Recent
reports in Science and Medicine for June 2005
Some
of these links are very transient and may expire within days of posting.
Some may require prior registration. Check-in and view frequently to
avoid missing great news items. I welcome any suggested articles. (email
link). "§" or
"* "indicates
a recommended article.
- A Comparison of Lipid and Glycemic Effects of Pioglitazone and Rosiglitazone
in Patients With Type 2 Diabetes and Dyslipidemia. Diabetes
Care 2005 28: 1547-1554. [Eurekalert]
- * Effects of Doxycyline
on Progression of Osteoarthritis: Results of a Randomized, Placebo-Controlled,
Double-Blind Trial. Arthritis & Rheumatism
2005; 52:7; 2015-2025. [Eurekalert]
- * Weight Loss Reduces Knee-Joint
Loads in Overweight and Obese Older Adults With Knee Osteoarthritis. Arthritis & Rheumatism,
July 2005; 52:7; pp. 2026-2032. [Eurekalert]
- Staffing and Worker Injury in Nursing Homes. Am
J Public Health 2005 95: 1220-1225. [Eurekalert]
- Saturated and cis/trans Unsaturated Acyl CoA Esters Differentially Regulate
Wild-Type and Polymorphic ß-Cell ATP-Sensitive K+ Channels. Diabetes
2005 54: 2070-2079. [Eurekalert]
- Effects of Noncardiovascular Comorbidities on Antihypertensive Use in
Elderly Hypertensives. Hypertension
published June 27, 2005, 10.1161 [Medscape]
- Archives
of Internal Medicine Vol. 165 No. 12 June 27, 2005
- Antiepileptic drug use of women with epilepsy and congenital malformations
in offspring. Neurology
2005;64:1874-1878. [Medscape]
- BMJ 25
June 2005 (Vol 330, No 7506)
- Methods of hysterectomy: systematic review and meta-analysis of randomised
controlled trials. BMJ 2005:330:
1478.
- Long term effects of hysterectomy on mortality: nested cohort study. BMJ 2005:330:
1482.
- Sleep-dependent motor memory plasticity in the human brain. Neuroscience 205;
133, Issue 4 , 2005, Pages 911-917. (via Science
Direct) [Eurekalert:
Study shows how sleep improves memory]
- Helicobacter pylori “Test and Treat” or Endoscopy for Managing
Dyspepsia: An Individual Patient Data Meta-analysis. Gastroenterol
2005;128:1838-1844. [Medscape]
- Immunosuppressive Therapy May Not Be Needed in Asymptomatic Autoimmune
Hepatitis. Hepatology. 2005;42:53-62. (limited access) [Medscape]
- Influence of Caffeine on Frequency of Hypoglycemia Detected by Continuous
Interstitial Glucose Monitoring System in Patients With Long-Standing Type
1 Diabetes. Diabetes
Care 2005 28: 1316-1320.[Medscape]
- Autoimmune Hepatitis: Effect of Symptoms and Cirrhosis on Natural History
and Outcome. Hepatology;
2005; 42: 53 - 62. [Eurekalert]
- Common drugs can calm essential tremor June 28 issue of the journal Neurology.[Eurekalert]
- * Increased Risk
of Common Infections in Patients with Type 1 and Type 2 Diabetes Mellitus. Clinical
Infectious Diseases 2005;41:00. [IDSA
Report]
| June
24 |
Weekend
Reading - Basic Science and general interest articles |
|
- Medwatch Alerts:
- Class 1 Recall of Betac Announced in Canada and
U.S.[Medscape report]
- FDA
Medwatch: Certain PRIZM and CONTAK Defibrillators Recalled
Due to Potential Malfunction [Medscape report]
- Guidant Recalls Some ICDs After Failures, Deaths.
[Medscape]
- FDA
ALERT : New labeling: Iressa should be used only
in cancer patients who have already taken the medicine and whose doctor
believes it is helping them.
- FDA Approvals:
- Alinia (nitazoxanide) expanded
indication for allowing use for the treatment of diarrhea caused
by Cryptosporidium parvum in adults and adolescents aged 12 years
and older. It is the first drug approved for this indication in
this population.
- Aptivus (tipranavir HIV
protease inhibitor) given with ritonavir for treatment of HIV-1
infected adults. This is the second drug approved for patients
with advanced HIV disease, and provides a new therapy for patients
with limited treatment options.
- BiDil for
heart failure in Black Patients
- [Medscape reports]
- Revatio (sildenafil ) to
improve exercise ability in patients with early-stage pulmonary
arterial hypertension.
