Recent
reports in Science and Medicine for July 2005
Some
of these links are very transient and may expire within days of posting.
Some may require prior registration. Check-in and view frequently to
avoid missing great news items. I welcome any suggested articles. (email
link). "§" or
"* "indicates
a recommended article.
| ::::::: July 29 ::::::: |
Weekend
Reading - Basic Science and general interest articles
|
|
- FDA Approvals: [Medscape]
- Rozerem [Eurekalert]
(ramelteon) for the treatment of insomnia characterized by difficulty
with sleep onset.
- Synera (lidocaine-tetracaine topical
patch) for use on intact skin to provide local dermal analgesia
for superficial venous access and dermatologic procedures such
as excision electrodessication and shave biopsy of skin lesions.
- Avelox IV (moxifloxacin) new indication
for the treatment of complicated skin and skin structure infections
(cSSSI) caused by methicillin-susceptible Staphylococcus aureus, Escherichia
coli, Klebsiella pneumoniae, or Enterobacter
cloacae.
- FDA: Orphan Drug Approvals: [Medscape]
- Bronchitol (mannitol)
to facilitate mucus clearance in patients with cystic fibrosis
(CF) at risk for bronchiectasis.
- Prestara (prasterone) indication
for the prevention of loss of bone mineral density (BMD) in patients
with systemic lupus erythematosus receiving glucocorticoid therapy.
- GTI-2040 (antisense 20-mer phosphorothioate
oligonucleotide) for the treatment of acute myeloid leukemia (AML).
- Guidant ICD Recommendation: Risk of Malfunction. [Medscape]
in VENTAK PRIZM, VITALITY, and CONTAK RENEWAL AVT implantable cardioverter
defibrillators (ICDs) Erk Associates with and Primes GSK-3? for Its Inactivation
Resulting in Upregulation of ?-Catenin. Molecular
Cell 2005;19:159-170. [Eurekalert:
Hepatitis B virus and liver cancer]
- Dynamics of Mammalian Chromosome Evolution Inferred from Multispecies
Comparative Maps. Science
22 July 2005: 613-617. [Eurekalert:
Comparative chromosome study finds breakage trends, cancer ties]
- The Role of Innate Immune Responses in the Outcome of Interspecies Competition
for Colonization of Mucosal Surfaces. PLOS-Pathogens
2005:1:1. [ScienceNOW review]
- New method shows it is possible to grow bone for grafts within a patient's
body Published online in PNAS.
[Eurekalert]
[ScienceNOW]
- Stem cells can treat heart attacks in pigs [ScienceDaily]
from PNAS
- Myocardial Substrate Metabolism in the Normal and Failing Heart. Physiol.
Rev. 85: 1093-1129, 2005 [Eurekalert]
- Journal of Clinical
Pathology 2005; 58: 823, 860 New
Scientist , Chronic fatigue is not all in the mind
- Obesity and Risk of Nonfatal Unintentional Injuries. Am
J Prev Med 2005; 29: 41-45. (ScienceDirect) [Science
Daily] [News
report]
- * Moraxella
catarrhalis in Chronic Obstructive Pulmonary Disease: Burden of Disease
and Immune Response. Am.
J. Respir. Crit. Care Med. 2005; 172: 195-199.[Science
Direct]
- * Day
After the Night Before: Influence of evening alcohol on risk of hypoglycemia
in patients with type 1 diabetes. Diabetes
Care 2005 28: 1801-1802. [Medscape]
- Folate, Vitamin B12, and Risk of Ischemic and Hemorrhagic Stroke: A
Prospective, Nested Case-Referent Study of Plasma Concentrations and Dietary
Intake. Stroke
2005 36: 1426 - 1431. [Medscape]
- * Pulsed
High-Dose Corticosteroids Combined With Low-Dose Methotrexate in Severe
Localized Scleroderma. Arch
Dermatol. 2005;141:847-852. [Medscape review]
- Archives of Internal Medicine Vol. 165 No. 14, July 25, 2005
- New
England Journal of Medicine Volume 353 July 21, 2005 Number 3
- * Inhibition
of Awake Sympathetic Nerve Activity of Heart Failure Patients With Obstructive
Sleep Apnea by Nocturnal Continuous Positive Airway Pressure. J
Am Coll Cardiol 2005 45: 2008-2011. [Medscape]
- * Metabolic
Syndrome and Risk of Cardiovascular Events After Myocardial Infarction. J
Am Coll Cardiol, 2005; 46:277-283.
