Recent
reports in Science and Medicine for March 2005
Some
of these links are very transient and may expire within days of posting.
Some may require prior registration. Check-in and view frequently to avoid
missing great news items. I welcome any suggested articles. (email
link). "§" indicates
a recommended article.
§ Treatment
exhaustion of highly active antiretroviral therapy (HAART) among
individuals infected with HIV in the United Kingdom: multicentre
cohort study. BMJ 2005;330:695,
Economic evaluation of nurse led intermediate care versus standard
care for post-acute medical patients: cost minimisation analysis
of data from a randomised controlled trial. BMJ 2005;330:699.
Depression and anxiety in women with early breast cancer: five
year observational cohort study. BMJ 2005;330:702
Insulin resistance and depressive symptoms in middle aged men:
findings from the Caerphilly prospective cohort study. BMJ 2005;330:705-706
Primary care Cost effectiveness of nurse led secondary prevention
clinics for coronary heart disease in primary care: follow up of
a randomised controlled trial. BMJ 2005;330:707
§ Clinical
review Recent developments in the use of biologics in psoriasis and
autoimmune disorders. The role of autoantibodies. BMJ 2005;330:716-720
Efficacy of nine-valent pneumococcal conjugate vaccine against
pneumonia and invasive pneumococcal disease in The Gambia: randomised,
double-blind, placebo-controlled trial. The
Gambian Pneumococcal Vaccine Trial Group*
Epidemiology and reporting of randomised trials published in PubMed
journals [Summary]
Always trust your gut feeling
March
30
Colorectal Cancer in African Americans . Am
J Gastroenterol 2005;100;515-523. (limited access; use Medscape review:
Screening for Colorectal Cancer Recommended to Begin 5 Years Earlier
in Blacks)
Risk Factors for Relapse in Health Care Professionals With Substance
Use Disorders. JAMA.
2005;293:1453-1460.
Association of Transmission Intensity and Age With Clinical Manifestations
and Case Fatality of Severe Plasmodium falciparum Malaria. JAMA.
2005;293:1461-1470.
Incidence of Cervical Squamous Intraepithelial Lesions Associated
With HIV Serostatus, CD4 Cell Counts, and Human Papillomavirus Test
Results. JAMA.
2005;293:1471-1476.
Preliminary Communications: Nitrite Infusions to Prevent Delayed
Cerebral Vasospasm in a Primate Model of Subarachnoid Hemorrhage JAMA.
2005;293:1477-1484.
Thiopurine Methyltransferase (TPMT) Genotype and Early Treatment
Response to Mercaptopurine in Childhood Acute Lymphoblastic Leukemia. JAMA.
2005;293:1485-1489.
Mortality and Malnutrition Among Populations Living in South Darfur,
Sudan: Results of 3 Surveys, September 2004. JAMA.
2005;293:1490-1494.
Fighting Unequal Treatment: The Robert
Wood Johnson Foundation and a Quality-Improvement Approach
to Disparities. Circulation
2005 111: 1208 - 1209.
Cardiovascular Surgery: Patient and Hospital
Differences Underlying Racial Variation in Outcomes After
Coronary Artery Bypass Graft Surgery. Circulation
2005 111: 1210 - 1216.
Coronary Heart Disease: Influence of
Race on Death and Ischemic Complications in Patients
With Non–ST-Elevation Acute Coronary Syndromes
Despite Modern, Protocol-Guided Treatment. Circulation
2005 111: 1217 - 1224.
Racial Variations in Treatment and Outcomes
of Black and White Patients With High-Risk Non–ST-Elevation
Acute Coronary Syndromes: Insights From CRUSADE (Can
Rapid Risk Stratification of Unstable Angina Patients
Suppress Adverse Outcomes With Early Implementation of
the ACC/AHA Guidelines?) Circulation
2005 111: 1225 - 1232. [Eurekalert]
Sex Hormone–Binding Globulin and
the Free Androgen Index Are Related to Cardiovascular
Risk Factors in Multiethnic Premenopausal and Perimenopausal
Women Enrolled in the Study of Women Across the Nation
(SWAN). Circulation
2005 111: 1242 - 1249.
Racial Misclassification and Disparities
in Cardiovascular Disease Among American Indians and
Alaska Natives. Circulation
2005 111: 1250 - 1256.
