Recent
reports in Science and Medicine for January 2005
Some
of these links are very transient and may expire within days of posting.
Some may require prior registration. Check-in and view frequently to avoid
missing great news items. I welcome any suggested articles. (email
link). "§" indicates
a recommended article.
Anti-A antibody treatment promotes the rapid recovery of amyloid-associated
neuritic dystrophy in PDAPP transgenic mice. JCI
published online [Mouse brain cells rapidly recover after Alzheimer's
plaques are cleared. Eurekalert]
Sildenafil effectively treats enlarged hearts, mouse study shows be published
in the journal Nature Medicine online Jan. 23, [Eurekalert and Science
now]
New leukemia drug shows promise in overriding all Gleevec resistance.
[Eurekalert report
in PNAS]
Lack of enzyme turns fat cells into fat burners [Eurekalert report
from PNAS]
Cells see the light with melanopsin. Nature News
published online: 27 January 2005; | doi:10.1038/news050124-13 [Eurekalert:
Researchers discover way to make cells in the eye sensitive to light]
Clinical characteristics of African Americans vs Caucasian Americans
with multiple sclerosis Neurology
2004 63: 2039-2045.
Exercise treatment for depression: Efficacy and dose response. Am J
Prev Med 2005; 28: 1-8. (via
Science Direct) [Eurekalert:
Exercise helps reduce symptoms of depression]
Effects of Reviparin, a Low-Molecular-Weight Heparin,
on Mortality, Reinfarction, and Strokes in Patients With Acute
Myocardial Infarction Presenting With ST-Segment Elevation. The
CREATE Trial Group Investigators. JAMA.
2005;293:427-435.
Effect of Glucose-Insulin-Potassium Infusion on
Mortality in Patients With Acute ST-Segment Elevation Myocardial
Infarction: The CREATE-ECLA Randomized Controlled Trial. The CREATE-ECLA
Trial Group Investigators. JAMA.
2005;293:437-446.
§ Sodium
Channel Mutations and Susceptibility to Heart Failure and Atrial
Fibrillation. JAMA.
2005;293:447-454.
Caring for the Critically Ill Patient: Effect
of Exogenous Surfactant (Calfactant) in Pediatric Acute Lung Injury:
A Randomized Controlled Trial. Pediatric Acute Lung Injury and
Sepsis Investigators. JAMA.
2005;293:470-476.
Clinical Review: Angina With "Normal" Coronary
Arteries: A Changing Philosophy. JAMA.
2005;293:477-484.
Commentaries: Disease Management and the Organization
of Physician Practice. JAMA.
2005;293:485-488.
§ Prevalence
of diastolic dysfunction as a possible cause of dyspnea in the elderly. Abstract
Editorial:
Dyspnea and diastolic function: Weighing the evidence.
Association between physician specialty and volumes
of treated patients and mortality among patients hospitalized for newly
diagnosed heart failure. Abstract
Endocrine and neuroanatomic features associated with
weight gain and obesity in adult patients with hypothalamic damage. Abstract
§ Differential
effect of weight loss on insulin resistance in surgically treated obese
patients. Abstract [Euekalert]
Cost-effectiveness of training unselected laypersons
in cardiopulmonary resuscitation and defibrillation. Abstract
Vaccination versus treatment of influenza in working
adults: A cost-effectiveness analysis. Abstract
Reviews:
Mortality in systemic sclerosis: An International meta-analysis of
individual patient data.
Reviews:
Subglottic secretion drainage for preventing ventilator-associated
pneumonia: A meta-analysis.
January
26
MMWR: Antiretroviral
Postexposure Prophylaxis After Sexual, Injection-Drug Use, or Other Nonoccupational
Exposure to HIV in the United States Recommendations from the U.S. Department
of Health and Human Services
A common LRRK2 mutation in idiopathic Parkinson's
disease [Summary]
Early online publication
Articles:
Risk of acute myocardial infarction and sudden cardiac death
in patients treated with cyclo-oxygenase 2 selective and non-selective
non-steroidal anti-inflammatory drugs: nested case-control study.
Articles:
The whole truth and nothing but the truth? The research that
Philip Morris did not want you to see.