- * Efficacy
of Breast Cancer Screening in the Community According to Risk Level. JNCI
2005; 97: 1035-1043. [Medscape]
- JAMA
Vol. 294 No. 3, pp. 281-390, July 20, 2005
- Administrative Data Feedback for Effective Cardiac
Treatment: AFFECT, A Cluster Randomized Trial. JAMA.
2005;294:309-317.
- Chronic Conditions, Functional Limitations, and
Special Health Care Needs of School-aged Children Born With Extremely
Low-Birth-Weight in the 1990s. JAMA.
2005;294:318-325.
- * Non–HDL
Cholesterol, Apolipoproteins A-I and B100, Standard Lipid Measures,
Lipid Ratios, and CRP as Risk Factors for Cardiovascular Disease
in Women. JAMA.
2005;294:326-333.
- * Insulin
Resistance and Risk of Congestive Heart Failure. JAMA.
2005;294:334-341. [Medscape]
- Perioperative N-acetylcysteine to Prevent Renal
Dysfunction in High-Risk Patients Undergoing CABG Surgery: A Randomized
Controlled Trial. JAMA.
2005;294:342-350.
- Essential Nutrients: Food or Supplements?: Where
Should the Emphasis Be? JAMA.
2005;294:351-358.
- * Beyond
Advance Directives: Importance of Communication Skills at the End
of Life. JAMA.
2005;294:359-365.
- Commentaries: Patent Foramen Ovale Closure Devices:
Moving Beyond Equipoise. JAMA.
2005;294:366-369.
- Editorials: Optimizing the Science of Quality
Improvement. JAMA.
2005;294:369-371.
- Outcomes for Extremely Low-Birth-Weight Infants:
Disappointing News. JAMA.
2005;294:371-373.
- Detection and Isolation of Mycobacterium avium Subspecies paratuberculosis
from Intestinal Mucosal Biopsies of Patients with and without Crohn's Disease
in Sardinia. Am
J Gastroenterol 2005;100:1529–1536. [Medscape]
- Acute Otitis Media Caused by Streptococcus pyogenes in Children. Clin
Infect Dis 2005;41:35-41 [Medscape]
- * The relationship
between primary care antibiotic prescribing and bacterial resistance in
adults in the community: a controlled observational study using individual
patient data. J
Antimicrobial Chemother 2005 doi:10.1093/jac/dki181 [News
release]
- Annals of Internal
Medicine 19
July 2005 Volume 143 Issue 2
- Cost-Effectiveness of Full Medicare Coverage
of Angiotensin-Converting Enzyme Inhibitors for Beneficiaries
with Diabetes. Rosen,
and Others.
- * The
Wells Rule Does Not Adequately Rule Out Deep Venous Thrombosis
in Primary Care Patients. Oudega,
Hoes, and Moons
- Echocardiographic Evaluation in Asymptomatic
Relatives of Patients with Dilated Cardiomyopathy Reveals
Preclinical Disease. Mahon,and
Others.
- Brief Communication: The Prevalence of
High Intake of Vitamin E from the Use of Supplements among
U.S. Adults. Ford,
and Others.
- Patient Safety Concerns Arising from Test
Results That Return after Hospital Discharge. Roy,
and Others.
- REVIEWS: Meta-Analysis: The Value of Clinical
Assessment in the Diagnosis of Deep Venous Thrombosis. Goodacre,
and Others.
- EDITORIALS: Use of a Clinical Prediction
Score in Patients with Suspected Deep Venous Thrombosis:
Two Steps Forward, One Step Back? Douketis
- Editorial Update: Annus horribilis for
Vitamin E. Guallar,
Hanley, and Miller
- Is This Clinical Trial Fully Registered?
