-1185.
2. The cognitive cost of being a twin: evidence from comparisons within families in the Aberdeen children of the 1950s cohort study. BMJ online 18 Nov 2005.
3. Effect of comorbidities and postoperative complications on mortality after hip fracture in elderly people: prospective observational cohort study. BMJ online 18 Nov 2005.
4. *  Risk of cervical and other cancers after treatment of cervical intraepithelial neoplasia: retrospective cohort study. BMJ 2005;331:1183-1185. [Eurekalert]
5. *  Cytoplasmic Inclusion Bodies Are Detected by Synthetic Antibody in Ciliated Bronchial Epithelium during Acute Kawasaki Disease. J Inf Dis 2005;192:1757-1766.
6. *  Differences in the Management and Prognosis of Women and Men Who Suffer From Acute Coronary Syndromes . J Am Coll Cardiol 2005 46: 1845-1851. [ScienceDaily]
7. *  Detection of High-Risk Young Adults and Women by Coronary Calcium and National Cholesterol Education Program Panel III Guidelines. J Am Coll Cardiol 2005 46: 1931-1936.
8. The Relationship Between Blood Pressure and C-Reactive Protein in the Multi-Ethnic Study of Atherosclerosis (MESA). J Am Coll Cardiol 2005 46: 1869-1874.
9. Risk of High Blood Pressure Among Young Men Increases With the Degree of Immaturity at Birth. Circulation online Nov 21, 2005. [Medscape]
10. *  Emergent Stenting of Extracranial Internal Carotid Artery Occlusion in Acute Stroke Has a High Revascularization Rate. Stroke 2005; 36: 2426 - 2430.
11. *  Self-Monitoring of Blood Pressure Promotes Achievement of Blood Pressure Target in Primary Health Care. Am J Hypertension 2005; 18: 1415-1420. [Med-News]
12. Development of the Metabolic Syndrome in Black and White Adolescent Girls: A Longitudinal Assessment. Pediatrics 2005;116:1178-1182. [Medscape]

 

:::::::       November 30      :::::::

1. New England Journal of Medicine Volume 353 November 24, 2005 Number 21
   • The Origins of Pandemic Influenza — Lessons from the 1918 Virus. R. B. Belshe
   • Biomedical Research and Biosecurity. R. Steinbrook
   • Hostile Use of the Life Sciences. M.-K. Lim
     
   • Neuroblastoma — from Genetic Profiles to Clinical Challenge. B. H. Kushner and N.-K. V. Cheung
     
   • *  Mycophenolate Mofetil or Intravenous Cyclophosphamide for Lupus Nephritis. E. M. Ginzler and Others
   • High-Dose Acetylcysteine in Idiopathic Pulmonary Fibrosis. M. Demedts and Others [Medscape]
   • Chromosome 1p and 11q Deletions and Outcome in Neuroblastoma. E. F. Attiyeh and Others
   • *  Beta-Blockers to Prevent Gastroesophageal Varices in Patients with Cirrhosis. R. J. Groszmann and Others
   • Current Concepts: Basal-Cell Carcinoma. A. I. Rubin, E. H. Chen, and D. Ratner
   • Mycophenolate Mofetil for Lupus Nephritis. W. J. McCune
   • Antioxidant Therapy for Idiopathic Pulmonary Fibrosis. G. W. Hunninghake
   • Beta-Blockers to Prevent Esophageal Varices — An Unfulfilled Promise. S. Mukherjee and M. F. Sorrell
   • Jumping Frogs, Endangered Toads, and California's Medical-Marijuana Law. G. J. Annas
     
   • Inducing Intestinal Growth. C. Abraham and J. H. Cho

:::::::       November 29      :::::::

1. Low-fat dairy consumption and reduced risk of hypertension: the Seguimiento Universidad de Navarra (SUN) cohort. Am J Clin Nutr 2005 82: 972-979. [Medscape]
2. *  Carbohydrate restriction improves the features of Metabolic Syndrome. Metabolic Syndrome may be defined by the response to carbohydrate restriction. Nutrition & Metabolism 2005, 2:31 doi:10.1186/1743-7075-2-31 [Science Daily]
3. Characterization and consequences of pain variability in individuals with fibromyalgia. Arth & Rheum 2005; 52: 3670 - 3674. [Eurekalert: Pain research helps identify who responds to 'placebo effect']
4. The Association of Comorbid Depression With Mortality in Patients With Type 2 Diabetes. Diabetes Care 2005;28:2668-2672. [Medscape]
5. JAMA Vol. 294 No. 20, pp. 2539-2660, November 23/30, 2005
   • Effect of Muraglitazar on Death and Major Adverse Cardiovascular Events in Patients With Type 2 Diabetes Mellitus. JAMA. 2005;294:2581-2586.
   • Risk of Pelvic Fractures in Older Women Following Pelvic Irradiation. JAMA. 2005;294:2587-2593. [Medscape]
   • *  High-Risk Patients With Acute Coronary Syndromes Treated With Low-Molecular-Weight or Unfractionated Heparin: Outcomes at 6 Months and 1 Year in the SYNERGY Trial. JAMA. 2005;294:2594-2600. [Medscape]
   • Duration of Lactation and Incidence of Type 2 Diabetes. JAMA. 2005;294:2601-2610.
   • Hospital Characteristics Associated With the Management of Pediatric Splenic Injuries. JAMA. 2005;294:2611-2617.
   • Special Communications: Quality, Innovation, and Value for Money: NICE and the British National Health Service. JAMA. 2005;294:2618-2622.
   • Clinical Review: Value and Limitations of Chest Pain History in the Evaluation of Patients With Suspected Acute Coronary Syndromes. JAMA. 2005;294:2623-2629.
   • Commentaries: Drug Prices and Value for Money: The Australian Pharmaceutical Benefits Scheme: JAMA. 2005;294:2630-2632.
   • Editorials: Selling Safety—Lessons From Muraglitazar. JAMA. 2005;294:2633-2635.
   • Postradiotherapy Pelvic Fractures: Cause for Concern or Opportunity for Future Research? JAMA. 2005;294:2635-2637.

