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Recent reports in Science and Medicine for July 2004

Some of these links are very transient and may expire within days of posting. Some may require prior registration. Check-in and view frequently to avoid missing great news items. I welcome any suggested articles. (email link). "§" indicates a recommended article.

July 30

Weekend Reading - Basic Science and general interest articles

  1. Francis Crick, DNA pioneer, dies in San Diego, Californi. He was 88.[New Scientist]
  2. Functional Adaptation of BabA, the H. pylori ABO Blood Group Antigen Binding Adhesin.. Aspholm-Hurtig, et al. Science 2004; 305: 519-522.
  3. Human Intelligence Determined By Volume And Location Of Gray Matter Tissue In Brain [Science Daily]
  4. Dissecting Cancer Vaccines [Science now]
  5. Heritable Integration of kDNA Minicircle Sequences from Trypanosoma cruzi into the Avian Genome: Insights into Human Chagas Disease. 23 July issue of Cell [The Scientist and Science now report ]
  6. Muscle mechanoreceptor modulation of sweat rate during recovery from moderate exercise J Appl Physiol 96: 2115-2119, 2004.
  7. Stem cells fill gap left by stroke, say Stanford researchers [Eurekalert report from PNAS: Transplanted human fetal neural stem cells survive, migrate, and differentiate in ischemic rat cerebral cortex. Kelly, et al. PNAS published July 27, 2004, 10.1073/pnas.0404474101 ]
  8. Scientists finger surprise culprit in spinal cord injury. Eurekalert report from issue of Nature Medicine.
  9. FDA Safety Labeling Changes: July 28, 2004 [Medscape report]
  10. Brain not body makes athletes feel tired [New Scientist report from the Canadian Journal of Applied Physiology.]

July 29

  1. Effect of Clonidine on Cardiovascular Morbidity and Mortality after Noncardiac Surgery. Wallace, et al. Anesthesiology 2004; 101: August [Eurekalert]
  2. § Eurekalert report: Migraines more likely to occur around menstruation, medication may prevent more than half in the July 27 issue of Neurology.
  3. § Use of antihypertensive agents in the management of patients with acute ischemic stroke. Neurology 2004 63: 318-323. [Medcape review]
  4. Archives of Internal Medicine | 2004;164:1479.

July 28

  1. § Dietary Protein and the Risk of Cholecystectomy in a Cohort of US Women: The Nurses’ Health Study. Am. J. Epidemiol. 2004 160: 11-18.
  2. Quality of life and survival prediction in terminal cancer patients. Cancer Published online: 26 Jul 2004. Vigano, et al. [Eurekalert: Physical symptoms appear to predict cancer prognosis]
  3. Use of oral glucocorticoids and risk of cardiovascular and cerebrovascular disease in a population based case–control study. Heart 2004; 90: 859-865. [Medscape: Oral Glucocorticoids Increase Risk of Cardiovascular, Cerebrovascular Disease]
  4. § Caffeine Impairs Glucose Metabolism in Type 2 Diabetes. Diabetes Care 2004; J.D. Lane, C.E. Barkauskas, R.S. Surwit, M.N. Feinglos
  5. The Lancet | Volume 364, Number 9431 | 24 July 2004
    • § Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial. The MATCH investigators
    • Pupil-led sex education in England (RIPPLE study): cluster-randomised intervention trial. The RIPPLE study team
    • Long-term effects of darusentan on left-ventricular remodelling and clinical outcomes in the EndothelinA Receptor Antagonist Trial in Heart Failure (EARTH): randomised, double-blind, placebo-controlled trial. The EARTH investigators
    •  Mechanisms of Disease: In-vivo dominant immune responses in aplastic anaemia: molecular tracking of putatively pathogenetic T-cell clones by TCR ß-CDR3 sequencing. Risitano, et al.
    • § Effectiveness of meningococcal serogroup C conjugate vaccine 4 years after introduction. Trotter, et al.
    • Osteomyelitis. Lew and Waldvogel
    • Viewpoint:"Neglected" diseases but unrecognised successes--challenges and opportunities for infectious disease control. Molyneux
    • Peace through health: key concepts. Santa Barbara and MacQueen
    • Uses of Error: Intuition, evidence, and safety. Edwards
    • Case Report: The world through tinted glasses. Bennett, et al.
  6. BMJ 24 July 2004 (Vol 329, No 7459)
    • Effect of bottles, cups, and dummies on breast feeding in preterm infants: a randomised controlled trial. BMJ 2004;329:193-198
    • Infertility among male UK veterans of the 1990-1 Gulf war: reproductive cohort study. BMJ 2004;329:196-201.
    • § Passive smoking and risk of coronary heart disease and stroke: prospective study with cotinine measurement. BMJ 2004;329:200-205
    • § Acquisition of Helicobacter pylori infection after outbreaks of gastroenteritis: prospective cohort survey in institutionalised young people. BMJ 2004; 329: 204-205.
    • DRUG POINTS: Anterior uveitis is associated with travopros. BMJ  2004;329:205
    • Primary care: Predicting bacterial cause in infectious conjunctivitis: cohort study on informativeness of combinations of signs and symptoms. BMJ 2004;329: 206-210
    • Information in practice: Ruling a diagnosis in or out with "SpPIn" and "SnNOut": a note of caution. BMJ 2004;329:209-213.
    • Clinical review: Sex, sun, sea, and STIs: sexually transmitted infections acquired on holiday. BMJ 2004;329:214-217
    • Lesson of the week: Acute visual loss and pituitary apoplexy after surgery. BMJ 2004;329:218-219
    • ABC of burns: Intensive care management and control of infection. BMJ 2004;329:220-223
    • Education and debate: National Institute for Clinical Excellence and its value judgments. BMJ 2004;329:224-227
    • Challenges for the National Institute for Clinical Excellence. BMJ 2004;329:227-229

