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Recent reports in Science and Medicine for May 2006

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::::::::::            May 26            ::::::::::

1. FDA
• Approvals:
• Remicade ((infliximab) to treat children with active Crohn's disease, a chronic, inflammatory condition of the bowel that can be severely debilitating.
• Zostavax Vaccine to reduce the risk of shingles (herpes zoster) for use in people 60 years of age and older.

::::::::::            May 25             ::::::::::

1. Lung Function Decline and Outcomes in an Adult Population. Am. J. Respir. Crit. Care Med. 2006; 173: 985-990. [Eurekalert]
2. Colon Pathology Detected After a Positive Screening Flexible Sigmoidoscopy: A Prospective Study in an Ethnically Diverse Cohort. Am J Gastroenterol 2006;101:823-830. [Medscape]
3. Mediterranean diet and risk for Alzheimer's disease. Ann Neurol. Online April 18, 2006. [Medscape]
4. Alcohol Intake, Carotid Plaque, and Cognition. The Northern Manhattan Study. Stroke published online April 6, 2006. [Medscape]
5. Modulation of Hepatic Inflammatory Risk Markers of Cardiovascular Diseases by PPAR– Activators. Arteriosclerosis, Thrombosis, and Vascular Biology. 2006;26:977.
6. Realizing the Potential of Carotid Artery Stenting. Proposed Paradigms for Patient Selection and Procedural Technique. Circulation. 2006;113:2021-2030.

::::::::::            May 24            ::::::::::

1. JAMA Vol. 295 No. 19, pp. 2217-2320, May 17, 2006
   • Effect of Hypobaric Hypoxia, Simulating Conditions During Long-Haul Air Travel, on Coagulation, Fibrinolysis, Platelet Function, and Endothelial Activation. JAMA. 2006;295:2251-2261.
   • Effect of Policosanol on Lipid Levels Among Patients With Hypercholesterolemia or Combined Hyperlipidemia: A Randomized Controlled Trial. JAMA. 2006;295:2262-2269.
   • Reported Outcomes in Major Cardiovascular Clinical Trials Funded by For-Profit and Not-for-Profit Organizations: 2000-2005. JAMA. 2006;295:2270-2274.
   • Reviews: Anti-TNF Antibody Therapy in Rheumatoid Arthritis and the Risk of Serious Infections and Malignancies: Systematic Review and Meta-analysis of Rare Harmful Effects in Randomized Controlled Trials. JAMA. 2006;295:2275-2285.
   • Clinical Review: Spontaneous Spinal Cerebrospinal Fluid Leaks and Intracranial Hypotension. JAMA. 2006;295:2286-2296.
   • Editorials: How Thrombogenic Is Hypoxia? JAMA. 2006;295:2297-2299.

::::::::::            May 23            ::::::::::

1. Annals of Internal Medicine 2 May 2006 Volume 144 Issue 9
   • Treatment of Mild to Moderate Obesity with Laparoscopic Adjustable Gastric Banding or an Intensive Medical Program: A Randomized Trial. P. E. O'Brien, and Others.
   • Withholding Resuscitation: A New Approach to Prehospital End-of-Life Decisions. S. Feder, and Others.
   • Regional Variations in Health Care Intensity and Physician Perceptions of Quality of Care. B. E. Sirovich, and Others.
   • Time to Sputum Culture Conversion in Multidrug-Resistant Tuberculosis: Predictors and Relationship to Treatment Outcome. T. H. Holtz, and Others.
   • Ramipril Markedly Improves Walking Ability in Patients with Peripheral Arterial Disease: A Randomized Trial. A. Ahimastos, and Others.
     
   • Improving Patient Care: Patients' Global Ratings of Their Health Care Are Not Associated with the Technical Quality of Their Care. J. T. Chang, and Others.
   • Informed Consent for Research and Authorization under the Health Insurance Portability and Accountability Act Privacy Rule: An Integrated Approach. D. Shalowitz and D. Wendler
   • Reviews: Meta-Analysis: Low-Molecular-Weight Heparin and Bleeding in Patients with Severe Renal Insufficiency. W. Lim, and Others.
   • Editorials: Bariatric Surgery: Crossing a Body Mass Index Threshold. T. A. Wadden and A. G. Tsai
   • Withholding Resuscitation in Prehospital Care. A. Kellermann and J. Lynn
   • Does More Health Care Spending Produce Better Health and Happier Doctors? R. A. Berenson
     
   • On Being a Doctor. Working against the Grain
2. Annals of Internal Medicine  16 May 2006 Volume 144 Issue 10
   • The Prevalence of Hepatitis C Virus Infection in the United States, 1999 through 2002. G. L. Armstrong, and Others.
   • The Sensitivity and Specificity of a Simple Test To Distinguish between Urge and Stress Urinary Incontinence. J S. Brown, and Others.
   • Long-Term Cardiac Outcomes of Treating Chronic Chagas Disease with Benznidazole versus No Treatment: A Nonrandomized Trial. R. Viotti, and Others.
   • Brief Communication: Glomerulonephritis in Patients with Hepatitis C Cirrhosis Undergoing Liver Transplantation. B. M. McGuire, and Others.
     