- Xeloda (capecitabine) new
indication for the adjuvant treatment (after complete resection
of the primary tumor) of Dukes' C colon cancer when fluoropyrimidine
therapy alone is preferred.
- Reporting Complaints
Related to FDA-Regulated Clinical Trials (Report to the office handling
the type of study involved)
- Statement on
First Meeting of FDA's Drug Safety Oversight Board
- First US West Nile Case of 2005 Reported in Kansas. [Medscape]
- Expression Profiles and Functional Analyses of Wnt-Related Genes in Human
Joint Disorders. Am
J Pathol 2005 167: 97-105. [ScienceDaily:
The cellular signaling protein Wnt, contributes to disease progression
of both rheumatoid arthritis and osteoarthritis.]
- In Asthma, Dietary Salt Loading May Decrease Lung Function, Diffusion
Capacity After Exercise. Med Sci Sports Exerc. 2005;37:904-917. (limited
access) [Medscape]
- New
England Journal of Medicine Volume 352 June 23, 2005 Number
25
- Annals
of Internal Medicine 21 June 2005 Volume 142 Issue 12
- Early Release Articles:
- The Effect of Combined Estrogen and Progesterone
Hormone Replacement Therapy on Disease Activity in Systemic Lupus
Erythematosus: A Randomized Trial. Buyon,
and others.
- The Clinical Course of Patients with Idiopathic
Pulmonary Fibrosis. Martinez,
and others
- An Electrocardiogram-Based Algorithm To Detect
Loss of Left Ventricular Capture during Cardiac Resynchronization
Therapy. Ammann,
and others
- Meta-Analysis: Antibiotic Prophylaxis Reduces
Mortality in Neutropenic Patients. Gafter-Gvili,
Fraser, Paul, and Leibovici
- Independent Medical Examinations: An Expanding
Source of Physician Liability. Baum [Medscape]
- High and Rising Health Care Costs. Part 3: The
Role of Health Care Providers. Bodenheimer
- National Institutes of Health State-of-the-Science
Conference Statement: Management of Menopause-Related Symptoms. NIH
State-of-the-Science Panel
- EDITORIALS:
Help for Menopausal Patients with Lupus?
- Annals 2004–2005: A Peek Back and a Look
Forward. The
Editors
- Reviews: Making Sense of an Often Tangled Skein
of Evidence. The
Editors
- ON
BEING A DOCTOR: One in Three
- Liver Cancer on the Rise. Fisher
Wilson
- SUPPLEMENT:
Challenges of Summarizing Better Information for Better Health:
The Evidence-based Practice Center Experience
- In Asthma, Dietary Salt Loading May Decrease Lung Function, Diffusion
Capacity After Exercise [Medscape]
- Helicobacter pylori and atrial fibrillation: a possible pathogenic link. Heart.
2005;91:960-961.[Medscape]
- In the current era, complete revascularization improves survival after
coronary artery bypass surgery. J
Thorac Cardiovasc Surg 2005 129: 1283-1291. [Eurekalert]
- Superiority of thalidomide and dexamethasone over vincristine-doxorubicindexamethasone
(VAD) as primary therapy in preparation for autologous transplantation
for multiple myeloma. Blood
2005 106: 35-39. [Eurekalert]
- Early Lung Cancer Detection Using Spiral Computed Tomography and Positron
Emission Tomography. Am
J Respir Crit Care Med 2005;171:1378-1383. [Medscape]
- New
England Journal of Medicine Volume 352 June 16, 2005 Number
24
| June
17 |
Weekend
Reading - Basic Science and general interest articles |
|
- FDA Updates
- § FDA
Medwatch: Sustiva (efavirenz) revisions
to the prescribing information. The revisions are a result of
four retrospective reports of neural tube defects in infants
born to women first trimester exposure to Sustiva, including
three cases of meningomyelocele and one Dandy Walker Syndrome.
As Sustiva may cause fetal harm when administered during the
first trimester to a pregnant woman, pregnancy should be avoided
in women receiving Sustiva.
- FDA
Approval: Adacel (Combination vaccine to
help protect both adolescents and adults against whooping cough).
[Medscape]
- Xeloda (capecitabine) oral chemotherapy
drug for post-surgical treatment of patients with colon cancer
that has spread to the lymph nodes. [Medscape]
- First-Time Generic Approvals: Foscarnet sodium
(reference: Foscavir), anagrelide (reference: Agrylin), estradiol
plus estradiol/norgestimate (reference Prefest). [Medscape]
- FDA Safety Labeling Changes: [Medscape]
- Maxaquin (lomefloxacin)
warning of the risk of peripheral neuropathy and tendon effects
associated with its use.