July 27

  1. § Patients' Cells From Tumors, The Immune System Merged For Customized Cancer Therapy [Science Daily report from J Clin Cancer Res ] July 15 issue of the journal Clinical Cancer Research,
  2. Acetaminophen hepatoxicity: What do we know, what don't we know, and what do we do next? Kaplowitz Hepatology 2004 Published online: DOI: 10.1002/hep.20312
  3. Conventional Adjuvant Chemotherapy Versus Single-Cycle, Autograft-Supported, High-Dose, Late-Intensification Chemotherapy in High-Risk Breast Cancer Patients: A Randomized Trial. J Natl Cancer Inst 2004; 96: 1076-1083, July 21, 2004
  4. New England Journal of Medicine Volume 351 July 22, 2004 Number 4

July 26

  1. CMAJ July 20 2004, Volume 171, Issue 2
  2. JAMA.Vol. 292 No. 3, pp. 305-402, July 21, 2004
    • Efficacy and Safety of Statin Therapy in Children With Familial Hypercholesterolemia: A Randomized Controlled Trial. JAMA 2004;292:331-337.
    • § Antidepressants and the Risk of Suicidal Behaviors. JAMA 2004;292:338-343.
    • § Trends in Heart Failure Incidence and Survival in a Community-Based Population. JAMA 2004;292:344-350.
    • MMR Vaccination and Febrile Seizures: Evaluation of Susceptible Subgroups and Long-term Prognosis. JAMA 2004;292:351-357.
    • Role of Vitamin K2 in the Development of Hepatocellular Carcinoma in Women With Viral Cirrhosis of the Liver. JAMA 2004;292:358-361.
    • Early vs Late Administration of Glycoprotein IIb/IIIa Inhibitors in Primary Percutaneous Coronary Intervention of Acute ST-Segment Elevation Myocardial Infarction: A Meta-analysis. JAMA 2004;292:362-366.
    • Pharmacological Management to Reduce Exacerbations in Adults With Asthma: A Systematic Review and Meta-analysis. JAMA 2004;292:367-376.
    • Targeting High-Risk Young Patients for Statin Therapy. JAMA 2004;292:377-378.
    • Suicide Risk and the SSRIs. JAMA 2004;292:379-381.

July 23

Weekend Reading - Basic Science and general interest articles

  1. § MRSA Strains Spreading Outside US Hospitals [Medscape review]
  2. News Along the Pike (CDER Newsletter) Archives and July issue.
  3. Progress and problems in the biology, diagnostics, and therapeutics of prion diseases J. Clin. Invest. 2004 114: 153-160.
  4. § Prolonging the Agony. Jean Marx. Science, Vol 305, Issue 5682, 326-329 , 16 July 2004 [Researchers are deciphering the biological changes that can turn pain into a debilitating, chronic state--and they are uncovering new targets for potential painkilling drugs]

July 22

  1. British Medical Journal 17 July 2004 (Vol 329, No 7458)
    • Results of the first round of a demonstration pilot of screening for colorectal cancer in the United Kingdom BMJ  2004;329:133.
    • Effect of joint crisis plans on use of compulsory treatment in psychiatry: single blind randomised controlled trial. BMJ  2004;329:136.
    • Trends in blood pressure over 10 years in adolescents: analyses of cross sectional surveys in the Northern Ireland Young Hearts project. BMJ  2004;329:139.
    • Are there socioeconomic gradients in stage and grade of breast cancer at diagnosis? Cross sectional analysis of UK cancer registry data. BMJ 2004; 329: 142.
    • Blood pressure control by home monitoring: meta-analysis of randomised trials. BMJ  2004;329:145
    • § Quality improvement report: Eradication of methicillin resistant Staphylococcus aureus by "ring fencing" of elective orthopaedic beds. BMJ  2004;329:149-151.
    • Lesson of the week: Musculoskeletal pain in female asylum seekers and hypovitaminosis D3. BMJ  2004;329:156-157
    • § ABC of burns: Management of burn injuries of various depths. BMJ  2004;329:158-160.
    • Ethics in practice: Genetic information: a joint account? BMJ  2004;329:165-167
    • § Statistics Notes: Diagnostic tests 4: likelihood ratios. BMJ  2004;329:168-169.
  2. The Lancet Volume 364, Number 9430     17 July 2004
    • The cervical cancer epidemic that screening has prevented in the UK . Peto, et al.
    • Association between child and adolescent television viewing and adult health: a longitudinal birth cohort study. Hancox, et al.