A Statement from the International Committee of Medical
Journal Editors. International
Committee of Medical Journal Editors
- ON BEING A DOCTOR Food for Thought. Badve
- CURRENT CLINICAL ISSUES. Gene Therapy
Yields to RNA Interference. Wilson
| ::::::: July 22 ::::::: |
Weekend
Reading - Basic Science and general interest articles
|
|
- * Tau Suppression
in a Neurodegenerative Mouse Model Improves Memory Function.Science,
2005; 309, 476-481 [ScienceNow:
Memory Loss Reversed in Mice]
- FDA Public Health Advisory on
the Fentanyl Patch [Medscape]
- Medwatch:
- Mefiprex [Medscape] FDA
Warning
- Natrecor (nesiritide)
a consensus statement from an expert panel of cardiology and heart failure clinicians.
[Medscape review]
- Raptiva (efalizumab)
revised the labeling to include reports of immune-mediated hemolytic anemia and thrombocytopenia and serious infections including necrotizing
fasciitis, tuberculous pneumonia, bacterial sepsis with seeding of distant sites, severe pneumonia with neutropenia, and worsening
of infection (e.g. cellulitis, pneumonia) despite antimicrobial treatment.
[Medscape]
- Medscape Alert: As
Many as 28,000 Guidant Pacemakers May Need Replacement
- FDA: Orphan Drug Approvals [Medscape
review]
- CTCE-9908 (a cytostatic
drug) for the treatment of osteogenic sarcoma.
- PEAC an orally administered
galenic version of valproic acid for the treatment of
familial adenomatous polyposis (FAP), a condition that
indicates a genetic predisposition for colon cancer.
- Arimoclomol for the
treatment of amyotrophic lateral sclerosis (ALS, Lou
Gehrig's disease).
- FDA Approvals: [Medscape]
- Aptivus, accelerated approval of the
protease inhibitor tipranavir for coadministration with low-dose ritonavir
as part of combination antiretroviral therapy for HIV-1 in adults with
evidence of viral replication who are highly treatment experienced
or have HIV-1 strains resistant to multiple PIs.
- MetroGel (metronidazole 1% topical
gel) for the treatment of inflammatory lesions due to rosacea.
- Topamax (topiramate) new indication
for use as initial monotherapy for partial onset or primary generalized
tonic-clonic seizures in patients aged 10 years and older.
- * Insulin acutely
decreases hepatic fatty acid synthase activity. Cell
Metabolism, 2005;2:43-53. [Eurekalert:
Insulin pulses keep the liver lean]
- Prostate Cancer Hormone Therapy May Affect Cognition. [Medscape report
from Br J Urology - International - limited access]
- Buccal Midazolam May Be Better Than Rectal Diazepam for Acute Seizures
in Children. [Medscape review
from the Lancet (limited availabliity)]
- Serum retinol binding protein 4 contributes to insulin resistance in
obesity and type 2 diabetes. Nature doi:
10.1038/nature03711. [Eurekalert Study
identifies fat-secreted protein linked to insulin resistance.]
- Golfers with low-back pain may be helped by University of Pittsburgh
research [Eurekalert]
- Archives
of Internal Medicine Vol. 165 No. 13, pp. 1451-1555, July
11, 2005
- JAMA.Vol.
294 July 13, 2005
- BMJ 16
July 2005 (Vol 331, No 7509)
- Treatment of ocular hypertension and open angle
glaucoma: meta-analysis of randomised controlled trials. BMJ
2005:134, doi:10.1136/bmj.38506.
- Selective chromosome analysis in couples with two
or more miscarriages: case-control study. BMJ
2005:137-141
- Survey of informed consent for registration of
congenital anomalies in Europe BMJ
2005:140-141
- Lifetime intellectual function and satisfaction
with life in old age: longitudinal cohort study. BMJ
2005:141-142 [Science
Daily]
- Response to antibiotics of women with symptoms
of urinary tract infection but negative dipstick urine test results:
double blind randomised controlled trial. BMJ
2005:143
- Clinical review: Managing ophthalmic herpes zoster
in primary care. BMJ
2005:147-151,
- Education and debate: Efficacy of antidepressants
in adults. BMJ
2005:155-157 [Medscape:
Antidepressant Efficacy May Be Overblown]
- Distinctive neurocognitive effects of repetitive transcranial magnetic
stimulation and electroconvulsive therapy in major depression. Br
J Psychiatry 2005 186: 410-416. [Science
Daily]
- New
England Journal of Medicine Volume 353 July 14, 2005 Number 2
| ::::::: July 15 ::::::: |
Weekend
Reading - Basic Science and general interest articles
|
|
- FDA MEDWATCH:
- Duragesic (fentanyl
transdermal system) change to the prescribing information.