§ Accuracy
of Screening for Fecal Occult Blood on a Single Stool Sample Obtained
by Digital Rectal Examination: A Comparison with Recommended Sampling
Practice. Veterans
Affairs Cooperative Study #380 Group
A National Survey of Primary Care Physicians' Methods
for Screening for Fecal Occult Blood. Nadel,
and others.
A Randomized Trial of a Strategy for Increasing
High-Density Lipoprotein Cholesterol Levels: Effects on Progression
of Coronary Heart Disease and Clinical Events. Whitney,
and others.
Antiviral Therapy for Cirrhotic Hepatitis C: Association
with Reduced Hepatocellular Carcinoma Development and Improved
Survival. Tokyo-Chiba
Hepatitis Research Group
Improving Patient Care The Cognitive Psychology
of Missed Diagnoses. Redelmeier
Locoregional Radiation Therapy in Patients With High-Risk Breast Cancer
Receiving Adjuvant Chemotherapy: 20-Year Results of the British Columbia
Randomized Trial . J
Natl Cancer Inst 2005; 97: 116-126.
§ High
frequency of antitumor T cells in the blood of melanoma patients before
and after vaccination with tumor antigens. J.
Exp. Med. 2005 201: 241-248. [Eurekalert]
§ Racial
Differences in Surgical Evaluation, Treatment, and Outcome of Locoregional
Esophageal Cancer: A Population-Based Analysis of Elderly Patients. JCO
Jan 20 2005: 510–517.
Health-related quality of life after interventional or conservative
strategy in patients with unstable angina or non–ST-segment elevation
myocardial infarction: One-year results of the third randomized intervention
trial of unstable angina (RITA-3) . J Am Coll Cardiol 2005;45:221-228.[Via
Science Direct] [Medscape
review]
January
21
Weekend
Reading - Basic Science and general interest articles
Ramipril (Altace) Linked to
Risk of Intestinal Angioedema
Extended-Release Bupropion (Wellbutrin
XL) Linked to Dose-Related Risk of Seizures
Levofloxacin (Levaquin) Animal
Studies Show Possible Risk of Arthropathy
OTC Famotidine (Pepcid) Not
to Be Used for Symptoms of Serious Conditions.
Medwatch:
Added warning to Aranesp,
higher doses can cause blood clots and death. [Similar to Eprex,
and NeoRecormon]
Viramune (nevirapine):
Indications and Usage section now recommends against starting
nevirapine treatment in women with CD4+cell counts greater than
250 cells/mm3 unless benefits clearly outweigh risks.
Insulin-treated diabetes is associated with a marked increase in mortality
in patients with advanced heart failure. Fonarow, and others. Am
Heart J.2005 149: 168. [Eurekalert]
Adolescents’ Reports of Parental Knowledge
of Adolescents’ Use of Sexual Health Services and Their Reactions
to Mandated Parental Notification for Prescription Contraception. JAMA.
2005;293:340-348.[Eurekalert]
§ A
Simplified Approach to the Management of Non–ST-Segment Elevation
Acute Coronary Syndromes. JAMA.
2005;293:349-357. [Eurekalert]
§ Early online publication: Isolation of patients
in single rooms or cohorts to reduce spread of MRSA in intensive-care
units: prospective two-centre study [Summary]
Analysis of air contrast barium enema, computed
tomographic colonography, and colonoscopy: prospective comparison [Summary]
The whole truth and nothing but the truth? The
research that Philip Morris did not want you to see [Summary]
Global burden of hypertension: analysis of worldwide
data [Summary]
Homocysteine and stroke: evidence on a causal
link from mendelian randomisation [Summary] [Medscape]
Effect of Plasmodium falciparum malaria on concentration
of HIV-1-RNA in the blood of adults in rural Malawi: a prospective
cohort study [Full
Text]
§ Original
Investigations: Overweight and Obese Patients in a Primary Care
Population Report Less Sleep Than Patients With a Normal Body Mass
Index. Arch
Intern Med. 2005;165:25-30. [Medscape]
Development of Fatness, Fitness, and Lifestyle
From Adolescence to the Age of 36 Years: Determinants of the Metabolic
Syndrome in Young Adults: The Amsterdam Growth and Health Longitudinal
Study. Arch
Intern Med. 2005;165:42-48
Lipid Management in Patients With Coronary Artery
Disease by a Clinical Pharmacy Service in a Group Model Health