July 21

  1. Molecular mediators of hepatic steatosis and liver injury. J. Clin. Invest. 2004 114: 147-152.
  2. Fish Intake and Risk of Incident Atrial Fibrillation. Circulation 2004: online July 19, 2004, 10.1161
  3. § Midlife Blood Pressure and the Risk of Hippocampal Atrophy: The Honolulu Asia Aging Study, Hypertension 2004 44: 29-34
  4. Fish Consumption and Incidence of Stroke: A Meta-Analysis of Cohort Studies. Stroke 2004 35: 1538 - 1542
  5. Annals of Internal Medicine 20 July 2004 Volume 141 Issue 2
    • Benefits and Harms of Doxycycline Treatment for Gulf War Veterans' Illnesses: A Randomized, Double-Blind, Placebo-Controlled Trial. ST Donta, et al.
    • § The Incidence of End-Stage Renal Disease Is Increasing Faster than the Prevalence of Chronic Renal Insufficiency Y-C Hsu, et al,
    • § Mortality Rates in Elderly Patients Who Take Different Angiotensin-Converting Enzyme Inhibitors after Acute Myocardial Infarction: A Class Effect? L Pilote, et al.
    • § The Relationship between Having a Living Will and Dying in Place. HB Degenholtz, et al.
    • § Improving Patient Care A Three-Part Intervention To Change the Use of Hormone Replacement Therapy in Response to New Evidence. CL Roumie, et al.
    • Allergic to Generics. Brennan and Lee
    • Managed Care and the Changing Health Care Environment: Medicine as a Profession Managed Care Ethics Working Group Statement..G J Povar, et al
    • Meta-Analysis: Apolipoprotein E Genotypes and Risk for Coronary Heart Disease. Y Song,
    • § Evaluation and Management of the Cardiovascular Patient Embarking on Air Travel. Possick and Barry.
    • Editorials The Long Aftermath of the 1991 Gulf War.
    • Is Improved Survival a Class Effect of Angiotensin-Converting Enzyme Inhibitors? Hennessy and Kimmel
    • Advance Directives: Time To Move On. JM Teno

July 20

  1. Combinatorial Therapy with Neurotrophins and cAMP Promotes Axonal Regeneration beyond Sites of Spinal Cord Injury.J. Neurosci. 2004 24: 6402-6409.
  2. Editorial: Altruism and Coverage of the Uninsured.Sessums LL. Journal of General Internal Medicine 2004; 19: 896–897 (Ovid via PHD Library) [Eurekalert]
  3. § Mortality associated with hormone replacement therapy in younger and older women. Salpeter SR; et al. J Gen Intern Med 2004 Jul;19(7):791-804. (Ovid via PHS library) [Press release: Hormone replacement therapy could have more benefits than risks when started early in menopause, new study finds.]
  4. CLINICAL PERSPECTIVE: Proscar and Propecia—A Therapeutic Perspective. J Clin Endocrinol Metab 2004 89: 3096-3098
  5. § Immunotherapeutic Potential of B7-DC (PD-L2) Cross-Linking Antibody In Conferring Antitumor Immunity. Cancer Res 2004 64: 4965-4972. [Science Daily report: Researchers Use Human Antibody To Cure Malignant Melanoma In Mice]
  6. § Vaccination with Tumor Lysate-Pulsed Dendritic Cells Elicits Antigen-Specific, Cytotoxic T-Cells in Patients with Malignant Glioma. Cancer Res 2004 64: 4973-4979. [Eurekalert report]
  7. New England Journal of Medicine Volume 351 July 15, 2004
    • Single-Dose Perinatal Nevirapine plus Standard Zidovudine to Prevent Mother-to-Child Transmission of HIV-1 in Thailand. M. Lallemant and Others
    • Intrapartum Exposure to Nevirapine and Subsequent Maternal Responses to Nevirapine-Based Antiretroviral Therapy. G. Jourdain and Others
    • § Timing and Magnitude of Increases in Levothyroxine Requirements during Pregnancy in Women with Hypothyroidism. E. K. Alexander and Others
    • § Lymphoma-Specific Genetic Aberrations in Microvascular Endothelial Cells in B-Cell Lymphomas. B. Streubel and Others
    • Mannose-Binding Lectin Variant Alleles and the Risk of Arterial Thrombosis in Systemic Lupus Erythematosus. T. Øhlenschlæger, and Others.
    • Treatment of Deep-Vein Thrombosis. S. M. Bates and J. S. Ginsberg
    • Embryo Ethics — The Moral Logic of Stem-Cell Research. M. J. Sandel
    • Zygote and "Clonote" — The Ethical Use of Embryonic Stem Cells. P. R. McHugh
    • Business and Medicine: The Business of Stem Cells. D. Spar
    • "Medicine Is My Lawful Wife" — Anton Chekhov, 1860–1904. R. S. Schwartz
    • Neoplastic Angiogenesis — Not All Blood Vessels Are Created Equal. I. J. Fidler and L. M. Ellis
    • Antiretroviral Agents — How Best to Protect Infants from HIV and Save Their Mothers from AIDS. H. Coovadia
    • Increased Levothyroxine Requirements in Pregnancy — Why, When, and How Much? A. Toft
July 19
  1. Decreased Arginine Bioavailability and Increased Serum Arginase Activity in Asthma. Am. J. Respir. Crit. Care Med. 2004; 170: 148-153.
  2. Molecular Signatures in Biopsy Specimens of Lung Cancer. Am. J. Respir. Crit. Care Med. 2004; 170: 167-174.
  3. Respiratory Viral Infections Are a Distinct Risk for Bronchiolitis Obliterans Syndrome and Death. Am. J. Respir. Crit. Care Med. 2004; 170: 181-187.
  4. Ventilatory Responses to Inhaled Carbon Dioxide, Hypoxia, and Exercise in Idiopathic Hyperventilation. Am. J. Respir. Crit. Care Med. 2004; 170: 118-125.
  5. High frequency of use of rofecoxib at greater than recommended doses: cause for concern. Pharmacoepidemiology and Drug Safety
    Volume 13, Issue 6 , Pages 339 - 343.
  6. Association of Atrial Fibrillation and Obstructive Sleep Apnea. Circulation 2004: online 10.1161/01.CIR.0000136587.
  7. This Issue of Archives of Internal Medicine Arch Intern Med. 2004;164:1361.
July 16

