Recent
reports in Science and Medicine for November 2005
Some
of these links are very transient and may expire within days of posting.
Some may require prior registration. Check-in and view frequently to
avoid missing great news items. I welcome any suggested articles. (email
link). An "*" indicates
a recommended article.
| ::::::: November
30 ::::::: |
|
- New
England Journal of Medicine Volume 353 November 24, 2005 Number
21
| ::::::: November
29 ::::::: |
|
- Low-fat dairy consumption and reduced risk of hypertension: the Seguimiento
Universidad de Navarra (SUN) cohort. Am
J Clin Nutr 2005 82: 972-979. [Medscape]
- * Carbohydrate
restriction improves the features of Metabolic Syndrome. Metabolic Syndrome
may be defined by the response to carbohydrate restriction. Nutrition & Metabolism
2005, 2:31 doi:10.1186/1743-7075-2-31 [Science
Daily]
- Characterization and consequences of pain variability in individuals
with fibromyalgia. Arth & Rheum
2005; 52: 3670 - 3674. [Eurekalert:
Pain research helps identify who responds to 'placebo effect']
- The Association of Comorbid Depression With Mortality in Patients With
Type 2 Diabetes. Diabetes
Care 2005;28:2668-2672. [Medscape]
- JAMA Vol.
294 No. 20, pp. 2539-2660, November 23/30, 2005
| ::::::: November
28 ::::::: |
|
- Preoperative Prostate Specific Antigen Doubling Time and Velocity Are
Strong and Independent Predictors of Outcomems Following Radical Prostatectomy. J
Urology 2005;174: 2191-2196. [Eurekalert]
- Sedative hypnotics in older people with insomnia: meta-analysis of risks
and benefits. BMJ
online 11 Nov 2005. [Eurekalert and Medscape]
- * Clinical
review: Shoulder pain: diagnosis and management in primary care. BMJ
2005;331:1124-1128.
- * NT-proBNP
testing for diagnosis and short-term prognosis in acute destabilized heart
failure: an international pooled analysis of 1256 patients. The International
Collaborative of NT-proBNP Study. Eur
Heart J published online on Nov 17, 2005. [Eurekalert]
[Medscape]
- Annals of Internal
Medicine 15 November 2005 Volume 143 Issue 10 Previous Issue
- Trends in the Incidence of Venous Thromboembolism
during Pregnancy or Postpartum: A 30-Year Population-Based Study. JA
Heit, and Others. [Medscape]
- The Relationship between Condom Use and Herpes
Simplex Virus Acquisition. A
Wald, and Others.
- Impact of Efavirenz on Neuropsychological Performance
and Symptoms in HIV-Infected Individuals. D
B Clifford, and Others.
- * The
Metabolic Syndrome as a Predictor of Nonalcoholic Fatty Liver Disease. M
Hamaguchi, and Others.
- Improving Patient Care. Quality of HIV Care Provided
by Nurse Practitioners, Physician Assistants, and Physicians. I
B Wilson, and Others
- Update in Cardiology. P
H Stone
- Perspectives: The Terri Schiavo Case: Legal, Ethical,
and Medical Perspectives. J
E Perry, and Others.
- Editorials: Thromboembolism in Pregnancy: A Continuing
Conundrum. R
V Lee
- An Ounce of Prevention. E
W Hook
- Dangerous Liaisons: The Metabolic Syndrome and
Nonalcoholic Fatty Liver Disease. E
E Powell, and Others.
- On
Being a Doctor. Looking for Betty.
| ::::::: November
23 - 25 ::::::: |
::::::: Holiday
and Weekend Reading - Basic Science and general interest articles ::::::: |
- MedWatch:
FDA:
- Serevent, Advair,
and Foradil Linked to Risk of Severe Asthma Exacerbations,
Death [Medscape]
- Public
Health Advisory: Several long-acting bronchodilator medicines have
been associated with possible increased risk of worsening wheezing
(bronchospasm) in some people, and the agency is requesting that manufacturers
update warnings in their existing product labeling.
