Recent
reports in Science and Medicine for December 2005
Some
of these links are very transient and may expire within days of posting.
Some may require prior registration. Check-in and view frequently to
avoid missing great news items. I welcome any suggested articles. (email
link). An "*" indicates
a recommended article.
Holiday
Break - Dec 22 - Jan 2
| ::::::: December
22 ::::::: |
::::::: Holiday
Reading - Basic Science and general interest articles ::::::: |
|
- Medwatch Alert:
- NeutroSpec (technetium
[99m Tc] fanolesomab) reports of serious and life-threatening cardiopulmonary
events after administration. [Medscape]
- FDA
- Approval: Nexavar (sorafenib
tosylate), a new anti-cancer medicine used to treat adults with advanced
renal cell carcinoma, the most common type of kidney cancer.
- News:
FDA to Require Food Manufacturers to List Food Allergens. Consumers with
Allergies Will Benefit From Improved Food Labels
| ::::::: December
21 ::::::: |
|
- New
England Journal of Medicine Volume 353 December 15,
2005 Number 24
- Efficacy and safety of mometasone furoate nasal spray in nasal polyposis. J
Allergy Clin Immunol. 2005;116:1272-1281. [Medscape]
- Nasal sensory nerve populations responding to histamine and capsaicin. J
Allergy Clin Immunol. 2005;116: 1282-1288.
| ::::::: December
20 ::::::: |
|
- JAMA.
2005 Vol. 294 No. 22, pp. 2811-2934, December 14, 2005
| ::::::: December
19 ::::::: |
|
- * A
Low-Glycemic Load Diet Facilitates Greater Weight Loss in Overweight Adults
With High Insulin Secretion but Not in Overweight Adults With Low Insulin
Secretion in the CALERIE Trial. Diabetes
Care 2005 28: 2939-2941. [ScienceDaily]
[Medscape]
- * Appetite
assessment: simple appetite questionnaire predicts weight loss in community-dwelling
adults and nursing home residents. Am
J Clin Nutr 2005 82: 1074-1081. [Eurekalert]
- * MMWR
Recommendations and Reports: December 9, 2005 / Vol. 54 / No. RR–14
Recommended Antimicrobial Agents for Treatment
and Postexposure Prophylaxis of Pertussis: 2005 CDC Guidelines [Medscape]
- * The
Metabolic Syndrome: Time for a Critical Appraisal: Joint statement from
the American Diabetes Association and the European Association for the
Study of Diabetes. Diabetes
Care 2005 9;28(9):2289-304.
- Study Provides First Estimate Of US Population Affected By Barrett's
Esophagus According to estimates put forth in a study published today in
the American Gastroenterological Association (AGA) journal Gastroenterology,
[ScienceDaily]
- * Generation
of Neoantigenic Epitopes After Posttranslational Modification of Type II
Collagen by Factors Present Within the Inflamed Joint. Arthritis & Rheumatism,
December 2005; 52:12; pp. 3829-3838. [Eurekalert]
- Ototoxicity in Children Receiving Platinum Chemotherapy: Underestimating
a Commonly Occurring Toxicity That May Influence Academic and Social Development. JCO
Dec 1 2005: 8588-8596. [Eurekalert and Science
Daily]
| ::::::: December
16 ::::::: |
::::::: Weekend
Reading - Basic Science and general interest articles ::::::: |
|
- FDA
ALERT [12/2005] Biaxin (clarithromycin). BMJ
article [Medscape]
- * Lost
in Translation: Challenges and Opportunities in Physician-to-Physician
Communication During Patient Handoffs. Acad
Med 2005 80: 1094-1099. [Eurekalert]
- Late-Breaking Basic Science Abstracts from AHA
Scientific Sessions 2005.
- * Phytosterol
Composition of Nuts and Seeds Commonly Consumed in the United States. J.
Agric. Food Chem., 53 (24), 9436 -9445, 2005. [Science
Daily]
- Use of a dummy (pacifier) during sleep and risk of sudden infant death
syndrome (SIDS): population based case-control study. BMJ
2005; published online. [Online
First PDF] . [Eurekalert]
- Anti-A42- and anti-A40-specific mAbs attenuate amyloid deposition in
an Alzheimer disease mouse model. JCI
Published December 8, 2005. [Science
Daily]
- Thinking the Pain Away -- Science
2005 (1212): 1 -- ScienceNOW
| ::::::: December
15 ::::::: |
|
- * ACC/AHA
Guidelines for the Management of Patients With Peripheral Arterial Disease
(Lower Extremity, Renal, Mesenteric, and Abdominal Aortic) - Executive
Summary.