Maintenance Organization. Clinical Pharmacy Cardiac Risk Service
(CPCRS) Study Group. Arch
Intern Med. 2005;165:49-54
§ Hospitalization
and Death Associated With Potentially Inappropriate Medication
Prescriptions Among Elderly Nursing Home Residents. Arch
Intern Med. 2005;165:68-74
When Patients Choose Faith Over Medicine: Physician
Perspectives on Religiously Related Conflict in the Medical Encounter. Arch
Intern Med. 2005;165:88-91
The Ethics of Research Using Biobanks: Reason
to Question the Importance Attributed to Informed Consent. Arch
Intern Med. 2005;165:97-100
Incidence and Characteristics of Non-Hodgkin Lymphomas
in a Multicenter Case File of Patients With Hepatitis C Virus–Related
Symptomatic Mixed Cryoglobulinemias. Arch
Intern Med. 2005;165:101-105
Caloric restriction attenuates ?-amyloid neuropathology in a mouse model
of Alzheimer's disease. FASEB
J. online Jan 13, 2005,. [Eurekalert:
Reduced calorie and carbohydrate diet slows progression of Alzheimer's
disease in mouse model]
January
13
The mortality of untreated pulmonary embolism in emergency department
patients. K.K.Calder, and others. Ann
Emerg Med online 2005 [Medscape:
Mortality of Untreated Pulmonary Embolism in ER Patients Lower Than Thought]
Sirolimus-Eluting Stent or Paclitaxel-Eluting Stent
vs Balloon Angioplasty for Prevention of Recurrences in Patients
With Coronary In-Stent Restenosis: A Randomized Controlled Trial. JAMA.
2005;293:165-171.
§ Increased
CD4+ T cell infiltrates in rheumatoid arthritis-associated interstitial
pneumonitis compared with idiopathic interstitial pneumonitis. C. Turesson,
and others. Arth & Rheum.
2004; 52: 73 - 79. [Eurekalert]
§ Oleic
acid, the main monounsaturated fatty acid of olive oil, suppresses Her-2/neu
(erbB-2) expression and synergistically enhances the growth inhibitory
effects of trastuzumab (HerceptinTM) in breast cancer cells with Her-2/neu
oncogene amplification. J. A. Menendez, and others.Annals
of Oncology online January 10, 2005. [Eurekalert]
§ Risk
of ischaemic stroke in people with migraine: systematic review
and meta-analysis of observational studies. BMJ 2005;330:63
Comparing estimates of cost effectiveness submitted
to the National Institute for Clinical Excellence (NICE) by different
organisations: retrospective study. BMJ 2005;330:65,
§ Optimal
search strategies for retrieving systematic reviews from Medline:
analytical survey. BMJ 2005;330:68
Rise in "no indicated risk" primary caesareans
in the United States, 1991-2001: cross sectional analysis. BMJ 2005;330:71-72
Implementation of recommendations for the care
of children in UK emergency departments: national postal questionnaire
survey. BMJ 2005;330:73-74,
DRUG POINTS: Synovitis induced by alendronic acid
can present as acute carpal tunnel syndrome. BMJ 2005;330:74
Randomised trial of a brief physiotherapy intervention
compared with usual physiotherapy for neck pain patients: outcomes
and patients' preference. BMJ 2005;330:75,
A Longitudinal Study of Genital Human Papillomavirus Infection in a Cohort
of Closely Followed Adolescent Women. J
Inf Dis 2005;191:182-192. [Eurekalert:
Study reveals high infection rate in teens for virus linked to cervical
cancer]
A Randomized Study to Decrease the Use of Potentially Inappropriate Medications
Among Community-dwelling Older Adults in a Southeastern Managed Care Organization
. Am J Manag Care. 2004;10:761-768. [Eurekalert]
§ Comparison
of the Atkins, Ornish, Weight Watchers, and Zone Diets for Weight
Loss and Heart Disease Risk Reduction: A Randomized Trial. JAMA.
2005;293:43-53. [Eurekalert]
§ Direct
Access to Emergency Contraception Through Pharmacies and Effect
on Unintended Pregnancy and STIs: A Randomized Controlled Trial. JAMA.
2005;293:54-62.
§Early
online publication: Isolation of patients in single rooms
or cohorts to reduce spread of MRSA in intensive-care units:
prospective two-centre study
Early
online publication: Analysis of air contrast barium enema,
computed tomographic colonography, and colonoscopy: prospective
comparison.