- Palladone (hydromorphone
hydrochloride) suspended sales and marketing because of the potential
for severe side effects if Palladone is taken with alcohol.
- FDA Talk
Paper FDA Updates Labeling for Viagra, Cialis and Levitra for Rare
Post-Marketing Reports of Eye Problems
- Cialis (Tadalafil) Levitra (Vardenafil
hydrochloride) Viagra (Sildenafil
citrate)
reports of sudden vision loss, attributed to NAION (non arteritic ischemic
optic neuropathy), a condition where blood flow is blocked to the optic
nerve.
- FDA Safety Labeling Changes: [Medscape]
- Plavix (clopidogrel)
warning that rare reports of thrombotic thrombocytopenic purpura
(TTP) have been associated with its use, sometimes after only a
short exposure (less than two weeks).
- Sustiva (efavirenz) warning of
the risk of fetal harm associated with its use during the first
trimester of pregnancy.
- Prevpac (lansoprazole, amoxicillin,
and clarithromycin) warning of the risk of pseudomembranous colitis
associated with use of nearly all antibacterial agents, including
clarithromycin and amoxicillin.
- FDA Approvals: [Medscape
review]
- BiDil (dinitrate/hydralazine)
for the treatment of heart failure (HF) as an adjunct to standard
therapy in self-identified black patients to improve survival,
prolong time to hospitalization for HF, and improve patient-reported
functional status.
- Megace ES (megestrol) for the
treatment of anorexia, cachexia, or unexplained significant weight
loss in patients diagnosed as having AIDS.
- Aczone (dapsone 5% gel) for
the topical treatment of acne vulgaris.
- Targeted Exercise May Reduce Hip Fragility [Medscape review
from Lancet 2005;366:98-99,129-135.]
- Ephrin-B3 is a myelin-based inhibitor of neurite outgrowth. PNAS
published July 14, 2005. [Researchers find molecule that inhibits
regrowth of spinal nerve cells. Eurekalert]
- Pre-existing hypertension and the impact of stroke on cognitive function. Ann
Neurol 2005;58:68-74. [Medscape]
- * A Comparison of Lipid
and Glycemic Effects of Pioglitazone and Rosiglitazone in Patients With
Type 2 Diabetes and Dyslipidemia. Diabetes
Care 2005;28:1547-1554. [Medscape]
- Influenza Vaccination Is Associated With a Reduced Risk of Stroke. Stroke
2005;36:1501-1506.[Medscape]
- A Randomized Controlled Trial To Assess the Optimal Dose and Effect
of Nebulized Albuterol in Acute Exacerbations of COPD. Chest
2005 128: 48-54. [Medscape]
- Exercise Capacity Deterioration in Patients With COPD: Longitudinal Evaluation
Over 5 Years. Chest.
2005;128:62-69.
- A Clinical Trial of Continuous Subcutaneous Insulin Infusion Versus Multiple
Daily Injections in Older Adults With Type 2 Diabetes. Diabetes
Care 2005 28: 1568-1573.
- Use of Multisystemic Therapy to Improve Regimen Adherence Among Adolescents
With Type 1 Diabetes in Chronic Poor Metabolic Control: A randomized controlled
trial. Diabetes
Care 2005;28:1604-1610. [Medscape]
- Association between the Current Use of Low-Dose Oral Contraceptives and
Cardiovascular Arterial Disease: A Meta-Analysis. J
Clin Endocrinol Metab 2005 90: 3863-3870. [Science
Daily]
- Psychosocial and psychological interventions for prevention of postnatal
depression: systematic review. BMJ
2005;331:15. [Eurekalert]
- Cardiorespiratory Fitness Is Inversely Associated With the Incidence
of Metabolic Syndrome. A Prospective Study of Men and Women. Circulation
2005: published online before print July 11, 2005. [Medscape]
- Hyperoxia-Induced Hypocapnia: An Underappreciated Risk. Chest
2005 128: 430-433. [Eurekalert]
- Follow-up of 89 Asymptomatic Patients With Adrenoleukodystrophy Treated
With Lorenzo’s Oil. Arch
Neurol. 2005;62:1073-1080. [Eurekalert]
- A Clinical Trial of Continuous Subcutaneous Insulin Infusion Versus Multiple
Daily Injections in Older Adults With Type 2 Diabetes. Diabetes
Care 2005 28: 1568-1573.