- Temodar (temozolomide) warning
of the potential risk of malignancies associated with its
use.
- Trileptal (oxcarbazepine)
warning of the risk of serious hypersensitivity reactions
associated with its use.
- Expert Panel Urges Limited Use of Nesiritide [Medscape]
- FDA
MedWatch - COX-2 Selective and Non-Selective NSAIDs :
Safety labeling changes.
- Accelerated Intestinal Epithelial Cell Turnover: A New Mechanism of Parasite
Expulsion. Science
3 June 2005; 308: 1463-1465. [Eurekalert:
A study of how the body expels parasitic worms has led to a surprising
new discovery about the immune system that could help in the treatment
of bowel cancer.]
- Science Special
Issue: 10 June 2005 issue: Women's Health.
- JAMA Vol.
293 No. 23, pp. 2831-2958, June 15, 2005
- Bevacizumab in Combination With Fluorouracil and Leucovorin: An Active
Regimen for First-Line Metastatic Colorectal Cancer. JCO
May 20 2005: 3502–3508.[Medscape]
- The
Lancet Volume 365, Number 9476, 11 June 2005 (Registration is now
required)
- § Immediate
versus deferred antiepileptic drug treatment for early epilepsy and
single seizures: a randomised controlled trial. Summary [Eurekalert]
[Medscape]
- Comparison of physical treatments versus a brief pain-management
programme for back pain in primary care: a randomised clinical trial
in physiotherapy practice. Summary
- Children need 60 minutes of daily physical activity, expert panel says.
[Eurekalert] J.
Pediatrics.
- Changes in the Numeric Descriptive Scale for Pain After Sublingual Nitroglycerin
Do Not Predict Cardiac Etiology of Chest Pain. Ann
Emerg Med 2005;45:581-585. [Medscape]
- Archives
of Internal Medicine Vol. 165 No. 11, pp. 1209-1320, June 13, 2005
- § Inflammation
of Atrium After Cardiac Surgery Is Associated With Inhomogeneity of Atrial
Conduction and Atrial Fibrillation. Circulation
2005 111: 2881 - 2888. [Eurekalert]
- Dose-Response Relationship of Oral Insulin Spray in Healthy Subjects. Diabetes
Care 2005 28: 1353-1357. [Medscape]
- New
England Journal of Medicine Volume 352 June 9,
2005 Number 23
- JAMA.
Vol. 293 No. 22, pp. 2693-2820, June 8, 2005
- § The
tetanus, diphtheria, and five-component pertussis vaccine (Tdap) is safe
and effective in adults and adolescents, supporting its potential as a
routine vaccination booster, according to the results of a randomized trial
published in the June
22/29 issue of JAMA and posted online June 2. [Medscape]
Weekend
Reading - Basic Science and general interest articles
- § Nature
News Published online : 5 June 2005: Success in primates sparks hope
for Marburg vaccine. Live inoculations join the fight against fatal fevers.[New
Scientist: Marburg and Ebola vaccine success in monkeys]
- FDA Safety Labeling Changes: [Medscape]
- Crestor (rosuvastatin) increased
risk of serious muscle toxicity (myopathy/rhabdomyolysis) associated
with its use, especially at the highest approved dose of 40 mg.
- Diamox Sequels (acetazolamide
extended-release) to warn of the potential for serious adverse
reactions associated with their use.
- Femring (estradiol acetate vaginal
ring ) to warn of the increased risks of coronary heart disease,
stroke, and venous thromboembolism (VTE) associated with its use.
- FDA Approvals: [Medscape
report]
- Zemplar (capsule
formulation of paricalcitol ) for the prevention and treatment
of secondary hyperparathyroidism (SHPT) in patients with stage
III and IV chronic kidney disease (CKD), prior to the need for
dialysis or renal transplantation.
- Arixtra (fondaparinux) for the
prophylaxis of deep vein thrombosis (DVT) that may lead to pulmonary
embolism (PE) in patients undergoing abdominal surgery who are
at risk for thromboembolic complications.
- Glumetza (once-daily, extended-release
formulation of metformin) for the treatment of type 2 diabetes
mellitus.
- FDA Report:
Drug-Induced Liver Toxicity
- Enhanced Pseudomonas aeruginosa Biofilm Development Mediated by Human
Neutrophils. Infect.
Immun. 2005 73: 3693-3701.(Immune-System Cells May Promote Chronic
Infections in Cystic Fibrosis)
- Google Scholar: A source for clinicians? CMAJ
June 7, 2005; 172 (12).