Health Services and Outcomes Research:
Racial Profiling: The Unintended Consequences of Coronary
Artery Bypass Graft Report Cards. Circulation
2005 111: 1257 - 1263.
Hypertension: General Practitioners’ Approach
to Hypertension in Urban Pakistan: Disturbing Trends
in Practice. Circulation
2005 111: 1278 - 1283.
Interventional Cardiology: Influence
of Racial Disparities in Procedure Use on Functional
Status Outcomes Among Patients With Coronary Artery Disease. Circulation
2005 111: 1284 - 1290.
Pediatric Cardiology: Children in South
Asia Have Higher Body Mass–Adjusted Blood Pressure
Levels Than White Children in the United States: A Comparative
Study. Circulation
2005 111: 1291 - 1297.
Preventive Cardiology: Impact of a Community-Based
Multiple Risk Factor Intervention on Cardiovascular Risk
in Black Families With a History of Premature Coronary
Disease. Circulation
2005 111: 1298 - 1304. [Eurekalert report]
Stroke: American Heart Association and
American Stroke Association National Survey of Stroke
Risk Awareness Among Women . Circulation
2005 111: 1321 - 1326. [Eurekalert report]
Ischemic Stroke Subtype Incidence Among
Whites, Blacks, and Hispanics: The Northern Manhattan
Study. Circulation
2005 111: 1327 - 1331.
Valvular Heart Disease: Relationship
Between Race and Mortality and Morbidity After Valve
Replacement Surgery. Circulation
2005 111: 1305 - 1312.
Vascular Medicine: Ethnic Differences
in Coronary Calcification: The Multi-Ethnic Study of
Atherosclerosis (MESA). Circulation
2005 111: 1313 - 1320,
Special Reports: Eliminating Disparities
in Cardiovascular Health: Six Strategic Imperatives and
a Framework for Action. Circulation
2005 111: 1332 - 1336.
Clinical Trial Registration: A Statement
From the International Committee of Medical Journal Editors. Circulation
2005 111: 1337 - 1338
AHA Conference Proceedings: Discovering
the Full Spectrum of Cardiovascular Disease: Minority
Health Summit 2003: Report of the Basic Science Writing
Group. Circulation
2005 111: e120 - e123.
Discovering the Full Spectrum of Cardiovascular
Disease: Minority Health Summit 2003: Report of the Outcomes
Writing Group. Circulation
2005 111: e124 - e133.
Discovering the Full Spectrum of Cardiovascular
Disease: Minority Health Summit 2003: Report of the Obesity,
Metabolic Syndrome, and Hypertension Writing Group . Circulation
2005 111: e134 - e139.
Discovering the Full Spectrum of Cardiovascular
Disease: Minority Health Summit 2003: Report of the Advocacy
Writing Group. Circulation
2005 111: e140 - e149.
Discovering the Full Spectrum of Cardiovascular
Disease: Minority Health Summit 2003: Executive Summary. Circulation
2005 111: 1339 - 1349.
The Lancet Volume 365, Number 9464 19 March 2005
Infection with multidrug resistant, dual-tropic HIV-1 and rapid
progression to AIDS: a case report [Full
Text]
Effect of topical treatment with skin barrier-enhancing emollients
on nosocomial infections in preterm infants in Bangladesh: a randomised
controlled trial [Full
Text]
Long-term cardiovascular outcomes in men with obstructive sleep
apnoea-hypopnoea with or without treatment with continuous positive
airway pressure: an observational study [Summary]
Mechanisms of Disease: Acquired mutation of the tyrosine kinase
JAK2 in human myeloproliferative disorders [Summary] he
Cancer Genome Project
Deficiency of a subset of T cells with immunoregulatory properties
in sarcoidosis [Summary]
Seminar: Shiga-toxin-producing Escherichia coli and haemolytic
uraemic syndrome [Summary]
Millennium Project: Reinventing global health: the role of science,
technology, and innovation [Full
Text]
Social determinants of health inequalities [Full
Text]
ON-LINE FIRST : Effects of acupuncture and stabilising exercises
as adjunct to standard treatment in pregnant women with pelvic girdle
pain: randomised single blind controlled trial.BMJ,
doi:10.1136/bmj. [Eurekalert]
ON-LINE FIRST : Opportunity cost of antidepressant prescribing
in England: analysis of routine data BMJ,
doi:10.1136/bmj.[Eurekalert]
How well does B-type natriuretic peptide predict death and cardiac
events in patients with heart failure: systematic review. BMJ 2005;330:625
Sharing stories: complex intervention for diabetes education in
minority ethnic groups who do not speak English. BMJ 2005;330:628.