:::::::       November 28      :::::::

1. Preoperative Prostate Specific Antigen Doubling Time and Velocity Are Strong and Independent Predictors of Outcomems Following Radical Prostatectomy. J Urology 2005;174: 2191-2196. [Eurekalert]
2. Sedative hypnotics in older people with insomnia: meta-analysis of risks and benefits. BMJ online 11 Nov 2005. [Eurekalert and Medscape]
3. *  Clinical review: Shoulder pain: diagnosis and management in primary care. BMJ 2005;331:1124-1128.
4. *  NT-proBNP testing for diagnosis and short-term prognosis in acute destabilized heart failure: an international pooled analysis of 1256 patients. The International Collaborative of NT-proBNP Study. Eur Heart J published online on Nov 17, 2005. [Eurekalert] [Medscape]
5. Annals of Internal Medicine   15 November 2005 Volume 143 Issue 10 Previous Issue
   • Trends in the Incidence of Venous Thromboembolism during Pregnancy or Postpartum: A 30-Year Population-Based Study. JA Heit, and Others. [Medscape]
   • The Relationship between Condom Use and Herpes Simplex Virus Acquisition. A Wald, and Others.
   • Impact of Efavirenz on Neuropsychological Performance and Symptoms in HIV-Infected Individuals. D B Clifford, and Others.
   • *  The Metabolic Syndrome as a Predictor of Nonalcoholic Fatty Liver Disease. M Hamaguchi, and Others.
     
   • Improving Patient Care. Quality of HIV Care Provided by Nurse Practitioners, Physician Assistants, and Physicians. I B Wilson, and Others
     
   • Update in Cardiology. P H Stone
   • Perspectives: The Terri Schiavo Case: Legal, Ethical, and Medical Perspectives. J E Perry, and Others.
   • Editorials: Thromboembolism in Pregnancy: A Continuing Conundrum. R V Lee
   • An Ounce of Prevention. E W Hook
   • Dangerous Liaisons: The Metabolic Syndrome and Nonalcoholic Fatty Liver Disease. E E Powell, and Others.
     
   • On Being a Doctor. Looking for Betty.

:::::::       November 23 - 25        :::::::

:::::::  Holiday and Weekend Reading - Basic Science and general interest articles  :::::::

1. MedWatch: FDA:
• Serevent, Advair, and Foradil Linked to Risk of Severe Asthma Exacerbations, Death [Medscape]
• Public Health Advisory: Several long-acting bronchodilator medicines have been associated with possible increased risk of worsening wheezing (bronchospasm) in some people, and the agency is requesting that manufacturers update warnings in their existing product labeling.
• Flomax (tamsulosin HCl) revision to the prescribing information for Flomax, indicated for the treatment of the signs and symptoms of benign prostatic hyperplasia (BPH). A surgical condition termed Intraoperative Floppy Iris Syndrome (IFIS) has been observed during phacoemulsification cataract surgery in some patients treated with alpha-1 blockers including Flomax. It is recommended that male patients being considered for cataract surgery, as part of their medical history, be specifically questioned to ascertain whether they have taken Flomax or other alpha-1 blockers.
2. FDA drug prescribing warnings: is the black box half empty or half full? Pharmacoepidemiology and Drug Safety online in advance of print.
3. *  Obestatin, a Peptide Encoded by the Ghrelin Gene, Opposes Ghrelin's Effects on Food Intake. Science 11 November 2005: 996-999. [LiveScience]
4. *  A primate virus generates transformed human cells by fusion. JCB 2005; 171: 493-503. Common viruses may cause cancer: Study implicates viral-mediated cell fusion as a possible engine of tumor formation. [Eurekalert] JCB Editorial
5. Enlightening the adrenal gland. Cell Metabolism 2005; 2: 278-281. [Eurekalert]

:::::::       November 22      :::::::