Weekend Reading - Basic Science and general interest articles

  1. § Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR.-gama Nature \ 429, 771 - 776 . [Study identifies genetics of fat metabolism, red wine link- Eurekalert]
  2. § Amyotrophic Lateral Sclerosis-Associated SOD1 Mutant Proteins Bind and Aggregate with Bcl-2 in Spinal Cord Mitochondria. Neuron, Vol 43, 19-30, 8 July 2004. [Eurekalert: Mitochondria in spinal cords is ALS target according to UCSD medical researchers]
  3. Long Nursing Shifts Raise Error Risk, U.S. Study Finds. [Medscape report]
  4. MS analysis of single-nucleotide differences in circulating nucleic acids: Application to noninvasive prenatal diagnosis. PNAS, DOI:10.1073/pnas.
  5. Genetic mutation found that is major contributor to type 1 diabetes [Eurekalert report from Nature Genetics online releaase]
  6. Pharmaceutical Research and Manufacturers of America (PhRMA) Issues New Guidelines [The Scientist report]
  7. Self-reported ill health in male UK Gulf War veterans: a retrospective cohort study. BMC Public Health 2004, 4:27 (13 July 2004) [Eurekalert]
  8. Eurekalert report: Thalidomide's promising future in fighting cancer explored in July Mayo Clinic proceedings
  9. FDA News: FDA Approves New Use of Drug to Treat Superficial Basal Cell Carcinoma, a Type of Skin Cancer
  10. FDA News: NMEs Approved in Calendar Year 2004- Updated through June 30, 2004
  11. FDA News: NDA Approvals for Callendar Year 2004 - Updated through June 30, 2004
  12. FDA Safety Labeling Changes: Celexa, Lexapro, Premarin, and Others [Medscape summary report]
July 15
  1. National Heart, Lung, and Blood Institute (NHLBI) News release: Implications of Recent Clinical Trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines. Scott M. Grundy, and others, for the Coordinating Committee of the National Cholesterol Education Program, Endorsed by the National Heart, Lung, and Blood Institute, American College of Cardiology Foundation, and American Heart Association
    Circulation 2004 110: 227 - 239, doi:10.1161/01.
  2. § Measurement of Interleukin 8 in Combination With C-Reactive Protein Reduced Unnecessary Antibiotic Therapy in Newborn Infants: A Multicenter, Randomized, Controlled Trial. Pediatrics 2004; 114: 1-8.
  3. § Increasing Evidence for a Human Breast Carcinoma Virus with Geographic Differences. Cancer;(DOI: 10.1002/cncr.20436) (Early release online); Print Issue Date: August 15, 2004.{Eurekalert]
  4. Decline in Blood Pressure Over Time and Risk of Dementia. A Longitudinal Study From the Kungsholmen Project. Stroke published July 1, 2004, 10.1161 [AHA press release]
  5. This Week in JAMA 2004;292:143.
    • Efficacy of an HIV Prevention Intervention for African American Adolescent Girls: A Randomized Controlled Trial. JAMA 2004;292:171-179.
    • § Efficacy and Safety of Emtricitabine vs Stavudine in Combination Therapy in Antiretroviral-Naive Patients: A Randomized Trial. JAMA 2004;292:180-189.
    • Efficacy and Safety of Tenofovir DF vs Stavudine in Combination Therapy in Antiretroviral-Naive Patients: A 3-Year Randomized Trial. JAMA 2004;292:191-201.
    • Nevirapine and Zidovudine at Birth to Reduce Perinatal Transmission of HIV in an African Setting: A Randomized Controlled Trial. JAMA 2004;292:202-209.
    • § Growth Hormone–Releasing Hormone in HIV-Infected Men With Lipodystrophy: A Randomized Controlled Trial. JAMA 2004;292:210-218.
    • § Rapid HIV-1 Testing During Labor: A Multicenter Study. JAMA 2004;292:219-223.
    • Highly Active Antiretroviral Therapy and Sexual Risk Behavior: A Meta-analytic Review. JAMA 2004;292:224-236.
    • Clinical Trials in Sub-Saharan Africa and Established Standards of Care: A Systematic Review of HIV, Tuberculosis, and Malaria Trials. JAMA 2004;292:237-242.
    • Treatment for Adult HIV Infection: 2004 Recommendations of the International AIDS Society-USA Panel. JAMA 2004;292:251-265.
    • HIV Infection, Hepatitis C Infection, and HAART: Hard Clinical Choices. JAMA 2004;292:243-250.
    • Editorials: Treatment of HIV/AIDS: Do the Dilemmas Only Increase? JAMA 2004;292:266-268.
    • The Long Journey to Health Equity. JAMA 2004;292:269-271.
July 14
  1. § NCEP Report: Implications of Recent Clinical Trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines. S M. Grundy, et al., for the Coordinating Committee of the National Cholesterol Education Program, Endorsed by the National Heart, Lung, and Blood Institute, American College of Cardiology Foundation, and American Heart Association.Circulation 2004 110: 227 - 239, doi:10.1161/01. [Eurekalert review]
  2. CMAJ July 6 2004, Volume 171, Issue 1
    • Editorial: First, the bad news... CMAJ 2004 171: 5
    • § Clostridium difficile infection in hospitals: a brewing storm. CMAJ 2004 171: 27-29.
    • Does tighter perioperative glycemic control improve outcomes for diabetic patients undergoing coronary artery bypass graft surgery? CMAJ 2004 171: 30-31.
    • Risk of Clostridium difficile diarrhea among hospital inpatients prescribed proton pump inhibitors: cohort and case–control studies. CMAJ 2004 171: 33-38
    • Lack of insurance coverage for testing supplies is associated with poorer glycemic control in patients with type 2 diabetes. CMAJ 2004 171: 39-43
    • Clostridium difficile infection in hospitals: risk factors and responses. CMAJ 2004 171: 45-46
    • Clostridium difficile: a formidable foe. CMAJ 2004 171: 47-48
    • Glycemic self-monitoring and insurance coverage. CMAJ 2004 171: 48-49