Commentary: Using patients' narratives in complex research. BMJ 2005;330:631.
What should undergraduate medical students know about psoriasis?
Involving patients in curriculum development: modified Delphi technique. BMJ 2005;330:633-636.
Commentary: Trials should inform structures and processes needed
for tailoring interventions. BMJ 2005;330:665-666.
Doctor-patient relationships in chronic illness: insights from
forensic psychiatry. BMJ 2005;330:667-670.
March
18
Weekend
Reading - Basic Science and general interest articles
Medwatch FDA
§Xigris [drotrecogin
alfa (activated)] revisions to the WARNINGS section of labeling
based upon analyses of two clinical trial databases. Among patients
with single organ dysfunction and recent surgery, all-cause mortality
was numerically higher in the Xigris group compared to the placebo
group. Patients with single organ dysfunction and recent surgery
may not be at high risk of death and therefore may not be among
the indicated population. Xigris should be used in these patients
only after careful consideration of the risks and benefits.
Avonex (interferon
beta-1a) revisions to the WARNINGS, PRECAUTIONS/Drug Interactions
and ADVERSE REACTIONS/Post-Marketing Experience sections and
Medication Guide. Severe hepatic injury, including cases of hepatic
failure, has been reported in patients taking Avonex. The potential
risk of Avonex used in combination with known hepatotoxic drugs
or other products (e.g. alcohol) should be considered prior to
Avonex administration.
FDA
Talk Paper: Temodar Approved for Glioblastoma Multiforme
FDA
Talk Paper: New Drug to Treat Type I and Type II Diabetes - Symlin,
an injectable medicine to control blood sugar for adults with type 1
and type 2 diabetes. Symlin is to be used in addition to insulin therapy
in patients who cannot achieve adequate control of their blood sugars
on intensive insulin therapy alone.
AKonya Eliminator Plus, a second-generation
mechanical thrombectomy device (AKonya Eliminator Plus, made by
IDev Technologies, Inc.) for use in the maceration and removal
of adherent clots in native arteriovenous fistulae and synthetic
dialysis grafts.
ACUSONAcuNav,
an 8F ultrasound catheter (ACUSON AcuNav, made by Siemens Medical
Solutions of Siemens AD) for visualization of the entire vascular
and cardiac anatomy and physiology, measurement of blood flow,
and visualization of other devices during diagnostic and therapeutic
procedures.
Stratus NT-proBNPexpanded indication
for an N-terminal pro brain natriuretic peptide (BNP) immunoassay
allowing its use with the company's Stratus CS Acute Care system
to aid in the diagnosis of congestive heart failure (CHF) and for
the assessment of CHF severity.
Rebif (interferon beta-1a injection),
warning of the risk of severe hepatic injury rarely associated with
its use.
Neupogen ( filgrastim injection )
to warn of the risk of splenic rupture rarely associated with its use.
Children's/Junior Advil (ibuprofen
chewable tablets) to warn that severe or persistent sore throat accompanied
by other symptoms (high fever, headache, nausea, and vomiting) may
be serious and requires prompt evaluation by a physician.
Hepatitis Drug Baraclude Wins Unanimous Approval of FDA Committee entecavir
[News
Release]
§ Comparative
efficacy of hand hygiene agents in the reduction of bacteria and viruses. Am
J Inf Control March 2005 • Volume 33. [Eurekalert:
Study: Soap and water work best in ridding hands of disease viruses.]
§ Prostate
Cancer Screening in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer
Screening Trial: Findings From the Initial Screening Round of a Randomized
Trial .J
Natl Cancer Inst 2005; 97: 433-438. [Eurekalert]
Long-term Outcomes of Regional Variations in Intensity of Invasive
vs Medical Management of Medicare Patients With Acute Myocardial
Infarction. JAMA.
2005;293:1329-1337.
§ Effects
of Long-term Vitamin E Supplementation on Cardiovascular Events and
Cancer: A Randomized Controlled Trial. The HOPE and HOPE-TOO Trial
Investigators. JAMA.
2005;293:1338-1347. [Medscape]
Potentially Inappropriate Medication Use Among Elderly Home Care
Patients in Europe. JAMA.