1. Duration of protection with RTS,S/AS02A malaria vaccine in prevention of Plasmodium falciparum disease in Mozambican children: single-blind extended follow-up of a randomised controlled trial. Early Release from The Lancet.
2. Tamoxifen for the Prevention of Breast Cancer: Current Status of the National Surgical Adjuvant Breast and Bowel Project P-1 Study. J Natl Cance Inst 2005; 97: 1652-1662. [Medscape]
3. Lifetime Recreational Exercise Activity and Breast Cancer Risk Among Black Women and White Women. J Natl Cancer Inst 2005;97:1671-1679. [Medscape]
4. Diabetes Mellitus and Risk of Colorectal Cancer: A Meta-Analysis. J Natl Cancer Inst 2005; 97: 1679-1687. [Medscape]
5. Archives of Internal Medicine   Vol. 165   No. 20   November 14, 2005
   • Editorials: How Much and What Type of Physical Activity Is Enough?: What Physicians Should Tell Their Patients. Arch Intern Med. 2005;165:2324-2325.
   • The Tension Between E-Health Innovation and E-Valuation. Arch Intern Med. 2005;165:2329-2330.
   • Special Articles: Implications of Pharmacogenomics for Drug Development and Clinical Practice. Arch Intern Med. 2005;165:2331-2336.
   • Review Articles: The Risk of Lymphoma Development in Autoimmune Diseases: A Meta-analysis. Arch Intern Med. 2005;165:2337-2344.
   • Atherosclerotic Plaque Imaging: Contemporary Role in Preventive Cardiology. Arch Intern Med. 2005;165:2345-2353.
   • Effects of Physical Activity on Life Expectancy With Cardiovascular Disease. Arch Intern Med. 2005;165:2355-2360. [Medscape]
   • Prescribing Exercise at Varied Levels of Intensity and Frequency: A Randomized Trial. Arch Intern Med. 2005;165:2362-2369. [Medscape]
   • Relationship of Day-to-day Reproductive Hormone Levels to Sleep in Midlife Women. Arch Intern Med. 2005;165:2370-2376.
   • To Tell or Not to Tell: Primary Care Patients’ Disclosure Deliberations. Arch Intern Med. 2005;165:2378-2383.
   • A Randomized Outpatient Trial of a Decision-Support Information Technology Tool. Arch Intern Med. 2005;165:2388-2394.
   • Improving Laboratory Monitoring at Initiation of Drug Therapy in Ambulatory Care: A Randomized Trial. Arch Intern Med. 2005;165:2395-2401.
   • Symptoms and Related Functioning in a Traumatized Community. Arch Intern Med. 2005;165:2402-2407.
   • Progression and Regression of Sleep-Disordered Breathing With Changes in Weight: The Sleep Heart Health Study. Arch Intern Med. 2005;165:2408-2413.
   • Compliance With Osteoporosis Medications. Arch Intern Med. 2005;165:2414-2419.
   • A Prospective Study of Plasma Lipid Levels and Hypertension in Women. Arch Intern Med. 2005;165:2420-2427. [Medscape]

:::::::       November 21      :::::::

1. *  Plasma Lipoproteins and Apolipoproteins as Predictors of Cardiovascular Risk and Treatment Benefit in the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) . Circulation 2005: published online before print Nov 7. [Medscape]
2. *  Obesity and Risk of New-Onset Atrial Fibrillation After Cardiac Surgery. Circulation published online Nov 14, 2005. [Medscape]
3. *  Angiographic and Clinical Outcomes in Patients Receiving Low-Molecular-Weight Heparin Versus Unfractionated Heparin in ST-Elevation Myocardial Infarction Treated With Fibrinolytics in the CLARITY-TIMI 28 Trial. Circulation published online Nov 15, 2005.
4. *  Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells. Respiratory Research, 2005, in press. [Science Daily]
5. New England Journal of Medicine Volume 353 November 17, 2005 Number 20
   • The Promise of Global Cervical-Cancer Prevention. M. Schiffman and P. E. Castle
   • Genetic Diversity in Melanoma. P. S. Meltzer
   • So Where's My Medal? P. Klass
   • *   Randomized Trial of Lifestyle Modification and Pharmacotherapy for Obesity. T. A. Wadden and Others [Medscape]
   • *   Effects of Rimonabant on Metabolic Risk Factors in Overweight Patients with Dyslipidemia. J.-P. Després, A. Golay, and L. Sjöström
   • Distinct Sets of Genetic Alterations in Melanoma. J. A. Curtin and Others
   • *  Sildenafil Citrate Therapy for Pulmonary Arterial Hypertension. N. Galiè and Others
   • *   Cost-Effectiveness of Cervical-Cancer Screening in Five Developing Countries. S. J. Goldie and Others
   • Long-Acting Methods of Contraception. H. B. Peterson and K. M. Curtis
   • Pharmacotherapy for Obesity — Promise and Uncertainty. S. Z. Yanovski

:::::::       November 18        :::::::

:::::::  Weekend Reading - Basic Science and general interest articles  :::::::

1. FDA Approvals:
   • [Medscape]
     • Clobex (clobetasol propionate spray) for the treatment of moderate to severe plaque psoriasis affecting up to 20% of body surface area (BSA) in patients aged 18 years and older
     • Tarceva/Gemzar (erlotinib) new indication for use in combination with gemcitabine for the first-line treatment of locally advanced, unresectable, or metastatic pancreatic cancer.
   • [Medscape]
     • Exjade (deferasirox) for the treatment of chronic transfusional hemosiderosis in patients aged two years and older.
     • Oncaspar (pegaspargase) intravenous preparation as alaternative to intramuscular injection, which is often painful to patients.
     • Invanz (ertapenem) new indication for once-daily administration for the treatment of moderate to severe complicated foot infection due to designated pathogens in diabetic patients without osteomyelitis.
2. FDA Updates Labeling for Ortho Evra Contraceptive Patch.
3. FDA MedWatch
• Ortho Evra (norelgestromin/ethinyl estradiol transdermal system) Revisions to the labeling to include a bolded warning about higher exposure to estrogen for women using the weekly patch compared to taking a daily birth control pill containing 35 micrograms of estrogen. A woman on Ortho Evra may be exposed to approximately 60% more estrogen than if she were taking a typical 35 microgram estrogen birth control pill. [Medscape]
4. Separation of Conjoined Hormones Yields Appetite Rivals. Science, Vol 310, Issue 5750, 985-986 , 11 November 2005. [Science NOW: Taking a Bite Out of Hunger ]
5. Oct. 28 issue of the Morbidity and Mortality Weekly Report on the decreased quality of life and increased prevalence of disability in adults with epilepsy. [Medscape] MMWR. 2005;54;1073-1096.
6. *  Cleavage of the MLL gene by activators of apoptosis is independent of topoisomerase II activity. Leukemia 2005; ; advance online publication. [Eurekalert: Mechanism of how chemotherapy-induced leukemia develops]
7. From Cancer Patient to Cancer Survivor: Lost in Transition. Institue of Medicine Report. [Eurekalert]
8. The Cost Of Health Insurance Administration In California: Estimates For Insurers, Physicians, And Hospitals. Health Affairs 2005; 24: 1629-1639. [Science Daily] [News]
9. Health Care Reform: Why? What? When? Health Affairs 2005; 24:1399-1414.
10. *  Risk Indicators for Tooth Loss Due to Periodontal Disease. J Periodontology 2005; 76: 1910-1918. [Eurekalert]

