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Recent reports in Science and Medicine for August 2004

Some of these links are very transient and may expire within days of posting. Some may require prior registration. Check-in and view frequently to avoid missing great news items. I welcome any suggested articles. (email link). "§" indicates a recommended article.

August 31

  1. CT angiography for the assessment of carotid stenosis. Neurology 2004 63: 412-413.[Medscape report]
  2. The Lancet | Volume 364, Number 9436 | 28 August 2004
    • § Early online publication: Comparison of endovascular aneurysm repair with open repair in patients with abdominal aortic aneurysm (EVAR trial 1), 30-day operative mortality results: randomised controlled trial. The EVAR trial participants*
    • § Resistant influenza A viruses in children treated with oseltamivir: descriptive study. Kiso, et al.
    • Growth and transplantation of a custom vascularised bone graft in a man. Warnke, Iet al.
    • §Mortality and incidence of cancer during 10-year follow-up of the Scandinavian Simvastatin Survival Study (4S). The 4S Group*
    • Mechanisms of Disease: § Effects of dietary glycaemic index on adiposity, glucose homoeostasis, and plasma lipids in animals. Pawlak, et al.
    • A population-based nationwide study of parents' perceptions of a questionnaire on their child's death due to cancer. Kreicbergs, et al.
    • Efficacy of 10-day melarsoprol schedule 2 years after treatment for late-stage gambiense sleeping sickness. Schmid, et al.
    • Treatment of stable chronic obstructive pulmonary disease. Rennard
    • Clinical trials in children. Caldwell, et al.
  3. BMJ :: 28 August 2004 (Vol 329, No 7464)
    • To scan or not to scan in headache. BMJ  2004;329:469-470
    • § Screening research papers by reading abstracts. BMJ  2004;329:470-471
    • Is good cholesterol always good? BMJ  2004;329:471-472,
    • § Influence of personal characteristics of individual women on sensitivity and specificity of mammography in the Million Women Study: cohort study. BMJ  2004;329:477,
    • § Corticosteroids for severe sepsis and septic shock: a systematic review and meta-analysis. BMJ  2004;329:480
    • The long term clinical course of acute deep vein thrombosis of the arm: prospective cohort study. BMJ  2004;329:484-485,
    • Factors associated with difference in prevalence of asthma in children from three cities in China: multicentre epidemiological survey. BMJ  2004;329:486
    • Respiratory symptoms and atopy in children in Aberdeen: questionnaire studies of a defined school population repeated over 35 years. BMJ 2004;329:489-490.
    • Using rapid-cycle quality improvement methodology to reduce feeding tubes in patients with advanced dementia: before and after study. BMJ 2004;329:491-494.
    • Spinal immobilisation for unconscious patients with multiple injuries. BMJ  2004;329:495-499
    • Interactive case report: Abnormal liver function found after an unplanned consultation: case outcome. BMJ  2004;329:500.
    • ABC of burns: When we leave hospital: a patient's perspective of burn injury. BMJ  2004;329:504-506,
    • Use of decision aids to support informed choices about screening. BMJ  2004;329:507-51
    • Experiences of the BMJ ethics committee. BMJ  2004;329:510-51

August 30

  1. NIH Releases Research Strategy to Fight Obesity Epidemic :: NIH Obesity Research [Medscape report]
  2. Synovial Fibroblasts from Patients with Rheumatoid Arthritis, Like Fibroblasts from Graves’ Disease, Express High Levels of IL-16 When Treated with Igs against Insulin-Like Growth Factor-1 Receptor. J Immunol 2004 173: 3564-3569.
  3. Which Medical Conditions Account For The Rise In Health Care Spending? Health Affairs 10.1377/hlthaff.w4.437 [15 Illnesses Drive Up Costs: Conditions Linked to 56% of Increase in Health Care Bills WP News report]
  4. The Outcome of Physical Symptoms with Treatment of Depression. Greco T, et al J Gen Int Med 2004: 19:813 [Ovid full-text via library]
  5. Unused back muscles switch themselves off.  25 August 04 New Scientist.
  6. New England Journal of Medicine | Volume 351 August 26, 2004 Number 9

August 27

Weekend Reading - Basic Science and general interest articles

  1. FDA Safety Labeling Changes: NephrAmine and Neumega [Medscape summary:: Oprelvekin (Neumega) May Cause Serious/Fatal Fluid Retention After Myeloablative Therapy]
  2. Remicade (infliximab) revised the WARNINGS and ADVERSE REACTIONS section was updated to include neutropenia, pericardial effusion and systemic and cutaneous vasculitis.
  3. NHLBI Communications: Increasing Number of Adults with High Blood Pressure
  4. Intracellular Acidosis Enhances the Excitability of Working Muscle. Science, Vol 305, Issue 5687, 1144-1147 , 20 August 2004 [Science now report]
  5. Pancreas stem cells for diabetes. [Science now and BBC news report from Nature Biotechnology]
  6. § Regulation of Muscle Fiber Type and Running Endurance by PPAR. PLoS Biology Volume 2 | Issue 10 | October 2004.[Marathoning mice could have Olympian effects on obesity Eurekalert and New Science]
  7. [Eurekalert: Clues about how antibodies specialize] Aug. 26 issue of the journal Nature
  8. Muscle Mechanical Advantage of Human Walking and Running: Implications for Energy Cost. J Appl Physiol 2004. doi:10.1152 [APS news report]
  9. Muscle metabolism with blood flow restriction in chronic fatigue syndrome. J Appl Physiol 96: 871-878, 2004.
  10. Viruses On The Attack: Details Of A Common Mechanism For Infection [ScienceDaily review from Cell, Vol 118, 419-429, 20 August 2004 :: Three-Dimensional Rearrangement of Proteins in the Tail of Bacteriophage T4 on Infection of Its Host]
  11. Women who become caregivers to elderly parents are more likely to end up living in poverty later in life [News report from study presented at the American Sociological Association's meeting]. Link to Caregiver Stress page.
  12. Elisabeth Kubler-Ross, Psychiatrist Who Changed Perception of Terminally Ill, Dies at 78 [News release]