2005;293:1348-1358.
Perspectives on Care at the Close of Life. Dealing With Conflict
in Caring for the Seriously Ill: "It Was Just Out of the Question" JAMA.
2005;293:1374-1381. [Eurekalert]
Perspectives on Care at the Close of Life: CODA. Caring for the
Child With Cancer at the Close of Life. JAMA.
2005;293:1382.
Regionalization of Care for Acute Coronary Syndromes: More Evidence
Is Needed. JAMA.
2005;293:1383-1387.
§ Improving
clinical practice using clinical decision support systems: a systematic
review of trials to identify features critical to success. BMJ, online
[Abstract]
Utility of testing for monoclonal bands in serum of patients with
suspected osteoporosis: retrospective, cross sectional study. BMJ,
online [Abstract]
Effectiveness of a home-based balance-training program in reducing sports-related
injuries among healthy adolescents: a cluster randomized controlled trial. CMAJ
2005 172: 749-754.
§ Relative
Importance of Borderline and Elevated Levels of Coronary Heart
Disease Risk Factors. [Abstract]
[Medscape]
Effect of a Low-Carbohydrate Diet on Appetite,
Blood Glucose Levels, and Insulin Resistance in Obese Patients
with Type 2 Diabetes. [Abstract]
Thyroid Hormone Replacement Therapy in Primary
Hypothyroidism: A Randomized Trial Comparing L-Thyroxine plus Liothyronine
with L-Thyroxine Alone.[Abstract]
C-Reactive Protein Levels Are Not Associated with
Increased Risk for Colorectal Cancer in Women. [Abstract]
This year's Update in Nephrology and Hypertension
incorporates articles on clinical hypertension; proteinuria, lipids,
and renal disease; blood pressure, angiotensin II antagonists,
and renal disease; smoking and renal disease; hypertension and
coronary artery disease; and chronic kidney disease detection.
[Full
Text]
§ Reviews Recommendations
for the Diagnosis and Treatment of the Acute Porphyrias. [Abstract]
Meta-Analysis: Methods for Diagnosing Intravascular
Device–Related Bloodstream Infection. [Abstract]
Appendix Table Editorials The Middle-Aged
and Older American: Wrong Prototype for a Preventive Polypill?
[Full
Text] [Medscape]
Is There Something Special about Low-Carbohydrate
Diets? [Text]
Leukocyte Count as a Predictor of Cardiovascular
Events and Mortality in Postmenopausal Women: The Women’s
Health Initiative Observational Study. Arch
Intern Med. 2005;165:500-508. [News report]
A Population-Based Study of Bilateral Prophylactic
Mastectomy Efficacy in Women at Elevated Risk for Breast Cancer
in Community Practices. Arch
Intern Med. 2005;165:516-520.
Effect of Nandrolone Decanoate Therapy on Weight
and Lean Body Mass in HIV-Infected Women With Weight Loss: A Randomized,
Double-blind, Placebo-Controlled, Multicenter Trial. Arch
Intern Med. 2005;165:578-585.
Risk factors for pre-eclampsia at antenatal booking:
systematic review of controlled studies. BMJ 2005;330:565.
Systematic review and meta-analysis of proton
pump inhibitor therapy in peptic ulcer bleeding. BMJ 2005;330:568.
International retrospective cohort study of neural
tube defects in relation to folic acid recommendations: are the
recommendations working? BMJ 2005;330:571.
Preventing neural tube defects in Europe: population
based study. BMJ 2005;330:574-575.
The pre-eclampsia community guideline (PRECOG):
how to screen for and detect onset of pre-eclampsia in the community. BMJ 2005;330:576-580,.
Effect of electronic health records in ambulatory
care: retrospective, serial, cross sectional study. BMJ 2005;330:581.
Early online publication: Human embryonic stem cells derived without
feeder cells [Summary]
Review: Multiple birth resulting from ovarian stimulation for subfertility
treatment [Summary]
March
14
Inner City Asthma Study: Relationships among sensitivity, allergen exposure,
and asthma morbidity. R.S. Gruchalla and Others. J
All Clin Imm. 2005 115. [Eurekalert:
Allergen exposure in inner cities varies throughout the U.S].[Eurekalert:Cockroach
allergens have greatest impact on childhood asthma]
Thalidomide in the treatment of cancer cachexia: a randomised placebo
controlled trial. Gut
2005 54: 540-545. (Also see editorial)
Diabetes increases the risk of hepatocellular carcinoma in the United
States: a population based case control study. Gut
2005; 54: 533-539. [Medscape]
Mild cognitive impairment is related to Alzheimer disease pathology and
cerebral infarctions. Neurology
2005 64: 834-841.