:::::::       November 17      :::::::

1. *   JAMA EARLY RELEASE: Efficacy and Safety of Edifoligide, an E2F Transcription Factor Decoy, for Prevention of Vein Graft Failure Following Coronary Artery Bypass Graft Surgery. PREVENT IV: A Randomized Controlled Trial. PREVENT IV Investigators* JAMA. 2005;294.19.2446. [Eurekalert]
2. *   JAMA-EXPRESS EARLY RELEASE: Effect of Muraglitazar on Death and Major Adverse Cardiovascular Events in Patients With Type 2 Diabetes Mellitus. JAMA. 2005;29450147.
3. JAMA Vol. 294 No. 19, pp. 2395-2528, November 16, 2005
   • *   High-Dose Atorvastatin vs Usual-Dose Simvastatin for Secondary Prevention After Myocardial Infarction: The IDEAL Study: A Randomized Controlled Trial. JAMA. 2005;294:2437-2445.
   • *   Efficacy and Safety of Edifoligide, an E2F Transcription Factor Decoy, for Prevention of Vein Graft Failure Following Coronary Artery Bypass Graft Surgery: PREVENT IV: A Randomized Controlled Trial. JAMA. 2005;294:2446-2454.
   • *   Effects of Protein, Monounsaturated Fat, and Carbohydrate Intake on Blood Pressure and Serum Lipids: Results of the OmniHeart Randomized Trial. JAMA. 2005;294:2455-2464. [Medscape]
   • Molecular Classification of Patients With Unexplained Hamartomatous and Hyperplastic Polyposis. JAMA. 2005;294:2465-2473. [Medscape]
   • Pregnancy Characteristics and Maternal Risk of Breast Cancer. JAMA. 2005;294:2474-2480. [Medscape]
   • Grand Rounds: Adrenal Insufficiency. JAMA. 2005;294:2481-2488.
   • *   Why America Needs a Strong FDA. JAMA. 2005;294:2489-2491.
   • Editorials: The IDEAL Cholesterol: Lower Is Better. JAMA. 2005;294:2492-2494.
   • Gene Therapy and Vein Graft Patency in Coronary Artery Bypass Graft Surgery. JAMA. 2005;294:2495-2497.
   • More Novel Effects of Diet on Blood Pressure and Lipids. JAMA. 2005;294:2497-2498.
   • Unwinding the Heterogeneous Nature of Hamartomatous Polyposis Syndromes. JAMA. 2005;294:2498-2500.

:::::::       November 16      :::::::

1. Paternity Following Treatment for Testicular Cancer. J Natl Cancer Inst 2005; 97: 1580-1588. [News}
2. HIV-infected individuals receiving effective antiviral therapy for extended periods of time continually replenish their viral reservoir. J. Clin. Invest. 2005 115: 3250-3255.
3. *   The natural history of tree nut allergy. JACI 2005; Published online. [Eurekalert, Science Daily]
4. Non-steroidal anti-inflammatory drugs and risk of neoplastic progression in Barrett's oesophagus: a prospective study. Vaughan TL, and Others. Lancet Oncology 2005; (via ScienceDirect) [News report]
5. PLoS: Malaria Special Collection: [Science NOW] (Malaria Vaccine Initiative, Malaria Information from WHO, List of vaccines in development)
   • Promising Functional Readouts of Immunity in a Blood-Stage Malaria Vaccine Trial. Perspective
   • A Malaria Vaccine That Elicits in Humans Antibodies Able to Kill Plasmodium falciparum. Synopsis; Article
6. Is there cognitive decline 1 year after CABG?: Comparison with surgical and nonsurgical controls. Neurology 2005 65: 991-999. [Eurekalert]
7. Overdiagnosis of multiple sclerosis and magnetic resonance imaging criteria. Ann Neurol 2005;58:781-783 [Eurekalert: Neurologists refine multiple sclerosis diagnostic criteria]
8. Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis. Rheumatology published online Nov 9, 2005. [Eurekalert]
9. Moving Forward in Fall Prevention: An Intervention to Improve Balance Among Older Adults in Real-World Settings. Am J Public Health 2005 95: 2049-2056.
10. Treatment of pancreatic carcinoma by adenoviral mediated gene transfer of vasostatin in mice. Gut published Online First: 15 November 2005. [New Scientist]

:::::::       November 15      :::::::

1. New England Jourdnal of Medicine  Volume 353 November 10, 2005 Number 19
   • Recertification for Internists — One "Grandfather's" Experience. T. A. Brennan
   • Personal Metrics for Practice — How'm I Doing? R. J. Baron
   • Renewing Board Certification. R. Steinbrook
   • *  Glioblastoma Multiforme and the Epidermal Growth Factor Receptor. H. S. Friedman and D. D. Bigner
   • First-Trimester or Second-Trimester Screening, or Both, for Down's Syndrome. F. D. Malone and Others [Medscape and Eurekalert]
   • *   Molecular Determinants of the Response of Glioblastomas to EGFR Kinase Inhibitors. I. K. Mellinghoff and Others
   • *  Continuous Positive Airway Pressure for Central Sleep Apnea and Heart Failure. T. D. Bradley and Others [Medscape]
   • *  Obstructive Sleep Apnea as a Risk Factor for Stroke and Death. H. K. Yaggi and Others
     