- Groundbreaking Guidelines Promote Early Detection, News Treatment
of Arterial Disease. ACC Guidelines JACC and
Guidelines
- * Patent
Foramen Ovale: Innocent or Guilty? Evidence From a Prospective Population-Based
Study. J
Am Coll Cardiol, Published online 5 December 2005. [Medscape]
[Eurekalert]
- * Time
Is Brain - Quantified. Stroke
published December 8, 2005. [Medscape]
- Fast Food, Central Nervous System Insulin Resistance, and Obesity. Arterioscler
Thromb Vasc Biol. 2005 Dec;25(12):2451-62.
- Cross-Sectional Relations of Peripheral Microvascular Function, Cardiovascular
Disease Risk Factors, and Aortic Stiffness: The Framingham Heart Study. Circ
2005;112:3722-3728.
- Adherence to candesartan and placebo and outcomes in chronic heart failure
in the CHARM programme: double-blind, randomised, controlled clinical trial. The
Lancet Early Online Publication, 7 December 2005. [Medscape:
Medication Adherence Linked to Improved Heart Failure Survival]
- Arrhythmogenic Mutation-Linked Defects in Ryanodine Receptor Autoregulation
Reveal a Novel Mechanism of Ca2+ Release Channel Dysfunction. Circulation
Research published December 8, 2005. [Eurekalert Breakthrough
in unravelling the causes of sudden cardiac death in young people]
- Mechanisms of Mineralocorticoid Action. Hypertension.
2005;46:1227.
- Arrhythmogenic Right Ventricular Dysplasia. A United States Experience. Circulation
2005: published online before print December 12, 2005. [Eurekalert]
- Cost-Effectiveness of Fixed-Dose Combination of Isosorbide Dinitrate
and Hydralazine Therapy for Blacks With Heart Failure. Circulation
2005 112: 3745 - 3753. [Eurekalert]
| ::::::: December
14 ::::::: |
|
* Expression
of Concern: Bombardier et al., "Comparison of Upper Gastrointestinal
Toxicity of Rofecoxib and Naproxen in Patients with Rheumatoid Arthritis," N
Engl J Med 2000;343:1520-8. Published
at www.nejm.org December 8, 2005 . [Medscape]
New
England Journal of Medicine Volume 353 December 8, 2005
Number 23
| ::::::: December
13 ::::::: |
|
- JAMA Vol.
294 No. 21, pp. 2669-2800, December 7, 2005
- Endothelial Function in Healthy 11-Year-Old Children After Dietary Intervention
With Onset in Infancy. The Special Turku Coronary Risk Factor Intervention
Project for Children (STRIP) Circulation
2005: published online before print December 5, 2005. [Medscape]
- Quick Assessment of Literacy in Primary Care: The Newest Vital Sign. Ann
Fam Med. 2005;3:514-522. [Medscape]
| ::::::: December
12 ::::::: |
|
- Cannabinoids in multiple sclerosis (CAMS) study: safety and efficacy
data for 12 months follow up. J
Neurol Neurosurg Psychiatry 2005;76:1612,1664-1669. [Medscape]
- Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in
Humans. J.
Neurosci. 2005 25: 11489-11493. [Eurekalert]
- Annals
of Internal Medicine 6 December 2005 Volume 143 Issue 11
- Plasma Exchange When Myeloma Presents as Acute
Renal Failure: A Randomized, Controlled Trial. Clark,
and Others.
- * A
Community-Based Study of Stroke Incidence after Myocardial Infarction. Witt,
and Others. [Medscape]
- Treatment of Lateral Epicondylitis with Botulinum
Toxin: A Randomized, Double-Blind, Placebo-Controlled Trial. Wong,
and Others.
- * Hospital at Home: Feasibility and Outcomes of a
Program To Provide Hospital-Level Care at Home for Acutely Ill Older
Patients. Leff,
and Others. [Medscape]
- The Practitioner's Dilemma: Can We Use a Patient's
Race To Predict Genetics, Ancestry, and the Expected Outcomes of
Treatment? Barr
- Update in Women's Health. Crandall
and Pregler
- REVIEWS: Pathogenesis of Early Lung Disease in
Cystic Fibrosis: A Window of Opportunity To Eradicate Bacteria. Starner
and McCray
- HISTORY OF MEDICINE: Benjamin Franklin and Medicine. Hirschmann
- Managing Myeloma Kidney. Gertz
- The Myriad Uses of Botulinum Toxin. Pullman
- Hospital at Home: The Evidence Is Not Compelling. Shepperd
- ON BEING A DOCTOR: An Arctic Moon. Glazer
| ::::::: December
9 ::::::: |
::::::: Weekend
Reading - Basic Science and general interest articles ::::::: |
|
- FDA
- * News:
FDA Advising of Risk of Birth Defects with Paxil
- MedWatch:
- NeutroSpec (Technetium
[99m Tc] fanolesomab, murine IgM monoclonal antibody labeled
with technetium) reports of serious and life-threatening cardiopulmonary
events following the administration. Onset generally occurred
within minutes of injection and included two deaths attributed
to cardiopulmonary failure within 30 minutes of injection.