- Flomax (tamsulosin
HCl) revision to the prescribing information for Flomax, indicated for
the treatment of the signs and symptoms of benign prostatic hyperplasia
(BPH). A surgical condition termed Intraoperative Floppy Iris Syndrome
(IFIS) has been observed during phacoemulsification cataract surgery
in some patients treated with alpha-1 blockers including Flomax. It is
recommended that male patients being considered for cataract surgery,
as part of their medical history, be specifically questioned to ascertain
whether they have taken Flomax or other alpha-1 blockers.
- FDA drug prescribing warnings: is the black box half empty or half full? Pharmacoepidemiology
and Drug Safety online in advance of print.
- * Obestatin,
a Peptide Encoded by the Ghrelin Gene, Opposes Ghrelin's Effects on Food
Intake. Science
11 November 2005: 996-999. [LiveScience]
- * A primate
virus generates transformed human cells by fusion. JCB
2005; 171: 493-503. Common viruses may cause cancer: Study implicates
viral-mediated cell fusion as a possible engine of tumor formation. [Eurekalert] JCB
Editorial
- Enlightening the adrenal gland. Cell
Metabolism 2005; 2: 278-281. [Eurekalert]
| ::::::: November
22 ::::::: |
|
- Duration of protection with RTS,S/AS02A malaria vaccine in prevention
of Plasmodium falciparum disease in Mozambican children: single-blind extended
follow-up of a randomised controlled trial. Early
Release from The Lancet.
- Tamoxifen for the Prevention of Breast Cancer: Current Status of the
National Surgical Adjuvant Breast and Bowel Project P-1 Study. J
Natl Cance Inst 2005; 97: 1652-1662. [Medscape]
- Lifetime Recreational Exercise Activity and Breast Cancer Risk Among
Black Women and White Women. J
Natl Cancer Inst 2005;97:1671-1679. [Medscape]
- Diabetes Mellitus and Risk of Colorectal Cancer: A Meta-Analysis. J
Natl Cancer Inst 2005; 97: 1679-1687. [Medscape]
- Archives
of Internal Medicine Vol. 165 No. 20 November
14, 2005
| ::::::: November
21 ::::::: |
|
- * Plasma
Lipoproteins and Apolipoproteins as Predictors of Cardiovascular Risk and
Treatment Benefit in the PROspective Study of Pravastatin in the Elderly
at Risk (PROSPER) . Circulation
2005: published online before print Nov 7. [Medscape]
- * Obesity
and Risk of New-Onset Atrial Fibrillation After Cardiac Surgery. Circulation
published online Nov 14, 2005. [Medscape]
- * Angiographic
and Clinical Outcomes in Patients Receiving Low-Molecular-Weight Heparin
Versus Unfractionated Heparin in ST-Elevation Myocardial Infarction Treated
With Fibrinolytics in the CLARITY-TIMI 28 Trial. Circulation
published online Nov 15, 2005.
- * Proinflammatory
cytokine responses induced by influenza A (H5N1) viruses in primary human
alveolar and bronchial epithelial cells. Respiratory
Research, 2005, in press. [Science
Daily]
- New
England Journal of Medicine Volume 353 November 17, 2005 Number 20
| ::::::: November
18 ::::::: |
::::::: Weekend
Reading - Basic Science and general interest articles ::::::: |
|
- FDA Approvals:
- [Medscape]
- Clobex (clobetasol propionate
spray) for the treatment of moderate to severe plaque psoriasis
affecting up to 20% of body surface area (BSA) in patients
aged 18 years and older
- Tarceva/Gemzar (erlotinib)
new indication for use in combination with gemcitabine for
the first-line treatment of locally advanced, unresectable,
or metastatic pancreatic cancer.
- [Medscape]
- Exjade (deferasirox) for
the treatment of chronic transfusional hemosiderosis in patients
aged two years and older.
- Oncaspar (pegaspargase)
intravenous preparation as alaternative to intramuscular injection,
which is often painful to patients.
- Invanz (ertapenem) new indication
for once-daily administration for the treatment of moderate
to severe complicated foot infection due to designated pathogens
in diabetic patients without osteomyelitis.
- FDA Updates Labeling
for Ortho Evra Contraceptive Patch.
- FDA MedWatch
- Ortho
Evra (norelgestromin/ethinyl estradiol transdermal system)
Revisions to the labeling to include a bolded warning about higher
exposure to estrogen for women using the weekly patch compared to
taking a daily birth control pill containing 35 micrograms of estrogen.