   • Improving Patient Care: Impact of Health Information Technology on Quality, Efficiency, and Costs of Medical Care. B. Chaudhry, and Others.
     
   • Systematic Review: Bisphosphonates and Osteonecrosis of the Jaws. S-B Woo, and Others.
   • A Framework for Management of Hepatitis C in Prisons. A. C. Spaulding, and Others.
     
   • Editorials: Hepatitis C: A Bitter Harvest. J. L. Dienstag
   • The Treatment of Chagas Disease (South American Trypanosomiasis). J. C. Pinto Dias
   • Health Information Technology: Shall We Wait for the Evidence? J. D. Halamka
   • On Being a Doctor: Joan's Education. M. Overland
   • On Being a Patient: Transformation: From Medical Student to Patient. S. Hilgenberg

::::::::::            May 22             ::::::::::

• News in Cardiology
  • Knowledge About Risk Factors for Stroke: A Population-Based Survey With 28 090 Participants. Stroke. 2006;37:946.
  • Relationship Between Increasing Body Weight, Insulin Resistance, Inflammation, Adipocytokine Leptin, and Coronary Circulatory Function. J Am Coll Cardiol. 2006;97(6):1188-1195. [Medscape]
  • Comparison of the Relation Between Renal Impairment, Angiographic Coronary Artery Disease, and Long-Term Mortality in Women Versus Men. Am J Cardiol 2006;97:630-632. [Medscape]
  • Preeclampsia and the Risk of Ischemic Stroke Among Young Women: Results From the Stroke Prevention in Young Women Study. Stroke 2006 37: 1055 - 1059. [Medscape]
  • Value of Noninvasive Hemodynamics to Achieve Blood Pressure Control in Hypertensive Subjects. Blood Pressure Levels Study Group. Hypertension 2006 47: 771-777.
  • Oral Rapamycin After Coronary Bare-Metal Stent Implantation to Prevent Restenosis. The Prospective, Randomized Oral Rapamycin in Argentina (ORAR II) Study. J Am Coll Cardiol, 2006; 47:1.
  • Effect of Statin Treatment on Coronary Collateral Development in Patients With Diabetes Mellitus. Am J Cardiol 2006;97:772-774. [Medscape]
  • Short Sleep Duration as a Risk Factor for Hypertension: Analyses of the First National Health and Nutrition Examination Survey. Hypertension. 2006;47:833.
  • Distal Left Main Coronary Disease Is a Major Predictor of Outcome in Patients Undergoing Percutaneous Intervention in the Drug-Eluting Stent Era
  • An Integrated Clinical and Angiographic Analysis Based on the Rapamycin-Eluting Stent Evaluated At Rotterdam Cardiology Hospital (RESEARCH) and Taxus-Stent Evaluated At Rotterdam Cardiology Hospital (T-SEARCH) Registries. J Am Coll Cardiol, 2006; 47:1530-1537.
  • Aerobic Training Decreases B-Type Natriuretic Peptide Expression and Adrenergic Activation in Patients With Heart Failure. J Am Coll Cardiol 2006 47: 1835-1839. [Science Daily]

::::::::::            May 19            ::::::::::

1. FDA
• MedWatch:
  • Oral Sodium Phosphates (OSP) linked to rare risk for acute nephropathy. Medscape Alert
  • Paxil (paroxetine) Labeling changes to the Clinical Worsening and Suicide Risk subsection of the WARNINGS section in the prescribing Information for Paxil. These labeling changes relate to adult patients, particularly those who are younger adults. A recent meta-analysis showed a higher frequency of suicidal behavior in young adults treated with paroxetine compared with placebo. [Medscape: Paxil Products Linked to Increased Risk for Suicidality in Young Adults]
• Approval: Chantix (varenicline tartrate) tablets, to help cigarette smokers stop smoking.
• FDA Statement: Bausch & Lomb Global Recall of ReNu with MoistureLoc Contact Lens Cleaning Solution. FDA: Inspection findings.

::::::::::            May 12            ::::::::::

1. FDA
• MedWatch: Oral Sodium Phosphates (OSP) linked to rare risk for acute nephropathy. Medscape Alert
• Approval: Chantix (varenicline tartrate) tablets, to help cigarette smokers stop smoking.