- Paroxetine (Paxil
and generic) exposure to paroxetine in the first trimester of pregnancy
may increase the risk for congenital malformations, particularly
cardiac malformations.Paroxetine’s pregnancy category has
been changed from C to D and added new data and recommendations
to the WARNINGS section of paroxetine’s prescribing information.
[Medscape]
- FDA Approvals: [Medscape]
- Angiomax (bivalirudin) expanded indication
for use in patients with or at risk of heparin-induced thrombocytopenia
and thrombosis syndrome (HIT/HITTS) undergoing percutaneous
coronary intervention (PCI).
- Depakote (divalproex) new indication for use
in the treatment of acute manic or mixed episodes associated with
bipolar disorder (with or without psychotic features).
- Hylenex (recombinant hyaluronidase) for use
as an adjuvant to increase the absorption and dispersion of other
injected drugs; for hypodermoclysis; and as an adjunct in subcutaneous
urography for improving resorption of radiopaque agents.
- * From Medscape Med
Students: The Examining Room of
Dr. Charles. (The medical weblog as a newliterature paradigm.)
- Sex differences in the relationship between body image change and subjective
and objective physical changes following a 12-week strength-training program. Body
Image 2005; 2: 363-372.
- * A Causal
Role for Uric acid in Fructose-induced Metabolic Syndrome. Am
J Physiol Renal Physiol online before publicaiton. [Eurekalert]
- Upregulation of Forebrain NMDA NR2B Receptors Contributes to Behavioral
Sensitization after Inflammation. J.
Neurosci. 2005 25: 11107-11116. [Eurekalert]
- Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine
adaptations to maintenance of reduced weight. J.
Clin. Invest. 115:3579-3586. [ScienceNOW]
| ::::::: December
8 ::::::: |
|
- * Severe
Clostridium difficile--Associated Disease in Populations Previously at
Low Risk. MMWR
December 2, 2005 / Vol. 54 / No. 47. [Medscape]
- Systematic review and meta-analysis of randomised controlled trials of
gastro-oesophageal reflux interventions for chronic cough associated with
gastro-oesophageal reflux. BMJ
online before print (published 5 December 2005).
- Risk of adverse gastrointestinal outcomes in patients taking cyclo-oxygenase-2
inhibitors or conventional non-steroidal anti-inflammatory drugs: population
based nested case-control analysis. BMJ
2005;331:1310-1312. [Medscape]
- * The
diagnosis and management of sinusitis: A practice parameter update. J
All Clin Immun 2005; 116 (Supplement): S13-S47 [Medscape]
- Acetaminophen-induced acute liver failure: Results of a United States
multicenter, prospective study. Hepatology.
2005;42:1252-1254, 1364-1372. [Medscape]
- Efficacy of bystander cardiopulmonary resuscitation and out-of-hospital
automated external defibrillation as life-saving therapy in commotio cordis. J
Pediatrics 2005; 147, Number 6 (December 2005), published by [Eurekalert].
- * The
Break-Even Point: When Medical Advances Are Less Important Than Improving
the Fidelity With Which They Are Delivered. Ann
Fam Med 2005 3: 545-552. [Eurekalert]
| ::::::: December
7 ::::::: |
|
- New England Journal of Medicine online
before print Dec 1, 2005.
- New
England Journal of Medicine Volume 353 December 1, 2005 Number
22
| ::::::: December
6 ::::::: |
|
- * The diagnosis
and management of sinusitis: A practice parameter up. JACI
online before print Dec 2005. [Eurekalert]
- Long-Term NSAIDs May Not Be Useful for Osteoarthritis. [Medscape]
- * Gender
and perceived severity of cardiac disease: Evidence that women are “tougher” Am
J Med 2005; 118: 1256-1261.[Eurekalert and Science
Daily]
- Endotoxin Exposure Is a Risk Factor for Asthma: The National Survey of
Endotoxin in United States Housing. Am.
J. Respir. Crit. Care Med. 2005; 172: 1371-1377. [Eurekalert]
- Association of Sleep-disordered Breathing and the Occurrence of Stroke. Am.