A woman on Ortho Evra may be exposed to approximately 60% more estrogen
than if she were taking a typical 35 microgram estrogen birth control
pill. [Medscape]
- Separation of Conjoined Hormones Yields Appetite Rivals. Science,
Vol 310, Issue 5750, 985-986 , 11 November 2005. [Science
NOW: Taking a Bite Out of Hunger ]
- Oct. 28 issue of the Morbidity and Mortality Weekly Report on the decreased
quality of life and increased prevalence of disability in adults with epilepsy.
[Medscape] MMWR.
2005;54;1073-1096.
- * Cleavage
of the MLL gene by activators of apoptosis is independent of topoisomerase
II activity. Leukemia
2005; ; advance online publication. [Eurekalert:
Mechanism of how chemotherapy-induced leukemia develops]
- From Cancer Patient to Cancer Survivor: Lost in Transition. Institue
of Medicine Report. [Eurekalert]
- The Cost Of Health Insurance Administration In California: Estimates
For Insurers, Physicians, And Hospitals. Health
Affairs 2005; 24: 1629-1639. [Science
Daily] [News]
- Health Care Reform: Why? What? When? Health
Affairs 2005; 24:1399-1414.
- * Risk
Indicators for Tooth Loss Due to Periodontal Disease. J
Periodontology 2005; 76: 1910-1918. [Eurekalert]
| ::::::: November
17 ::::::: |
|
- * JAMA
EARLY RELEASE: Efficacy and Safety of Edifoligide, an E2F Transcription
Factor Decoy, for Prevention of Vein Graft Failure Following Coronary
Artery Bypass Graft Surgery. PREVENT IV: A Randomized Controlled Trial.
PREVENT IV Investigators* JAMA.
2005;294.19.2446. [Eurekalert]
- * JAMA-EXPRESS
EARLY RELEASE: Effect of Muraglitazar on Death and Major Adverse
Cardiovascular Events in Patients With Type 2 Diabetes Mellitus. JAMA.
2005;29450147.
- JAMA
Vol. 294 No. 19, pp. 2395-2528, November 16, 2005
| ::::::: November
16 ::::::: |
|
- Paternity Following Treatment for Testicular Cancer. J
Natl Cancer Inst 2005; 97: 1580-1588. [News}
- HIV-infected individuals receiving effective antiviral therapy for extended
periods of time continually replenish their viral reservoir. J.
Clin. Invest. 2005 115: 3250-3255.
- * The
natural history of tree nut allergy. JACI
2005; Published online. [Eurekalert, Science
Daily]
- Non-steroidal anti-inflammatory drugs and risk of neoplastic progression
in Barrett's oesophagus: a prospective study. Vaughan TL, and Others. Lancet
Oncology 2005; (via ScienceDirect)
[News
report]
- PLoS:
Malaria Special Collection: [Science NOW] (Malaria
Vaccine Initiative, Malaria
Information from WHO, List
of vaccines in development)
- Promising Functional Readouts of Immunity in a Blood-Stage Malaria
Vaccine Trial. Perspective
- A Malaria Vaccine That Elicits in Humans Antibodies Able to Kill
Plasmodium falciparum. Synopsis; Article
- Is there cognitive decline 1 year after CABG?: Comparison with surgical
and nonsurgical controls. Neurology
2005 65: 991-999. [Eurekalert]
- Overdiagnosis of multiple sclerosis and magnetic resonance imaging criteria. Ann
Neurol 2005;58:781-783 [Eurekalert:
Neurologists refine multiple sclerosis diagnostic criteria]
- Preliminary assessment of the efficacy, tolerability and safety of a
cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid
arthritis. Rheumatology
published online Nov 9, 2005. [Eurekalert]
- Moving Forward in Fall Prevention: An Intervention to Improve Balance
Among Older Adults in Real-World Settings. Am
J Public Health 2005 95: 2049-2056.
- Treatment of pancreatic carcinoma by adenoviral mediated gene transfer
of vasostatin in mice. Gut
published Online First: 15 November 2005. [New
Scientist]
| ::::::: November
15 ::::::: |
|
- New
England Jourdnal of Medicine Volume 353 November 10, 2005
Number 19
- * Incremental
shuttle walking is associated with activation of haemostatic and haemorheological
markers in patients with coronary artery disease: the Birmingham rehabilitation
uptake maximisation study (BRUM). Heart
2005;91:1413-1417. [Eurekalert :
Sudden Exertional Stress Activates Hemostatic Markers in Heart Disease]
- Waist-to-Hip Ratio vs BMI May Be More Accurate Predictor of CV Risk.