- Use of Multisystemic Therapy to Improve Regimen Adherence Among Adolescents
With Type 1 Diabetes in Chronic Poor Metabolic Control: A randomized controlled
trial. Diabetes
Care 2005;28:1604-1610. [Medscape]
- Association between the Current Use of Low-Dose Oral Contraceptives and
Cardiovascular Arterial Disease: A Meta-Analysis. J
Clin Endocrinol Metab 2005 90: 3863-3870. [Science
Daily]
- Life course determinants of insulin secretion and sensitivity at age
50 years: the Newcastle thousand families study. Diabetes/Metabolism
Research and Reviews. Published Online: 24 Jun 2005 [Science
Daily and New
Scientist]
- New
England Journal of Medicine Volume 353 July 7, 2005 Number
1
| ::::: July
8 ::::: |
Weekend
Reading - Basic Science and general interest articles |
|
- FDA Safety Labeling Changes: [Medscape]
- Novantrone (mitoxantrone):
risk of cardiotoxicity and secondary acute myelogenous leukemia
(AML) associated with its use.
- Mevaco (lovastatin) risk of liver
dysfunction associated with its use.
- Nitro-Dur (nitroglycerin transdermal):
amplification of its vasodilatory effects by concurrent use of
phosphodiesterase inhibitors such as sildenafil may result in severe
hypotension.
- FDA
Talk Paper: FDA Reviews Data for Antidepressant Use in Adults
- FDA Approvals: [Medscape
Report]
- Levemir (insulin detemir
- rDNA origin) for once- or twice-daily subcutaneous
administration in the treatment of adult patients with
diabetes mellitus who require basal insulin for the control
of hyperglycemia.
- Venofer(iron sucrose
injection), new indication allowing use for the treatment
of iron deficiency anemia in nondialysis-dependent patients
with chronic kidney disease.
- Adacel (combination
tetanus toxoid, reduced diphtheria toxoid, and acellular
pertussis booster vaccine, adsorbed) for administration
as a single dose to adolescents and adults aged 11 to
64 years.
- Ceftriaxone Effective Against Epidemic Meningococcal Meningitis. [Medscape
report from The Lancet]
- Pregabalin-withdrawal encephalopathy and splenial edema: A link to high-altitude
illness? Annals
of Neurology Published Online: 30 Jun 2005 DOI: 10.1002/ana.20583.[Eurekalert]
- * Association
Between Streptococcal Infection and Obsessive-Compulsive Disorder, Tourette's
Syndrome, and Tic Disorder. Pediatrics
2005; 116:56-60. [Medscape
report]
- Blood Pressure in Adulthood and Life Expectancy With Cardiovascular Disease
in Men and Women. Life Course Analysis. Hypertension
published online June 27, 2005, 10.1161/01.HYP. [Eurekalert]
- JAMA.
Vol. 294 No. 1, pp. 9-146, July 6, 2005.
- * Low-Dose
Aspirin in the Primary Prevention of Cancer: The Women’s
Health Study: A Randomized Controlled Trial. JAMA.
2005;294:47-55.
- Vitamin E in the Primary Prevention of Cardiovascular
Disease and Cancer: The Women’s Health Study: A Randomized
Controlled Trial. JAMA.
2005;294:56-65.
- * Operating
Characteristics of Prostate-Specific Antigen in Men With an Initial
PSA Level of 3.0 ng/mL or Lower. JAMA.
2005;294:66-70. [Medscape]
- Thyroid Function and Mortality in Patients Treated
for Hyperthyroidism. JAMA.
2005;294:71-80.
- Dysregulated Arginine Metabolism, Hemolysis-Associated
Pulmonary Hypertension, and Mortality in Sickle Cell Disease. JAMA.
2005;294:81-90.
- Circulating Androgen Levels and Self-reported
Sexual Function in Women. JAMA.
2005;294:91-96.
- Reviews: Coffee Consumption and Risk of Type 2
Diabetes: A Systematic Review. JAMA.
2005;294:97-104.