    • Clostridium difficile-associated diarrhea in adults. CMAJ 2004 171: 51-58
  3. The Lancet Volume 364, Number 9429;10 July 2004
  4. BMJ 10 July 2004 (Vol 329, No 7457)
    • Atypical antipsychotic drugs in the treatment of behavioural and psychological symptoms of dementia: systematic review. BMJ  2004;329:75.
    • Prospective cohort study of retinal vessel diameters and risk of hypertension. BMJ  2004;329:79.
    • Severe acute respiratory syndrome and its impact on professionalism: qualitative study of physicians' behaviour during an emerging healthcare crisis. BMJ  2004;329:83.
    • § Patients' evaluation of informed consent to postponed information: cohort study. BMJ  2004;329:86.
    • § Commentary: Methodological reasons for not gaining prior informed consent are sometimes justified. BMJ  2004;329:87
    • Comparison of reporting of ethnicity in US and European randomised controlled trials. BMJ  2004;329:87-88
    • CHI ratings and HSMRs: is there a relation? BMJ  2004;329:73
    • Reform of undergraduate medical teaching in the United Kingdom: a triumph of evangelism over common sense. BMJ  2004;329:92-94,
    • Common skin infections in children. BMJ  2004;329:95-99.
    • Lesson of the week: Avulsion fracture of the ischial tuberosity in adolescents—an easily missed diagnosis. BMJ  2004;329:99-100.
    • ABC of burns: Initial management of a major burn: II—assessment and resuscitation. BMJ  2004;329:101-103.
July 13
  1. The relationship of allergen-specific IgE levels and oral food challenge outcome. J All Clin Immu 2004 (July) [Eurekalert]
  2. Dog allergen (Can f 1) and cat allergen (Fel d 1) in US homes: Results from the National Survey of Lead and Allergens in Housing. Journal of Allergy and Clinical Immunology. [Eurekalert report: National study shows dog and cat allergens are universally present in U.S. homes]
  3. Human papillomavirus, smoking, and sexual practices in the etiology of anal cancer. Cancer 2004; 101: 270-280.
  4. Circulating Ghrelin Is Sensitive to Changes in Body Weight during a Diet and Exercise Program in Normal-Weight Young Women. J. Clin. Endocrinol. Metab., Jun 2004; 89: 2659 - 2664.
  5. Dairy Foods, Calcium, and Colorectal Cancer: A Pooled Analysis of 10 Cohort Studies. J Natl Cancer Inst 2004; 96: 1015-1022.
  6. New England Journal of Medicine Volume 351 July 8, 2004 Number 2
  7. MMWR July 9, 2004 / Vol. 53 / No. 26 (pdf document)
    • § Trends in Primary and Secondary Syphilis and HIV Infections in Men Who Have Sex with Men --- San Francisco and Los Angeles, California, 1998--2002
    • Adult Blood Lead Epidemiology and Surveillance --- United States, 2002
    • Lead Poisoning Associated with Ayurvedic Medications --- Five States, 2000--2003
    • West Nile Virus Activity --- United States, June 30--July 6, 2004
    • § Investigation of Rabies Infections in Organ Donor and Transplant Recipients --- Alabama, Arkansas, Oklahoma, and Texas, 2004
    • Notice to Readers: Updated Recommendations for Use of Pneumococcal Conjugate Vaccine: Reinstatement of the Third Dose
July 12
  1. New England Journal of Medicine EARLY RELEASE
    • ARTICLE: Single-Dose Perinatal Nevirapine plus Standard Zidovudine to Prevent Mother-to-Child Transmission of HIV-1 in Thailand
    • ARTICLE: Intrapartum Exposure to Nevirapine and Subsequent Maternal Responses to Nevirapine-Based Antiretroviral Therapy
    • EDITORIAL:  Antiretroviral Agents — How Best to Protect Infants from HIV and Save Their Mothers from AIDS
  2. Caffeinated coffee consumption and mortality after acute myocardial infarction. Mukamal, et al. Am Heart J 2004; Vol 147
  3. Hospitalized cancer patients with severe sepsis: analysis of incidence, mortality, and associated costs of care. Critical Care 2004, 8:R291-R298 [Eurekalert: Severe sepsis causes almost 10% of cancer deaths]
  4. This Week in JAMA 2004; 292:11.
    • § Enoxaparin vs Unfractionated Heparin in High-Risk Patients With Non–ST-Segment Elevation Acute Coronary Syndromes Managed With an Intended Early Invasive Strategy: Primary Results of the SYNERGY Randomized Trial. SYNERGY Trial Investigators. JAMA 2004;292:45-54.
    • § Safety and Efficacy of Enoxaparin vs Unfractionated Heparin in Patients With Non–ST-Segment Elevation Acute Coronary Syndromes Who Receive Tirofiban and Aspirin: A Randomized Controlled Trial. JAMA 2004;292:55-64.
    • § Effect of Soy Protein Containing Isoflavones on Cognitive Function, Bone Mineral Density, and Plasma Lipids in Postmenopausal Women: A Randomized Controlled Trial. JAMA 2004;292:65-74.
    • Preliminary Communications: Transfer of Fetal Cells With Multilineage Potential to Maternal Tissue. JAMA 2004;292:75-80.
    • Endometrial Cells Derived From Donor Stem Cells in Bone Marrow Transplant Recipients. JAMA 2004;292:81-85.
    • Authorship Criteria and Disclosure of Contributions: Comparison of 3 General Medical Journals With Different Author Contribution Forms. JAMA 2004;292:86-88.
    • § Efficacy and Bleeding Complications Among Patients Randomized to Enoxaparin or Unfractionated Heparin for Antithrombin Therapy in Non–ST-Segment Elevation Acute Coronary Syndromes: A Systematic Overview. JAMA 2004;292:89-96.
    • Renal Cell Carcinoma. JAMA 2004;292:97-100.
    • Fractionating Heparins and Their Clinical Trial Data—Something for Everyone. JAMA 2004;292:101-103.
    • Stem Cell Transfer and the Uterus: The Egg Teaches the Chicken. JAMA 2004;292:104-105.
July 9