[Eurekalert report
from Lancet. 2005;366:1589-1591,
1640-1649.]
| ::::::: November
14 ::::::: |
|
- * Body
Fat Distribution, Liver Enzymes, and Risk of Hypertension: Evidence From
the Western New York Study. Hypertension
2005 46: 1186-1193. [Science
Daily]
- Journal of the American
College of Cardiology Volume 46, Issue 10, November 15, 2005
- Circulation Volume
112, Issue 19; November 8, 2005
| ::::::: November
11 ::::::: |
::::::: Weekend
Reading - Basic Science and general interest articles ::::::: |
|
- FDA Approvals Orphan Drugs [Medscape]
- Zactima ( ZD6474) for the treatment
of follicular, medullary, anaplastic, and locally advanced and metastatic
papillary thyroid cancer.
- Surfaxin (lucinactant) for the treatment
of bronchopulmonary dysplasia (chronic lung disease [CLD]) in premature
infants.
- IL-21 (interleukin 21) for the treatment
of advanced or aggressive melanoma.
- FDA Approval:
- Exjade (deferasirox)
an oral iron chelator developed to treat chronic iron overload due to
multiple blood transfusions.
- FDA MedWatch Safety Labeling Changes:
- Celebrex. [Medscape]
- Amevive (alefacept:
indicated for the treatment of adult patients with chronic plaque psoriasis)
revision to prescribing information Amevive should not be administered
to patients infected with HIV. Amevive reduces CD4+ T lymphocyte counts.
- Parenteral Maltose/Parenteral
Galactose/Oral Xylose-Containing Products. Warning
of the potential for life-threatening falsely elevated glucose
readings. A preliminary listing of U.S. products that may cause
glucose test interference is provided.
- CDC Committee Recommends Routine Hepatitis A Vaccination for Children.
The Advisory
Committee on Immunization Practices (ACIP) unanimously agreed on universal
hepatitis A vaccination for children between 12 to 35 months of age, with
catch-up vaccination through the pre-school years. [Medscape]
- * Indicators:
Gut Reaction: Lying Is Tied to Digestive Changes. [NYT
report from the annual meeting of the American College of Gastroenterology
(Medscape) ; the
study began as a high school project]
- Regulation of Oxidative Stress by the Anti-aging Hormone Klotho. J.
Biol. Chem. 2005 280: 38029-38034.
- Treatment of Autoimmune Neuroinflammation with a Synthetic Tryptophan
Metabolite. Science,
2005; 310 4 Nov. [NewScientist New
treatment for multiple sclerosis tested]
- Neurogenesis in the Hypothalamus of Adult Mice: Potential Role in Energy
Balance. Science
2005: p.679-683; 28 October . [ScienceNOW More
Brain, Less Gain. Ciliary neurotrophic factor (CNTF) induces weight loss
in obese rodents and humans, and for reasons that are not understood, its
effects persist after the cessation of treatment.] [Nature
news]
- A recipe for overeating: Studies outline dangers of mixing stress, deprivation
and tempting foods: [Eurekalert]
Behavioral Neuroscience Volume 119, Issue 4
- Various Aspects of Feeding Behavior Can Be Partially
Dissociated in the Rat by the Incentive Properties of Food and the Physiological
State. Barbano
and Others.
- Combined Dieting and Stress Evoke Exaggerated Responses
to Opioids in Binge-Eating Rats. Boggiano,
et al.
- Portal sensing of intestinal gluconeogenesis is a mechanistic link in
the diminution of food intake induced by diet protein. Cell
Metabolism 2005; 2: 321-329. [Science
NOW] [Eurekalert]
| ::::::: November
10 ::::::: |
|
- JAMA Vol.
294 No. 18, pp. 2273-2386, November 9, 2005
- American Gastroenterological Association Updates Dyspepsia Guidelines, Gastroenterology.