   • Mechanisms of Disease: Acute Oxygen-Sensing Mechanisms. E. K. Weir, J. López-Barneo, K. J. Buckler, and S. L. Archer
     
   • Choosing the Best Prenatal Screening Protocol. J. L. Simpson
   • Sleep — A New Cardiovascular Frontier. V. K. Somers [Eurekalert]
     
   • Health-Information Altruists — A Potentially Critical Resource. I. S. Kohane and R. B. Altman
     
   • One Commensal Bacterial Molecule — All We Need for Health? C. Fiocchi
2. *  Incremental shuttle walking is associated with activation of haemostatic and haemorheological markers in patients with coronary artery disease: the Birmingham rehabilitation uptake maximisation study (BRUM). Heart 2005;91:1413-1417. [Eurekalert : Sudden Exertional Stress Activates Hemostatic Markers in Heart Disease]
3. Waist-to-Hip Ratio vs BMI May Be More Accurate Predictor of CV Risk. [Eurekalert report from Lancet. 2005;366:1589-1591, 1640-1649.]

:::::::       November 14      :::::::

1. *   Body Fat Distribution, Liver Enzymes, and Risk of Hypertension: Evidence From the Western New York Study. Hypertension 2005 46: 1186-1193. [Science Daily]
2. Journal of the American College of Cardiology Volume 46, Issue 10, November 15, 2005
   • Phenolic Content of Virgin Olive Oil Improves Ischemic Reactive Hyperemia in Hypercholesterolemic Patients. J Am Coll Cardiol 2005 46: 1864-1868.
   • *   The Influence of Race on Health Status Outcomes One Year After an Acute Coronary Syndrome. J Am Coll Cardiol 2005 46: 1838-1844. [Eurekalert]
   • Granulocyte Colony-Stimulating Factor and Stem Cell Factor Improve Contractile Reserve of the Infarcted Left Ventricle Independent of Restoring Muscle Mass. J Am Coll Cardiol 2005 46: 1662-1669.
   • *   Regeneration of Human Infarcted Heart Muscle by Intracoronary Autologous Bone Marrow Cell Transplantation in Chronic Coronary Artery Disease: The IACT Study. J Am Coll Cardiol 2005 46: 1651-1658. [Eurekalert]
3. Circulation Volume 112, Issue 19; November 8, 2005
   • *   Sildenafil in the Treatment of Raynaud’s Phenomenon Resistant to Vasodilatory Therapy. Circulation 2005 112: 2980 - 2985. [News]
   • Low Thyroid Function Leads to Cardiac Atrophy With Chamber Dilatation, Impaired Myocardial Blood Flow, Loss of Arterioles, and Severe Systolic Dysfunction. Circulation 2005: published online before print November 7, 2005.
   • *   Optimal Timing of Intervention in Non-ST-Segment Elevation Acute Coronary Syndromes. Insights From the CRUSADE (Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the ACC/AHA guidelines) Registry. Circulation 2005: published online before print November 7, 2005.
   • Vascular Endothelial Growth Factor Gene Therapy Increases Survival, Promotes Lung Angiogenesis, and Prevents Alveolar Damage in Hyperoxia-Induced Lung Injury. Circulation. 2005;112:2477-2486. [Science Daily  , Eurekalert]
   • *   Cardioprotection by Intermittent Fasting in Rats. Circulation 2005, doi:10.1161/ published online.

:::::::       November 11        :::::::

:::::::  Weekend Reading - Basic Science and general interest articles  :::::::

1. FDA Approvals Orphan Drugs [Medscape]
• Zactima ( ZD6474) for the treatment of follicular, medullary, anaplastic, and locally advanced and metastatic papillary thyroid cancer.
• Surfaxin (lucinactant) for the treatment of bronchopulmonary dysplasia (chronic lung disease [CLD]) in premature infants.
• IL-21 (interleukin 21) for the treatment of advanced or aggressive melanoma.
2. FDA Approval:
• Exjade (deferasirox) an oral iron chelator developed to treat chronic iron overload due to multiple blood transfusions.
3. FDA MedWatch Safety Labeling Changes:
   1. Celebrex. [Medscape]
   2. Amevive (alefacept: indicated for the treatment of adult patients with chronic plaque psoriasis) revision to prescribing information Amevive should not be administered to patients infected with HIV. Amevive reduces CD4+ T lymphocyte counts.
   3. Parenteral Maltose/Parenteral Galactose/Oral Xylose-Containing Products. Warning of the potential for life-threatening falsely elevated glucose readings. A preliminary listing of U.S. products that may cause glucose test interference is provided.
4. CDC Committee Recommends Routine Hepatitis A Vaccination for Children. The Advisory Committee on Immunization Practices (ACIP) unanimously agreed on universal hepatitis A vaccination for children between 12 to 35 months of age, with catch-up vaccination through the pre-school years. [Medscape]
5. *  Indicators: Gut Reaction: Lying Is Tied to Digestive Changes. [NYT report from the annual meeting of the American College of Gastroenterology (Medscape) ; the study began as a high school project]
6. Regulation of Oxidative Stress by the Anti-aging Hormone Klotho. J. Biol. Chem. 2005 280: 38029-38034.
7. Treatment of Autoimmune Neuroinflammation with a Synthetic Tryptophan Metabolite. Science, 2005; 310 4 Nov. [NewScientist New treatment for multiple sclerosis tested]
8. Neurogenesis in the Hypothalamus of Adult Mice: Potential Role in Energy Balance. Science 2005: p.679-683; 28 October . [ScienceNOW More Brain, Less Gain. Ciliary neurotrophic factor (CNTF) induces weight loss in obese rodents and humans, and for reasons that are not understood, its effects persist after the cessation of treatment.] [Nature news]
9. A recipe for overeating: Studies outline dangers of mixing stress, deprivation and tempting foods: [Eurekalert] Behavioral Neuroscience Volume 119, Issue 4
• Various Aspects of Feeding Behavior Can Be Partially Dissociated in the Rat by the Incentive Properties of Food and the Physiological State. Barbano and Others.
• Combined Dieting and Stress Evoke Exaggerated Responses to Opioids in Binge-Eating Rats. Boggiano, et al.
10. Portal sensing of intestinal gluconeogenesis is a mechanistic link in the diminution of food intake induced by diet protein. Cell Metabolism 2005; 2: 321-329. [Science NOW] [Eurekalert]