Pegylated interferon alfa-2b alone or in combination
with lamivudine for HBeAg-positive chronic hepatitis B: a randomised
trial [Summary]
Induced sputum versus gastric lavage for microbiological
confirmation of pulmonary tuberculosis in infants and young children:
a prospective study [Full
Text]
Congenital rubella syndrome burden in Morocco:
a rapid retrospective assessment [Full
Text]
Mechanisms
of Disease: An immunoepidemiological approach to asthma:
identification of in-vitro T-cell response patterns associated
with different wheezing phenotypes in children .
Research
Letters: Diagnosis of sputum-scarce HIV-associated pulmonary
tuberculosis in Lima, Peru [Full Text]
FDA approval of Lunesta, the first sleeping pill
whose label will not recommend it be taken for only 7 to 10 days.News and WebMD
Clolar (clofarabine) IV approved for the treatment
of pediatric patients 1 to 21 years old with relapsed or refractory
acute lymphoblastic leukemia after at least two prior regimens. [Medscape]
[FDA News]
Prialt (ziconotide intrathecal infusion), the
first in a new class of drugs that blocks the nerve channels responsible
for transmitting pain signals, approved for the management of severe
chronic pain in patients for whom intrathecal (IT) therapy is warranted
and who are intolerant of or refractory to other treatment, such
as systemic analgesics, adjunctive therapies, or IT morphine. [Medscape]
Eligard (Leuprolide Acetate Implant) 6-month
formulation for prostate cancer. [Medscape]
FDA releases Patient and Healthcare Provider Information Sheets
for Naproxen. Naproxen
Information. (12/23/2004)
FDA and Centocor revise the labeling for Remicade to include a
warning on severe hepatic reactions. Remicade is used to treat rheumatoid
arthritis, Crohn's disease and ankylosing spondylitis. MedWatch
Safety Info (12/23/2004)
FDA
Statement Patients who are currently taking over-the-counter
naproxen products carefully follow the instructions on the label.(12/21/2004)
FDA asks Pfizer, Inc. to voluntarily suspend direct-to- consumer
advertising on Celebrex during the time the Agency is obtaining and
evaluating the new and conflicting scientific data on adverse events
associated with the drug. FDA
Statement (12/21/2004)
FDA Safety Labeling Changes:
Lupron (Leuprolide Acetate associated with
transient testosterone-related adverse events), Tikosyn (Dofetilide
hydrochlorothiazide increases Tikosync oncentrations and may
prolong QT interval), Cuprimine (Penicillamine)
associated with risk of fetal harm. [Medscape
report]
2004: The year in biology and medicine [New
Scientist review]
§ Marked
prolongation of porcine renal xenograft survival in baboons through the
use of 1,3-galactosyltransferase gene-knockout donors and the cotransplantation
of vascularized thymic tissue. Nature
Medicine 11, 32 - 34 (2004)
Protease-Resistant Human Prion Protein and Ferritin Are Cotransported
across Caco-2 Epithelial Cells: Implications for Species Barrier in Prion
Uptake from the Intestine. J.
Neurosci. 2004 24: 11280-11290.[Science
Daily review]
Stat3 links activated keratinocytes and immunocytes required for development
of psoriasis in a novel transgenic mouse model. Nature
Medicine published online Dec.12. [Science
Daily Researchers Discover Key Protein In Psoriasis]
§ IL-7
is a potent and proviral strain–specific inducer of latent HIV-1
cellular reservoirs of infected individuals on virally suppressive HAART. J.
Clin. Invest. 115:128-137 (2005).
Plant sterols and endurance training combine to favorably alter plasma
lipid profiles in previously sedentary hypercholesterolemic adults after
8 wk. Am J
Clin Nutr 2004 80: 1159-1166.[Eurekalert]
FDA to review "missing" drug company
documents. BMJ 2005;330:7
Warnings issued over COX 2 inhibitors in US and
UK. BMJ 2005;330:9,
§ Prospective
cohort study of cannabis use, predisposition for psychosis, and
psychotic symptoms in young people . BMJ 2005;330:11,
doi:10.1136
Cognitive behaviour therapy for adolescents with
chronic fatigue syndrome: randomised controlled trial. BMJ 2005;330:14
Insulin resistance and depression: cross sectional
study. BMJ 2005;330:17-18
Incidence of Haemophilus influenzae type b meningitis
during 18 years of vaccine use: observational study using routine
hospital data. BMJ 2005;330:18-19
Concealment of drugs in food and beverages in nursing
homes: cross sectional study. BMJ 2005;330:20,
§ Parents'
awareness of overweight in themselves and their children: cross
sectional study within a cohort (EarlyBird 21). BMJ 2005;330:23-24
Incidence of hepatitis C virus and HIV among new
injecting drug users in London: prospective cohort study . BMJ 2005;330:24-25.