Early
Release: March 9, 2005 § Addition
of Clopidogrel to Aspirin and Fibrinolytic Therapy for Myocardial
Infarction with ST-Segment Elevation. The CLARITY-TIMI 28 Investigators
[Medscape]
Early
Release :March 8, 2005 § Intensive
Lipid Lowering with Atorvastatin in Patients with Stable Coronary
Disease J.C. LaRosa and Others [Medscape review]
Atacand (candesartan cilexitil),
approved use in the treatment of chronic heart failure (CHF; New
York Heart Association [NYHA] class II-IV and ejection fraction
[EF] of 40% or less) to reduce the risk of death from cardiovascular
causes and reduce heart failure–related hospitalizations
as an alternative drug for patients who have developed tolerance
to angiotensin-converting enzyme (ACE) inhibitor therapy, or it
may be used in addition to ongoing therapeutic regimens (with or
without ACE inhibitors).
Pegasys Plus Copegus (peginterferon
alfa-2a [40 KD] and ribavirin) approved an expanded indication
for combination therapy in the treatment of chronic hepatitis C
virus (HCV) in patients coinfected with HIV.
Triage APAP TOX Screen (TOX Drug
Screen with Acetaminophen) approved screening test the qualitative
detection of acetaminophen in urine.
FDA Alert:
Paxil
CR (paroxetine
hydrochloride) and Avandamet (rosiglitazone
maleate + metformin hydrochloride) FDA and DOJ have seized
the remaining stocks of Paxil CR and Avandamet tablets manufactured
by GlaxoSmithKline, Inc. Manufacturing practices failed to
meet the standards laid out by FDA.
Elidel
(pimecrolimus) and Protopic (tacrolimus) Public health advisory
to inform about a potential cancer risk from use based on information
from animal studies, case reports in a small number of patients,
and how these drugs work.
Pegasys (peginterferon alfa-2a)
risks associated with coadministered Copegus (ribavirin) during
pregnancy. Ribavirin may cause teratogenic and/or embryocidal effects
in exposed fetuses.
Elitek (rasburicase injection)
to warn of the risk of hypersensitivity reactions associated with
its use.
Neulasta (pegfilgrastim injection)
to warn of the risk of splenic rupture associated with its use.
Clarinex-D 24 Hour
(desloratadine 5 mg plus pseudoephedrine sulfate 240 mg extended-release
tablets) for the relief of nasal and nonnasal symptoms associated
with seasonal allergic rhinitis (including nasal congestion) in
patients aged 12 years and older.
Abilify (aripiprazole) expanded
indication for use in bipolar I disorder after a recent manic or
mixed episode who have been stabilized and maintained for at least
six weeks.
Isovorin (intravenous levofolinic
acid) two orphan drug designation allowing use with 5-fluorouracil
for the treatment of colon cancer, and in conjunction with methotrexate
(MTX) for osteosarcoma.
New CDC Recommendations Seek to Lower Nosocomial Infections [CDC link
and Medscape report]
The Smallpox Vaccination Program: Public Health in an Age of Terrorism
[IOM Report]
§ Calcium,
Dairy Products, and Bone Health in Children and Young Adults: A Reevaluation
of the Evidence. Pediatrics
2005; 115: 736-743.
§ Role
of Computerized Physician Order Entry Systems in Facilitating Medication
Errors. JAMA.
2005;293:1197-1203.
Timeliness of Childhood Vaccinations in the United
States: Days Undervaccinated and Number of Vaccines Delayed. JAMA.
2005;293:1204-1211.
§ Chromosomal
Instability in Amniocytes From Fetuses of Mothers Who Smoke. JAMA.
2005;293:1212-1222.
§ Effects
of Computerized Clinical Decision Support Systems on Practitioner
Performance and Patient Outcomes: A Systematic Review. JAMA.
2005;293:1223-1238.