August 26

  1. American Society of Clinical Oncology Recommendations on Adjuvant Chemotherapy for Stage II Colon Cancer. JCO Aug 15 2004: 3408–3419. [Medscape review]
  2. Diabetes, impaired fasting glucose, and development of cognitive impairment in older women. Neurology 2004 63: 658-663.
  3. The Burden of Adult Hypertension in the United States 1999 to 2000. A Rising Tide. Hypertension published August 23, 2004, 10.1161
  4. BNP May Not Obviate Need for Invasive Pulmonary Artery Pressure Monitoring. [Medscape review from the Aug. 19 issue of Critical Care Medicine (no acess)]
  5. JAMA. 2004;292:895.
    • § Sugar-Sweetened Beverages, Weight Gain, and Incidence of Type 2 Diabetes in Young and Middle-Aged Women. JAMA. 2004;292:927-934.
    • Distinct Clinical Features of Paraganglioma Syndromes Associated With SDHB and SDHD Gene Mutations. European-American Paraganglioma Study Middle-Aged Women. JAMA. 2004;292:927-934.
    • Telephone Psychotherapy and Telephone Care Management for Primary Care Patients Starting Antidepressant Treatment: A Randomized Controlled Trial. JAMA. 2004;292:935-942.
      • Group. JAMA. 2004;292:943-951.
    • § Cost-Lowering Strategies Used by Medicare Beneficiaries Who Exceed Drug Benefit Caps and Have a Gap in Drug Coverage. JAMA. 2004;292:952-960.
    • Long-term Care Placement of Dementia Patients and Caregiver Health and Well-being. JAMA. 2004;292:961-967.
    • Effect of a Clinic-Based Referral System to Head Start: A Randomized Controlled Trial. JAMA. 2004;292:968-971.
    • Modulating Angiogenesis: More vs Less. JAMA. 2004;292:972-977.
    • Editorials : Sugar-Sweetened Soft Drinks, Obesity, and Type 2 Diabetes. JAMA. 2004;292:978-979.
  6. Influence of age and physical activity on the primary in vivo antibody and T cell-mediated responses in men. J Appl Physiol 97: 491-498, 2004; 10.1152 [News report]

August 25

  1. The Lancet Volume 364, Number 9435     21 August 2004
    • § Editorial: How complicit are doctors in abuses of detainees?  
    • Editorial: Ejecting the FDA from the courtroom
    • Comparison of lumiracoxib with naproxen and ibuprofen in the Therapeutic Arthritis Research and Gastrointestinal Event Trial (TARGET), reduction in ulcer complications: randomised controlled trial. The TARGET Study Group*
    • Comparison of lumiracoxib with naproxen and ibuprofen in the Therapeutic Arthritis Research and Gastrointestinal Event Trial (TARGET), cardiovascular outcomes: randomised controlled trial. The TARGET Study Group* [Medscape review]
    • § Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial. The CARDS investigators*
    • Tonsillectomy technique as a risk factor for postoperative haemorrhage. National Prospective Tonsillectomy Audit* [Medscape review]
    • Risk and outcome of nosocomial Staphylococcus aureus bacteraemia in nasal carriers versus non-carriers. Wertheim, et al.
    • Routine terminations of pregnancy--should we screen for gestational trophoblastic neoplasia? Seckl, et al.
    • Pathophysiology of airflow limitation in chronic obstructive pulmonary disease. JC Hogg
    • Pathogenetic mechanisms of parkin in Parkinson's disease. Hattori & Mizuno
    • § Health and Human Rights: Abu Ghraib: its legacy for military medicine. Miles
  2. BMJ | 21 August 2004 (Vol 329, No 7463)
    • Improving mortality of coronary surgery over first four years of independent practice: retrospective examination of prospectively collected data from 15 surgeons. BMJ  2004;329:421
    • Commentary: The learning curve. BMJ  2004;329:424
    • National questionnaire survey on what influences doctors' decisions about admission to intensive care. BMJ  2004;329:425
    • Effects of reduction in heroin supply on injecting drug use: analysis of data from needle and syringe programmes. BMJ  2004;329:428-429
    • DRUG POINTS: Fatal liver failure associated with pioglitazone. BMJ  2004;329:429
    • § DRUG POINTS: Severe necrotising leucocytoclastic vasculitis in a patient taking bosentan. BMJ  2004;329:430
    • § Effectiveness of a multiple intervention to reduce antibiotic prescribing for respiratory tract symptoms in primary care: randomised controlled trial. BMJ  2004;329:431
    • § 10-minute consultation: Using the NO TEARS tool for medication review. BMJ  2004;329:434
    • Email consultations in health care: 1—scope and effectiveness . BMJ  2004;329:435-438
    • Email consultations in health care: 2—acceptability and safe application. BMJ  2004;329:439-442
    • Radial artery access for coronary angiography and percutaneous coronary intervention . BMJ  2004;329:443-446
    • ABC of burns: Burns in the developing world and burn disasters . BMJ  2004;329:447-449
    • The legacy of Bristol: public disclosure of individual surgeons' results. BMJ  2004;329:450-454
    • Development of an AIDS vaccine: perspective from the South African AIDS Vaccine Initiative. BMJ  2004;329:454-456