Weekend Reading - Basic Science and general interest articles

  1. American Journal of Physiology –Regulatory, Integrative and Comparative Physiology - news reports
    • § Interaction between GLP-1 and CCK-33 in Inhibiting Food Intake and Appetite in Men. Gutzwiller, et al.
    • Comparison of the Effects of Exercise and Diuretic on Left Ventricular Geometry, Mass, and Insulin Resistance in Older Hypertensive Adults. Rinder, et al.
    • Metabolic Adjustments with the Development, Treatment, and Recurrence of Obesity in Obesity-Prone Rats. MacLean, et al.
  2. Medical Debt a Problem for Almost 20 Million American Families [Report from Center for Studying Health System Change]
  3. FDA Safety Labeling Changes: June 30, 2004 [Medscape Summary]
    • Cetrorelix Acetate for Injection (Cetrotide) Contraindicated in Severe Renal Impairment
    • Doxapram HCl Injection USP (Dopram Injection) Contraindicated in Patients with Mechanical Disorders of Ventilation
    • Voriconazole (Vfend) Adversely Interacts With Ritonavir and Efavirenz
    • Conjugated Estrogen USP for Injection (Premarin Intravenous) Associated With Malignant Neoplasms
    • Vitamin D and Derivatives Should Not Be Administered Concurrently With Doxercalciferol (Hectorol)
  4. Animal research suggests plant estrogens in soy do not increase breast cancer risk [Eurekalert and Science Daily report from Journal of Clinical Endocrinology & Metabolism.
  5. § Plasma Ghrelin in Obesity before and after Weight Loss after Laparoscopical Adjustable Gastric Banding . J Clin Endocrinol Metab 2004 89: 3352-3358.
  6. § Elderly crucial to evolutionary success of humans. NewScientist.com news service Proceedings of the National Academy of Sciences.
  7. Researchers identify gene regulating aging and fertility. Eurekalert report from Nature Genetics. [Baker, D.J. et al. (2004). Nat. Genet. 36, 744-749.]
July 8
  1. Annals of Internal Medicine 6 July 2004 Volume 141 Issue 1
  2. Persistence of Asthma Symptoms during Adolescence: Role of Obesity and Age at the Onset of Puberty. Am. J. Respir. Crit. Care Med. 2004; 170: 78-85.
  3. § Study proves that cutting Rx drugs due to cost harms health. Long-term study of 8,000 seniors shows heart, overall health most affected [Eurekalert report from Medical Care - subscription access only]
  4. § Effect of Dextromethorphan, Diphenhydramine, and Placebo on Nocturnal Cough and Sleep Quality for Coughing Children and Their Parents. Pediatrics 2004; 114: e85-e90.
  5. § Extended-Interval Aminoglycoside Administration for Children: A Meta-analysis. Pediatrics 2004; 114: e111-e118.
  6. Predicting Preschooler Obesity at Birth: The Role of Maternal Obesity in Early Pregnancy. Pediatrics 2004; 114: e29-e36.
  7. Early Infant Multivitamin Supplementation Is Associated With Increased Risk for Food Allergy and Asthma. Pediatrics 2004; 114: 27-32.
  8. Randomized Trial of Brief Office-Based Interventions to Reduce Adolescent Alcohol Use. Arch Pediatr Adolesc Med. 2004;158:635-642.
  9. Decreased Catalytic Activity and Expression of Protein Kinase C Isozymes in Teenage Suicide Victims: A Postmortem Brain Study. Arch Gen Psychiatry. 2004;61:685-693.
  10. Combined Pharmacotherapy and Psychological Treatment for Depression: A Systematic Review. Arch Gen Psychiatry. 2004;61:714-719
July 7
  1. MMWR Dispatch July 1, 2004 / Vol. 53
  2. § Science in Medicine:: Acute renal failure: definitions, diagnosis, pathogenesis, and therapy.J. Clin. Invest. 2004 114: 5-14.
  3. The Lancet Volume 364, Number 9428     03 July 2004
    • Effectiveness and safety of a generic fixed-dose combination of nevirapine, stavudine, and lamivudine in HIV-1-infected adults in Cameroon: open-label multicentre trial. ANRS 1274 study group
    • HIV prevalence and trends in sub-Saharan Africa: no decline and large subregional differences. Asamoah-Odei, et al.
    • Effects of a behavioural intervention to reduce acquisition of HIV infection among men who have sex with men: the EXPLORE randomised controlled study The EXPLORE Study Team
    • Predictors of trend in CD4-positive T-cell count and mortality among HIV-1-infected individuals with virological failure to all three antiretroviral-drug classes. The PLATO Collaboration
    • Uses of Error: A middle-aged man
    • No "access for all" to US Government HIV/AIDS research
  4. BMJ 3 July 2004 (Vol 329, No 7456)
    • § Editor's choice: Think harm always. BMJ  2004;329
    • This week in the BMJ: § Adverse drug reactions cause too many hospital admissions
    • Editorials: The road to health care. BMJ  2004;329:1-2
    • § Benefits and harms of drug treatments. BMJ  2004;329:2-3
    • New interventional procedures. BMJ  2004;329:3-4
    • § Pharmacogenetics—expectations and reality. BMJ  2004;329:4-6,
    • § Collecting and sharing information about harms. BMJ  2004;329:6-7
    • § Assessing the benefit-harm balance at the bedsid. BMJ  2004;329:7-8
    • § Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients. BMJ  2004;329:15-19
    • Systematic review of the incidence and consequences of uterine rupture in women with previous caesarean section. BMJ  2004;329:19-25
    • Operative vaginal delivery and neonatal and infant adverse outcomes: population based retrospective analysis. BMJ  2004;329:24-29
    • § Interaction of St John's wort with conventional drugs: systematic review of clinical trials. BMJ  2004;329:27-30
    • § Balancing benefits and harms: the example of non-steroidal anti-inflammatory drugs. BMJ  2004;329:31-34
    • Antidepressants and suicide: what is the balance of benefit and harm. BMJ  2004;329:34-38
    • Commentary: Is evidence based patient choice feasible? BMJ  2004;329:39,
    • Commentary: Decision aids in clinical practice. BMJ  2004;329:39-40
    • Commentary: Patients' view. BMJ  2004;329:40
    • Education and debate: Balancing benefits and harms in public health prevention programmes mandated by governments. BMJ  2004;329:41-43
    • Commentary: silent prevention. BMJ  2004;329:43-44
    • § Detection, verification, and quantification of adverse drug reactions. BMJ  2004;329:44-47
    • § Making decisions about benefits and harms of medicines. BMJ  2004;329:47-50
July 6
  1. § Special Reviews: Digitalis Therapy for Patients in Clinical Heart Failure. Circulation 2004 109: 2942 - 2946
  2. Chronic psychosocial stress predicts long-term cardiovascular morbidity and mortality in middle-aged men. Eur Heart Journal 2004; 25: 867-873
  3. § The effect of moderate alcohol consumption on bone mineral density: a study of female twins. Ann Rheum Dis. Online July 2004; doi:10.1136/ard
  4. Elevated Neuron Number in the Limbic Thalamus in Major Depression. Am J Psychiatry 2004 161: 1270-1277.
  5. § Improved Glycemic Control Without Weight Gain Using Triple Therapy in Type 2 Diabetes. Diabetes Care 2004 27: 1577-1583.
  6. Mayo Clinic Proceedings July 2004  Volume 79  Number 7
    • On the "Significance" of Monoclonal Gammopathy of Undetermined Significance
    • Myelofibrosis: Thalidomide Finds a New Disease
    • Long-term Follow-up of 241 Patients With Monoclonal Gammopathy of Undetermined Significance: The Original Mayo Clinic Series 25 Years Later
    • Clinical Course of Patients With Relapsed Multiple Myelom
    • Thalidomide for Patients With Relapsed Multiple Myeloma After High-Dose Chemotherapy and Stem Cell Transplantation: Results of an Open-Label Multicenter Phase 2 Study of Efficacy, Toxicity, and Biological Activity
    • Durable Responses to Thalidomide-Based Drug Therapy for Myelofibrosis With Myeloid Metaplasia
    • Characteristics of 100 Consecutive Patients Presenting With Orthostatic Hypotension
    • Clinicoradiological Features of Pulmonary Infarctions Mimicking Lung Cancer
    • Thalidomide: Tragic Past and Promising Future
    • The Increasing Need for Anticoagulant Therapy to Prevent Stroke in Patients With Atrial Fibrillation
    • An Algorithm for the Management of Restless Legs Syndrome
    • 70-Year-Old Woman With Rash and Muscle Weakness
    • Linezolid-Associated Peripheral Neuropathy
    • Tracheal Myxoma: A Rare Benign Tracheal Tumor
    • Symposium on Cerebrovascular Diseases
    • Evaluation and Management of Asymptomatic Carotid Artery Stenosis
  7. § Antimicrobial Prophylaxis for Surgery: An Advisory Statement from the National Surgical Infection Prevention Project. Surgical Infection Prevention Guidelines Writers Workgroup. Clin Infect Dis 2004;38:1706-1715.
  8. Suppression of Drug-Resistant Staphylococcal Infections by the Quorum-Sensing Inhibitor RNAIII-Inhibiting Peptide. JID  2004;190:318-320. [Researchers recommend new approach to combat drug-resistant staph infections. Eurekalert ]
  9. § Bicalutamide Monotherapy Versus Leuprolide Monotherapy for Prostate Cancer: Effects on Bone Mineral Density and Body Composition. J Clin Onc 2004; 22: 2546-2553. [Eurekalert]
July 5
  1. New England Journal of Medicine Volume 351 July 1, 2004 Number 1
  2. Principles for National and Regional Guidelines on Cardiovascular Disease Prevention: A Scientific Statement From the World Heart and Stroke Forum . Circulation 2004 109: 3112 - 3121.
  3. § Cardiovascular Complications of Cancer Therapy: Diagnosis, Pathogenesis, and Management . Circulation 2004 109: 3122 - 3131. [Eurekalert report]
  4. Clinical and Economic Outcomes of Percutaneous Coronary Interventions in the Elderly. An Analysis of Medicare Claims Data. Circulation 2004: published online.
  5. § Postmenopausal Hormone Therapy Is Associated With Atherosclerosis Progression in Women With Abnormal Glucose Tolerance. Circulation 2004: published online
  6. § Hypertensive Therapy: Part I : Circulation. 2004;109:2953–2958 and Part II. : Circulation. 2004;109:3081-3088.
  7. § Dietary Sodium Restriction Rapidly Improves Large Elastic Artery Compliance in Older Adults With Systolic Hypertension. Hypertension 2004 44: 35-41
July 2