- Annual meeting of the American Society of Clinical Oncology: Possible
treatment found for 'chemobrain' [Eurekalert]
- Nature
Insight: Autoimmunity Vol. 435, No. 7042 pp583-627.
- § New
England Journal of Medicine Early Release
- Progressive Multifocal Leukoencephalopathy after
Natalizumab Therapy for Crohn's Disease [Abstract]
- Progressive Multifocal Leukoencephalopathy Complicating
Treatment with Natalizumab and Interferon Beta-1a for Multiple
Sclerosis [Abstract]
- Progressive Multifocal Leukoencephalopathy in a
Patient Treated with Natalizumab[Abstract]
- EDITORIAL: Progressive
Multifocal Leukoencephalopathy and Natalizumab — Unforeseen
Consequences
- EDITORIAL: Patients
at Risk
- CORRESPONDENCE: Natalizumab
and Progressive Multifocal Leukoencephalopathy
- Fourth Case of PML Linked to Natalizumab [Medscape]
- Annals of Internal
Medicine 7 June 2005 Volume 142 Issue 11
- Archives
of General Psychiatry Vol. 62 No. 6, pp. 586-696, June 2005
- § Science
now: A nationwide psychological survey
indicates that the mental health of Americans hasn't gotten any
worse over the past decade. Still, some 6% of the population
has mental illnesses that are "seriously debilitating," which
makes the U.S. sicker psychologically than other developed nations.[NYTimes
report]
- Lifetime Prevalence and Age-of-Onset Distributions
of DSM-IV Disorders in the National Comorbidity Survey Replication. Arch
Gen Psychiatry. 2005;62:593-602.
- Failure and Delay in Initial Treatment Contact
After First Onset of Mental Disorders in the National Comorbidity
Survey Replication. Arch
Gen Psychiatry. 2005;62:603-613.
- Prevalence, Severity, and Comorbidity of 12-Month
DSM-IV Disorders in the National Comorbidity Survey Replication. Arch
Gen Psychiatry. 2005;62:617-627.
- Twelve-Month Use of Mental Health Services in
the United States: Results From the National Comorbidity Survey
Replication.Arch
Gen Psychiatry. 2005;62:629-640.
- Influence of Caffeine on Frequency of Hypoglycemia Detected by Continuous
Interstitial Glucose Monitoring System in Patients With Long-Standing Type
1 Diabetes. Diabetes
Care 2005 28: 1316-1320. [Medscape]
- BMJ 4
June 2005 (Vol 330, No 7503)
- Childhood cancer in relation to distance from high
voltage power lines in England and Wales: a case-control study. BMJ 2005:1290,
- Day care in infancy and risk of childhood acute
lymphoblastic leukaemia: findings from UK case-control study. BMJ 2005:1294.
- Cost utility analysis of co-prescribed heroin
compared with methadone maintenance treatment in heroin addicts
in two randomised trials. BMJ 2005:1297.[Eurekalert]
- Epidemiological modelling of routine use of low
dose aspirin for the primary prevention of coronary heart disease
and stroke in those aged 70. BMJ
2005;330:1306
- Music and Ambient Operating Room Noise in Patients Undergoing Spinal
Anesthesia. Anesth
Analg 2005 100: 1316-1319.[New
Scientist]
- Nonsevere Acute Otitis Media: A Clinical Trial Comparing Outcomes of
Watchful Waiting Versus Immediate Antibiotic Treatment. Pediatrics
2005; 115: 1455-1465. [Eurekalert]
- MMWR
Guidelines: Prevention and Control of Meningococcal Disease: Recommendations
of the Advisory Committee on Immunization Practices (ACIP)
- Dietary Glycemic Index, Glycemic Load, Fiber, Simple Sugars, and Insulin
Resistance: The Inter99 study. Diabetes
Care 2005 28: 1397-1403. [Medscape]
- Saline-Filled Breast Implant Contamination with Curvularia Species among
Women Who Underwent Cosmetic Breast Augmentation.. J
Inf Dis 2005;192:000 online.
- Arthritis & Rheumatism
2005 Volume 52, Issue 6
- § Blood
pressure change with weight loss is affected by diet type in men. Am
J Clin Nutr 2005 81: 983-989. [Medscape]
- § Phase
III Trial of Ursodeoxycholic Acid To Prevent Colorectal Adenoma Recurrence. J
Natl Cancer Inst 2005; 97: 846-853. [Medscape]
- Detection of Lung Cancer by Sensor Array Analyses of Exhaled Breath. Am.