August 24

  1. Treatment of Diabetic Ketoacidosis With Subcutaneous Insulin Aspart. Diabetes Care 27:1873-1878, 2004
  2. § Long-term prognosis for clinical West Nile virus infection. Emerg Infect Dis 2004 Aug vol10no8/03-0879. [Medscape review]
  3. New England Journal of Medicine | Volume 351 August 19, 2004 Number 8

August 23

  1. Treatment of Refractory Status Epilepticus With Inhalational Anesthetic Agents Isoflurane and Desflurane. Arch Neurol. 2004;61:1254-1259.
  2. Lifetime Risk for Development of Atrial Fibrillation. The Framingham Heart Study. Circulation 2004: online Aug 16, 2004, 10.1161 [Medscape]
  3. JAMA. Vol. 292 No. 7, pp. 773-886, August 18, 2004
    • Fluoxetine, Cognitive-Behavioral Therapy, and Their Combination for Adolescents With Depression: Treatment for Adolescents With Depression Study (TADS) Randomized Controlled Trial. JAMA. 2004;292:807-820.
    • 6-Month Androgen Suppression Plus Radiation Therapy vs Radiation Therapy Alone for Patients With Clinically Localized Prostate Cancer: A Randomized Controlled Trial. JAMA. 2004;292:821-827.
    • Vitamin E and Respiratory Tract Infections in Elderly Nursing Home Residents: A Randomized Controlled Trial. JAMA. 2004;292:828-836.
    • Effects of Extended Outpatient Rehabilitation After Hip Fracture: A Randomized Controlled Trial. JAMA. 2004;292:837-846.
    • Surgical Mortality as an Indicator of Hospital Quality: The Problem With Small Sample Size. JAMA. 2004;292:847-851.
    • Clinical Review Small Intestinal Bacterial Overgrowth: A Framework for Understanding Irritable Bowel Syndrome. JAMA. 2004;292:852-858.
    • Editorials Treatment of Adolescents With Major Depression: Contributions of a Major Trial. JAMA. 2004;292:861-863.
    • Radiation Therapy and Androgen Suppression as Treatment for Clinically Localized Prostate Cancer: The New Standard? JAMA. 2004;292:864-866.
    • West Nile Virus Encephalomyelitis in Transplant Recipients. JAMA. 2004;292:859-860.
  4. § Relationship between stress-induced myocardial ischemia and atherosclerosis measured by coronary calcium tomography. J Am Coll Card 2004; 44: 923-930 (via CardioSource)
  5. Normalized Proliferation of Normal and Psoriatic Keratinocytes by Suppression of sAPP-Release. J Invest Dermatol 2004 123: 556-563. (New Cure For Psoriasis? Science Daily)
  6. Neuropeptide S: A Neuropeptide Promoting Arousal and Anxiolytic-like Effects. Neuron, Vol 43, 487-497, 19 August 2004 (BBC news report)

August 20

Weekend Reading - Basic Science and general interest articles

  1. FDA report: Lovenox (enoxaparin) FDA and Aventis Pharmaceuticals revised labeling; dosage adjustment for patients with severe renal impairment
  2. § FDA MedWatch: Avastin (bevacizumab) FDA and Genentech, Inc. issued warning that there is an increased risk of serious arterial thromboembolic events, including CVA, MI, TIA, and angina related to Avastin. The risk of fatal arterial thrombotic events is also increased.
  3. FDA Safety Labeling Changes: Taxotere, Twinject, Paxil, and Others [Medscape review]
  4. FDA Approvals: Adderall XR for Adults, Topamax for Migraines, and Others [Medscape review]
  5. § Efficacy of Pollen Blocker Cream in the Treatment of Allergic Rhinitis. Arch Otolaryngol Head Neck Surg. 2004;130:979-984.[New Scientist and Medscape review]
  6. Prions act as stepping stones in evolution journal Nature.[Eurekalert]
  7. § Natural Antibiotic Function of a Human Gastric Mucin Against Helicobacter pylori Infection. Science 13 August 2004: 1003-1006.
  8. MarketWatch: Managed Care Rebound? Recent Changes In Health Plans’ Cost Containment Strategies. Health Affairs 2004; 10.1377/hlthaff.
  9. Antimicrobial Cycling Not Likely to Reduce Spread of Resistant Bacteria. [Medscape report from PNAS]
  10. Bacterial Persistence as a Phenotypic Switch. Science online 12 August 2004 [DOI: 10.1126]
  11. SOS Response Induction by -Lactams and Bacterial Defense Against Antibiotic Lethality. Science online 12 August 2004
  12. Crash victims' head injuries spotted by 'pupilometer' [New Scientist][BBC news report]