:::::::       November 10      :::::::

1. JAMA  Vol. 294 No. 18, pp. 2273-2386, November 9, 2005
   • *   Clinical Decision Support and Appropriateness of Antimicrobial Prescribing: A Randomized Trial. JAMA. 2005;294:2305-2314. [Eurekalert]
   • *   Antibiotic Treatment of Children With Sore Throat. JAMA. 2005;294:2315-2322. [Medscape]
   • Left Atrial Radiofrequency Ablation During Mitral Valve Surgery for Continuous Atrial Fibrillation: A Randomized Controlled Trial. JAMA. 2005;294:2323-2329. [Medscape]
   • *   Habitual Caffeine Intake and the Risk of Hypertension in Women. JAMA. 2005;294:2330-2335. [Medscape]
   • Relationship Between Serum Parathyroid Hormone Levels, Vitamin D Sufficiency, and Calcium Intake. JAMA. 2005;294:2336-2341. [Medscape]
   • Clinical Review: Ricin Poisoning: A Comprehensive Review. JAMA. 2005;294:2342-2351.
   • Editorials: Appropriate Use of Antimicrobial Drugs: A Better Prescription Is Needed. JAMA. 2005;294:2354-2356.
   • Making Sense of the Maze: Which Patients With Atrial Fibrillation Will Benefit? JAMA. 2005;294:2357-2359.
   • From the Archives Journals: Immunization With -Amyloid(1-42) Protein for Alzheimer Disease: Genomics Predicts the Response. JAMA. 2005;294:2352-2353.
2. American Gastroenterological Association Updates Dyspepsia Guidelines, Gastroenterology. 2005;129:1753-1780. [Medscape]
3. Risk factors and comorbidities in primary biliary cirrhosis. USA PBC Epidemiology Group. Hepatology 2005; 42: 1194 - 1202. [Eurekalert]

:::::::       November 9      :::::::

1. *   Advancing Human Circadian Rhythms with Afternoon Melatonin and Morning Intermittent Bright Light. J Clin Endocrinol Metab published November 1, 2005. [Eurekalert]
2. *   Effect of a High-Carbohydrate Versus a High—cis-Monounsaturated Fat Diet on Blood Pressure in Patients With Type 2 Diabetes. Diabetes Care. 2005;28:2607-2612. [Medscape]
3. Laparoscopic Gastric Banding Prevents Type 2 Diabetes and Arterial Hypertension and Induces Their Remission in Morbid Obesity: A 4-year case-controlled study. Diabetes Care 2005;28:2703-2709. [Medscape]
4. Peptide YY(3–36) Inhibits Morning, but Not Evening, Food Intake and Decreases Body Weight in Rhesus Macaques. Diabetes 2005 54: 3198-3204. [Eurekalert: Study reveals hormone can reduce food intake, body weight]
5. Prevalence of Impaired Fasting Glucose and Its Relationship With Cardiovascular Disease Risk Factors in US Adolescents, 1999–2000. Pediatrics Vol. 116 No. 5 November 2005, pp. 1122-1126
6. MMWR November 4, 2005 / Vol. 54 / No. 43
   • Incidence of End-Stage Renal Disease Among Persons With Diabetes. United States, 1990 - 2002. MMWR. 2005;54;1097 [Medscape]
   • Controlling Tuberculosis in the United States: Recommendations from the American Thoracic Society, CDC, and the Infectious Diseases Society of America. MMWR 2005; 54: No. RR–12

:::::::       November 8      :::::::