::::::::::            May 5

:::::::::  Weekend Reading - Basic Science and general interest articles  :::::::::

1. FDA
• News: FDA Approves First Treatment for Pompe Disease [News report]
• FDA Approves Dacogen (decitabine) injection for the treatment of myelodysplastic syndromes (MDS).

::::::::::            May 2            ::::::::::

1. New England Journal of Medicine Volume 354 April 27, 2006 Number 17
   • The South Asian Earthquake Six Months Later — An Ongoing Crisis. R. J. Brennan and R. J. Waldman
   • Becoming a Physician: The New Medical "Missionaries" — Grooming the Next Generation of Global Health Workers. C. Panosian and T. J. Coates
   • Lung Recruitment in Patients with the Acute Respiratory Distress Syndrome. L. Gattinoni and Others
   • Thyroxine in Goiter, Helicobacter pylori Infection, and Chronic Gastritis. M. Centanni and Others
   • Vitamins C and E and the Risks of Preeclampsia and Perinatal Complications. A. R. Rumbold and Others
   • Brief Report: Variant of Hepatitis B Virus with Primary Resistance to Adefovir. O. Schildgen and Others
   • Medical Progress: Hematopoietic Stem-Cell Transplantation. E. A. Copelan
   • PEEP or No PEEP — Lung Recruitment May Be the Solution. A. S. Slutsky and L. D. Hudson
   • Antioxidants and the Prevention of Preeclampsia — Unresolved Issues. A. Jeyabalan and S. N. Caritis
   • Disciplining the Stem Cell into Myogenesis. T. Partridge
   • Aspirin to Prevent Gentamicin-Induced Hearing Loss. Correspondence. [Medscape]

::::::::::            May 1            ::::::::::

1. Neuroanatomic correlates of stroke-related myocardial injury. Neurology published March 8, 2006. [Eurekalert]
2. Characteristics of Adolescents and Young Adults With ADHD Who Divert or Misuse Their Prescribed Medications. J Am Acad Child and Adolesc Psych [Eurekalert]
3. Linking Implicit and Explicit Memory: Common Encoding Factors and Shared Representations. Neuron 2006; 49: 917-927. [ScienceDaily]
4. Polyethylene glycol treatment after traumatic brain injury reduces -amyloid precursor protein accumulation in degenerating axons. J Neuroscience Online: 22 Mar 2006
5. Hydralazine rescues PC12 cells from acrolein-mediated death (p NA). J Neurosci Res. 2006; Published Online: 17 Apr 2006 [ScienceDaily]
6. Pyridostigmine Treatment Trial in Neurogenic Orthostatic Hypotension. Arch Neurol. 2006;63:513-518.
7. Antihypertensive Medication Use and Incident Alzheimer Disease; The Cache County Study. Arch Neurol. 2006;63:(early release)
8. JAMA  Vol. 295 No. 16, pp. 1867-1964, April 26, 2006
   • Pacemaker and ICD Generator Malfunctions: Analysis of Food and Drug Administration Annual Reports. JAMA. 2006;295:1901-1906.
   • Complications Associated With Implantable Cardioverter-Defibrillator Replacement in Response to Device Advisories . The Canadian Heart Rhythm Society Working Group on Device Advisories. JAMA. 2006;295:1907-1911.
   • Association Between Hospital Process Performance and Outcomes Among Patients With Acute Coronary Syndromes. JAMA. 2006;295:1912-1920. [Medscape]
   • Financial Conflict of Interest Disclosure and Voting Patterns at Food and Drug Administration Drug Advisory Committee Meetings. JAMA. 2006;295:1921-1928. [Medscape]
   • Review: Pacemaker and ICD Generator Reliability: Meta-analysis of Device Registries. JAMA. 2006;295:1929-1934.
   • Using Clinical Guidelines Designed for Older Adults With Diabetes Mellitus and Complex Health Status. JAMA. 2006;295:1935-1940.
   • Physician-Assisted Suicide: A Legitimate Medical Practice? JAMA. 2006;295:1941-1943.
   • Editorial: Pacemaker and ICD Malfunction—An Incomplete Picture. JAMA. 2006;295:1944-1946.
   • From the Centers for Disease Control and Prevention
     • Primary and Secondary Syphilis—United States, 2003-2004. JAMA. 2006;295:1890-1891.
     • Human Rabies—Mississippi, 2005. JAMA. 2006;295:1892-1894.
     • QuickStats: Trends in Mean Total Cholesterol Among Adults Aged 20-74 Years, by Age Group—United States, 1960-1962 to 1999-2002. JAMA. 2006;295:1894.

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