August 19

  1. CMAJ | August 17 2004, Volume 171, Issue 4
    • § Effect of a topical diclofenac solution for relieving symptoms of primary osteoarthritis of the knee: a randomized controlled trial. CMAJ 2004 171: 333-338.
    • Family physician workloads and access to care in Winnipeg: 1991 to 2001. CMAJ 2004 171: 339-342.
    • Maternal ethnicity and risk of neural tube defects: a population-based study. CMAJ 2004 171: 343-345.
    • § Tips for learning and teaching evidence-based medicine: introduction to the series. CMAJ 2004 171: 347-348.
    • Opportunities and challenges for improving the quality of reporting clinical research: CONSORT and beyond. CMAJ 2004 171: 349-350.
    • § Tips for learners of evidence-based medicine: 1. Relative risk reduction, absolute risk reduction and number needed to treat. The Evidence-Based Medicine Teaching Tips Working Group. CMAJ 2004 171: 353-358.
  2. § Associations With Reduced Length of Stay and Costs on an Academic Hospitalist Service associated with these efficiencies.[ Eurekalert report from August issue of The American Journal of Managed Care.]
  3. Highly Active Antiretroviral Therapy and Cervical Squamous Intraepithelial Lesions in Human Immunodeficiency Virus–Positive Women. J Natl Cancer Inst 2004; 96: 1070-1076.
  4. Different effects of red wine and gin consumption on inflammatory biomarkers of atherosclerosis: a prospective randomized crossover trial. Effects of wine on inflammatory markers. Atherosclerosis 2004;175: 117-123 (via ScienceDirect and PHS Library)
  5. Statins Inhibit HIV-1 Infection by Down-regulating Rho Activity . J. Exp. Med. 2004 200: 541-547.
  6. Annals of Internal Medicine | 17 August 2004 Volume 141 Issue 4
    • § Below-Knee Elastic Compression Stockings To Prevent the Post-Thrombotic Syndrome: A Randomized, Controlled Trial. Prandoni, et al. [Medscape review]
    • § The Effect of a 13-Hour Curriculum To Improve Residents' Teaching Skills: A Randomized Trial. Morrison, et al.
    • Are Physicians Doing Too Much Colonoscopy? A National Survey of Colorectal Surveillance after Polypectomy. Mysliwiec, et al.
    • § Diabetes Care Quality in the Veterans Affairs Health Care System and Commercial Managed Care: The TRIAD Study
    • Oversight of Human Participants Research: Identifying Problems To Evaluate Reform Proposals. Emanuel, et al.
    • § In the Balance Primary Angioplasty and Thrombolysis Are Both Reasonable Options in Acute Myocardial Infarction. Brophy and Bogaty
    • Primary Percutaneous Coronary Intervention for Every Patient with ST-Segment Elevation Myocardial Infarction: What Stands in the Way? Keeley and Grines
    • § Clinical Guidelines Evidence-Based Clinical Practice Guideline for the Prevention of Ventilator-Associated Pneumonia. Dodek, et al.
    • Editorials Routine Stocking Therapy after Deep Venous Thrombosis: A Clinical Dilemma. Ginsberg
    • Creating a Culture of Quality: The Remarkable Transformation of the Department of Veterans Affairs Health Care System. Greenfield and Kaplan
    • On Being a Patient Elevators on His Mind. Stack

August 18

  1. MMWR August 13, 2004 / Vol. 53 / No. 31
    • Assessment of the Effectiveness of the 2003--04 Influenza Vaccine Among Children and Adults --- Colorado, 2003
    • Aseptic Meningitis Outbreak Associated With Echovirus 9 Among Recreational Vehicle Campers --- Connecticut, 2003
    • Epidemiology of Measles --- United States, 2001--2003
  2. Monoamine oxidase type B inhibitors in early Parkinson's disease: meta-analysis of 17 randomised trials involving 3525 patients. Online pub. BMJ, doi:10.1136/bmj.38184.
  3. BMJ 14 August 2004 (Vol 329, No 7462)
  4. The Lancet Volume 364, Number 9434     14 August 2004
    • A hierarchical Bayesian meta-analysis of randomised clinical trials of drug-eluting stents  Babapulle, et al
    • Risk of developing a mitochondrial DNA deletion disorder . Chinnery, et al.
    • Mechanisms of Disease: Defective vasculogenesis in systemic sclerosis . Kuwana, et al.
    • § Burden and clinical features of chronic obstructive pulmonary disease (COPD)   Pauwels, et al.
    • Faecal incontinence in adults. Madoff, et al.
  5. Mayo Clinic Proceedings: August 2004  Volume 79  Number 8
    • Clinical Epidemiology, Clinical Care, and the Public's Health
    • § Tight Blood Glucose Control With Insulin in "Real-Life" Intensive Care. 977
    • Near-Death Experiences Delivered to Your Home by Your Friends on the Internet
    • § Evidence-Based Therapies for Myocardial Infarction: Secular Trends and Determinants of Practice in the Community 983
    • § Effect of an Intensive Glucose Management Protocol on the Mortality of Critically Ill Adult Patients Summary 992
    • Impact of FUTON and NAA Bias on Visibility of Research
    • Left Atrial Volume in the Prediction of First Ischemic Stroke in an Elderly Cohort Without Atrial Fibrillation
    • Imaging of Congenital Coronary Anomalies With Multislice Computed Tomography
    • Quality of Life in 650 Lung Cancer Survivors 6 Months to 4 Years After Diagnosis
    • Taking the Physician Out of "Physician Shopping": A Case Series of Clinical Problems Associated With Internet Purchases of Medication 1031
    • Obstructive Sleep Apnea and Cardiovascular Disease
    • Treatment of Uncomplicated Urinary Tract Infections in an Era of Increasing Antimicrobial Resistance
    • Exercise-Induced Syncope Associated With QT Prolongation and Ephedra-Free Xenadrine
    • Acquired Long QT Syndrome and Monomorphic Ventricular Tachycardia After Alternative Treatment With Cesium Chloride for Brain Cancer
    • Evaluation and Management of Transient Ischemic Attack and Minor Cerebral Infarction