1. New England Journal of Medicine Volume 353 November 3, 2005 Number 18
   • Betting on a Malaria Vaccine. S. Okie
   • Beyond Red Lake — The Persistent Crisis in American Indian Health Care. Y. Roubideaux
   • Paving the Way — Providing Opportunities for Native American Students. T. D. Sequist
   • The Complexity of Microbial Diversity in Bacterial Vaginosis. S. L. Hillier [News report]
   • Prognostic Significance of Dyspnea in Patients Referred for Cardiac Stress Testing. A. Abidov and Others [Eurekalert]
   • Molecular Identification of Bacteria Associated with Bacterial Vaginosis. D. N. Fredricks, T. L. Fiedler, and J. M. Marrazzo [Euerkalert]
   • Natalizumab Induction and Maintenance Therapy for Crohn's Disease. W. J. Sandborn and Others
   • Brief Report: Congenital Glutamine Deficiency with Glutamine Synthetase Mutations. J. Häberle and Others
   • Allergic Rhinitis. M. Plaut and M. D. Valentine
   • Current Concepts: Bacterial Infections in Drug Users. R. J. Gordon and F. D. Lowy
   • Traumatic Cranial Nerve Palsy. C. Baker and J. Cannon
   • Actinomyces Hepatic Abscess with Cutaneous Fistula. M. Saad and J. Moorman
   • A Perfect Storm. W. J. Janssen, H. R. Collard, S. Saint, and S. E. Weinberger
   • Dyspnea and Risk in Suspected Coronary Disease. T. H. Marwick
   • Selective Adhesion-Molecule Therapy and Inflammatory Bowel Disease — A Tale of Janus? D. K. Podolsky
   • Metabolic Disorders in the Center of Genetic Medicine. H. L. Levy

:::::::       November 7      :::::::

1. JAMA   Vol. 294   No. 17   November 2, 2005
   • *   Screen-and-Treat Approaches for Cervical Cancer Prevention in Low-Resource Settings: A Randomized Controlled Trial. JAMA. 2005;294:2173-2181.
   • *   Feasibility of Management of High-Grade Cervical Lesions in a Single Visit: A Randomized Controlled Trial. JAMA. 2005;294:2182-2187.
   • Neurological and Neuromuscular Disease as a Risk Factor for Respiratory Failure in Children Hospitalized With Influenza Infection. JAMA. 2005;294:2188-2194.
   • History and Molecular Genetics of Lynch Syndrome in Family G: A Century Later. JAMA. 2005;294:2195-2202.
   • *   Reviews: Randomized Trials Stopped Early for Benefit: A Systematic Review. JAMA. 2005;294:2203-2209. [Medscape]
   • Clinical Crossroads: A 21-Year-Old Woman With Atypical Squamous Cells of Undetermined Significance. JAMA. 2005;294:2210-2218.
   • Commentaries: Role of the Urban Academic Medical Center in US Health Care. JAMA. 2005;294:2219-2220.
   • Psychiatry as a Clinical Neuroscience Discipline. JAMA. 2005;294:2221-2224.
   • Editorials: Cervical Cancer Prevention: Making Programs More Appropriate and Pragmatic. JAMA. 2005;294:2225-2228. [Medscape]
   • When (Not) to Stop a Clinical Trial for Benefit. JAMA. 2005;294:2228-2230.

:::::::       November 4        :::::::

:::::::  Weekend Reading - Basic Science and general interest articles  :::::::

1. FDA MedWatch
• Zevalin (ibritumomab tiuxetan) Revision of the Prescribing Information to describe severe cutaneous or mucocutaneous reactions, some with fatal outcome, that have been reported in association with the Zevalin therapeutic regimen in the post-marketing experience. Patients experiencing a severe cutaneous or mucocutaneous reaction should not receive any further components of the Zevalin therapeutic regimen and should seek prompt medical evaluation. [Medscape]
• Avinza (morphine extended-release) revisions to the prescribing information to highlight and strengthen the warning that patients should not consume alcohol while taking Avinza. Additionally, patients must not use prescription or non-prescription medications containing alcohol while on Avinza therapy.
2. FDA Approvals:
• Arranon (nelarabine) for rare leukemia and lymphoma approved under Orphan Drug and Accelerated Approval Program for the treatment of T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL) in patients who have not responded to or have relapsed after treatment with at least two chemotherapy regimens.
• Medscape report
  • Kaletra (a new yellow tablet formulation of 200 mg/50 mg of lopinavir/ritonavir) that will replace the 133.3-mg/33.3-mg orange capsules by March 2006. Unlike the capsules, the film-coated tablets can be taken with or without food and do not require refrigeration before or after dispensing. Moreover, fewer tablets than capsules are required per 800-mg/200-mg dose per day (four tablets vs six capsules).
  • Soltamox (10-mg/5-mL oral solution of tamoxifen) for the treatment of breast cancer in adjuvant and metastatic settings; to reduce the risk of breast cancer in women with ductal carcinoma in situ; and to reduce breast cancer incidence in women at high risk of the disease.
• Medscape report
  • Lunar iDXA, a total-body dual-energy x-ray absorptiometry (DXA) system for use as an aid in the detection and diagnosis of osteoporosis, and for monitoring subsequent treatment.
  • Urgent PC, a percutaneous tibial nerve stimulation system for the minimally invasive treatment of overactive bladder symptoms such as urinary urgency, urinary frequency, and urge incontinence.
  • MimyX a nonsteroidal dressing for the management and relief of burning and itching associated with atopic dermatitis, allergic-contact dermatitis, radiation dermatitis, and other physician-diagnosed dermatoses in adult and pediatric patients.
3. FDA News:
   • FDA News: FDA and Industry to Collaborate on Better Ways to Predict Liver Toxicity in Human Drug Trials
   • FDA News: FDA Announces the Use of New Electronic Drug Labels to Help Better Inform the Public and Improve Patient Safety [Medscape]
   • FDA Announces the Use of New Electronic Drug Labels to Help Better Inform the Public and Improve Patient Safety
4. Richard E. Smalley, 62, Dies; Chemistry Nobel Winner. [NYTimes Obituary] [NPR audio report]
5. Activation of Myogenic Differentiation Pathways in Adult Bone Marrow-Derived Stem Cells. Mol. Cell. Biol. 2005 25: 9509-9519. [News]
6. *  Restoration of immunity in lymphopenic individuals with cancer by vaccination and adoptive T-cell transfer. Nature Medicine (16 Oct 2005). [Eurekalert: Rapid restoration of immunity in immune-suppressed cancer patients using T-cell vaccines]
7. Discovery of human inversion polymorphisms by comparative analysis of human and chimpanzee DNA sequence assemblies. PLoS Genetics DOI: 0.1371. [Eurekalert]
8. *  Orbitofrontal cortex activity related to emotional processing changes across the menstrual cycle. PNAS published October 24, 2005, 10.1073. [ScienceNOW]