Weekend Reading - Basic Science and general interest articles

  1. MMWR Surveillance Summaries June 4, 2004 / 53(SS03);1-108 Cancer Mortality Surveillance --- United States, 1990--2000
  2. FDA Approval: first-time generic Levothyroxine Sodium for the treatment of hypothyroidism.
  3. FDA MedWatch: Effexor XR (venlafaxine HCl).
    • Neonates exposed to Effexor, other SNRIs (Serotonin and Norepinephrine Reuptake Inhibitors), or SSRIs (Selective Serotonin Reuptake Inhibitors), late in the third trimester of pregnancy have developed complications requiring prolonged hospitalization, respiratory support, and tube feeding. Such complications can arise immediately upon delivery
    • Patients with major depressive disorder, both adult and pediatric, may experience worsening of their depression and/or the emergence of suicidal ideation and behavior (suicidality), whether or not they are taking antidepressant medications. The warning recommends patients being treated with antidepressants be observed closely for clinical worsening and suicidality, especially at the beginning of a course of drug therapy, or at the time of dose changes, either increases or decreases.
  4. FDA Talk Paper: FDA Clears Medicinal Leeches for Marketing
  5. First Woman Pregnant After Ovarian Transplant [Medscape and New Scientist reports]
  6. New Insight Into Cancer Metastasis. [Science Daily and MIT report from June 25 Cell.]
  7. § Kaposi's Sarcoma Virus 'Reprograms' Blood Vessel Cells Into Lymphatic Cells. [Science Daily report from Nature Genetics.]
  8. Life without men. Nature News report from Nature.
  9. § Alterations in the dynamics of circulating ghrelin, adiponectin, and leptin in human obesity. PNAS 10.1073/pnas.0403465101 [Science Daily report]
  10. § Mice with hyperactive Wnt10b gene avoid obesity by inhibiting fat cell development. [J. Biol. Chem, 10.1074/jbc.M402937200 online]
  11. § Scientists discover obesity disrupts appetite hormone. [Eurekalert report from June 28 PNAS]
  12. § The Chemistry of Female Desire. [Science NOW report form PNAS]
  13. § Hunger Hormone Acts Differently in Fat Men [report from PNAS]
  14. Assessment and Management of Childhood and Adolescent Obesity [Medscape review]
July 1
  1. § Passive smoking and risk of coronary heart disease and stroke: prospective study with cotinine measurement. BMJ, doi:10.1136.
  2. § Reaction Time and Movement Time After Embryonic Cell Implantation in Parkinson Disease. Arch Neurol. 2004;61:858-861.
  3. Postmenopausal Estrogen Use Affects Risk for Parkinson Disease. Arch Neurol. 2004;61:886-888.
  4. § Improved Glycemic Control Without Weight Gain Using Triple Therapy in Type 2 Diabetes. Diabetes Care 2004 27: 1577-1583.
  5. Nandrolone Decanoate and Load Increase Remodeling and Strength in Human Supraspinatus Bioartificial Tendons. Am J Sports Med 2004 32: 934-943. (Anabolic steroids may improve surgical repair of torn shoulder tendons,: Eurekalert]
  6. In This Issue of Archives of Internal Medicine Arch Intern Med. 2004;164:1264.