August 17

  1. § Impact of Angiotensin-Converting Enzyme Inhibitors and Statins on Survival in Idiopathic Pulmonary Fibrosis. Chest 2004 126: 438-446.
  2. Association of Chronic Obstructive Pulmonary Disease Severity and Pneumocystis Colonization. Am. J. Respir. Crit. Care Med. 2004; 170: 408-413.
  3. § Combination Antibiotic Therapy Lowers Mortality among Severely Ill Patients with Pneumococcal Bacteremia . Am. J. Respir. Crit. Care Med. 2004; 170: 440-444.
  4. § Regulation of Regional Lung Perfusion by Nitric Oxide . Am. J. Respir. Crit. Care Med. 2004; 170: 450-455.
  5. Remotely Controlled Mandibular Positioner Predicts Efficacy of Oral Appliances in Sleep Apnea. Am. J. Respir. Crit. Care Med. 2004; 170: 366-370.
  6. New England Journal of Medicine Volume 351 | August 12, 2004
  7. Diet and Exercise Slow Atherosclerosis in Menopausal Women. Medscape report from J Am Coll Cardiol 2004;44:579-587. (via PHS library)

August 16

  1. Retinal Arteriolar Narrowing Is Associated With 5-Year Incident Severe Hypertension. The Blue Mountains Eye Study. Hypertension published August 9, 2004, 10.1161
  2. § Worker functions and traits associated with occupations and the development of AD. Neurology 2004 63: 498-503.
  3. § Acute Coronary Syndromes Without Chest Pain, An Underdiagnosed and Undertreated High-Risk Group: Insights From The Global Registry of Acute Coronary Events. Chest 2004 126: 461-469.
  4. African American/White differences in breast carcinoma: p53 Alterations and other tumor characteristics (p NA) . Cancer 2004 online 9Aug
  5. § ACC/AHA 2004 Guideline Update for Coronary Artery Bypass Graft Surgery: Full Text "Changes Highlighted" AHA publication download. Medscape report (Summary)
  6. Raloxifene to Prevent Gonadotropin-Releasing Hormone Agonist-Induced Bone Loss in Men with Prostate Cancer: A Randomized Controlled Trial .J Clin Endocrinol Metab 2004 89: 3841-3846,
  7. Archives of Internal Medicine 2004;164:1599.

August 13

Weekend Reading - Basic Science and general interest articles

  1. FDA Drug Approval Reports: NDA Approvals for Calendar Year 2004 | New Molecular Entities (NMEs) Approved in Calendar Year 2004
  2. FDA Approvals: Campral, Cymbalta, Truvada, and Epzicom [Medscape review]
    • Acamprosate (Campral) for Maintenance of Alcohol Abstinence
    • Duloxetine (Cymbalta) for Major Depressive Disorder
    • Emtricitabine and Tenofovir Combination (Truvada) for HIV-1
    • Abacavir and Lamivudine Combination (Epzicom) for HIV-1
    • Sculptra Injectable Filler for Facial Lipoatrophy in HIV Patients
  3. FDA Approves Drugs to Treat Internal Contamination from Radioactive Elements [pentetate calcium trisodium injection (Ca-DTPA) and pentetate zinc trisodium injection (Zn-DTPA)
  4. Steroids boost performance in just weeks. New Scientist 12 August 04. BBC news report
  5. When Remembering Might Mean Forgetting. [The Scientist article ]
  6. In Hospital Deaths from Medical Errors at 195,000 per Year USA [Health Grades report]
  7. Therapeutic cancer vaccines: Using unique antigens. PNAS published August 5, 2004, 10.1073
  8. Allergy vaccine hopes get boost PNAS Rudolf Valenta BBC
  9. Elderly Who Exercise Some Live Longe WebMD report from Am J Prev Med 2004; 27, 22 -27. [Science Direct access]
  10. Mimetics of caloric restriction include agonists of lipid-activated nuclear receptors. J. Biol. Chem., Aug 2004; 10.1074.
  11. Scientists find gene expression pattern may predict behavior of leukemia [Eurekalert report from PNAS]
  12. DNA targeting of rhinal cortex D2 receptor protein reversibly blocks learning of cues that predict reward. [Eurekalert report from PNAS published August 9, 2004, 10.1073/pnas.0403639101
  13. Blood stem cell gives rise to bone. [Eurekalert report from Aug 10 issue of the PNAS].