:::::::       November 3      :::::::

1. *   Enzyme-linked Immunospot and Tuberculin Skin Testing to Detect Latent Tuberculosis Infection. Am. J. Respir. Crit. Care Med. 2005; 172: 1161-1168. [Eurekalert]
2. Clinical and Pathologic Features of Familial Interstitial Pneumonia. Am. J. Respir. Crit. Care Med. 2005; 172: 1146-1152. [Eurekalert]
3. *   The Long-term Predictive Accuracy of the Short Synacthen (Corticotropin) Stimulation Test For Assessment of the Hypothalamic-Pituitary-Adrenal Axis. J Clin Endocrinol Metab online October 25, 2005. [Medscape]
4. Annals of Internal Medicine   1 November 2005 Volume 143 Issue 9
   • Predictors of Relapse and Treatment Resistance in Antineutrophil Cytoplasmic Antibody–Associated Small-Vessel Vasculitis. S. L. Hogan, and Others.
   • Antineutrophil Cytoplasmic Antibodies and the Churg–Strauss Syndrome. The French Vasculitis Study Group.
   • *   Limitations on Physical Performance and Daily Activities among Long-Term Survivors of Childhood Cancer. K. K. Ness, and Others. [Medscape]
   • Transmission of Hepatitis C Virus to Several Organ and Tissue Recipients from an Antibody-Negative Donor. B. D. Tugwell, and Others.
   • Improving Patient Care: The Academic Hospice. C.F. von Gunten and T. Ryndes
     
   • Update in Endocrinology. L. Wartofsky
   • Reviews: Meta-Analysis: Secondary Prevention Programs for Patients with Coronary Artery Disease. A. M. Clark, and Others. [Medscape]
   • Editorials: Are There Different Forms of Life in the Antineutrophil Cytoplasmic Antibody Universe? G. S. Hoffman and C. A. Langford
     
   • On Being a Doctor: Lessons from a Label Maker
   • Failing the Grandparent Test. A. Zusman

:::::::       November 2      :::::::

1. The Association of Comorbid Depression With Mortality in Patients With Type 2 Diabetes. Diabetes Care 2005 28: 2668-2672. [Eurekalert]
2. MMWR. 2005;54;1041-1072 [Medscape]
3. Subacute Sclerosing Panencephalitis: More Cases of This Fatal Disease Are Prevented by Measles Immunization than Was Previously Recognized. J Inf Dis 2005;192:1686-1693. [Editorial] [IDSA Statement]
4. Risk Factors for Perinatal Transmission of Hepatitis C Virus (HCV) and the Natural History of HCV Infection Acquired in Infancy. J Inf Dis 2005; 192:000. [Eurekalert]
5. Positive effects of moderate exercise on glycosaminoglycan content in knee cartilage: A four-month, randomized, controlled trial in patients at risk of osteoarthritis. Arthritis & Rheumatism 2005; 52: 3507-3514. [News Report] [Eurekalert: Regular physical activity may strenghten knee cartilage]
6. Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (the BeSt study): A randomized, controlled trial. Arthritis & Rheumatism 2005; 53: 3381-3390.
7. Early and Late Benefits of High-Dose Atorvastatin in Patients With Acute Coronary Syndromes: Results From the PROVE IT-TIMI 22 Trial. J Am Coll Cardiol 2005 46: 1405-1410. [Medscape]
8. Results of a randomized controlled trial to increase colorectal cancer screening in a managed care health plan (p NA) . Cancer 2005 Nove 15 published online DOI: 10.1002/cncr.21434. [Medscape]

:::::::       November 1      :::::::

1. New England Journal of Medicine   Volume 353 October 27, 2005 Number 17
   • Aiding and Abetting — Nursing Crises at Home and Abroad. S. Chaguturu and S. Vallabhaneni
   • Just Fading Away? The Closing of Walter Reed. H. Markel
   • Genomic Cartography — Presenting the HapMap. E. G. Phimister
   • MicroRNAs as Oncogenes and Tumor Suppressors. C.-Z. Chen
   • Diagnostic Performance of Digital versus Film Mammography for Breast-Cancer Screening. E. D. Pisano and Others
   • Effect of Screening and Adjuvant Therapy on Mortality from Breast Cancer. D. A. Berry and Others [Medscape]
   • A MicroRNA Signature Associated with Prognosis and Progression in Chronic Lymphocytic Leukemia. G. A. Calin and Others
   • Trajectories of Growth among Children Who Have Coronary Events as Adults. D.J.P. Barker and Others [New Scientist]
   • The Metrics of the Physician Brain Drain. F. Mullan
   • Drug Therapy: The Medical Management of Depression. J. J. Mann
   • Film or Digital Mammographic Screening? D. D. Dershaw
   • Developmental Origins of Health and Disease. M. W. Gillman
   • Fatal Flows — Doctors on the Move. L. C. Chen and J. I. Boufford
   • Tangles and Neurodegenerative Disease — A Surprising Twist. R. E. Tanzi