Hybrid Approach Improves Outcomes in Patients With Coronary and Valve
Disease [Medscape review
from J Am Coll Cardiol 2005;45:14-18.(limited access)]
§ Invasive
Lobular Carcinoma Classic Type: Response to Primary Chemotherapy and Survival
Outcomes. JCO
Jan 1 2005: 41–48.[Medscape review]
Adherence with osteoporosis practice guidelines: A multilevel analysis
of patient, physician, and practice setting characteristics. Am
J Med 2004; 117: 919-924.
§ Helicobacter
pylori test and eradicate versus prompt endoscopy for management of dyspeptic
patients: 6.7 year follow up of a randomised trial. A T Lassen, J Hallas,
and O B Schaffalitzky de Muckadell. Gut
2004; 53: 1758-17 .[Medscape
review]
§ Cardiac
Mortality Is Higher Around Christmas and New Year’s Than at Any Other
Time: The Holidays as a Risk Factor for Death. Circulation
2004 110: 3781 - 3788.
Repeat sudden unexpected and unexplained infant
deaths: natural or unnatural? [Full
Text]
§ Fast-food
habits, weight gain, and insulin resistance (the CARDIA study):
15-year prospective analysis [Summary] [Eurekalert
report and review]
Incidences of vaccine-preventable Haemophilus influenzae
type b pneumonia and meningitis in Indonesian children: hamlet-randomised
vaccine-probe trial [Full
Text ]
§ Mechanisms
of Disease: Protection of hepatocyte mitochondrial ultrastructure
and function by strict blood glucose control with insulin in critically
ill patients [Summary]
Results of the ATAC (Arimidex, Tamoxifen, Alone
or in Combination) trial after completion of 5 years' adjuvant
treatment for breast cancer [Summary]
§ Circulating
Tumor Cells in Patients with Breast Cancer Dormancy. Clin
Cancer Res 2004 10: 8152-8162. [Circulating tumor cells in long-term
cancer survivors Eurekalert report]
Plant sterols and endurance training combine to favorably alter plasma
lipid profiles in previously sedentary hypercholesterolemic adults after
8 wk. Am J
Clin Nutr 2004 80: 1159-1166. [Eurekalert]
Annals of Internal Medicine
Early
Release Article: Patients Exposed to Rofecoxib and Celecoxib
Have Different Odds of Nonfatal Myocardial Infarction.
Early
Release Article: Cardiovascular Risks of Cyclooxygenase-2
Inhibitors: Where We Stand Now
Early
Release Article: Meta-Analysis: High-Dosage Vitamin E Supplementation
May Increase All-Cause Mortality
Effectiveness of Acupuncture as Adjunctive Therapy
in Osteoarthritis of the Knee: A Randomized, Controlled Trial. Berman,
and Others.
Acupuncture versus Placebo for the Treatment of
Chronic Mechanical Neck Pain: A Randomized, Controlled Trial. White,
and Others.
A Clinical Prediction Rule To Identify Patients
with Low Back Pain Most Likely To Benefit from Spinal Manipulation:
A Validation Study. Childs,
and Others.
Using Serum Creatinine To Estimate Glomerular
Filtration Rate: Accuracy in Good Health and in Chronic Kidney
Disease. Rule,
and Others.
Comparison of Quality of Care for Patients in
the Veterans Health Administration and Patients in a National Sample. Asch,
and Others.
Narrative Review: Hepatobiliary Disease in Type
2 Diabetes Mellitus. Tolman,
and Others.
EDITORIALS: Treatments for Back Pain: Can We Get
Past Trivial Effects? Deyo
Clinical Implications of Estimating Equations for
Glomerular Filtration Rate. Stevens
and Levey
ON BEING A DOCTOR: Another Brand of Medicine. Druss