August 12

  1. African American/White differences in breast carcinoma: p53 Alterations and other tumor characteristics (p NA). Cancer 2004; published Online: 9 Aug 2004 [Eurekalert]
  2. Latinos have high levels of visual impairment and eye disease [Eurekalert report from Opthalmology]
    • Prevalence of open-angle glaucoma and ocular hypertension in Latinos. pp. 1439-1448
    • Prevalence of lens opacities in Latinos pp 1449-1456
  3. § Persistent Colonization by Haemophilus influenzae in Chronic Obstructive Pulmonary Disease. Am. J. Respir. Crit. Care Med. 2004; 170: 266-272.
  4. A historic issue of the Annals: three papers examine paracetamol in osteoarthritis. Ann Rheum Dis 2004; 63: 897-900.
    • Does paracetamol (acetaminophen) reduce the pain of osteoarthritis?: a meta-analysis of randomised controlled trials. Ann Rheum Dis 2004; 63: 901-907.
    • Paracetamol in osteoarthritis of the knee. Ann Rheum Dis 2004; 63: 923-930.
    • Patient Preference for Placebo, Acetaminophen (paracetamol) or Celecoxib Efficacy Studies (PACES): two randomised, double blind, placebo controlled, crossover clinical trials in patients with knee or hip osteoarthritis. Ann Rheum Dis 2004; 63: 931-939.
  5. This Week in JAMA. 2004;292:657.
    • § Fetal Loss Associated With Excess Thyroid Hormone Exposure. JAMA. 2004;292:691-695.
    • Long-term Efficacy of Bivalirudin and Provisional Glycoprotein IIb/IIIa Blockade vs Heparin and Planned Glycoprotein IIb/IIIa Blockade During Percutaneous Coronary Revascularization: REPLACE-2 Randomized Trial. JAMA. 2004;292:696-703.
    • § Contagiousness of Varicella in Vaccinated Cases: A Household Contact Study. JAMA. 2004;292:704-708.
    • § Safety and Immunogenicity of a Recombinant Multivalent Group A Streptococcal Vaccine in Healthy Adults: Phase 1 Trial. JAMA. 2004;292:709-715.
    • Association Between Carriage of Streptococcus pneumoniae and Staphylococcus aureus in Children. JAMA. 2004;292:716-720.
    • Feasibility of Eliminating Ocular Chlamydia trachomatis With Repeat Mass Antibiotic Treatments. JAMA. 2004;292:721-725.
    • Treatment of Acne Vulgaris. JAMA. 2004;292:726-735.
    • Restricted Visiting Hours in ICUs: Time to Change. JAMA. 2004;292:736-737.
    • Editorials Group A Streptococcal Vaccines. JAMA. 2004;292:738-739.

August 11

  1. Increased Levels of C-Reactive Protein in Serum From Blood Donors Before the Onset of Rheumatoid Arthritis. Arthr & Rheum 2004; 50: 2423-2427.
  2. § Travelers' diarrhea not improved by restricted diet August 1 issue of Clinical Infectious Diseases, co-author Dr. Herbert DuPont, [Eurekalert]
  3. Epidemiological evidence of higher susceptibility to vCJD in the young. BMC Infectious Diseases 2004, 4:26.
  4. The Lancet Issue 9433, 07 August 2004
    • Mycophenolate mofetil versus azathioprine for prevention of acute rejection in renal transplantation (MYSS): a randomised trial. MYSS Study Group*
    • Infant wellbeing at 2 years of age in the Growth Restriction Intervention Trial (GRIT): multicentred randomised controlled trial. The GRIT study group*
    • Novel methods for disinfection of prion-contaminated medical devices . Lancet 2004; 364: 521-26
    • § Preclinical vCJD after blood transfusion in a PRNP codon 129 heterozygous patient  Lancet 2004; 264: 527-29
    • Effectiveness of leucoreduction for removal of infectivity of transmissible spongiform encephalopathies from blood. Gregori, et al.
    • Kawasaki syndrome . Burns and Glodé
    • § Multiorgan failure is an adaptive, endocrine-mediated, metabolic response to overwhelming systemic inflammation. Singer, et al
    • Necrotic arachnidism: the mythology of a modern plague   Isbister
  5. BMJ | 7 August 2004 Vol. 329, No. 7461

August 10

  1. § Inhaled Corticosteroids and the Risk of Fractures in Children and Adolescents. Pediatrics ontent/abstract/114/2/469">Pediatrics 2004; 114: 469-473.
  2. § The 2004; 114: 555-576.
  3. Neural and Behavioral Responses to Tryptophan Depletion in Unmedicated Patients With Remitted Major Depressive Disorder and Controls. Arch Gen Psychiatry. 2004;61:765-773. [Eurekalert report]
  4. Signs and Symptoms Predictive of Death in Patients with Foodborne Botulism Republic of Georgia, 1980 - 2002. Clin Inf Dis 2004;39:357-362
  5. JAMA. 2004;292:531.