- Editorials: Low-Dose Aspirin and Vitamin E: Challenges
and Opportunities in Cancer Prevention. JAMA.
2005;294:105-106.
- Vitamin E and Cardiovascular Health: Does Sex
Matter? JAMA.
2005;294:107-109.
- * Reporting
Conflicts of Interest, Financial Aspects of Research, and Role
of Sponsors in Funded Studies. JAMA.
2005;294:110-111.
- * Evidence-Based
Guidelines Needed for Osteoporosis Screening and Treatment JAMA.
2005;294:34.
- From the Centers for Disease Control and Prevention:
Transmission of Hepatitis B Virus Among Persons Undergoing Blood
Glucose Monitoring in Long-Term–Care Facilities—Mississippi,
North Carolina, and Los Angeles County, California, 2003-2004. JAMA.
2005;294:35-38.
- CDC Announces Landmark Reorganization. JAMA.
2005;294:38.
- * Comparative Impact of
Morbid Obesity vs Heart Failure on Cardiorespiratory Fitness. Chest
2005 127: 2197-2203..[Medscape]
[news report]
- Early Changes of Cardiac Structure and Function in COPD Patients With
Mild Hypoxemia. Chest
2005 127: 1898-1903. [Medscape]
- Annals of Internal
Medicine: 5 July 2005 Volume 143 Issue 1
- Effect of Soybean Protein on Blood Pressure: A
Randomized, Controlled Trial. He,
and Others [Medscape]
- A Randomized Clinical Trial of Acupuncture Compared
with Sham Acupuncture in Fibromyalgia. Assefi,
and Others.
- Reporting of Harm in Randomized, Controlled Trials
of Nonpharmacologic Treatment for Rheumatic Disease. Ethgen,
and Others.
- High and Rising Health Care Costs. Part 4: Can
Costs Be Controlled While Preserving Quality? Bodenheimer
and Fernandez
- Screening for HIV: Recommendation Statement. U.S.
Preventive Services Task Force
- Prenatal Screening for HIV: A Review of the Evidence
for the U.S. Preventive Services Task Force. Chou,
and Others.
- Screening for HIV: A Review of the Evidence for
the U.S. Preventive Services Task Force. Chou,
and Others.
- Nutrition and Blood Pressure: Is Protein One Link?
Toward a Strategy of Hypertension Prevention. Cutler
and Obarzanek
- Health Care Expenditures Reexamined. Fuchs
- An Editorial Update: What Level of Blood Pressure
Control in Chronic Kidney Disease? Levey
and Mulrow
- ON
BEING A DOCTOR: Unintended Consequences: The Accreditation
Council for Graduate Medical Education Work-Hour Rules in Practice.
- New
England Journal of Medicine Volume 352 June 30, 2005 Number
26
| ::: July
1 ::: Weekend
Reading - Basic Science and general interest articles |
|
- FDA
Statement on USDA BSE Positive Test Results
- FDA Approvals:Orphan Drugs [Medscape]
- Troxatyl (troxacitabine) for
the treatment of acute myelogenous leukemia (AML).
- Tilarginine Acetate, (tilarginine
injection) for the treatment of cardiogenic shock (CS).
- Aerosolized Gene Therapy (nonviral DNA vector
mist) in the treatment of cystic fibrosis (CF).
- FDA Approvals: [Medscape]
- CMV Vaccine bivalent (two-plasmid)
formulation of a cytomegalovirus (CMV) DNA vaccine that encodes
two highly immunogenic viral proteins: phosphoprotein 65 and
glycoprotein B.
- PulmoLAR, orphan drug designation
for 2-methoxyestradiol sustained-release injection indicated
for the treatment of pulmonary arterial hypertension (PAH).
- Annamycin, second-generation
anthracycline indicated for the treatment of acute lymphoblastic
leukemia (ALL) and acute myelogenous leukemia (AML).
- Serine Protease Cathepsin G Regulates Adhesion-Dependent Neutrophil
Effector Functions by Modulating Integrin Clustering. Immunity
2005; 22: 679-691.(Enzyme’s newly discovered role may
make it target for arthritis treatment - news)
- Effect of Dark Chocolate on Arterial Function in Healthy Individuals.
Am J Hypertens 2005;18:785-791. (ScienceDirect)
[Dark Chocolate May Protect Cardiovascular System Medscape]