2005;129:1753-1780. [Medscape]
- Risk factors and comorbidities in primary biliary cirrhosis. USA PBC
Epidemiology Group. Hepatology
2005; 42: 1194 - 1202. [Eurekalert]
| ::::::: November
9 ::::::: |
|
- * Advancing
Human Circadian Rhythms with Afternoon Melatonin and Morning Intermittent
Bright Light. J
Clin Endocrinol Metab published November 1, 2005. [Eurekalert]
- * Effect
of a High-Carbohydrate Versus a High—cis-Monounsaturated
Fat Diet on Blood Pressure in Patients With Type 2 Diabetes. Diabetes
Care. 2005;28:2607-2612. [Medscape]
- Laparoscopic Gastric Banding Prevents Type 2 Diabetes and Arterial Hypertension
and Induces Their Remission in Morbid Obesity: A 4-year case-controlled
study. Diabetes
Care 2005;28:2703-2709. [Medscape]
- Peptide YY(3–36) Inhibits Morning, but Not Evening, Food Intake
and Decreases Body Weight in Rhesus Macaques. Diabetes
2005 54: 3198-3204. [Eurekalert:
Study reveals hormone can reduce food intake, body weight]
- Prevalence of Impaired Fasting Glucose and Its Relationship With Cardiovascular
Disease Risk Factors in US Adolescents, 1999–2000. Pediatrics
Vol. 116 No. 5 November 2005, pp. 1122-1126
- MMWR November 4, 2005 / Vol.
54 / No. 43
- Incidence of End-Stage Renal Disease Among Persons
With Diabetes. United States, 1990 - 2002. MMWR.
2005;54;1097 [Medscape]
- Controlling Tuberculosis in the United States: Recommendations
from the American Thoracic Society, CDC, and the Infectious Diseases
Society of America. MMWR
2005; 54: No. RR–12
| ::::::: November
8 ::::::: |
|
- New
England Journal of Medicine Volume 353 November 3, 2005 Number 18
| ::::::: November
7 ::::::: |
|
- JAMA Vol.
294 No. 17 November 2, 2005
| ::::::: November
4 ::::::: |
::::::: Weekend
Reading - Basic Science and general interest articles ::::::: |
|
- FDA MedWatch
- Zevalin (ibritumomab
tiuxetan) Revision of the Prescribing Information to describe severe
cutaneous or mucocutaneous reactions, some with fatal outcome, that have
been reported in association with the Zevalin therapeutic regimen in
the post-marketing experience. Patients experiencing a severe cutaneous
or mucocutaneous reaction should not receive any further components of
the Zevalin therapeutic regimen and should seek prompt medical evaluation.
[Medscape]
- Avinza (morphine
extended-release) revisions to the prescribing information to highlight
and strengthen the warning that patients should not consume alcohol while
taking Avinza. Additionally, patients must not use prescription or non-prescription
medications containing alcohol while on Avinza therapy.
- FDA Approvals:
- Arranon (nelarabine)
for rare leukemia and lymphoma approved under Orphan Drug and Accelerated
Approval Program for the treatment of T-cell acute lymphoblastic leukemia
(T-ALL) and T-cell lymphoblastic lymphoma (T-LBL) in patients who have
not responded to or have relapsed after treatment with at least two chemotherapy
regimens.
- Medscape report
- Kaletra (a new yellow tablet
formulation of 200 mg/50 mg of lopinavir/ritonavir) that will replace
the 133.3-mg/33.3-mg orange capsules by March 2006. Unlike the
capsules, the film-coated tablets can be taken with or without
food and do not require refrigeration before or after dispensing.
Moreover, fewer tablets than capsules are required per 800-mg/200-mg
dose per day (four tablets vs six capsules).
- Soltamox (10-mg/5-mL oral solution of tamoxifen)
for the treatment of breast cancer in adjuvant and metastatic settings;
to reduce the risk of breast cancer in women with ductal carcinoma
in situ; and to reduce breast cancer incidence in women at high risk
of the disease.
- Medscape report
- Lunar iDXA, a total-body dual-energy
x-ray absorptiometry (DXA) system for use as an aid in the detection
and diagnosis of osteoporosis, and for monitoring subsequent treatment.
- Urgent PC, a percutaneous tibial
nerve stimulation system for the minimally invasive treatment of
overactive bladder symptoms such as urinary urgency, urinary frequency,
and urge incontinence.