August 9

  1. Carbohydrates and the risk of Breast Cancer among Mexican Women. Isabelle Romieu et al.Cancer Epidemiol Biomarkers Prev 2004 13.
  2. Prevalence of overweight and obesity in a provincial population of Canadian preschool children. CMAJ 2004 171: 240-242.
  3. Early childhood obesity: a call for early surveillance and preventive measures. CMAJ 2004 171: 243-244. CMAJ 2004 171: 245-247.
  4. Ethics review procedures for research in developing countries: a basic presumption of guilt. CMAJ 2004 171: 248-249.
  5. Vitamin B12 (cobalamin) deficiency in elderly patients. CMAJ 2004 171: 251-259.
  6. New England Journal of Medicine August 5, 2004, Volume 351 Number 6

August 6

Weekend Reading - Basic Science and general interest articles

  1. FDA Approves Sculptra for HIV Patients
  2. FDA and Janssen revise labeling; increased risk of hyperglycemia and diabetes in patients taking Risperdal.
  3. Landmark Survey Reports the Prevalence of Personality Disorders in the United States. NIAAA report from the Journal of Clinical Psychiatry (Volume 65:948-958).
  4. In Drug Research, the Guinea Pigs of Choice Are, Well, Human [NYTimes, registration required or pdf of article]
  5. Regulation of hypothalamic prohormone convertases 1 and 2 and effects on processing of prothyrotropin-releasing hormone. J. Clin. Invest. 2004 114: 357-369. [Science Daily report: Two Enzymes Key To Calorie-burning]
  6. Acne bug's nasty secrets spotted. [NewScientist report from Science]
  7. FDA Talk Paper: FDA Approves New Drug for Treatment of Alcoholism
  8. Pioneering the basics for new kind of cancer vaccine [Eurekalert report from Nature: Biotechnology]
  9. In national survey, 45% of specialists report a recent medical error [Eurekalert report from American Academy of Otolaryngology-Head and Neck Surgery in Laryngoscope]
  10. FDA approves two fixed-dose combination drug products. for the treatment of HIV-1 infection: Epzicom (abacavir/lamivudine) and Truvada (tenofovir disoproxil/emtricitabine) [Eurekalert report].

August 5

  1. Progression of Asthma Measured by Lung Function in the Childhood Asthma Management Program. Am J Respir Crit Care Med. 2004; 170: 234-241.
  2. Headache, Stomachache, Backache, and Morning Fatigue Among Adolescent Girls in the United States: Associations With Behavioral, Sociodemographic, and Environmental Factors. Arch Pediatr Adolesc Med. 2004;158:797-803.
  3. Long-Term Cardiac Follow-Up in Relapse-Free Patients After Six Courses of Fluorouracil, Epirubicin, and Cyclophosphamide, With Either 50 or 100 mg of Epirubicin, As Adjuvant Therapy for Node-Positive Breast Cancer: French Adjuvant Study Group. JCO Aug 1 2004: 3070–3079.[Eurekalert report]
  4. Childhood Overweight and Parent- and Teacher-Reported Behavior Problems: Evidence From a Prospective Study of Kindergartners. Arch Pediatr Adolesc Med. 2004;158:804-810.
  5. The Lancet Volume 364, Number 9432     31 July 2004
  6. BMJ 31 July 2004 (Vol 329, No 7460)
    • § Does the cannabinoid dronabinol reduce central pain in multiple sclerosis? Randomised double blind placebo controlled crossover trial. BMJ  2004;329:253
    • Science commentary: High hopes for cannabinoid analges. BMJ  2004;329:257-258.
    • Randomised controlled trial assessing the impact of a nurse delivered, flow monitored protocol for optimisation of circulatory status after cardiacsurgery.  BMJ 2004;329:258.
    • Change in suicide rates for patients with schizophrenia in Denmark, 1981-97: nested case-control study. BMJ  2004;329:261.
    • Photo-onycholysis associated with the use of doxycycline. BMJ  2004;329:265
    • Impact of counselling on careseeking behaviour in families with sick children: cluster randomised trial in rural India. BMJ  2004;329:266.
    • Commentary: Advice to parents has limited effect—where next? BMJ  2004;329:269.
    • Evidence based case report: Corticosteroids for HELLP (haemolysis, elevated liver enzymes, low platelets) syndrome.BMJ  2004;329:270-272.
    • Interactive case report: Abnormal liver function found after an unplanned consultation: case presentation. BMJ  2004;329:273.
    • ABC of burns: Burns reconstruction. BMJ  2004;329:274-276