J. Respir. Crit. Care Med. 2005; 171: 1286-1291. [Medscape]
- JAMA
EARLY RELEASE: Combined Tetanus, Diphtheria, and 5-Component Pertussis
Vaccine for Adolescents and Adults [Eurekalert]
- § Nonsteroidal
Anti-Inflammatory Drug Use and Breast Cancer Risk by Stage and Hormone
Receptor Status. J
Natl Cancer Inst 2005; 97: 805-812. [Eurekalert]
- § Low-Molecular-Weight
Heparin (Dalteparin) in Women With Gynecologic Malignancy. Obstet
Gynecol 2005 105: 1006-1011.[Medscape]
- Long term failure of endoscopic gastroplication (EndoCinch).Gut
2005; 54: 752-758. [Medscape]
- New
England Journal of Medicine Volume 352 June 2,
2005 Number 22
Weekend
Reading - Basic Science and general interest articles
- FDA probes links to Viagra and blindness. [Medscape][Science
Daily]
- FDA Approvals: [Medscape]
- Focalin XR (extended-release formulation
of dexmethylphenidate) for treatment of adults, adolescents, and
children with attention deficit/hyperactivity disorder (ADHD).
- Merrem (meropenem) for treatment
of complicated skin and skin structure infections (cSSSI) in adults
and children.
- Tramadol ODT (tramadol) for the
treatment of moderate to moderately severe pain in adults.
- Nature
News: Published online: 27 May 2005; Mouse study claims plastics
pose cancer risk.
- Despite Vow, Drug Makers Still Withhold Data [NYTimes
May 31, 2005]
- Longevity controlled by calorie quality, not quantity [Eurekalert]
- § Six
sessions of sprint interval training increases muscle oxidative potential
and cycle endurance capacity in humans. J
Appl Physiol 98: 1985-1990, 2005. [Eurekalert:
A few 30 second sprints as beneficial as hour long jog]
- Linezolid versus Vancomycin in Treatment of Complicated Skin and Soft
Tissue Infections. Antimicrob.
Agents Chemother. 2005 49: 2260-2266. [Eurekalert]
- JAMA Vol.
293 No. 21, pp. 2565-E3, June 1, 2005
- Milk consumption, stroke, and heart attack risk: evidence from the Caerphilly
cohort of older men. J
Epidemiol Community Health 2005; 59: 502-505. [Eurekalert]
[Medscape]
- Circulation Volume
111, Issue 20; May 24, 2005
- Editorials: Dr Jerome Kassirer’s Book On
The Take: How Medicine’s Complicity With Big Business Can
Endanger Your Health: Worthy of Comment. Circulation
2005 111: 2552 - 2554.
- § AHA
Scientific Statements: Practical Implementation of the Guidelines
for Unstable Angina/Non–ST-Segment Elevation Myocardial Infarction
in the Emergency Department: A Scientific Statement From the American
Heart Association Council on Clinical Cardiology (Subcommittee
on Acute Cardiac Care), Council on Cardiovascular Nursing, and
Quality of Care and Outcomes Research Interdisciplinary Working
Group, in Collaboration With the Society of Chest Pain Centers. Circulation
2005 111: 2699 - 2710. [Eurekalert]
- BMJ 28
May 2005 (Vol 330, No 7502)
- § Randomised
controlled trial to compare surgical stabilisation of the lumbar
spine with an intensive rehabilitation programme for patients with
chronic low back pain: the MRC spine stabilisation trial . BMJ 2005:1233
- § Surgical
stabilisation of the spine compared with a programme of intensive
rehabilitation for the management of patients with chronic low back
pain: cost utility analysis based on a randomised controlled trial
. BMJ 2005:1239
- Systematic review and meta-analysis of studies of
the timing of tracheostomy in adult patients undergoing artificial
ventilation. BMJ 2005:1243.
- Perceptions and experiences of taking oral hypoglycaemic
agents among people of Pakistani and Indian origin: qualitative study. BMJ 2005:1247.
- Commentary: Barriers to concordance with antidiabetic
drugs—cultural differences or human nature? BMJ 2005:1250
- Management of pregnancies with RhD alloimmunisation. BMJ 2005:1255-1258,
- ABC of conflict and disaster: Natural disasters. BMJ 2005:1259-1261
- The
Lancet Volume 365, Number 9474, 28 May 2005
- Effectiveness of a large-scale distribution programme
of free nicotine patches: a prospective study. Summary
- Loss of health professionals from sub-Saharan
Africa: the pivotal role of the UK. Summary
- Abortion drugs must become WHO essential medicines. Full
Text
- Effectiveness of an educational intervention delivered
through the health services to improve nutrition in young children:
a cluster-randomised controlled trial. Summary