J. Respir. Crit. Care Med. 2005; 172: 1447-1451. [Eurekalert]
| ::::::: December
5 ::::::: |
|
- Archives
of Internal Medicine Vol. 165 No. 21, pp. 2447-2541, November
28, 2005
| ::::::: December
2 ::::::: |
::::::: Weekend
Reading - Basic Science and general interest articles ::::::: |
|
- FDA News
- MedWatch
- Aranesp (darbepoetin
alfa) and Epogen and Procrit (epoetin
alfa) Revised labeling: reports of pure red cell aplasia and
severe anemia, with or without other cytopenias, associated
with neutralizing antibodies to erythropoietin in patients
treated with Aranesp; predominantly in patients with CRF .
- NovoSeven Coagulation Factor VIIa (Recombinant) Revisioned prescribing
information to provide updated safety information on thrombotic
and thromboembolic adverse events, based on clinical studies
in non-hemophilia patients and on post-marketing safety surveillance.
A clinical study in elderly, non-hemophiliac, intracerebral
hemorrhage patients indicated a potential increased risk of
arterial thromboembolic adverse events with use of NovoSeven,
including myocardial ischemia, myocardial infarction, cerebral
ischemia and/or infarction.
- FDA
Patient Safety News: Video
News Show for Health Professionals
- FDA Labeling Approvals: [Medscape]
- Avelox (moxifloxacin) new indication for
the treatment of complicated intra-abdominal infections.
- Avandaryl (rosiglitazone plus glimepiride)
for use as an adjunct to diet and exercise to improve glycemic
control in patients with type 2 diabetes mellitus who are already
receiving rosiglitazone plus a sulfonylurea or who are not adequately
controlled on either drug alone.
- Trileptal (oxcarbazepine) expanded indication
for use as adjunctive therapy for partial seizures in epileptic
children aged 2 to 4 years.
- Giving Cancer Vaccines a Boost. [AAAS ScienceNOW report]
[News report]
- Enhancement of vaccine-mediated antitumor immunity in cancer patients
after depletion of regulatory T cells. J.
Clin. Invest. 115:3623-3633.
- Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response
to Nutrients. Science
18 November 2005: 1193-1196. [Study of genetic pathway linking nutrient
response and the aging process. Dramatically reducing food intake boosts
the lifespan of model organisms, but the new results point to a possible
mechanism through which drastic calorie restriction affects aging. [Science
Daily]
- Weblogs and Medicine: "Over My Med Body: A Proactive Med Student
Blog"
[Medscape]
| ::::::: December
1 ::::::: |
|
- * Risk
of cervical and other cancers after treatment of cervical intraepithelial
neoplasia: retrospective cohort study. BMJ
2005;331:1183-1185.
- The cognitive cost of being a twin: evidence from comparisons within
families in the Aberdeen children of the 1950s cohort study. BMJ
online 18 Nov 2005.
- Effect of comorbidities and postoperative complications on mortality
after hip fracture in elderly people: prospective observational cohort
study. BMJ
online 18 Nov 2005.
- * Risk
of cervical and other cancers after treatment of cervical intraepithelial
neoplasia: retrospective cohort study. BMJ
2005;331:1183-1185. [Eurekalert]
- * Cytoplasmic
Inclusion Bodies Are Detected by Synthetic Antibody in Ciliated Bronchial
Epithelium during Acute Kawasaki Disease. J
Inf Dis 2005;192:1757-1766.
- * Differences
in the Management and Prognosis of Women and Men Who Suffer From Acute
Coronary Syndromes . J
Am Coll Cardiol 2005 46: 1845-1851. [ScienceDaily]
- * Detection
of High-Risk Young Adults and Women by Coronary Calcium and National Cholesterol
Education Program Panel III Guidelines. J
Am Coll Cardiol 2005 46: 1931-1936.
- The Relationship Between Blood Pressure and C-Reactive Protein in the
Multi-Ethnic Study of Atherosclerosis (MESA). J
Am Coll Cardiol 2005 46: 1869-1874.
- Risk of High Blood Pressure Among Young Men Increases With the Degree
of Immaturity at Birth. Circulation
online Nov 21, 2005. [Medscape]
- * Emergent
Stenting of Extracranial Internal Carotid Artery Occlusion in Acute Stroke
Has a High Revascularization Rate. Stroke
2005; 36: 2426 - 2430.
- * Self-Monitoring
of Blood Pressure Promotes Achievement of Blood Pressure Target in Primary
Health Care. Am
J Hypertension 2005; 18: 1415-1420. [Med-News]
- Development of the Metabolic Syndrome in Black and White Adolescent Girls:
A Longitudinal Assessment. Pediatrics
2005;116:1178-1182. [Medscape]