The challenge of reducing neonatal mortality in middle-income countries:
findings from three Brazilian birth cohorts in 1982, 1993, and 2004 [Full
Text]
Incidence of macrolide resistance in Streptococcus pneumoniae after
introduction of the pneumococcal conjugate vaccine: population-based
assessment [Summary]
Where giving birth is a forecast of death: maternal mortality
in four districts of Afghanistan, 1999-2002 [Full
Text]
Mechanisms of Disease: Relation between muscle Na+K+ATPase activity
and raised lactate concentrations in septic shock: a prospective
study [Summary]
Incidence of Type 2 Diabetes in the Randomized
Multiple Risk Factor Intervention Trial. Multiple Risk Factor Intervention
Trial Research Group. Abstract
§ The
Cost-Effectiveness of Lifestyle Modification or Metformin in Preventing
Type 2 Diabetes in Adults with Impaired Glucose Tolerance. Diabetes
Prevention Program Research Group. Abstract
Antibody Levels and Protection after Hepatitis
B Vaccination: Results of a 15-Year Follow-up. Abstract
§ The
Effect of a Lower Target Blood Pressure on the Progression of Kidney
Disease: Long-Term Follow-up of the Modification of Diet in Renal
Disease Study. Abstract
Patient Care Fumbled Handoffs: One Dropped
Ball after Another. Abstract
Meta-Analysis: Test Performance of Ultrasonography
for Giant-Cell Arteritis. Abstract
Narrative Review: Aspirin Resistance and Its Clinical
Implications. Abstract
Primary Prevention of Type 2 Diabetes: Lifestyle
Intervention Works and Saves Money, but What Should Be Done with
Smokers? Full
Text
Long-Term Protection of Hepatitis B Vaccine: Lessons
from Alaskan Experience after 15 Years. Full
Text
BMJ Online: Incidence and risk factors for non-alcoholic
steatohepatitis: prospective study of 5408 women enrolled in Italian
tamoxifen chemoprevention trial. BMJ,
doi:10.1136/bmj.38391.663287.
§ Acute
treatment of moderate to severe depression with hypericum extract
WS 5570 (St John's wort): randomised controlled double blind non-inferiority
trial versus paroxetine. BMJ 2005;330:503.
Mortality data in adult cardiac surgery for named
surgeons: retrospective examination of prospectively collected
data on coronary artery surgery and aortic valve replacement. BMJ 2005;330:506-510.
The nature of medical evidence and its inherent
uncertainty for the clinical consultation: qualitative study BMJ 2005;330:511.
Commentary: Uncertainty, consultation, and the
context of medical care. BMJ 2005;330:515
Efficacy and tolerability of topical pimecrolimus
and tacrolimus in the treatment of atopic dermatitis: meta-analysis
of randomised controlled trials. BMJ 2005;330:516.
ACGME Requirements for Geriatrics Medicine Curricula in Medical Specialties:
Progress Made and Progress Needed. Acad
Med 2005 80: 279-285. .[Eurekalert]
Sleep Deprivation Potentiates Activation of Cardiovascular and Catecholamine
Responses in Abstinent Alcoholics. Hypertension.
2005;45:252
Post-myocardial infarction smoking cessation counseling: Associations
with immediate and late mortality in older Medicare patients. AJM
2005; 118: 269-275. [Medscape] [Eurekalert]
Clinical and Biological Features Associated With Epidermal Growth Factor
Receptor Gene Mutations in Lung Cancers. J
Natl Cancer Inst 2005; 97: 339-346.
American Journal of Medicine March 2005 (Vol. 118, Issue 3)
Association between fish consumption and all-cause
and cause-specific mortality in Japan: NIPPON DATA80, 1980–99. AJM
2005;118: 239-245.
Thalidomide for the treatment of resistant cutaneous
lupus: Efficacy and safety of different therapeutic regimens. AJM
2005;118: 246-250.
§ The
incidence of adverse drug events in two large academic long-term
care facilities. AJM
2005;118: 251-258 [Eurekalert:
Adverse drug events in nursing homes are far more common than previously
identified]
Distal Microcirculatory Protection During Percutaneous
Coronary Intervention in Acute ST-Segment Elevation Myocardial
Infarction: A Randomized Controlled Trial. the Enhanced Myocardial
Efficacy and Recovery by Aspiration of Liberated Debris (EMERALD)
Investigators. JAMA.
2005;293:1063-1072.
Adjuvant Chemotherapy in Older and Younger Women
With Lymph Node–Positive Breast Cancer. JAMA.