August 4

  1. § Association Between Cerebral Ischemia and Cytotoxin-Associated Gene-A–Bearing Strains of Helicobacter pylori. Stroke 2004 35: 1800 - 1804.
  2. § AHA Science Advisory: Antioxidant Vitamin Supplements and Cardiovascular Disease. Nutrition Committee of the American Heart Association Council on Nutrition, Physical Activity, and Metabolism Circulation 2004 110: 637 - 641.
  3. § ACC/AHA Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction—Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation 2004 110: 588 - 636.
  4. § Breast-feeding and the Risk of Breast Cancer in BRCA1 and BRCA2 Mutation Carriers.J Natl Cancer Inst 2004; 96: 1094-1098.
  5. Ropinirole Decreases Periodic Leg Movements and Improves Sleep Parameters in Patients with Restless Legs Syndrome.R Allen, et al. Sleep 2004; 27: 907-14. [Eurekalert report]
  6. § Female Children and Adolescents With Type 1 Diabetes Have More Pronounced Early Echocardiographic Signs of Diabetic Cardiomyopathy. Diabetes Care 2004 27: 1947-1953.
  7. Diastolic Function and Type 1 Diabetes. Diabetes Care 2004 27: 2081-2083.
  8. Annals of Internal Medicine 3 August 2004 Volume 141 Issue 3
    • Sildenafil Increased Exercise Capacity during Hypoxia at Low Altitudes and at Mount Everest Base Camp: A Randomized, Double-Blind, Placebo-Controlled Crossover Trial. Ghofrani, et al.
    • § Physician Reports of Terminal Sedation without Hydration or Nutrition for Patients Nearing Death in the Netherlands. Rietjens, et al
    • § The Effect of Routine, Early Invasive Management on Outcome for Elderly Patients with Non–ST-Segment Elevation Acute Coronary Syndromes. Bach, et al.
    • § Improving Patient Care The Impact of Peer Management on Test-Ordering Behavior. Neilson, et al.
    • Compensation and Advancement of Women in Academic Medicine: Is There Equity? Ash, etal.
    • Update in General Internal Medicine. Kroenke and Logio
    • From Unequal Treatment to Quality Care. Lavizzo-Mourey and Lumpkin
    • The Patient's Role in Reducing Disparities. Kaplan and Greenfield
    • Diversifying the Racial and Ethnic Composition of the Physician Workforce. Powe and Cooper
    • Will Racial and Ethnic Disparities in Health Be Resolved Primarily Outside of Standard Medical Care? Pincus
    • § Position Papers Racial and Ethnic Disparities in Health Care: A Position Paper of the American College of Physicians. American College of Physicians*
    • Sildenafil for Enhanced Performance at High Altitude? Rubin and Naeije
    • Terminal Sedation: An Acceptable Exit Strategy? Gillick
    • Unequal Pay for Equal Work: The Gender Gap in Academic Medicine. Laine and Turner
    • On Being a Doctor:  Of Ears and E-mails. Stone

Austust 3

  1. Annals of Family Medicine :§ Focus on Patient Safety
  2. MRI Helpful for Deep Pelvic Endometriosis. August issue of Radiology. [Medscape report]
  3. New England Journal of Medicine | Volume 351 July 29, 2004 Article Summaries

August 2

  1. § Occupational, Commuting, and Leisure-Time Physical Activity in Relation to Total and Cardiovascular Mortality Among Finnish Subjects With Type 2 Diabetes. Circulation 2004: published online before print July 26, 2004
  2. § Carotenoid bioavailability is higher from salads ingested with full-fat than with fat-reduced salad dressings as measured with electrochemical detection. Am J Clin Nutr 2004 80: 396-403.
  3. Cerebral Microbleeds: Prevalence and Associations With Cardiovascular Risk Factors in the Framingham Study . Stroke 2004; 35: 1831 - 1835
  4. JAMA 2004;292: 411 - 522.
    • § Effect of a Decision Aid on Knowledge and Treatment Decision Making for Breast Cancer Surgery: A Randomized Trial. JAMA. 2004;292:435-441.
    • § Effect of a Computer-Based Decision Aid on Knowledge, Perceptions, and Intentions About Genetic Testing for Breast Cancer Susceptibility: A Randomized Controlled Trial. JAMA 2004;292:442-452.
    • § Functional Decline in Peripheral Arterial Disease: Associations With the Ankle Brachial Index and Leg Symptoms. JAMA. 2004;292:453-461.
    • § Diagnosis of Intra-amniotic Infection by Proteomic Profiling and Identification of Novel Biomarkers. JAMA. 2004;292:462-469.
    • § Benefits of Adding a Drug to a Single-Agent or a 2-Agent Chemotherapy Regimen in Advanced Non–Small-Cell Lung Cancer: A Meta-analysis. JAMA. 2004;292:470-484.
    • Health Care Delivery in the Texas Prison System: The Role of Academic Medicine. JAMA. 2004;292:485-489.
    • Clinical Implications of the Osteoprotegerin/RANKL/RANK System for Bone and Vascular Diseases. JAMA. 2004;292:490-495.
    • Decision Aids From Genetics to Treatment of Breast Cancer: Long-term Clinical Utility or Temporary Solution? JAMA. 2004;292:496-498.
    • Can Current Treatments for Advanced Non–Small-Cell Lung Cancer Be Improved? JAMA. 2004;292:499-500.
    • Correctional Health Care Systems and Collaboration With Academic Medicine. JAMA. 2004;292:501-503.