- MimyX a nonsteroidal dressing
for the management and relief of burning and itching associated with
atopic dermatitis, allergic-contact dermatitis, radiation dermatitis,
and other physician-diagnosed dermatoses in adult and pediatric patients.
- FDA News:
- FDA
News: FDA and Industry to Collaborate on Better Ways to Predict
Liver Toxicity in Human Drug Trials
- FDA
News: FDA Announces the Use of New Electronic Drug Labels to
Help Better Inform the Public and Improve Patient Safety [Medscape]
- FDA
Announces the Use of New Electronic Drug Labels to Help Better
Inform the Public and Improve Patient Safety
- Richard E. Smalley, 62, Dies; Chemistry Nobel Winner. [NYTimes
Obituary] [NPR
audio report]
- Activation of Myogenic Differentiation Pathways in Adult Bone Marrow-Derived
Stem Cells. Mol.
Cell. Biol. 2005 25: 9509-9519. [News]
- * Restoration
of immunity in lymphopenic individuals with cancer by vaccination and adoptive
T-cell transfer. Nature
Medicine (16 Oct 2005). [Eurekalert:
Rapid restoration of immunity in immune-suppressed cancer patients using
T-cell vaccines]
- Discovery of human inversion polymorphisms by comparative analysis of
human and chimpanzee DNA sequence assemblies. PLoS
Genetics DOI: 0.1371. [Eurekalert]
- * Orbitofrontal
cortex activity related to emotional processing changes across the menstrual
cycle. PNAS
published October 24, 2005, 10.1073. [ScienceNOW]
| ::::::: November
3 ::::::: |
|
- * Enzyme-linked
Immunospot and Tuberculin Skin Testing to Detect Latent Tuberculosis Infection. Am.
J. Respir. Crit. Care Med. 2005; 172: 1161-1168. [Eurekalert]
- Clinical and Pathologic Features of Familial Interstitial Pneumonia. Am.
J. Respir. Crit. Care Med. 2005; 172: 1146-1152. [Eurekalert]
- * The
Long-term Predictive Accuracy of the Short Synacthen (Corticotropin) Stimulation
Test For Assessment of the Hypothalamic-Pituitary-Adrenal Axis. J
Clin Endocrinol Metab online October 25, 2005. [Medscape]
- Annals of Internal
Medicine 1 November 2005 Volume 143 Issue 9
| ::::::: November
2 ::::::: |
|
- The Association of Comorbid Depression With Mortality in Patients With
Type 2 Diabetes. Diabetes
Care 2005 28: 2668-2672. [Eurekalert]
- MMWR. 2005;54;1041-1072 [Medscape]
- Subacute Sclerosing Panencephalitis: More Cases of This Fatal Disease
Are Prevented by Measles Immunization than Was Previously Recognized. J
Inf Dis 2005;192:1686-1693. [Editorial]
[IDSA
Statement]
- Risk Factors for Perinatal Transmission of Hepatitis C Virus (HCV) and
the Natural History of HCV Infection Acquired in Infancy. J
Inf Dis 2005; 192:000. [Eurekalert]
- Positive effects of moderate exercise on glycosaminoglycan content in
knee cartilage: A four-month, randomized, controlled trial in patients
at risk of osteoarthritis. Arthritis & Rheumatism
2005; 52: 3507-3514. [News
Report] [Eurekalert:
Regular physical activity may strenghten knee cartilage]
- Clinical and radiographic outcomes of four different treatment strategies
in patients with early rheumatoid arthritis (the BeSt study): A randomized,
controlled trial. Arthritis & Rheumatism
2005; 53: 3381-3390.
- Early and Late Benefits of High-Dose Atorvastatin in Patients With Acute
Coronary Syndromes: Results From the PROVE IT-TIMI 22 Trial. J
Am Coll Cardiol 2005 46: 1405-1410. [Medscape]
- Results of a randomized controlled trial to increase colorectal cancer
screening in a managed care health plan (p NA) . Cancer
2005 Nove 15 published online DOI: 10.1002/cncr.21434. [Medscape]
| ::::::: November
1 ::::::: |
|
- New
England Journal of Medicine Volume 353 October 27, 2005 Number
17