2005;293:1073-1081.
§ Effect
of Folate and Mecobalamin on Hip Fractures in Patients With Stroke:
A Randomized Controlled Trial. JAMA.
2005;293:1082-1088. [Medscape]
§ Impact
of Participant and Physician Intervention Preferences on Randomized
Trials: A Systematic Review. JAMA.
2005;293:1089-1099.
Clinical Crossroads Update: A 73-Year-Old Man With
Hearing Loss, 1 Year Later. JAMA.
2005;293:1115.
Editorials: Distal Embolic Protection in Patients
With Acute Myocardial Infarction: Attractive Concept But No Evidence
of Benefit. JAMA.
2005;293:1116-1118.
Adjuvant Therapy of Breast Cancer in the Elderly:
Does One Size Fit All? JAMA.
2005;293:1118-1120.
Crestor (Rosuvastatin
Calcium) Rhabdomyolysis (serious muscle damage) has been reported in
patients taking Crestor as well as other statin drugs. To date,
it does not appear that the risk is greater with Crestor than with
other marketed statins. However, the labeling for Crestor is
being revised to highlight important information on the safe use of
Crestor to reduce the risk for serious muscle toxicity (myopathy/rhabdomyolysis),
especially at the highest approved dose of 40 mg. The labeling
will also be revised to reflect the results of a large pharmacokinetic
study involving a diverse population of Asian patients compared with
a Caucasian control group that found drug levels to be elevated approximately
2-fold. Kidney failure of various types has also been reported in patients
treated with Crestor as well as other statins. Patients who are
candidates for statin therapy (e.g., patients with diabetes, hypertension,
atherosclerosis, and/or heart failure) may also be at higher risk for
kidney failure even when they are not taking statins. At this
time, the FDA cannot conclude that recommended doses of Crestor can
cause or exacerbate renal failure, but is continuing to carefully evaluate
the data.[ Medscape report]
Vistaril (Hydroxyzine Pamoate)
use is contraindicated in patients who have demonstrated prior
hypersensitivity to the active moiety or components of the products.
Inert components of the capsule include hard gelatin (may contain
Yellow 10, Green 3, Yellow 6, Red 33, and other dyes), magnesium
stearate, sodium lauryl sulfate, starch, and sucrose. Inert components
of the oral solution include carboxymethylcellulose sodium, lemon
flavor, propylene glycol, sorbic acid, and sorbitol solution.
Estraderm (Estradiol Transdermal
System) revised contraindications and warnings associated with
its use. Use of estrogens, including the estradiol patch, is contraindicated
in individuals with liver dysfunction or disease. The FDA also
warned of the increased risk of developing probable dementia associated
with the use of conjugated estrogen (CE) plus medroxyprogesterone
acetate (MPA) therapy compared with placebo in postmenopausal women
aged 65 years and older. The FDA notes that it is unknown whether
the warning applies to younger postmenopausal women or to those
taking estrogen-only therapy.Results of the WHI also showed increased
risks of myocardial infarction, stroke, invasive breast cancer,
pulmonary emboli, and deep vein thrombosis in postmenopausal women
(aged 50-79 years) during five years of treatment with CE plus
MPA.
Nolvadex (Tamoxifen) revised safety
labeling to warn of the risk of uterine malignancies that may be
associated with its use based on results of the Breast Cancer Prevention
Trial that demonstrated increased risks of endometrial adenocarcinoma
and uterine sarcoma in patients receiving tamoxifen compared with
placebo (incidence rates per 1,000 women-years, 2.20 vs 0.71 and
0.17 vs 0.04, respectively).
Ammonul, sodium phenylacetate
plus sodium benzoate injection for treatment of acute hyperammonemia
and associated encephalopathy in patients with urea cycle disorder
(UCD).
VIGIV (Vaccinia Immune
Globulin Intravenous) for the treatment and modification of certain
rare complications of smallpox vaccination.
TQ-1017 orphan drug for a once-daily
secure-release formulation of tramadol for the management of HIV-related
neuropathic pain.
PediGuard-(PediGuard Nerve Detector
System) for real-time detection of possible penetration outside
the vertebral pedicle during pedicle screw placement in spine surgery.
OmniPod system consists of a continuous
subcutaneous insulin infusion device with an automatic inserter
and insulin reservoir and a wireless, hand-held personal diabetes
manager (PDM)
Regenafil, demineralized bone
matrix (DBM) allograft paste products for use in spinal and orthopaedic
applications to fill voids in bone. The products consist of allograft
DBM and a gelatin carrier. The DBM products are packaged and marketed
under different names according to their application: Regenafil and Regenafil
RT allograft pastes are used to fill small gaps in bones
of the maxillofacial area; Optefil and Optefil
RT allograft pastes/syringes are used to fill gaps in
bone; Osteofil and Osteofil RT DBM pastes are used as bone void
fillers in cervical and lumbar procedures.
UK Clears Chiron Factory to Make Flu Shots Again [Medscape report]
Editorials: Population-Based Screening for Celiac
Disease: Improvement in Morbidity and Mortality From Osteoporosis? Arch
Intern Med. 2005;165:370-372.
Invasive Amebiasis as an Emerging Parasitic Disease
in Patients With Human Immunodeficiency Virus Type 1 Infection
in Taiwan. Arch
Intern Med. 2005;165:409-415.
The Changing Incidence of AIDS Events in Patients
Receiving Highly Active Antiretroviral Therapy. The Antiretroviral
Therapy Cohort Collaboration. Arch
Intern Med. 2005;165:416-423.
Performance of Screening Questionnaires and Risk
Scores for Undiagnosed Diabetes: The KORA Survey 2000. Arch
Intern Med. 2005;165:436-441.
Pulse Oximetry as a Potential Screening Tool for
Lower Extremity Arterial Disease in Asymptomatic Patients With
Diabetes Mellitus. Arch
Intern Med. 2005;165:442-446.
Type 2 Diabetes, Glycemic Control, and Continuous
Positive Airway Pressure in Obstructive Sleep Apnea. Arch
Intern Med. 2005;165:447-452.
Prospective Validation of a Prediction Model for
Isolating Inpatients With Suspected Pulmonary Tuberculosis. Arch
Intern Med. 2005;165:453-457.
§ MEDWATCH: Tysabri (natalizumab)
Marketing of Tysabri (natalizumab) has been suspended due to two serious
adverse events reported with its use. FDA received reports of one confirmed,
fatal case and one possible case of progressive multifocal leukoencephalopathy
(PML) in patients receiving Tysabri for multiple sclerosis. Although the
relationship between Tysabri and PML is not known at this time, because
of the rare, serious and often fatal nature of PML, FDA announced the following,
effective immediately:
Biogen Idec is voluntarily suspending marketing
of Tysabri.
Biogen Idec is suspending dosing of Tysabri in
clinical trials and is notifying patients and investigators of
the possible association between Tysabri and PML.
Patients being treated with Tysabri should contact
their physician to discuss appropriate alternative treatments.
§ Deep
Brain Stimulation for Treatment-Resistant Depression. Neuron,
Volume 45, Number 5, March 3, 2005, pages 651–660: [Euekalert:
Brain stimulation treats resistant depression. Medscape]
Trouble on the pitch: are professional football players at increased
risk of developing amyotrophic lateral sclerosis? Brain
2005 128: 451-453.
§ Severely
increased risk of amyotrophic lateral sclerosis among Italian professional
football players. Brain Advance Access published on January 5, 2005. Brain
2005 128: 472-476.
Access to catheterisation facilities in patients
admitted with acute coronary syndrome: multinational registry study. BMJ 2005;330:441.
Atypical antipsychotic drugs and risk of ischaemic
stroke: population based retrospective cohort study. BMJ 2005;330:445.
Exercises to prevent lower limb injuries in youth
sports: cluster randomised controlled trial. BMJ 2005;330:449.
Reproduction of chest pain by palpation: diagnostic
accuracy in suspected pulmonary embolism. BMJ 2005;330:452-453.
Inequity of use of implantable cardioverter defibrillators
in England: retrospective analysis. BMJ 2005;330:454-455
DRUG POINTS: Nausea and vomiting due to insulin
glargine in patient with type 1 diabetes mellitus. BMJ 2005;330:455
§ Primary
care: Effectiveness of lactam antibiotics compared with antibiotics
active against atypical pathogens in non-severe community acquired
pneumonia: meta-analysis. BMJ 2005;330:456
Commentary: A step forward in the everyday management
of adults with community acquired pneumonia. BMJ 2005;330:460.